{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:35:27Z","timestamp":1758702927563},"reference-count":39,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2018.5835","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T09:42:50Z","timestamp":1517823770000},"source":"Crossref","is-referenced-by-count":8,"title":["Positive association between leptin serum levels and disease activity on endoscopy in inflammatory bowel disease: A case-control study"],"prefix":"10.3892","author":[{"given":"Fabiola","family":"Trejo\u2011Vazquez","sequence":"first","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas \u2018Francisco Garc\u00ef\u00bf\u00bda Salinas\u2019, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idalia","family":"Garza\u2011Veloz","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas \u2018Francisco Garc\u00ef\u00bf\u00bda Salinas\u2019, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Villela\u2011Ramirez","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas \u2018Francisco Garc\u00ef\u00bf\u00bda Salinas\u2019, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Ortiz\u2011Castro","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas \u2018Francisco Garc\u00ef\u00bf\u00bda Salinas\u2019, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panfilo","family":"Mauricio\u2011Saucedo","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas \u2018Francisco Garc\u00ef\u00bf\u00bda Salinas\u2019, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Cardenas\u2011Vargas","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas \u2018Francisco Garc\u00ef\u00bf\u00bda Salinas\u2019, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Diaz\u2011Baez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital General de Zacatecas, Instituto de Seguridad y Servicios Sociales Para Los Trabajadores del Estado, Zacatecas 98000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Cid\u2011Baez","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas \u2018Francisco Garc\u00ef\u00bf\u00bda Salinas\u2019, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Casta\u00ef\u00bf\u00bdeda\u2011Miranda","sequence":"additional","affiliation":[{"name":"Bioengineering Laboratory, Unidad Academica de Ingenieria Electrica, Universidad Autonoma de Zacatecas, Zacatecas 98000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Ortiz\u2011Rodriguez","sequence":"additional","affiliation":[{"name":"Bioengineering Laboratory, Unidad Academica de Ingenieria Electrica, Universidad Autonoma de Zacatecas, Zacatecas 98000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Solis\u2011Sanchez","sequence":"additional","affiliation":[{"name":"Bioengineering Laboratory, Unidad Academica de Ingenieria Electrica, Universidad Autonoma de Zacatecas, Zacatecas 98000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Martinez\u2011Fierro","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas \u2018Francisco Garc\u00ef\u00bf\u00bda Salinas\u2019, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"key20200713144129_b1-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"28","DOI":"10.11613\/BM.2013.006","article-title":"Serological markers of inflammatory bowel disease","volume":"23","author":"Kuna","year":"2013","journal-title":"Biochem Med (Zagreb)"},{"key":"key20200713144129_b2-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/MCG.0b013e31817a76b4","article-title":"Clinical epidemiology of ulcerative colitis in Mexico: A single hospital-based study in a 20-year period (1987\u20132006)","volume":"43","author":"Yamamoto-Furusho","year":"2009","journal-title":"J Clin Gastroenterol."},{"key":"key20200713144129_b3-etm-0-0-5835","unstructured":"CronicaIn Mexico there was a triple increase in the number of cases of inflammatory bowel diseasehttp:\/\/www.cronica.com.mx\/notas\/2017\/1015339.html(In Spanish)July212017"},{"key":"key20200713144129_b4-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1053\/j.gastro.2011.01.055","article-title":"Epidemiology and natural history of inflammatory bowel diseases","volume":"140","author":"Cosnes","year":"2011","journal-title":"Gastroenterology"},{"key":"key20200713144129_b5-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1080\/00365520802600961","article-title":"Clinical course during the first 10 years of ulcerative colitis: Results from a population-based inception cohort (IBSEN Study)","volume":"44","author":"Solberg","year":"2009","journal-title":"Scand J Gastroenterol"},{"key":"key20200713144129_b6-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1053\/gast.2002.31072","article-title":"A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease","volume":"122","author":"Sandborn","year":"2002","journal-title":"Gastroenterology"},{"key":"key20200713144129_b7-etm-0-0-5835","first-page":"11","article-title":"European