{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:52:27Z","timestamp":1785174747102,"version":"3.55.0"},"reference-count":53,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2018.5728","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T11:01:15Z","timestamp":1515495675000},"source":"Crossref","is-referenced-by-count":12,"title":["Antibiotic resistance of Klebsiella\u00ef\u00bf\u00bdpneumoniae through \u03b2-arrestin recruitment-induced \u03b2-lactamase signaling pathway"],"prefix":"10.3892","author":[{"given":"Jiang","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, Tianjin First Center Hospital, Tianjin 300192, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wenjie","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Tianjin First Center Hospital, Tianjin 300192, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Ping","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology of Tianjin First Center Hospital, Tianjin 300192, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Tianjin First Center Hospital, Tianjin 300192, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Haixia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tianjin First Center Hospital, Tianjin 300192, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Xuequn","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Tianjin First Center Hospital, Tianjin 300192, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,1,9]]},"reference":[{"key":"key20200713143753_b1-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"8049","DOI":"10.1002\/anie.201600205","article-title":"A \u03b2-Lactamase-imprinted responsive hydrogel for the treatment of antibiotic-resistant bacteria","volume":"55","author":"Li","year":"2016","journal-title":"Angew Chem Int Ed Engl"},{"key":"key20200713143753_b2-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"e1096996","DOI":"10.1080\/21597081.2015.1096996","article-title":"Counteracting selection for antibiotic-resistant bacteria","volume":"6","author":"Yosef","year":"2016","journal-title":"Bacteriophage"},{"key":"key20200713143753_b3-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"e0150396","DOI":"10.1371\/journal.pone.0150396","article-title":"How often are antibiotic-resistant bacteria said to \u2018evolve\u2019 in the news?","volume":"11","author":"Singh","year":"2016","journal-title":"PLoS One"},{"key":"key20200713143753_b4-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.chemosphere.2015.12.084","article-title":"A review of the influence of treatment strategies on antibiotic resistant bacteria and antibiotic resistance genes","volume":"150","author":"Sharma","year":"2016","journal-title":"Chemosphere"},{"key":"key20200713143753_b5-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.3855\/jidc.6731","article-title":"Antibiotics in surgical wards: Use or misuse? A newly industrialized country's perspective","volume":"9","author":"Lim","year":"2015","journal-title":"J Infect Dev Ctries"},{"key":"key20200713143753_b6-etm-0-0-5728","first-page":"30","article-title":"Combating antibiotic-resistant bacteria: The Microbiology lab answers the challenge","volume":"47","author":"Zimmer","year":"2015","journal-title":"MLO Med Lab Obs"},{"key":"key20200713143753_b7-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1089\/mdr.2015.0257","article-title":"Antibiotic resistance profiles and genetic similarities within a new generation of carbapenem-resistant Acinetobacter calcoaceticus-A. Baumannii complex resistotypes in bosnia and herzegovina","volume":"22","author":"\u00c7\u00f6l","year":"2016","journal-title":"Microb Drug Resist"},{"key":"key20200713143753_b8-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.micpath.2015.09.001","article-title":"Isolation and characterization of antibiotic-resistant bacteria from pharmaceutical industrial wastewaters","volume":"89","author":"Tahrani","year":"2015","journal-title":"Microb Pathog"},{"key":"key20200713143753_b9-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"e0120688","DOI":"10.1371\/journal.pone.0120688","article-title":"Microbiological screening is necessary to distinguish carriers of plasmid-mediated AmpC beta-lactamase-producing enterobacteriaceae and extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae because of clinical similarity","volume":"10","author":"Conen","year":"2015","journal-title":"PLoS One"},{"key":"key20200713143753_b10-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"e0119791","DOI":"10.1371\/journal.pone.0119791","article-title":"Improved detection of extended spectrum beta-lactamase (ESBL)-producing Escherichia coli in input and output samples of German biogas plants by a selective pre-enrichment procedure","volume":"10","author":"Schauss","year":"2015","journal-title":"PLoS