{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:44:28Z","timestamp":1791330268883,"version":"4.3.1"},"reference-count":31,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2017.5458","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T07:57:15Z","timestamp":1510041435000},"source":"Crossref","is-referenced-by-count":7,"title":["The inhibitory roles of Ihh downregulation on chondrocyte growth and differentiation"],"prefix":"10.3892","author":[{"given":"Ang","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha, Hunan 410078, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qile","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"key":"key20200713143310_b1-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1002\/jcp.25641","article-title":"Osteogenic differentiation of periosteal cells during fracture healing","volume":"232","author":"Wang","year":"2017","journal-title":"J Cell Physiol"},{"key":"key20200713143310_b2-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"pii: E2045","DOI":"10.3390\/ijms17122045","article-title":"Cell death in chondrocytes, osteoblasts, and osteocytes","volume":"17","author":"Komori","year":"2016","journal-title":"Int J Mol Sci"},{"key":"key20200713143310_b3-etm-0-0-5458","first-page":"2527","article-title":"Potential mechanisms underlying the Runx2 induced osteogenesis of bone marrow mesenchymal stem cells","volume":"7","author":"Xu","year":"2015","journal-title":"Am J Transl Res"},{"key":"key20200713143310_b4-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.2106\/JBJS.G.01174","article-title":"Wnt and hedgehog signaling pathways in bone development","volume":"90","author":"Day","year":"2008","journal-title":"J Bone Joint Surg Am"},{"key":"key20200713143310_b5-etm-0-0-5458","unstructured":"CaiHLiuASpop promotes skeletal development and homeostasis by positively regulating Ihh signalingProc Natl Acad Sci USA1131475114756201610.1073\/pnas.161252011427930311"},{"key":"key20200713143310_b6-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.3892\/mmr.2015.3959","article-title":"Overexpression of Indian hedgehog partially rescues short stature homeobox 2-overexpression-associated congenital dysplasia of the temporomandibular joint in mice","volume":"12","author":"Li","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20200713143310_b7-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/ijos.2015.14","article-title":"The hedgehog signalling pathway in bone formation","volume":"7","author":"Yang","year":"2015","journal-title":"Int J Oral Sci"},{"key":"key20200713143310_b8-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"e1005214","DOI":"10.1371\/journal.pgen.1005214","article-title":"FGFR3 deficiency causes multiple chondroma-like lesions by upregulating hedgehog signaling","volume":"11","author":"Zhou","year":"2015","journal-title":"PLoS Genet"},{"key":"key20200713143310_b9-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.bone.2015.11.017","article-title":"Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones","volume":"83","author":"Amano","year":"2016","journal-title":"Bone"},{"key":"key20200713143310_b10-etm-0-0-5458","first-page":"1","article-title":"Osteophyte formation and matrix mineralization in a TMJ osteoarthritis mouse model are associated with ectopic hedgehog signaling","author":"Bechtold","year":"2016","journal-title":"Matrix Biol 52\u201354"},{"key":"key20200713143310_b11-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1002\/jor.22899","article-title":"Ablating hedgehog signaling in tenocytes during development impairs biomechanics and matrix organization of the adult murine patellar tendon enthesis","volume":"33","author":"Breidenbach","year":"2015","journal-title":"J Orthop Res"},{"key":"key20200713143310_b12-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713143310_b13-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1272\/jnms.77.4","article-title":"The mechanism of mineralization and the role of alkaline phosphatase in health and disease","volume":"77","author":"Orimo","year":"2010","journal-title":"J Nippon Med Sch"},{"key":"key20200713143310_b14-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.2741\/4026","article-title":"Acidic bone matrix proteins and their roles in calcification","volume":"17","author":"Fujisawa","year":"2012","journal-title":"Front Biosci (Landmark Ed)"},{"key":"key20200713143310_b15-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"3788","DOI":"10.1002\/art.23985","article-title":"Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone-related protein in mice","volume":"58","author":"Chen","year":"2008","journal-title":"Arthritis Rheum"},{"key":"key20200713143310_b16-etm-0-0-5458","unstructured":"MaedaYNakamuraENguyenMTSuvaLJSwainFLRazzaqueMSMackemSLanskeBIndian hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular boneProc Natl Acad Sci USA10463826387200710.1073\/pnas.060844910417409191"},{"key":"key20200713143310_b17-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1002\/jbmr.2256","article-title":"Epiphyseal