evidence based consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis","volume":"1","author":"Stange","year":"2006","journal-title":"Gut"},{"key":"key20200713144129_b8-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.crohns.2009.12.003","article-title":"The second European evidence-based consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis","volume":"4","author":"Van Assche","year":"2010","journal-title":"J Crohns Colitis"},{"key":"key20200713144129_b9-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1056\/NEJMoa0904492","article-title":"Infliximab, azathioprine, or combination therapy for Crohn's disease","volume":"362","author":"Colombel","year":"2010","journal-title":"N Engl J Med"},{"key":"key20200713144129_b10-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/S0140-6736(09)61302-7","article-title":"Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: A prospective observational cohort study","volume":"374","author":"Beaugerie","year":"2009","journal-title":"Lancet"},{"key":"key20200713144129_b11-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1053\/j.gastro.2011.06.050","article-title":"Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease","volume":"141","author":"Peyrin-Biroulet","year":"2011","journal-title":"Gastroenterology"},{"key":"key20200713144129_b12-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"3806","DOI":"10.3748\/wjg.v18.i29.3806","article-title":"Clinical, serological and genetic predictors of inflammatory bowel disease course","volume":"18","author":"Beaugerie","year":"2012","journal-title":"World J Gastroenterol"},{"key":"key20200713144129_b13-etm-0-0-5835","first-page":"570","article-title":"Changes in body mass index and lipid profile in psoriatic patients after treatment with standard protocol of infliximab","volume":"54","author":"Ehsani","year":"2016","journal-title":"Acta Med Iran"},{"key":"key20200713144129_b14-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/oby.2008.607","article-title":"Innate immunity and adipocyte function: Ligand-specific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes","volume":"17","author":"Kopp","year":"2009","journal-title":"Obesity (Silver Spring)"},{"key":"key20200713144129_b15-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.it.2007.07.003","article-title":"Adipose tissue as an immunological organ: Toll-like receptors, C1q\/TNFs and CTRPs","volume":"28","author":"Sch\u00e4ffler","year":"2007","journal-title":"Trends Immunol"},{"key":"key20200713144129_b16-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.tem.2011.12.003","article-title":"CTRP family: Linking immunity to metabolism","volume":"23","author":"Sch\u00e4ffler","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"key20200713144129_b17-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/27376","article-title":"Leptin and the regulation of body weight in mammals","volume":"395","author":"Friedman","year":"1998","journal-title":"Nature"},{"key":"key20200713144129_b18-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3109\/00365528909091339","article-title":"Classification of inflammatory bowel disease","volume":"170","author":"Lennard-Jones","year":"1989","journal-title":"Scand J Gastroenterol Suppl"},{"key":"key20200713144129_b19-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0303-7207(02)00007-2","article-title":"Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro","volume":"190","author":"Bruun","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"key20200713144129_b20-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1172\/JCI119824","article-title":"Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes","volume":"100","author":"Kirchgessner","year":"1997","journal-title":"J Clin Invest"},{"key":"key20200713144129_b21-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"6912","DOI":"10.3748\/wjg.v20.i22.6912","article-title":"Serum adipokines in inflammatory bowel disease","volume":"20","author":"Waluga","year":"2014","journal-title":"World J Gastroenterol"},{"key":"key20200713144129_b22-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1097\/MCG.0000000000000660","article-title":"World gastroenterology organisation global guidelines inflammatory bowel disease: Update August 2015","volume":"50","author":"Bernstein","year":"2016","journal-title":"J Clin Gastroenterol"},{"key":"key20200713144129_b23-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/MCG.0b013e3182098e07","article-title":"Cascade colorectal cancer screening guidelines: A global conceptual model","volume":"45","author":"Winawer","year":"2011","journal-title":"J Clin Gastroenterol"},{"key":"key20200713144129_b24-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.gie.2014.10.030","article-title":"The