{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:11Z","timestamp":1771545611663,"version":"3.50.1"},"reference-count":43,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.3892\/etm.2016.3843","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T12:30:38Z","timestamp":1477485038000},"page":"3685-3693","source":"Crossref","is-referenced-by-count":5,"title":["Radioprotective effects of pyrroloquinoline quinone on parotid glands in C57BL\/6J mice"],"prefix":"10.3892","volume":"12","author":[{"given":"Yuanqing","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengshun","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2016,10,26]]},"reference":[{"key":"key20180108133718_b1-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.radonc.2011.12.013","article-title":"Organizing Committee for the Working Group for Head Neck Cancer: Results of carbon ion radiotherapy for head and neck cancer","volume":"103","author":"Mizoe","year":"2012","journal-title":"Radiother Oncol"},{"key":"key20180108133718_b2-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0360-3016(96)00604-9","article-title":"Mastication and swallowing in patients with postirradiation xerostomia","volume":"37","author":"Hamlet","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180108133718_b3-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/hed.10255","article-title":"Xerostomia: 12-month changes in saliva production and its relationship to perception and performance of swallow function, oral intake, and diet after chemoradiation","volume":"25","author":"Logemann","year":"2003","journal-title":"Head Neck"},{"key":"key20180108133718_b4-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0167-8140(96)01732-X","article-title":"Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells","volume":"39","author":"Nunez","year":"1996","journal-title":"Radiother Oncol"},{"key":"key20180108133718_b5-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10495-005-3346-1","article-title":"Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy","volume":"11","author":"Di Pietro","year":"2006","journal-title":"Apoptosis"},{"key":"key20180108133718_b6-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.freeradbiomed.2009.11.005","article-title":"Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells","volume":"48","author":"Wang","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"key20180108133718_b7-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1016\/S0021-9258(18)91183-X","article-title":"Glucose dehydrogenase of bacterium anitratum: An enzyme with a novel prosthetic group","volume":"239","author":"Hauge","year":"1964","journal-title":"J Biol Chem"},{"key":"key20180108133718_b8-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/1528-0691(2001)1:1<74::AID-TCR10>3.0.CO;2-E","article-title":"Cofactor diversity in biological oxidations: Implications and applications","volume":"1","author":"Duine","year":"2001","journal-title":"Chem Rec"},{"key":"key20180108133718_b9-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/abio.1999.4039","article-title":"Characterization of pyrroloquinoline quinone amino acid derivatives by electrospray ionization mass spectrometry and detection in human milk","volume":"269","author":"Mitchell","year":"1999","journal-title":"Anal Biochem"},{"key":"key20180108133718_b10-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1042\/bj3070331","article-title":"Levels of pyrroloquinoline quinone in various foods","volume":"307","author":"Kumazawa","year":"1995","journal-title":"Biochem J"},{"key":"key20180108133718_b11-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/jn\/130.4.719","article-title":"Physiological importance of quinoenzymes and the O-quinone family of cofactors","volume":"130","author":"Stites","year":"2000","journal-title":"J Nutr"},{"key":"key20180108133718_b12-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/jn\/124.5.744","article-title":"Dietary pyrroloquinoline quinone: Grono irradiationh and immune response in BALB\/c mice","volume":"124","author":"Steinberg","year":"1994","journal-title":"J Nutr"},{"key":"key20180108133718_b13-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/153537020322800205","article-title":"Pyrroloquinoline quinone improves grono irradiationh and reproductive performance in mice fed chemically defined diets","volume":"228","author":"Steinberg","year":"2003","journal-title":"Exp Biol Med (Maywood)"},{"key":"key20180108133718_b14-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.brainres.2006.03.111","article-title":"Neuroprotection by pyrroloquinoline quinone (PQQ) in reversible middle cerebral artery occlusion in the adult rat","volume":"1094","author":"Zhang","year":"2006","journal-title":"Brain Res"},{"key":"key20180108133718_b15-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1046\/j.1460-9568.2002.02169.x","article-title":"The essential nutrient pyrroloquinoline quinone may act as a neuroprotectant by suppressing peroxynitrite formation","volume":"16","author":"Zhang","year":"2002","journal-title":"Eur J Neurosci"},{"key":"key20180108133718_b16-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/1074248406288757","article-title":"Comparison of pyrroloquinoline quinone and\/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia\/reperfusion injury","volume":"11","author":"Zhu","year":"2006","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"key20180108133718_b17-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3164\/jcbn.2008005","article-title":"Pyrroloquinoline Quinone (PQQ) prevents cognitive deficit caused by oxidative stress in rats","volume":"42","author":"Ohwada","year":"2008","journal-title":"J Clin Biochem Nutr"},{"key":"key20180108133718_b18-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1179\/174329210X12650506623762","article-title":"Role of glutathione in augmenting the anticancer activity of pyrroloquinoline quinone (PQQ)","volume":"15","author":"Shankar","year":"2010","journal-title":"Redox Rep"},{"key":"key20180108133718_b19-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1021\/jf802197d","article-title":"Kinetic study of the antioxidant activity of pyrroloquinolinequinol (PQQH(2), a reduced form of pyrroloquinolinequinone) in micellar solution","volume":"57","author":"Ouchi","year":"2009","journal-title":"J Agric Food Chem"},{"key":"key20180108133718_b20-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/jn\/136.2.390","article-title":"Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice","volume":"136","author":"Stites","year":"2006","journal-title":"J Nutr"},{"key":"key20180108133718_b21-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1271\/bbb.90764","article-title":"Pro-oxidant action of pyrroloquinoline quinone: Characterization of protein oxidative modifications","volume":"74","author":"Ishii","year":"2010","journal-title":"Biosci Biotechnol