chondrocyte secondary ossification centers require thyroid hormone activation of Indian hedgehog and osterix signaling","volume":"29","author":"Xing","year":"2014","journal-title":"J Bone Miner Res"},{"key":"key20200713143310_b18-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.matbio.2010.05.001","article-title":"Defective proteoglycan sulfation of the growth plate zones causes reduced chondrocyte proliferation via an altered Indian hedgehog signalling","volume":"29","author":"Gualeni","year":"2010","journal-title":"Matrix Biol"},{"key":"key20200713143310_b19-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"E1388","DOI":"10.1097\/BRS.0b013e3182a40489","article-title":"Indian hedgehog signaling promotes chondrocyte differentiation in enchondral ossification in human cervical ossification of the posterior longitudinal ligament","volume":"38","author":"Sugita","year":"2013","journal-title":"Spine (Phila Pa 1976)"},{"key":"key20200713143310_b20-etm-0-0-5458","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1242\/dev.129.12.2977","article-title":"PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps","volume":"129","author":"Kobayashi","year":"2002","journal-title":"Development"},{"key":"key20200713143310_b21-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3109\/03008207.2014.925885","article-title":"Indian hedgehog, a critical modulator in osteoarthritis, could be a potential therapeutic target for attenuating cartilage degeneration disease","volume":"55","author":"Zhou","year":"2014","journal-title":"Connect Tissue Res"},{"key":"key20200713143310_b22-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1242\/dev.018044","article-title":"Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy","volume":"135","author":"Mak","year":"2008","journal-title":"Development"},{"key":"key20200713143310_b23-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1177\/0192623311399788","article-title":"PTHrP treatment fails to rescue bone defects caused by hedgehog pathway inhibition in young mice","volume":"39","author":"Brechbiel","year":"2011","journal-title":"Toxicol Pathol"},{"key":"key20200713143310_b24-etm-0-0-5458","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1242\/dev.128.22.4523","article-title":"BMP and Ihh\/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation","volume":"128","author":"Minina","year":"2001","journal-title":"Development"},{"key":"key20200713143310_b25-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1196\/annals.1346.002","article-title":"PTHrP and skeletal development","volume":"1068","author":"Kronenberg","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"key20200713143310_b26-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ydbio.2011.11.013","article-title":"Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiation","volume":"362","author":"Tu","year":"2012","journal-title":"Dev Biol"},{"key":"key20200713143310_b27-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"118","DOI":"10.22203\/eCM.v024a09","article-title":"Molecular and biophysical mechanisms regulating hypertrophic differentiation in chondrocytes and mesenchymal stem cells","volume":"24","author":"Studer","year":"2012","journal-title":"Eur Cell Mater"},{"key":"key20200713143310_b28-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1002\/jcb.24089","article-title":"Ski inhibits TGF-\u03b2\/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes","volume":"113","author":"Kim","year":"2012","journal-title":"J Cell Biochem"},{"key":"key20200713143310_b29-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1038\/sj.emboj.7600729","article-title":"Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3","volume":"24","author":"Kang","year":"2005","journal-title":"EMBO J"},{"key":"key20200713143310_b30-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1091\/mbc.E06-08-0743","article-title":"Ihh\/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function","volume":"18","author":"Shimoyama","year":"2007","journal-title":"Mol Biol Cell"},{"key":"key20200713143310_b31-etm-0-0-5458","doi-asserted-by":"publisher","first-page":"24898","DOI":"10.1074\/jbc.M114.570507","article-title":"Indian hedgehog signaling regulates transcription and expression of collagen type X via Runx2\/Smads interactions","volume":"289","author":"Amano","year":"2014","journal-title":"J Biol Chem"}],"updated-by":[{"DOI":"10.3892\/etm.2025.12946","type":"expression_of_concern","label":"Expression of concern","source":"retraction-watch","updated":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"record-id":"68969"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T16:32:40Z","timestamp":1659803560000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2017.5458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,7]]},"references-count":31,"URL":"https:\/\/doi.org\/10.3892\/etm.2017.5458","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,7]]}}}