{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:15:19Z","timestamp":1791483319720,"version":"4.3.4"},"reference-count":52,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2017.5287","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T10:10:22Z","timestamp":1507716622000},"source":"Crossref","is-referenced-by-count":9,"title":["\u03b1\u2011klotho and anemia in patients with chronic kidney disease patients: A new perspective (Review)"],"prefix":"10.3892","author":[{"given":"Yang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Nephrology, Nanchang University School of Medicine, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Peng","sequence":"additional","affiliation":[{"name":"Nanchang University School of Medicine, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"key":"key20200713142838_b1-etm-0-0-5287","doi-asserted-by":"crossref","first-page":"197","DOI":"10.5507\/bp.2013.093","article-title":"Pathophysiology of anemia in chronic kidney diseases: A review","volume":"159","author":"Zadrazil","year":"2015","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"key20200713142838_b2-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.semnephrol.2016.05.004","article-title":"The patterns, risk factors and prediction of progression in chronic kidney disease: A narrative review","volume":"36","author":"Collister","year":"2016","journal-title":"Semin Nephrol"},{"key":"key20200713142838_b3-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1056\/NEJMoa065485","article-title":"CHOIR Investigators: Correction of anemia with epoetin alfa in chronic kidney disease","volume":"355","author":"Singh","year":"2006","journal-title":"N Engl J Med"},{"key":"key20200713142838_b4-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1056\/NEJMoa062276","article-title":"CREATE Investigators: Normalization of hemoglobin level in patients with chronic kidney disease and anemia","volume":"355","author":"Dr\u00fceke","year":"2006","journal-title":"N Engl J Med"},{"key":"key20200713142838_b5-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1056\/NEJMoa0907845","article-title":"A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease","volume":"361","author":"Pfeffer","year":"2009","journal-title":"N Engl J Med"},{"key":"key20200713142838_b6-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/bs.vh.2016.02.006","article-title":"Function and change with aging of alpha-klotho in the kidney","volume":"101","author":"Akasaka-Manya","year":"2016","journal-title":"Vitam and horm"},{"key":"key20200713142838_b7-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"key":"key20200713142838_b8-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.mce.2008.10.052","article-title":"The Klotho gene family as a regulator of endocrine fibroblast growth factors","volume":"299","author":"Kurosu","year":"2009","journal-title":"Mol Cell Endocrinol"},{"key":"key20200713142838_b9-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.kint.2016.04.009","article-title":"In vivo evidence for a limited role of proximal tubular klotho in renal phosphate handling","volume":"99","author":"Ide","year":"2016","journal-title":"Kidney Int"},{"key":"key20200713142838_b10-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1681\/ASN.2014101030","article-title":"Renal production, uptake and handling of circulating \u03b1Klotho","volume":"27","author":"Hu","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"key20200713142838_b11-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1016\/j.ajpath.2015.08.004","article-title":"Klotho ameliorates kidney injury and fibrosis and normalizes blood pressure by targeting the renin-angiotensin system","volume":"185","author":"Zhou","year":"2015","journal-title":"Am J Pathol"},{"key":"key20200713142838_b12-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s10157-015-1202-3","article-title":"Klotho attenuates renal hypertrophy and glomerular injury in Ins2Akita diabetic mice","volume":"20","author":"Kadoya","year":"2016","journal-title":"Clin Exp Nephrol"},{"key":"key20200713142838_b13-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1681\/ASN.2014040325","article-title":"Soluble klotho protects against uremic cardiomyopathy independently of fibroblast growth factor 23 and phosphate","volume":"26","author":"Xie","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"key20200713142838_b14-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"21","DOI":"10.17116\/terarkh201688621-25","article-title":"Impact of anemia correction on the production of the circulating morphogenetic protein alpha-Klotho in patients with stages 3B-4 chronic kidney disease: A new direction of cardionephroprotection","volume":"88","author":"Milovanov","year":"2016","journal-title":"Ter Arkh"},{"key":"key20200713142838_b15-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.arr.2008.10.002","article-title":"Current understanding of klotho","volume":"8","author":"Wang","year":"2009","journal-title":"Ageing Res Rev"},{"key":"key20200713142838_b16-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1210\/er.2013-1079","article-title":"Molecular basis of Klotho: from gene to function in aging","volume":"36","author":"Xu","year":"2015","journal-title":"Endocr Rev"},{"key":"key20200713142838_b17-etm-0-0-5287","unstructured":"ChenCDPodvinSGillespieELeemanSEAbrahamCRInsulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17Proc