Biochem"},{"key":"key20180108133718_b22-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bbrc.2007.08.041","article-title":"Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes","volume":"363","author":"Tao","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108133718_b23-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.febslet.2004.10.061","article-title":"Pyrroloquinoline-quinone: A reactive oxygen species scavenger in bacteria","volume":"578","author":"Misra","year":"2004","journal-title":"FEBS Lett"},{"key":"key20180108133718_b24-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"e21779","DOI":"10.1371\/journal.pone.0021779","article-title":"Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats","volume":"6","author":"Bauerly","year":"2011","journal-title":"PLoS One"},{"key":"key20180108133718_b25-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1677\/JOE-09-0247","article-title":"Distinctive anabolic roles of 1,25-dihydroxyvitamin D(3) and parathyroid hormone in teeth and mandible versus long bones","volume":"203","author":"Liu","year":"2009","journal-title":"J Endocrinol"},{"key":"key20180108133718_b26-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/BF00331373","article-title":"Distinction of apoptotic and necrotic cell death by in situ labelling of fragmented DNA","volume":"278","author":"Kressel","year":"1994","journal-title":"Cell Tissue Res"},{"key":"key20180108133718_b27-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/hmg\/ddi160","article-title":"Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development","volume":"14","author":"Xue","year":"2005","journal-title":"Hum Mol Genet"},{"key":"key20180108133718_b28-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1084\/jem.182.2.367","article-title":"Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death","volume":"182","author":"Zamzami","year":"1995","journal-title":"J Exp Med"},{"key":"key20180108133718_b29-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"868","DOI":"10.14219\/jada.archive.1965.0220","article-title":"Acquired dental defects and salivary gland lesions after irradiation for carcinoma","volume":"70","author":"Franke","year":"1965","journal-title":"J Am Dent Assoc"},{"key":"key20180108133718_b30-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1259\/0007-1285-32-381-596","article-title":"Injury and repair following irradiation of salivary glands in male rats","volume":"32","author":"Cherry","year":"1959","journal-title":"Br J Radiol"},{"key":"key20180108133718_b31-etm-0-0-3843","first-page":"432","article-title":"X-ray-induced changes in function and structure of the rat parotid gland","volume":"28","author":"Phillipe","year":"1970","journal-title":"J Oral Surg"},{"key":"key20180108133718_b32-etm-0-0-3843","first-page":"340","article-title":"Early radiation injury in the rat parotid gland. Reaction of acinar cells and vascular endothelium","volume":"31","author":"Sholley","year":"1974","journal-title":"Lab Invest"},{"key":"key20180108133718_b33-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1002\/cncr.22302","article-title":"Radiation-induced xerostomia in patients with head and neck cancer: A literature review","volume":"107","author":"Dirix","year":"2006","journal-title":"Cancer"},{"key":"key20180108133718_b34-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0167-8140(96)01732-X","article-title":"Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells","volume":"39","author":"Nu\u00f1ez","year":"1996","journal-title":"Radiother Oncol"},{"key":"key20180108133718_b35-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0891-5849(95)00033-T","article-title":"Whole body X-ray irradiation to mice decreases ascorbic acid concentration in bone marrow: Comparison between ascorbic acid and vitamin E","volume":"19","author":"Umegaki","year":"1995","journal-title":"Free Radic Biol Med"},{"key":"key20180108133718_b36-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0891-5849(94)90170-8","article-title":"Decrease in vitamin E levels in the bone marrow of mice receiving whole-body X-ray irradiation","volume":"17","author":"Umegaki","year":"1994","journal-title":"Free Radic Biol Med"},{"key":"key20180108133718_b37-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/BF01254473","article-title":"Evidence for early and persistent impairment of salivary gland excretion after irradiation of head and neck tumours","volume":"23","author":"Liem","year":"1996","journal-title":"Eur J Nucl Med"},{"key":"key20180108133718_b38-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3181\/00379727-221-44379A","article-title":"Preemptive pharmacologic intervention in radiation-induced salivary dysfunction","volume":"221","author":"Taylor","year":"1999","journal-title":"Proc Soc Exp Biol Med"},{"key":"key20180108133718_b39-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1034\/j.1601-0825.2002.02838.x","article-title":"The enigmatic mechanism of irradiation-induced damage to the major salivary glands","volume":"8","author":"Nagler","year":"2002","journal-title":"Oral Dis"},{"key":"key20180108133718_b40-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2307\/3578638","article-title":"Acute effects of X irradiation on the function of rat salivary glands","volume":"136","author":"Nagler","year":"1993","journal-title":"Radiat Res"},{"key":"key20180108133718_b41-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1590\/S1678-77572007000300003","article-title":"Ultrastructural evaluation of the radioprotective effect of sodium selenite on submandibular glands in rats","volume":"15","author":"Pontual","year":"2007","journal-title":"J Appl Oral Sci"},{"key":"key20180108133718_b42-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3109\/09553002.2010.533247","article-title":"Histamine prevents functional and morphological alterations of submandibular glands induced by ionising radiation","volume":"87","author":"Medina","year":"2011","journal-title":"Int J Radiat Biol"},{"key":"key20180108133718_b43-etm-0-0-3843","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1158\/1078-0432.CCR-07-0662","article-title":"Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging","volume":"13","author":"Cotrim","year":"2007","journal-title":"Clin Cancer Res"}],"updated-by":[{"DOI":"10.3892\/etm.2024.12644","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"record-id":"69372"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/etm.2016.3843\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T12:56:40Z","timestamp":1657544200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2016.3843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,26]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,10,26]]},"published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.3892\/etm.2016.3843"],"URL":"https:\/\/doi.org\/10.3892\/etm.2016.3843","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,26]]}}}