role of endoscopy in inflammatory bowel disease","volume":"81","author":"American Society for Gastrointestinal Endoscopy Standards of Practice Committee","year":"2015","journal-title":"Gastrointest Endosc"},{"key":"key20200713144129_b25-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1136\/gutjnl-2011-300486","article-title":"Developing an instrument to assess the endoscopic severity of ulcerative colitis: The Ulcerative colitis endoscopic index of severity (UCEIS)","volume":"61","author":"Travis","year":"2012","journal-title":"Gut"},{"key":"key20200713144129_b26-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1053\/j.gastro.2006.12.038","article-title":"A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis","volume":"132","author":"D'Haens","year":"2007","journal-title":"Gastroenterology"},{"key":"key20200713144129_b27-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.1097\/MIB.0000000000000903","article-title":"New biomarkers for diagnosing inflammatory bowel disease and assessing treatment outcomes","volume":"22","author":"Barnes","year":"2016","journal-title":"Inflamm Bowel Dis"},{"key":"key20200713144129_b28-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/jcp.21386","article-title":"The secretory function of adipocytes in the physiology of white adipose tissue","volume":"216","author":"Wang","year":"2008","journal-title":"J Cell Physiol"},{"key":"key20200713144129_b29-etm-0-0-5835","first-page":"4","article-title":"Recent advances in the relationship between obesity, inflammation, and insulin resistance","volume":"17","author":"Bastard","year":"2006","journal-title":"Eur Cytokine Netw"},{"key":"key20200713144129_b30-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1136\/gut.47.2.178","article-title":"Leptin secretion and leptin receptor in the human stomach","volume":"47","author":"Sobhani","year":"2000","journal-title":"Gut"},{"key":"key20200713144129_b31-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1097\/01.MIB.0000200345.38837.46","article-title":"Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease","volume":"12","author":"Karmiris","year":"2006","journal-title":"Inflamm Bowel Dis"},{"key":"key20200713144129_b32-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/j.1440-1746.2003.03300.x","article-title":"Leptin levels in the acute stage of ulcerative colitis","volume":"19","author":"Tuzun","year":"2004","journal-title":"J Gastroenterol Hepatol"},{"key":"key20200713144129_b33-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1042\/cs0940479","article-title":"Plasma leptin in chronic inflammatory bowel disease and HIV: Implications for the pathogenesis of anorexia and weight loss","volume":"94","author":"Ballinger","year":"1998","journal-title":"Clin Sci (Lond)"},{"key":"key20200713144129_b34-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1097\/00005176-199805000-00003","article-title":"Serum leptin in children and young adults with inflammatory bowel disease","volume":"26","author":"Hoppin","year":"1998","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"key20200713144129_b35-etm-0-0-5835","first-page":"987","article-title":"Overexpression of leptin mRNA in mesenteric adipose tissue in inflammatory bowel diseases","volume":"27","author":"Barbier","year":"2003","journal-title":"Gastroenterol Clin Biol"},{"key":"key20200713144129_b36-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/00054725-200606000-00005","article-title":"Profiling adipocytokine secretion from creeping fat in Crohn's disease","volume":"12","author":"Paul","year":"2006","journal-title":"Inflamm Bowel Dis"},{"key":"key20200713144129_b37-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"3510","DOI":"10.1210\/jc.2004-1222","article-title":"Impact of infliximab on serum leptin levels in patients with Crohn's disease","volume":"90","author":"Franchimont","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key20200713144129_b38-etm-0-0-5835","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/S0960-9822(02)70684-2","article-title":"A role for leptin and its cognate receptor in hematopoiesis","volume":"6","author":"Bennett","year":"1996","journal-title":"Curr Biol"},{"key":"key20200713144129_b39-etm-0-0-5835","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1182\/blood.V93.12.4444","article-title":"Relationship between levels of leptin and hemoglobin in Japanese men","volume":"93","author":"Togo","year":"1999","journal-title":"Blood"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T13:48:21Z","timestamp":1594648101000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2018.5835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,5]]},"references-count":39,"URL":"https:\/\/doi.org\/10.3892\/etm.2018.5835","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,5]]}}}