{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:50:05Z","timestamp":1759402205283},"reference-count":58,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2017.5108","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T08:28:40Z","timestamp":1504600120000},"source":"Crossref","is-referenced-by-count":4,"title":["Role of IL\u201115 in the modulation of TGF\u2011\u03b21\u2011mediated inflammation in asthma"],"prefix":"10.3892","author":[{"given":"Mateusz","family":"Jonakowski","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 90\u2011153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Zio\u0142o","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 90\u2011153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelina","family":"Ko\u0107win","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 90\u2011153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelina","family":"Przem\u0119cka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 90\u2011153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Mokros","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Lodz, 90\u2011153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Panek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 90\u2011153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Szemraj","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Medical University of Lodz, 92\u2011215 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Kuna","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 90\u2011153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"key":"key20200713142450_b1-etm-0-0-5108","volume-title":"Wydawnictwo Lekarskie PZWL","author":"Droszcz","year":"2007"},{"key":"key20200713142450_b2-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"15050","DOI":"10.1038\/npjpcrm.2015.50","article-title":"The GINA asthma strategy report: What's new for primary care?","volume":"25","author":"Reddel","year":"2015","journal-title":"Primary Care Respiratory Med"},{"key":"key20200713142450_b3-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/00063198-200401000-00008","article-title":"Clinical phenotypes of asthma","volume":"10","author":"Bel","year":"2004","journal-title":"Curr Opin Pulm Med"},{"key":"key20200713142450_b4-etm-0-0-5108","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1242\/jcs.115.17.3355","article-title":"Smad signalling network","volume":"115","author":"Moustakas","year":"2002","journal-title":"J Cell Sci"},{"key":"key20200713142450_b5-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1126\/science.1071809","article-title":"Signal transduction by the TGF-beta superfamily","volume":"296","author":"Attisano","year":"2002","journal-title":"Science"},{"key":"key20200713142450_b6-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1046\/j.1523-1747.2002.01641.x","article-title":"Transforming growth factor-beta signaling through the Smad pathway: Role in extracellular matrix gene expression and regulation","volume":"118","author":"Verrecchia","year":"2002","journal-title":"J Invest Dermatol"},{"key":"key20200713142450_b7-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1165\/rcmb.2010-0027TR","article-title":"Role of transforming growth factor-\u03b2 in airway remodeling in asthma","volume":"44","author":"Halwani","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20200713142450_b8-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1006\/clin.1997.4409","article-title":"TGF-beta: A critical modulator of immune cell function","volume":"84","author":"Letterio","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"key20200713142450_b9-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S1094-5539(03)00051-8","article-title":"Transforming growth factor-beta and its role in asthma","volume":"16","author":"Duvernelle","year":"2003","journal-title":"Pulm Pharmacol Ther"},{"key":"key20200713142450_b10-etm-0-0-5108","first-page":"1","article-title":"Role of cytokines in pathophysiology of asthma","volume":"5","author":"Mehta","year":"2006","journal-title":"Iranian J Pharmacol Therapeut"},{"key":"key20200713142450_b11-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.coph.2004.04.003","article-title":"Interleukin-15: A new cytokine target for the treatment of inflammatory diseases","volume":"4","author":"McInnes","year":"2004","journal-title":"Curr Opin Pharmacol"},{"key":"key20200713142450_b12-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/0888-7543(95)80013-C","article-title":"Chromosomal assignment and genomic structure of II15","volume":"25","author":"Anderson","year":"1995","journal-title":"Genomics"},{"key":"key20200713142450_b13-etm-0-0-5108","doi-asserted-by":"crossref","first-page":"735","DOI":"10.4049\/jimmunol.156.2.735","article-title":"Induction and regulation of IL-15 expression in murine macrophages","volume":"156","author":"Doherty","year":"1996","journal-title":"J Immunol"},{"key":"key20200713142450_b14-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/BF01540911","article-title":"Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex","volume":"16","author":"Kennedy","year":"1996","journal-title":"J Clin Immunol"},{"key":"key20200713142450_b15-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1084\/jem.184.2.325","article-title":"Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T\/natural killer progenitor cells","volume":"184","author":"Leclercq","year":"1996","journal-title":"J Exp Med"},{"key":"key20200713142450_b16-etm-0-0-5108","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4049\/jimmunol.154.2.483","article-title":"IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation","volume":"154","author":"Armitage","year":"1995","journal-title":"J Immunol"},{"key":"key20200713142450_b17-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s000110050331","article-title":"Interleukin-15 and its role in chronic inflammatory