One"},{"key":"key20200713143753_b11-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"e0141315","DOI":"10.1371\/journal.pone.0141315","article-title":"Comparison of extended-spectrum \u03b2-lactamase (ESBL) CTX-M genotypes in franklin gulls from Canada and Chile","volume":"10","author":"Bonnedahl","year":"2015","journal-title":"PLoS One"},{"key":"key20200713143753_b12-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.vetmic.2015.10.008","article-title":"Prevalence and genetic diversity of extended-spectrum \u03b2-lactamase (ESBL)-producing Escherichia coli in nursing homes in Bavaria, Germany","volume":"200","author":"Valenza","year":"2017","journal-title":"Vet Microbiol"},{"key":"key20200713143753_b13-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"32","DOI":"10.4103\/0974-2727.151689","article-title":"Klebsiella pneumoniae in septicemic neonates with special reference to extended spectrum \u03b2-lactamase, AmpC, metallo \u03b2-lactamase production and multiple drug resistance in tertiary care hospital","volume":"7","author":"Gajul","year":"2015","journal-title":"J Lab Physicians"},{"key":"key20200713143753_b14-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1089\/fpd.2014.1895","article-title":"Extended-spectrum \u03b2-lactamase (ESBL)-producing Klebsiella pneumoniae in bulk tank milk from dairy farms in Indonesia","volume":"12","author":"Sudarwanto","year":"2015","journal-title":"Foodborne Pathog Dis"},{"key":"key20200713143753_b15-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"380","DOI":"10.4103\/0255-0857.71834","article-title":"Nosocomial outbreak of septicaemia in neonatal intensive care unit due to extended spectrum \u03b2-lactamase producing Klebsiella pneumoniae showing multiple mechanisms of drug resistance","volume":"28","author":"Rastogi","year":"2010","journal-title":"Indian J Med Microbiol"},{"key":"key20200713143753_b16-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ijfoodmicro.2015.07.017","article-title":"Characterization of extended-spectrum \u03b2-lactamase (ESBL) producing non-typhoidal Salmonella (NTS) from imported food products","volume":"214","author":"Bae","year":"2015","journal-title":"Int J Food Microbiol"},{"key":"key20200713143753_b17-etm-0-0-5728","first-page":"421","article-title":"Suspected nosocomial infections with multi-drug resistant E. coli, including extended-spectrum beta-lactamase (ESBL)-producing strains, in an equine clinic","volume":"127","author":"Walther","year":"2014","journal-title":"Berl Munch Tierarztl Wochenschr"},{"key":"key20200713143753_b18-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"25334","DOI":"10.3402\/iee.v5.25334","article-title":"Putative connection between zoonotic multiresistant extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in dog feces from a veterinary campus and clinical isolates from dogs","volume":"5","author":"Schaufler","year":"2015","journal-title":"Infect Ecol Epidemiol"},{"key":"key20200713143753_b19-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"fiw013","DOI":"10.1093\/femsec\/fiw013","article-title":"Multidrug resistant, extended spectrum \u03b2-lactamase (ESBL)-producing Escherichia coli isolated from a dairy farm","volume":"92","author":"Ibrahim","year":"2016","journal-title":"FEMS Microbiol Ecol"},{"key":"key20200713143753_b20-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3201\/eid1901.120310","article-title":"Klebsiella pneumoniae antimicrobial drug resistance, United States, 1998\u20132010","volume":"19","author":"Sanchez","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"key20200713143753_b21-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1055\/s-0028-1100392","article-title":"Strategies for recognition, prevention and control of antimicrobial resistances in Germany-a draft from the Federal German Ministry of Health","volume":"70","author":"Barger","year":"2008","journal-title":"Gesundheitswesen"},{"key":"key20200713143753_b22-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1091\/mbc.E06-12-1080","article-title":"5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling","volume":"18","author":"Barthet","year":"2007","journal-title":"Mol Biol Cell"},{"key":"key20200713143753_b23-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"17221","DOI":"10.1074\/jbc.C800061200","article-title":"beta-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a beta-arrestin 1-mediated pathway","volume":"283","author":"Lipsky","year":"2008","journal-title":"J Biol Chem"},{"key":"key20200713143753_b24-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.celrep.2013.10.015","article-title":"Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and \u03b2-arrestin 1 pathway","volume":"5","author":"Mittal","year":"2013","journal-title":"Cell Rep"},{"key":"key20200713143753_b25-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"ra30.1","DOI":"10.1126\/scisignal.2003627","article-title":"\u03b2-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6","volume":"6","author":"Borroni","year":"2013","journal-title":"Sci