{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T07:56:04Z","timestamp":1753602964107},"reference-count":38,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2018.6520","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T09:27:58Z","timestamp":1532510878000},"source":"Crossref","is-referenced-by-count":12,"title":["Inhibition of endogenous hydrogen sulfide production exacerbates the inflammatory response during urine\u2011derived sepsis\u2011induced kidney injury"],"prefix":"10.3892","author":[{"given":"Huili","family":"Qiu","sequence":"first","affiliation":[{"name":"School of Nursing, Changsha Medical University, Changsha, Hunan 410219, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Second Affiliated Hospital of The University of South China, Hengyang, Hunan 421001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Urology, Second Affiliated Hospital of The University of South China, Hengyang, Hunan 421001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology, Second Affiliated Hospital of The University of South China, Hengyang, Hunan 421001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Second Affiliated Hospital of The University of South China, Hengyang, Hunan 421001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology, Second Affiliated Hospital of The University of South China, Hengyang, Hunan 421001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyang","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Urology, Second Affiliated Hospital of The University of South China, Hengyang, Hunan 421001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Urology, Second Affiliated Hospital of The University of South China, Hengyang, Hunan 421001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Second Affiliated Hospital of The University of South China, Hengyang, Hunan 421001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wujun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology, Second Affiliated Hospital of The University of South China, Hengyang, Hunan 421001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,7,25]]},"reference":[{"key":"key20200713114642_b1-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1097\/CCM.0000000000000026","article-title":"Two decades of mortality trends among patients with severe sepsis: A comparative meta-analysis","volume":"42","author":"Stevenson","year":"2014","journal-title":"Crit Care Med"},{"key":"key20200713114642_b2-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/CCM.0b013e3181cb0cdc","article-title":"The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis","volume":"38","author":"Levy","year":"2010","journal-title":"Crit Care Med"},{"key":"key20200713114642_b3-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000","volume":"348","author":"Martin","year":"2003","journal-title":"N Engl J Med"},{"key":"key20200713114642_b4-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1016\/j.mayocp.2014.07.009","article-title":"Severe sepsis and septic shock: Clinical overview and update on management","volume":"89","author":"Cawcutt","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"key20200713114642_b5-etm-0-0-6520","volume-title":"European Association of Urology","author":"Grabe","year":"2013"},{"key":"key20200713114642_b6-etm-0-0-6520","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/000313481207800102","article-title":"Sepsis, systemic inflammatory response, and multiple organ dysfunction: The mystery continues","volume":"78","author":"Fry","year":"2012","journal-title":"Am Surg"},{"key":"key20200713114642_b7-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.jhep.2008.12.025","article-title":"Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: A study in monozygotic and dizygotic twins","volume":"50","author":"Makkonen","year":"2009","journal-title":"J Hepatol"},{"key":"key20200713114642_b8-etm-0-0-6520","first-page":"3576","article-title":"Hydrogen sulfide and nervous system regulation","volume":"124","author":"Zhou","year":"2011","journal-title":"Chin Med J (Engl)"},{"key":"key20200713114642_b9-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1089\/ars.2009.2938","article-title":"Hydrogen sulfide: The third gasotransmitter in biology and medicine","volume":"12","author":"Wang","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"key20200713114642_b10-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s00726-010-0510-x","article-title":"Hydrogen sulfide: Its production, release and functions","volume":"41","author":"Kimura","year":"2011","journal-title":"Amino Acids"},{"key":"key20200713114642_b11-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1586\/ecp.10.134","article-title":"Hydrogen sulfide and inflammation: The good, the bad, the ugly and the promising","volume":"4","author":"Whiteman","year":"2011","journal-title":"Expert Rev Clin Pharmacol"},{"key":"key20200713114642_b12-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1089\/ars.2009.2882","article-title":"Novel insights into hydrogen sulfide-mediated cytoprotection","volume":"12","author":"Calvert","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"key20200713114642_b13-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.niox.2014.10.004","article-title":"Hydrogen sulphide and the kidney: Important roles in renal physiology and pathogenesis and treatment of kidney injury and disease","volume":"46","author":"Lobb","year":"2015","journal-title":"Nitric Oxide"},{"key":"key20200713114642_b14-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.niox.2015.01.005","article-title":"Hydrogen sulfide in renal physiology, disease and transplantation-the smell of renal protection","volume":"46","author":"Koning","year":"2015","journal-title":"Nitric Oxide"},{"key":"key20200713114642_b15-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1089\/ars.2011.4363","article-title":"Inhaled hydrogen sulfide prevents endotoxin-induced systemic inflammation and improves survival by altering sulfide metabolism in mice","volume":"17","author":"Tokuda","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"key20200713114642_b16-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1165\/rcmb.2013-0415OC","article-title":"Inhibitory effect of hydrogen sulfide on ozone-induced airway inflammation, oxidative stress, and bronchial hyperresponsiveness","volume":"52","author":"Zhang","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20200713114642_b17-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"e19766","DOI":"10.1371\/journal.pone.0019766","article-title":"Hydrogen sulfide attenuated tumor necrosis factor-alpha-induced inflammatory signaling and dysfunction in vascular endothelial cells","volume":"6","author":"Pan","year":"2011","journal-title":"PLoS