diseases","volume":"47","author":"Kirman","year":"1998","journal-title":"Inflamm Res"},{"key":"key20200713142450_b18-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1067\/mai.2001.119556","article-title":"Expression of IL-15 in inflammatory pulmonary diseases","volume":"108","author":"Muro","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"key20200713142450_b19-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1165\/ajrcmb.26.4.4517","article-title":"Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation","volume":"26","author":"Hoontrakoon","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20200713142450_b20-etm-0-0-5108","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.4049\/jimmunol.156.7.2400","article-title":"IL-15 promotes cytokine production of human T helper cells","volume":"156","author":"Mori","year":"1996","journal-title":"J Immunol"},{"key":"key20200713142450_b21-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.4049\/jimmunol.166.3.1991","article-title":"Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in a murine model of asthma","volume":"166","author":"Ishimitsu","year":"2001","journal-title":"J Immunol"},{"key":"key20200713142450_b22-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"e1002114","DOI":"10.1371\/journal.ppat.1002114","article-title":"The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations","volume":"7","author":"Laza-Stanca","year":"2011","journal-title":"PLoS Pathog"},{"key":"key20200713142450_b23-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1046\/j.1365-2222.2001.01174.x","article-title":"Immuno-regulatory cytokines in asthma: IL-15 and IL-13 in induced sputum","volume":"31","author":"Komai-Koma","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"key20200713142450_b24-etm-0-0-5108","year":"2017","journal-title":"Global Initiative for Asthma: Global Strategy for Asthma Management and Prevention, Updated"},{"key":"key20200713142450_b25-etm-0-0-5108","article-title":"Zalecenia Polskiego Towarzystwa Ftyzjopneumonologicznego dotycz\u0105ce wykonywania bada\u0144 spirometrycznych","volume":"74","year":"2006","journal-title":"PPneumonologia i Alergologia Polska"},{"key":"key20200713142450_b26-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"Miller","year":"2005","journal-title":"Eur Respir J"},{"key":"key20200713142450_b27-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jaci.2003.09.008","article-title":"Development of the asthma control test: A survey for assessing asthma control","volume":"113","author":"Nathan","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"key20200713142450_b28-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1249\/00005768-198205000-00012","article-title":"Psychophysical bases of perceived exertion","volume":"14","author":"Borg","year":"1982","journal-title":"Med Sci Sports Exerc"},{"key":"key20200713142450_b29-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nprot.2006.83","article-title":"The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: Twenty-something years on","volume":"1","author":"Chomczynski","year":"2006","journal-title":"Nat Protoc"},{"key":"key20200713142450_b30-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1006\/abio.1987.9999","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"key20200713142450_b31-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"key20200713142450_b32-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1006\/abio.1999.4085","article-title":"Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro","volume":"270","author":"Winer","year":"1999","journal-title":"Anal Biochem"},{"key":"key20200713142450_b33-etm-0-0-5108","first-page":"67","article-title":"Identification and association of TGF\u03b2-1 expression in patients with asthma in a Polish population-Lodz metropolitan area study","volume":"4","author":"Panek","year":"2013","journal-title":"Int J Biochem Mol Biol"},{"key":"key20200713142450_b34-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"290","DOI":"10.5603\/PiAP.2016.0037","article-title":"The role of the TGF-SMAD signalling pathway in the etiopathogenesis of severe asthma","volume":"84","author":"Ko\u0107win","year":"2016","journal-title":"Pneumonol Alergol Pol"},{"key":"key20200713142450_b35-etm-0-0-5108","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3892\/ijmm.2014.1894","article-title":"Identification and association of the single nucleotide polymorphisms, C-509T, C+466T and T+869C, of the TGF-\u03b21 gene in patients with asthma and their influence on the mRNA expression level of TGF-\u03b21","volume":"34","author":"Panek","year":"2014","journal-title":"Int J Mol Med"},{"key":"key20200713142450_b36-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1007\/s10753-015-0123-3","article-title":"The NR3C1 glucocorticoid receptor gene polymorphisms may modulate the TGF-beta mRNA expression in asthma patients","volume":"38","author":"Panek","year":"2015","journal-title":"Inflammation"},{"key":"key20200713142450_b37-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/sj.ejhg.5201541","article-title":"Family based association analysis of the IL2 and IL15 genes in allergic disorders","volume":"14","author":"Christensen","year":"2005","journal-title":"Eur J Hum Genet"},{"key":"key20200713142450_b38-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/j.1398-9995.2008.01830.x","article-title":"IL15 gene variants are not associated with asthma and atopy","volume":"64","author":"Pinto","year":"2009","journal-title":"Allergy"},{"key":"key20200713142450_b39-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1111\/j.1398-9995.2006.01059.x","article-title":"Confirmation of association of IL-15 with pediatric asthma and comparison of different controls","volume":"61","author":"Bierbaum","year":"2006","journal-title":"Allergy"},{"key":"key20200713142450_b40-etm-0-0-5108","first-page":"200","article-title":"Influence