Signal"},{"key":"key20200713143753_b26-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"20634","DOI":"10.1074\/jbc.M701391200","article-title":"Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2","volume":"282","author":"Zoudilova","year":"2007","journal-title":"J Biol Chem"},{"key":"key20200713143753_b27-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"736","DOI":"10.7150\/jca.14232","article-title":"Efficacy of beta1 integrin and EGFR targeting in sphere-forming human head and neck cancer cells","volume":"7","author":"Zscheppang","year":"2016","journal-title":"J Cancer"},{"key":"key20200713143753_b28-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/S1684-1182(10)60070-9","article-title":"Consensus statement on the adherence to Clinical and Laboratory Standards Institute (CLSI) Antimicrobial Susceptibility Testing Guidelines (CLSI-2010 and CLSI-2010-update) for Enterobacteriaceae in clinical microbiology laboratories in Taiwan","volume":"43","author":"Hsueh","year":"2010","journal-title":"J Microbiol Immunol Infect"},{"key":"key20200713143753_b29-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1038\/cdd.2016.59","article-title":"A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress","volume":"23","author":"Aguileta","year":"2016","journal-title":"Cell Death Differ"},{"key":"key20200713143753_b30-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3892\/etm_00000058","article-title":"Thymoquinone hydrazone derivatives cause cell cycle arrest in p53-competent colorectal cancer cells","volume":"1","author":"Wirries","year":"2010","journal-title":"Exp Ther Med"},{"key":"key20200713143753_b31-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1186\/1471-2105-11-S1-S50","article-title":"Discrete wavelet transform de-noising in eukaryotic gene splicing","volume":"11","author":"George","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"key20200713143753_b32-etm-0-0-5728","first-page":"397","article-title":"Identification of patterns of transmission of Salmonella within swine production systems using pulsed field gel electrophoresis (PFGE) and repetitive sequence polymerase chain reaction (REP-PCR): A quantitative analysis","volume":"114","author":"Weigel","year":"2001","journal-title":"Berl Munch Tierarztl Wochenschr"},{"key":"key20200713143753_b33-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"e276","DOI":"10.5301\/jbm.5000199","article-title":"MicroRNAs as noninvasive biomarkers in bladder cancer detection: A diagnostic meta-analysis based on qRT-PCR data","volume":"31","author":"Xiao","year":"2016","journal-title":"Int J Biol Markers"},{"key":"key20200713143753_b34-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713143753_b35-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00540-017-2327-1","article-title":"Sivelestat sodium and mortality in pneumonia patients requiring mechanical ventilation: Propensity score analysis of a Japanese nationwide database","volume":"31","author":"Kishimoto","year":"2017","journal-title":"J Anesth"},{"key":"key20200713143753_b36-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1128\/AAC.00188-13","article-title":"Successful ertapenem-doripenem combination treatment of bacteremic ventilator-associated pneumonia due to colistin-resistant KPC-producing Klebsiella pneumoniae","volume":"57","author":"Ceccarelli","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"key20200713143753_b37-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1093\/jac\/dkv310","article-title":"A systematic review of the public's knowledge and beliefs about antibiotic resistance-authors' response","volume":"71","author":"McCullough","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"key20200713143753_b38-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"i939","DOI":"10.1136\/bmj.i939","article-title":"Global prevalence of antibiotic resistance in paediatric urinary tract infections caused by Escherichia coli and association with routine use of antibiotics in primary care: Systematic review and meta-analysis","volume":"352","author":"Bryce","year":"2016","journal-title":"BMJ"},{"key":"key20200713143753_b39-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13756-016-0104-9","article-title":"Correlation between biofilm formation and resistance toward different commonly used antibiotics along with extended spectrum beta lactamase production in uropathogenic Escherichia coli isolated from the patients suspected of urinary tract infections visiting Shree Birendra Hospital, Chhauni, Kathmandu, Nepal","volume":"5","author":"Neupane","year":"2016","journal-title":"Antimicrob Resist Infect Control"},{"key":"key20200713143753_b40-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.phrp.2014.12.006","article-title":"Antibiotic