Natl Acad Sci USA1041979619801200710.1073\/pnas.070980510418056631"},{"key":"key20200713142838_b18-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1681\/ASN.2012010048","article-title":"Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism","volume":"23","author":"Olauson","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"key20200713142838_b19-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1152\/physrev.00002.2011","article-title":"Regulation and function of the FGF23\/klotho endocrine pathways","volume":"92","author":"Martin","year":"2012","journal-title":"Physiol Rev"},{"key":"key20200713142838_b20-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/jdi.12410","article-title":"Periodontitis aggravated pancreatic beta-cell dysfunction in diabetic mice through interleukin-12 regulation on Klotho","volume":"7","author":"Liu","year":"2016","journal-title":"J Diabetes Investig"},{"key":"key20200713142838_b21-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/acel.12494","article-title":"Deficiency in the anti-aging gene Klotho promotes aortic valve fibrosis through AMPK\u03b1-mediated activation of RUNX2","volume":"15","author":"Chen","year":"2016","journal-title":"Aging cell"},{"key":"key20200713142838_b22-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.ajpath.2013.11.016","article-title":"Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis","volume":"184","author":"Madathil","year":"2014","journal-title":"Am J Pathol"},{"key":"key20200713142838_b23-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1159\/000446273","article-title":"Novel masters of erythropoiesis: hypoxia inducible factors and recent advances in anemia of renal disease","volume":"42","author":"Solak","year":"2016","journal-title":"Blood purif"},{"key":"key20200713142838_b24-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1093\/gerona\/glu170","article-title":"Klotho prevents NF\u03baB translocation and protects endothelial cell from senescence induced by uremia","volume":"70","author":"Buendia","year":"2015","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"key20200713142838_b25-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s00424-009-0636-4","article-title":"Accelerated suicidal erythrocyte death in Klotho-deficient mice","volume":"458","author":"Kempe","year":"2009","journal-title":"Pflugers Arch"},{"key":"key20200713142838_b26-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1182\/blood-2012-09-453522","article-title":"Control of iron deficiency anemia in low- and middle-income countries","volume":"121","author":"Pasricha","year":"2013","journal-title":"Blood"},{"key":"key20200713142838_b27-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1053\/j.ajkd.2009.10.043","article-title":"Bone marrow iron, iron indices and the response to intravenous iron in patients with non-dialysis-dependent CKD","volume":"55","author":"Stancu","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"key20200713142838_b28-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1179\/1607845415Y.0000000004","article-title":"Bone marrow iron distribution, hepcidin and ferroportin expression in renal anemia","volume":"20","author":"Barsan","year":"2015","journal-title":"Hematology"},{"key":"key20200713142838_b29-etm-0-0-5287","first-page":"36","article-title":"Significance of the morphogenetic proteins FGF-23 and Klotho as predictors of prognosis of chronic kidney disease","volume":"86","author":"Milovanova","year":"2014","journal-title":"Ter Arkh"},{"key":"key20200713142838_b30-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S0014-5793(03)00894-9","article-title":"Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat","volume":"551","author":"Saito","year":"2003","journal-title":"FEBS Lett"},{"key":"key20200713142838_b31-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1053\/j.gastro.2011.03.007","article-title":"Hypoxia-inducible factor-2\u03b1 mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice","volume":"140","author":"Taylor","year":"2011","journal-title":"Gastroenterology"},{"key":"key20200713142838_b32-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"e107228","DOI":"10.1371\/journal.pone.0107228","article-title":"Vitamin D deficiency aggravates chronic kidney disease progression after ischemic acute kidney injury","volume":"9","author":"Goncalves","year":"2014","journal-title":"PLoS One"},{"key":"key20200713142838_b33-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1093\/ndt\/gfw082","article-title":"Pro: Should we correct vitamin D deficiency\/insufficiency in chronic kidney disease patients with inactive forms of vitamin D or just treat them with active vitamin D forms?","volume":"31","author":"Goldsmith","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"key20200713142838_b34-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1093\/ndt\/gfw080","article-title":"Con: Nutritional vitamin D replacement in chronic kidney disease and end-stage renal disease","volume":"31","author":"Agarwal","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"key20200713142838_b35-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"e1799","DOI":"10.1097\/MD.0000000000001799","article-title":"Vitamin d status and the risk of anemia in community-dwelling