of IL15 gene polymorphism on the course of bronchial asthma in children","volume":"16","author":"Jachnik","year":"2011","journal-title":"Alergia Astma Immunologia"},{"key":"key20200713142450_b41-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.immuni.2009.04.020","article-title":"Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells","volume":"31","author":"Sanjabi","year":"2009","journal-title":"Immunity"},{"key":"key20200713142450_b42-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1053\/j.gastro.2006.12.025","article-title":"Inhibition of TGF-beta signaling by IL-15: A new role for IL-15 in the loss of immune homeostasis in celiac disease","volume":"132","author":"Benahmed","year":"2007","journal-title":"Gastroenterology"},{"key":"key20200713142450_b43-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1183\/09031936.00099811","article-title":"RSV infection modulates IL-15 production and MICA levels in respiratory epithelial cells","volume":"39","author":"Zdrenghea","year":"2012","journal-title":"Eur Respir J"},{"key":"key20200713142450_b44-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"7338","DOI":"10.1128\/JVI.74.16.7338-7348.2000","article-title":"Viral activation of interleukin-15 (IL-15): Characterization of a virus-inducible element in the IL-15 promoter region","volume":"74","author":"Azimi","year":"2000","journal-title":"J Virol"},{"key":"key20200713142450_b45-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jim.2011.08.020","article-title":"Effect of IL-15 on IgG versus IgE antibody-secreting cells in vitro","volume":"375","author":"Esen","year":"2012","journal-title":"J Immunol Methods"},{"key":"key20200713142450_b46-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"e0136549","DOI":"10.1371\/journal.pone.0136549","article-title":"Serum IgE induced airway smooth muscle cell remodeling is independent of allergens and is prevented by omalizumab","volume":"10","author":"Roth","year":"2015","journal-title":"PLoS One"},{"key":"key20200713142450_b47-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s40265-014-0203-y","article-title":"Omalizumab for severe asthma: Efficacy beyond the atopic patient?","volume":"74","author":"Domingo","year":"2014","journal-title":"Drugs"},{"key":"key20200713142450_b48-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1710-1492-7-9","article-title":"Long-term benefits of omalizumab in a patient with severe non-allergic asthma","volume":"7","author":"Menzella","year":"2011","journal-title":"Allergy Asthma Clin Immunol"},{"key":"key20200713142450_b49-etm-0-0-5108","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5603\/ARM.27844","article-title":"Omalizumab, recombinant humanized monoclonal antibody anti-IgE-new fields of studies on the therapeutic indications","volume":"77","author":"Kupry\u015b-Lipi\u0144ska","year":"2009","journal-title":"Pneumonol Alergol Pol"},{"key":"key20200713142450_b50-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"906","DOI":"10.5114\/aoms.2013.33180","article-title":"HSP70\/CD80 DNA vaccine inhibits airway remodeling by regulating the transcription factors T-bet and GATA-3 in a murine model of chronic asthma","volume":"9","author":"Yan","year":"2013","journal-title":"Archives Med Sci"},{"key":"key20200713142450_b51-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1007\/s00262-011-1067-6","article-title":"Effect of the simultaneous administration of glucocorticoids and IL-15 on human NK cell phenotype, proliferation and function","volume":"60","author":"Moustaki","year":"2011","journal-title":"Cancer Immunol Immunother"},{"key":"key20200713142450_b52-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S0165-6147(98)01229-2","article-title":"Induction of cytokine receptors by glucocorticoids: Functional and pathological significance","volume":"19","author":"Wiegers","year":"1998","journal-title":"Trends Pharmacol Sci"},{"key":"key20200713142450_b53-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1038\/ni.2449","article-title":"Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15","volume":"13","author":"Ring","year":"2012","journal-title":"Nat Immunol"},{"key":"key20200713142450_b54-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1172\/JCI116963","article-title":"Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy","volume":"93","author":"Sher","year":"1994","journal-title":"J Clin Invest"},{"key":"key20200713142450_b55-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"L764","DOI":"10.1152\/ajplung.00342.2011","article-title":"Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts","volume":"302","author":"Sugiura","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key20200713142450_b56-etm-0-0-5108","first-page":"39","article-title":"Phosphodiesterase inhibitors as immunomodulatory drugs","volume":"22","author":"Layseca-Espinosa","year":"2003","journal-title":"Inmunologi\u0301a"},{"key":"key20200713142450_b57-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.cyto.2013.06.056","article-title":"53: Inhibition of interleukin-15 dependent cytotoxic T-cell proliferation by the action of adenosine on dendritic cell","volume":"63","author":"Cohen","year":"2013","journal-title":"Cytokine"},{"key":"key20200713142450_b58-etm-0-0-5108","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.mehy.2013.04.021","article-title":"Could interleukin-15 potentiate histone deacetylase inhibitor effects in haematological malignancy?","volume":"81","author":"Zdrenghea","year":"2013","journal-title":"Med Hypotheses"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:31:10Z","timestamp":1692966670000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2017.5108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,5]]},"references-count":58,"URL":"https:\/\/doi.org\/10.3892\/etm.2017.5108","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,5]]}}}