resistance of Acinetobacter baumannii in Iran: A systemic review of the published literature","volume":"6","author":"Moradi","year":"2015","journal-title":"Osong Public Health Res Perspect"},{"key":"key20200713143753_b41-etm-0-0-5728","first-page":"2","article-title":"Helicobacter pylori in Iran: A systematic review on the antibiotic resistance","volume":"18","author":"Khademi","year":"2015","journal-title":"Iran J Basic Med Sci"},{"key":"key20200713143753_b42-etm-0-0-5728","first-page":"1099","article-title":"Concomitant emphysematous prostatic and periurethral abscesses due to Klebsiella pneumoniae: A case report and review of the literature","volume":"45","author":"Lee","year":"2014","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"key20200713143753_b43-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cmi.2015.09.014","article-title":"Bactericidal and synergistic activity of double-carbapenem regimen for infections caused by carbapenemase-producing Klebsiella pneumoniae","volume":"22","author":"Oliva","year":"2016","journal-title":"Clin Microbiol Infect"},{"key":"key20200713143753_b44-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1093\/infdis\/jiv440","article-title":"Klebsiella pneumoniae FimK promotes virulence in murine pneumonia","volume":"213","author":"Rosen","year":"2016","journal-title":"J Infect Dis"},{"key":"key20200713143753_b45-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"e0139116","DOI":"10.1371\/journal.pone.0139116","article-title":"Genetic Characterization of carbapenem-resistant Enterobacteriaceae and the spread of carbapenem-resistant Klebsiella pneumonia ST340 at a university hospital in Thailand","volume":"10","author":"Netikul","year":"2015","journal-title":"PLoS One"},{"key":"key20200713143753_b46-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.ajic.2016.02.018","article-title":"Extended antibiotic resistance in carbapenemase-producing Klebsiella pneumoniae: A case series","volume":"44","author":"Walker","year":"2016","journal-title":"Am J Infect Control"},{"key":"key20200713143753_b47-etm-0-0-5728","first-page":"BR100","article-title":"Resistance of Klebsiella pneumoniae strains producing and not producing ESBL (extended-spectrum beta-lactamase) type enzymes to selected non-beta-lactam antibiotics","volume":"8","author":"Sekowska","year":"2002","journal-title":"Med Sci Monit"},{"key":"key20200713143753_b48-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S0924-8579(00)00277-6","article-title":"Bacterial agents of lower respiratory tract infections (LRTIs), beta-lactamase production, and resistance to antibiotics in elderly people. DEDALO Study Group","volume":"16","author":"Sanguinetti","year":"2000","journal-title":"Int J Antimicrob Agents"},{"key":"key20200713143753_b49-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1099\/mic.0.25926-0","article-title":"Catalytic properties of an endogenous beta-lactamase responsible for the resistance of Azospirillum lipoferum to beta-lactam antibiotics","volume":"149","author":"Boggio","year":"2003","journal-title":"Microbiology"},{"key":"key20200713143753_b50-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1515\/DMDI.2000.16.3.217","article-title":"beta-Lactamase activities and resistance to antibiotics of Haemophilus influenzae, H. parainfluenzae and H. aphrophilus strains identified in throat cultures from children","volume":"16","author":"Uraz","year":"2000","journal-title":"Drug Metabol Drug Interact"},{"key":"key20200713143753_b51-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1093\/jac\/dkl370","article-title":"New antibiotic resistance genes associated with CTX-M plasmids from uropathogenic Nigerian Klebsiella pneumoniae","volume":"58","author":"Soge","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"key20200713143753_b52-etm-0-0-5728","doi-asserted-by":"publisher","first-page":"e0127445","DOI":"10.1371\/journal.pone.0127445","article-title":"Monitoring \u03b2-arrestin recruitment via \u03b2-lactamase enzyme fragment complementation: Purification of peptide E as a low-affinity ligand for mammalian bombesin receptors","volume":"10","author":"Ikeda","year":"2015","journal-title":"PLoS One"},{"key":"key20200713143753_b53-etm-0-0-5728","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.PLAS-0016-2013","article-title":"Plasmid-Mediated antibiotic resistance and virulence in Gram-begatives: The Klebsiella pneumoniae paradigm","volume":"2","author":"Ramirez","year":"2014","journal-title":"Microbiol Spectr"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T13:45:10Z","timestamp":1594647910000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2018.5728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,9]]},"references-count":53,"URL":"https:\/\/doi.org\/10.3892\/etm.2018.5728","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,9]]}}}