adults: Results from the national health and nutrition examination survey 2001\u20132006","volume":"94","author":"Monlezun","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"key20200713142838_b36-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3346\/jkms.2016.31.1.25","article-title":"Prevalence and relationships of iron deficiency anemia with blood cadmium and vitamin D levels in Korean women","volume":"31","author":"Suh","year":"2016","journal-title":"J Korean Med Sci"},{"key":"key20200713142838_b37-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.bbrc.2011.09.117","article-title":"Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells","volume":"414","author":"Forster","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713142838_b38-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.pbiomolbio.2006.02.016","article-title":"Vitamin D physiology","volume":"92","author":"Lips","year":"2006","journal-title":"Prog Biophys Mol Biol"},{"key":"key20200713142838_b39-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/nrneph.2013.111","article-title":"Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism","volume":"9","author":"Kuro-o","year":"2013","journal-title":"Nat Rev Nephrol"},{"key":"key20200713142838_b40-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1159\/000355728","article-title":"25-Hydroxyvitamin D3 1-\u03b1-hydroxylase-dependent stimulation of renal klotho expression by spironolactone","volume":"37","author":"Alesutan","year":"2013","journal-title":"Kidney Blood Press Res"},{"key":"key20200713142838_b41-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1159\/000355773","article-title":"Calcitriol supplementation improves endothelium-dependent vasodilation in rat hypertensive renal injury","volume":"39","author":"Takenaka","year":"2014","journal-title":"Kidney Blood Press Res"},{"key":"key20200713142838_b42-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"24879","DOI":"10.1038\/srep24879","article-title":"1,25(OH)2D3 dependent overt hyperactivity phenotype in klotho-hypomorphic mice","volume":"6","author":"Leibrock","year":"2016","journal-title":"Sci Rep"},{"key":"key20200713142838_b43-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00418-016-1438-3","article-title":"Female cotton rats (Sigmodon hispidus) develop chronic anemia with renal inflammation and cystic changes","volume":"146","author":"Ichii","year":"2016","journal-title":"Histochem Cell Biol"},{"key":"key20200713142838_b44-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1681\/ASN.2010050510","article-title":"Chemokines in renal injury","volume":"22","author":"Chung","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"key20200713142838_b45-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/ki.2014.287","article-title":"Origin of myofibroblasts and cellular events triggering fibrosis","volume":"87","author":"Mack","year":"2015","journal-title":"Kidney Int"},{"key":"key20200713142838_b46-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/MOH.0000000000000236","article-title":"Hepcidin regulation in the anemia of inflammation","volume":"23","author":"Wang","year":"2016","journal-title":"Curr Opin Hematol"},{"key":"key20200713142838_b47-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1126\/science.1112766","article-title":"Suppression of aging in mice by the hormone Klotho","volume":"309","author":"Kurosu","year":"2005","journal-title":"Science"},{"key":"key20200713142838_b48-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1042\/CS20120198","article-title":"Inflammation and the pathogenesis of diabetic nephropathy","volume":"124","author":"Wada","year":"2013","journal-title":"Clin Sci (Lond)"},{"key":"key20200713142838_b49-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.2337\/db10-1262","article-title":"Klotho depletion contributes to increased inflammation in kidney of the db\/db mouse model of diabetes via RelA (serine)536 phosphorylation","volume":"60","author":"Zhao","year":"2011","journal-title":"Diabetes"},{"key":"key20200713142838_b50-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.mce.2015.09.024","article-title":"The function of miR-199a-5p\/Klotho regulating TLR4\/NF-kappaB p65\/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism","volume":"417","author":"Wu","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"key20200713142838_b51-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"F915","DOI":"10.1152\/ajprenal.00480.2015","article-title":"HMGB1\/TLR4 signaling induces an inflammatory response following high-pressure renal pelvic perfusion in a porcine model","volume":"311","author":"Shao","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"key20200713142838_b52-etm-0-0-5287","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.toxlet.2012.10.004","article-title":"Amelioration of uremic toxin indoxyl sulfate-induced endothelial cell dysfunction by Klotho protein","volume":"215","author":"Yang","year":"2012","journal-title":"Toxicol Lett"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T13:32:56Z","timestamp":1594647176000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2017.5287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,11]]},"references-count":52,"URL":"https:\/\/doi.org\/10.3892\/etm.2017.5287","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,11]]}}}