One"},{"key":"key20200713114642_b18-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"H888","DOI":"10.1152\/ajpheart.00432.2010","article-title":"Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: Role of heme oxygenase-1","volume":"301","author":"Zuidema","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key20200713114642_b19-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1164\/rccm.200907-1145OC","article-title":"Hydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activation","volume":"182","author":"Spiller","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"key20200713114642_b20-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"4778","DOI":"10.4049\/jimmunol.1101559","article-title":"Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin E metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation","volume":"187","author":"Ang","year":"2011","journal-title":"J Immunol"},{"key":"key20200713114642_b21-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"464","DOI":"10.3892\/etm.2014.1781","article-title":"Hydrogen sulfide reduces kidney injury due to urinary-derived sepsis by inhibiting NF-kappaB expression, decreasing TNF-alpha levels and increasing IL-10 levels","volume":"8","author":"Chen","year":"2014","journal-title":"Exp Ther Med"},{"key":"key20200713114642_b22-etm-0-0-6520","first-page":"321","article-title":"New understanding of the definition and diagnosis of sepsis","volume":"16","author":"Yao","year":"2004","journal-title":"Zhongguo Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"key20200713114642_b23-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1152\/ajprenal.00148.2011","article-title":"Erythropoietin prevents sepsis-related acute kidney injury in rats by inhibiting nuclear-factor kappa B and upregulating endothelial nitric oxide synthase","volume":"302","author":"Souza","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"key20200713114642_b24-etm-0-0-6520","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/path.2666","article-title":"Selective blockade of endothelial NF-kappaB pathway differentially affects systemic inflammation and multiple organ dysfunction and injury in septic mice","volume":"220","author":"Xu","year":"2010","journal-title":"J Pathol"},{"key":"key20200713114642_b25-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s11010-011-1001-4","article-title":"The association of receptor of advanced glycated end products and inflammatory mediators contributes to endothelial dysfunction in a prospective study of acute kidney injury patients with sepsis","volume":"359","author":"Sadik","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"key20200713114642_b26-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1042\/BST0381390","article-title":"Exploring the LPS\/TLR4 signal pathway with small molecules","volume":"38","author":"Peri","year":"2010","journal-title":"Biochem Soc Tran"},{"key":"key20200713114642_b27-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1042\/BST0381390","article-title":"Exploring the LPS\/TLR4 signal pathway with small molecules","volume":"38","author":"Peri","year":"2010","journal-title":"Biochem Soc Trans"},{"key":"key20200713114642_b28-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"455","DOI":"10.2119\/molmed.2011.00308","article-title":"Genipin attenuates sepsis by inhibiting toll-like receptor signaling","volume":"18","author":"Kim","year":"2012","journal-title":"Mol Med"},{"key":"key20200713114642_b29-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/S0960-9822(07)00352-1","article-title":"Identification of CARDIAK, a RIP-like kinase that associates with caspase-1","volume":"8","author":"Thome","year":"1998","journal-title":"Curr Biol"},{"key":"key20200713114642_b30-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1179\/016164113X13703372991516","article-title":"HSV-1 activates NF-kappaB in mouse astrocytes and increases TNF-alpha and IL-6 expression via Toll-like receptor 3","volume":"35","author":"Liu","year":"2013","journal-title":"Neurol Res"},{"key":"key20200713114642_b31-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.cppeds.2013.10.001","article-title":"Definitions and pathophysiology of sepsis","volume":"43","author":"Sagy","year":"2013","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"key":"key20200713114642_b32-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1002\/ibd.20148","article-title":"Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance","volume":"13","author":"Mudter","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"key20200713114642_b33-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.rvsc.2014.03.014","article-title":"Interleukin-6 dynamics as a basis for an early-warning monitor for sepsis and inflammation in individual pigs","volume":"96","author":"Tambuyzer","year":"2014","journal-title":"Res Vet Sci"},{"key":"key20200713114642_b34-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.surg.2011.07.019","article-title":"Neutralization of interleukin-10 or transforming growth factor-beta decreases the percentages of CD4+ CD25+ Foxp3+ regulatory T cells in septic mice, thereby leading to an improved survival","volume":"151","author":"Hiraki","year":"2012","journal-title":"Surgery"},{"key":"key20200713114642_b35-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"3814","DOI":"10.4049\/jimmunol.172.6.3814","article-title":"Aberrant toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-beta 1 signaling pathway","volume":"172","author":"McCartney-Francis","year":"2004","journal-title":"J Immunol"},{"key":"key20200713114642_b36-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1089\/ars.2011.4345","article-title":"Hydrogen sulfide is a signaling molecule and a cytoprotectant","volume":"17","author":"Kimura","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"key20200713114642_b37-etm-0-0-6520","doi-asserted-by":"publisher","first-page":"e21971","DOI":"10.1371\/journal.pone.0021971","article-title":"Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS\/NF-\u03baB\/COX-2 pathway","volume":"6","author":"Yang","year":"2011","journal-title":"Plos One"},{"key":"key20200713114642_b38-etm-0-0-6520","first-page":"1497","article-title":"Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty","volume":"5","author":"Ma","year":"2012","journal-title":"Mol Med Rep"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T17:19:17Z","timestamp":1604683157000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2018.6520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,25]]},"references-count":38,"URL":"https:\/\/doi.org\/10.3892\/etm.2018.6520","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,25]]}}}