{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:18:17Z","timestamp":1782890297711,"version":"3.54.5"},"reference-count":29,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2018.5961","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T11:07:30Z","timestamp":1521457650000},"source":"Crossref","is-referenced-by-count":4,"title":["Homocysteine induces oxidative stress to damage trabecular meshwork cells"],"prefix":"10.3892","author":[{"given":"Zhi\u2011Peng","family":"You","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2011Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2011Lan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,3,19]]},"reference":[{"key":"key20200713144906_b1-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"key20200713144906_b2-etm-0-0-5961","first-page":"3311","volume-title":"Clinical Ophthalmology: A systematic approach","author":"Kanski","year":"2011","edition":"7th edition"},{"key":"key20200713144906_b3-etm-0-0-5961","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-017-9140-8","article-title":"Mechanism of the reconstruction of aqueous outflow drainage","author":"Xin","year":"2017","journal-title":"Sci China Life Sci"},{"key":"key20200713144906_b4-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1002\/jcp.25305","article-title":"The outflow pathway: A tissue with morphological and functional unity","volume":"231","author":"Sacc\u00e0","year":"2016","journal-title":"J Cell Physiol"},{"key":"key20200713144906_b5-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.coph.2012.09.008","article-title":"Oxidative stress and mitochondrial dysfunction in glaucoma","volume":"13","author":"Chrysostomou","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"key20200713144906_b6-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"995","DOI":"10.3892\/ijmm.2016.2714","article-title":"Oxidative stress in the trabecular meshwork (Review)","volume":"38","author":"Zhao","year":"2016","journal-title":"Int J Mol Med"},{"key":"key20200713144906_b7-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3109\/02713680903548970","article-title":"Oxidative stress markers in patients with primary open-angle glaucoma","volume":"35","author":"Ghanem","year":"2010","journal-title":"Curr Eye Res"},{"key":"key20200713144906_b8-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1159\/000444900","article-title":"Homocysteine in Renal Injury","volume":"2","author":"Long","year":"2016","journal-title":"Kidney Dis (Basel)"},{"key":"key20200713144906_b9-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.jacc.2013.06.045","article-title":"The year in atherothrombosis","volume":"62","author":"Sanz","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"key20200713144906_b10-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1007\/s007020200097","article-title":"Homocysteine and risk of open-angle glaucoma","volume":"109","author":"Bleich","year":"2002","journal-title":"J Neural Transm (Vienna)"},{"key":"key20200713144906_b11-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1016\/j.ophtha.2012.06.025","article-title":"Homocysteine, B vitamins, methylenetetrahydrofolate reductase gene, and risk of primary open-angle glaucoma: A meta-analysis","volume":"119","author":"Xu","year":"2012","journal-title":"Ophthalmology"},{"key":"key20200713144906_b12-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3109\/02713683.2011.556299","article-title":"Evaluation of oxidative stress markers in aqueous humor of primary open angle glaucoma and primary angle closure glaucoma patients","volume":"39","author":"Goyal","year":"2014","journal-title":"Curr Eye Res"},{"key":"key20200713144906_b13-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"e430","DOI":"10.1038\/cddis.2012.171","article-title":"JC-1: Alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry","volume":"3","author":"Perelman","year":"2012","journal-title":"Cell Death Dis"},{"key":"key20200713144906_b14-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"241","DOI":"10.2174\/1389557516666151120114605","article-title":"The role oxidative stress in the pathogenesis of eye diseases: Current status and a dual role of physical activity","volume":"16","author":"Kruk","year":"2015","journal-title":"Mini Rev Med Chem"},{"key":"key20200713144906_b15-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1472-8206.2011.00969.x","article-title":"Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: Challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine","volume":"26","author":"Babizhayev","year":"2012","journal-title":"Fundam Clin Pharmacol"},{"key":"key20200713144906_b16-etm-0-0-5961","first-page":"249","article-title":"Oxidant\/antioxidant balance in the aqueous humor of patients with glaucoma","volume":"9","author":"Ergan","year":"2016","journal-title":"Int J Ophthalmol"},{"key":"key20200713144906_b17-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"712","DOI":"10.3109\/02713683.2012.669512","article-title":"Homocysteine and hydroxyproline levels in patients with primary open-angle glaucoma","volume":"37","author":"Ghanem","year":"2012","journal-title":"Curr Eye Res"},{"key":"key20200713144906_b18-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"e4858","DOI":"10.1097\/MD.0000000000004858","article-title":"Relationship between homocysteine and intraocular pressure in men and women: A population-based study","volume":"95","author":"Leibovitzh","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"key20200713144906_b19-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.2147\/OPTH.S64904","article-title":"Plasma homocysteine and genetic variants of homocysteine metabolism enzymes in patients from central Greece with primary open-angle glaucoma and pseudoexfoliation glaucoma","volume":"8","author":"Zacharaki","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"key20200713144906_b20-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1097\/ICU.0b013e3283360b1e","article-title":"Glaucoma in latinos\/hispanics","volume":"21","author":"Kim","year":"2010","journal-title":"Curr Opin Ophthalmol"},{"key":"key20200713144906_b21-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0039-6257(03)00028-6","article-title":"Primary open-angle glaucoma in blacks: A review","volume":"48","author":"Racette","year":"2003","journal-title":"Surv Ophthalmol"},{"key":"key20200713144906_b22-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2147\/ciia.2006.1.1.67","article-title":"Nutrition and aging: Assessment and treatment of compromised nutritional status in frail elderly patients","volume":"1","author":"Wells","year":"2006","journal-title":"Clin Interv Aging"},{"key":"key20200713144906_b23-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s00726-006-0432-9","article-title":"Mechanisms of homocysteine toxicity in humans","volume":"32","author":"Per\u0142a-Kaj\u00e1n","year":"2007","journal-title":"Amino Acids"},{"key":"key20200713144906_b24-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/S0006-291X(03)01385-8","article-title":"Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells","volume":"308","author":"Caballero","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713144906_b25-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"4912","DOI":"10.1167\/iovs.08-2192","article-title":"Mitochondrial defects and dysfunction in calcium regulation in glaucomatous trabecular meshwork cells","volume":"49","author":"He","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713144906_b26-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.jneumeth.2010.08.020","article-title":"Comparative evaluation of hypoxic-ischemic brain injury by flow cytometric analysis of mitochondrial membrane potential with JC-1 in neonatal rats","volume":"193","author":"Sung","year":"2010","journal-title":"J Neurosci Methods"},{"key":"key20200713144906_b27-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"e14567","DOI":"10.1371\/journal.pone.0014567","article-title":"Mitochondrial damage in the trabecular meshwork occurs only in primary open-angle glaucoma and in pseudoexfoliative glaucoma","volume":"6","author":"Izzotti","year":"2011","journal-title":"PLoS One"},{"key":"key20200713144906_b28-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1359\/jbmr.060406","article-title":"Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation","volume":"21","author":"Koh","year":"2006","journal-title":"J Bone Miner Res"},{"key":"key20200713144906_b29-etm-0-0-5961","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1074\/jbc.M307698200","article-title":"Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor necrosis factor-alpha","volume":"279","author":"Kang","year":"2004","journal-title":"J Biol Chem"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T13:50:09Z","timestamp":1594648209000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2018.5961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,19]]},"references-count":29,"URL":"https:\/\/doi.org\/10.3892\/etm.2018.5961","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,19]]}}}