{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:12:52Z","timestamp":1790698372904,"version":"4.1.0"},"reference-count":16,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2018.6767","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T07:36:52Z","timestamp":1537342612000},"source":"Crossref","is-referenced-by-count":16,"title":["AMPK\/TSC2\/mTOR pathway regulates replicative senescence of human vascular smooth muscle cells"],"prefix":"10.3892","author":[{"given":"Jun\u2011Kun","family":"Zhan","sequence":"first","affiliation":[{"name":"Geriatric Department, The Second Xiangya Hospital, Institute of Aging and Geriatrics, Central South University, Changsha, Hunan 410011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2011Jiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Geriatric Department, The Second Xiangya Hospital, Institute of Aging and Geriatrics, Central South University, Changsha, Hunan 410011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Geriatric Department, The Second Xiangya Hospital, Institute of Aging and Geriatrics, Central South University, Changsha, Hunan 410011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Geriatric Department, The Second Xiangya Hospital, Institute of Aging and Geriatrics, Central South University, Changsha, Hunan 410011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Tan","sequence":"additional","affiliation":[{"name":"Geriatric Department, The Second Xiangya Hospital, Institute of Aging and Geriatrics, Central South University, Changsha, Hunan 410011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je\u2011Yu","family":"He","sequence":"additional","affiliation":[{"name":"Geriatric Department, The Second Xiangya Hospital, Institute of Aging and Geriatrics, Central South University, Changsha, Hunan 410011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2011Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Geriatric Department, The Second Xiangya Hospital, Institute of Aging and Geriatrics, Central South University, Changsha, Hunan 410011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2011Qian","family":"Deng","sequence":"additional","affiliation":[{"name":"Geriatric Department, The Second Xiangya Hospital, Institute of Aging and Geriatrics, Central South University, Changsha, Hunan 410011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Huang","sequence":"additional","affiliation":[{"name":"Geriatric Department, The Second Xiangya Hospital, Institute of Aging and Geriatrics, Central South University, Changsha, Hunan 410011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Lin","sequence":"additional","affiliation":[{"name":"Geriatric Department, The Second Xiangya Hospital, Institute of Aging and Geriatrics, Central South University, Changsha, Hunan 410011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2011Shuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Geriatric Department, The Second Xiangya Hospital, Institute of Aging and Geriatrics, Central South University, Changsha, Hunan 410011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"key20200713115315_b1-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1159\/000368576","article-title":"The effect of ageing on vascular smooth muscle cell behaviour-a mini-review","volume":"61","author":"Monk","year":"2015","journal-title":"Gerontology"},{"key":"key20200713115315_b2-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.cjca.2016.02.051","article-title":"Cellular senescence and vascular disease: Novel routes to better understanding and therapy","volume":"32","author":"Yin","year":"2016","journal-title":"Can J Cardiol"},{"key":"key20200713115315_b3-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s10522-007-9082-x","article-title":"Identification of cultivation-independent markers of human endothelial cell. senescence in vitro","volume":"8","author":"Unterluggauer","year":"2007","journal-title":"Biogerontology"},{"key":"key20200713115315_b4-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1101\/gad.1212704","article-title":"Upstream and downstream of mTOR","volume":"18","author":"Hay","year":"2004","journal-title":"Genes Dev"},{"key":"key20200713115315_b5-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrm3025","article-title":"mTOR: From growth signal integration to cancer, diabetes and ageing","volume":"12","author":"Zoncu","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20200713115315_b6-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.3892\/ijo.2015.2928","article-title":"Effects of fucoidan on proliferation, AMP-activated protein kinase, and downstream metabolism- and cell cycle-associated molecules in poorly differentiated human hepatoma HLF cells","volume":"46","author":"Kawaguchi","year":"2015","journal-title":"Int J Oncol"},{"key":"key20200713115315_b7-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1128\/MCB.00983-10","article-title":"Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways","volume":"31","author":"Long","year":"2011","journal-title":"Mol Cell Biol"},{"key":"key20200713115315_b8-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1002\/jcb.21197","article-title":"Long-term activation of adenosine monophosphateactivated protein kinase attenuates pressure-overload-induced cardiac hypertrophy","volume":"100","author":"Li","year":"2007","journal-title":"J Cell Biochem"},{"key":"key20200713115315_b9-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1161\/HYPERTENSIONAHA.108.114702","article-title":"AMP activated protein kinase-alpha 2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice","volume":"52","author":"Zhang","year":"2008","journal-title":"Hypertension"},{"key":"key20200713115315_b10-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713115315_b11-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"H1673","DOI":"10.1152\/ajpheart.00455.2009","article-title":"Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition","volume":"297","author":"Nakano-Kurimoto","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key20200713115315_b12-etm-0-0-6767","first-page":"53","article-title":"Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory mechanism of mammalian sirtuin SIRT1 in vascular calcification: Impact of vascular smooth muscle cell senescence","volume":"21","author":"Iijima","year":"2011","journal-title":"Clin Calcium"},{"key":"key20200713115315_b13-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.yexcr.2014.02.016","article-title":"Adiponectin attenuates the osteoblastic differentiation of vascular smooth muscle cells through the AMPK\/mTOR pathway","volume":"323","author":"Zhan","year":"2014","journal-title":"Exp Cell Res"},{"key":"key20200713115315_b14-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-016-2796-9","article-title":"The PI3K\/Akt\/mTOR pathway regulates the replicative senescence of human VSMCs","volume":"422","author":"Tan","year":"2016","journal-title":"Mol Cell Biochem"},{"key":"key20200713115315_b15-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.ijcard.2015.04.086","article-title":"The protective effect of GLP-1 analogue in arterial calcification through attenuating osteoblastic differentiation of human VSMCs","volume":"189","author":"Zhan","year":"2015","journal-title":"Int J Cardiol"},{"key":"key20200713115315_b16-etm-0-0-6767","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1146\/annurev-pharmtox-010611-134537","article-title":"AMPK and mTOR in cellular energy homeostasis and drug targets","volume":"52","author":"Inoki","year":"2012","journal-title":"Annu Rev Pharmacol Toxicol"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T10:53:18Z","timestamp":1594637598000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2018.6767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,19]]},"references-count":16,"URL":"https:\/\/doi.org\/10.3892\/etm.2018.6767","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,19]]}}}