{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:36:52Z","timestamp":1781671012797,"version":"3.54.5"},"reference-count":39,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2018.6848","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T07:31:15Z","timestamp":1539243075000},"source":"Crossref","is-referenced-by-count":11,"title":["Electroacupuncture stimulates the proliferation and differentiation of endogenous neural stem cells in a rat model of ischemic stroke"],"prefix":"10.3892","author":[{"given":"Feng","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Neurology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan, Guangdong 528000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yunnan Provincial Hospital of Traditional Chinese Medical, Kunming, Yunnan 650000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaodan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"key":"key20200713115331_b1-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.pneurobio.2016.05.002","article-title":"Combinationtherapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: Is more better?","volume":"142","author":"Kline","year":"2016","journal-title":"Prog Neurobiol"},{"key":"key20200713115331_b2-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1634\/stemcells.2005-0281","article-title":"Persistent production of neurons from adult brain stem cells during recovery after stroke","volume":"24","author":"Thored","year":"2006","journal-title":"Stem Cells"},{"key":"key20200713115331_b3-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1002\/glia.22851","article-title":"Endogenous neural stem cell responses to stroke and spinal cord injury","volume":"63","author":"Gregoire","year":"2015","journal-title":"Glia"},{"key":"key20200713115331_b4-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1038\/jcbfm.2014.130","article-title":"Neurogenesis and inflammation after ischemic stroke: What is known and where we go from here","volume":"34","author":"Tobin","year":"2014","journal-title":"J Cereb Blood Flow Metab"},{"key":"key20200713115331_b5-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.pbb.2013.11.009","article-title":"Hydrogen sulfide promotes proliferation and neuronal differentiation of neural stem cells andprotects hypoxia-induced decrease in hippocampal neurogenesis","volume":"116","author":"Liu","year":"2014","journal-title":"Pharmacol Biochem Behav"},{"key":"key20200713115331_b6-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.brainres.2014.05.020","article-title":"Electroacupuncture pretreatment inhibits NADPH oxidase-mediated oxidative stress in diabetic mice with cerebral ischemia","volume":"1573","author":"Guo","year":"2014","journal-title":"Brain Res"},{"key":"key20200713115331_b7-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.brainresbull.2015.10.011","article-title":"Electro-acupuncture at LI11 and ST36 acupoints exerts neuroprotective effects via reactive astrocyte proliferation after ischemia and reperfusion injury in rats","volume":"120","author":"Tao","year":"2016","journal-title":"Brain Res Bull"},{"key":"key20200713115331_b8-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1111\/1440-1681.12413","article-title":"Effects of electroacupuncture on endothelial function and circulating endothelial progenitor cells in patients with cerebral infarction","volume":"42","author":"Lee","year":"2015","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"key20200713115331_b9-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1142\/S0192415X15500883","article-title":"Electroacupuncture for acute ischemic stroke: A meta-analysis of randomized controlled trials","volume":"43","author":"Liu","year":"2015","journal-title":"Am J Chin Med"},{"key":"key20200713115331_b10-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.3892\/ijmm.2014.1702","article-title":"Electroacupuncture promotes neural cell proliferation in vivo through activation of the ERK1\/2 signaling pathway","volume":"33","author":"Huang","year":"2014","journal-title":"Int J Mol Med"},{"key":"key20200713115331_b11-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"9438650","DOI":"10.1155\/2016\/9438650","article-title":"Electroacupuncture attenuatescerebral ischemia and reperfusion injury in middle cerebral artery occlusion of rat via modulation of apoptosis, inflammation, oxidative stress, and excitotoxicity","volume":"2016","author":"Shen","year":"2016","journal-title":"Evid Based Complement Alternat Med"},{"key":"key20200713115331_b12-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1161\/STROKEAHA.110.597336","article-title":"Activation of epsilon protein kinase C-mediated anti-apoptosis is involved in rapid tolerance induced by electroacupuncturepretreatment through cannabinoid receptor type 1","volume":"42","author":"Wang","year":"2011","journal-title":"Stroke"},{"key":"key20200713115331_b13-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.3892\/etm.2014.1619","article-title":"Electroacupuncture attenuates cervical spinal cord injury following cerebral ischemia\/reperfusion in stroke-prone renovascular hypertensive rats","volume":"7","author":"Tan","year":"2014","journal-title":"Exp Ther Med"},{"key":"key20200713115331_b14-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.neuint.2005.07.003","article-title":"Preconditioning-induced ischemic tolerance stimulates growth factor expression and neurogenesis in adult rat hippocampus","volume":"47","author":"Naylor","year":"2005","journal-title":"Neurochem Int"},{"key":"key20200713115331_b15-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3727\/036012905815901244","article-title":"Electroacupuncture enhances striatal neurogenesis in adult rat brains after a transient cerebral middle artery occlusion","volume":"30","author":"Yang","year":"2005","journal-title":"Acupunct Electrother Res"},{"key":"key20200713115331_b16-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"e90000","DOI":"10.1371\/journal.pone.0090000","article-title":"Electroacupuncture promotes post-stroke functional recovery via enhancing endogenous neurogenesis in mouse focal cerebral ischemia","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"key":"key20200713115331_b17-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"6911","DOI":"10.3892\/mmr.2015.4279","article-title":"Electroacupuncture promotes neural stem cell proliferation and neurogenesis in the dentate gyrus of rats following stroke via upregulation of Notch1 expression","volume":"12","author":"Zhao","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20200713115331_b18-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1073\/pnas.1214255110","article-title":"Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum","volume":"110","author":"Petrinovic","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713115331_b19-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.brainres.2012.06.040","article-title":"Nogo-A is associated with secondary degeneration of substantia nigra in hypertensive rats with focal cortical infarction","volume":"1469","author":"Wang","year":"2012","journal-title":"Brain Res"},{"key":"key20200713115331_b20-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00441-012-1432-6","article-title":"The role of Nogo-A in axonal plasticity, regrowth and repair","volume":"349","author":"Pernet","year":"2012","journal-title":"Cell Tissue Res"},{"key":"key20200713115331_b21-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"2987","DOI":"10.4238\/2011.November.29.9","article-title":"Neuroprotective effects of NEP1-40 and fasudil on Nogo-A expression in neonatal rats with hypoxic-ischemic brain damage","volume":"10","author":"Zhu","year":"2011","journal-title":"Genet Mol Res"},{"key":"key20200713115331_b22-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1161\/STROKEAHA.110.590083","article-title":"Delayed anti-nogo-a therapy improves function after chronic stroke in adult rats","volume":"42","author":"Tsai","year":"2011","journal-title":"Stroke"},{"key":"key20200713115331_b23-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1194\/jlr.R046458","article-title":"LPA receptor signaling: Pharmacology, physiology, and pathophysiology","volume":"55","author":"Yung","year":"2014","journal-title":"J Lipid Res"},{"key":"key20200713115331_b24-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1091\/mbc.e09-06-0506","article-title":"Plasticity-related gene 5 (PRG5) induces filopodia and neurite growth and impedes lysophosphatidic acid- and nogo-A-mediated axonal retraction","volume":"21","author":"Broggini","year":"2010","journal-title":"Mol Biol Cell"},{"key":"key20200713115331_b25-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"24956","DOI":"10.1074\/jbc.M114.597880","article-title":"Plasticity-related gene 5 promotes spine formation in murine hippocampal neurons","volume":"289","author":"Coiro","year":"2014","journal-title":"J Biol Chem"},{"key":"key20200713115331_b26-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1471-4159.2011.07542.x","article-title":"Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury","volume":"120","author":"Gu","year":"2012","journal-title":"J Neurochem"},{"key":"key20200713115331_b27-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/sj.onc.1207026","article-title":"Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer","volume":"23","author":"Attardi","year":"2004","journal-title":"Oncogene"},{"key":"key20200713115331_b28-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.3892\/mmr.2013.1392","article-title":"Electroacupuncture ameliorates cognitive impairment through inhibition of NF-\u03baB-mediatedneuronal cell apoptosis in cerebral ischemia-reperfusion injured rats","volume":"7","author":"Feng","year":"2013","journal-title":"Mol Med Rep"},{"key":"key20200713115331_b29-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1369\/0022155414564870","article-title":"Identification of 5-bromo-2\u2032-deoxyuridine-labeled cells during mouse spermatogenesis by heat-induced antigen retrieval in lectin staining and immunohistochemistry","volume":"63","author":"Wakayama","year":"2015","journal-title":"J Histochem Cytochem"},{"key":"key20200713115331_b30-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.neuroscience.2012.04.036","article-title":"Effects of minocycline on endogenous neural stem cells after experimental stroke","volume":"215","author":"Rueger","year":"2012","journal-title":"Neuroscience"},{"key":"key20200713115331_b31-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1002\/cne.23514","article-title":"DCX-expressing cells in the vicinity of the hypothalamic neurogenic niche: A comparative study between mouse, sheep, and human tissues","volume":"522","author":"Batailler","year":"2014","journal-title":"J Comp Neurol"},{"key":"key20200713115331_b32-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1179\/174313208X325182","article-title":"The influence of electro-acupuncture on neural plasticity in acute cerebral infarction","volume":"30","author":"Ren","year":"2008","journal-title":"Neurol Res"},{"key":"key20200713115331_b33-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.nbd.2009.11.002","article-title":"Forebrain neurogenesis after focal Ischemic andtraumatic brain injury","volume":"37","author":"Kernie","year":"2010","journal-title":"Neurobiol Dis"},{"key":"key20200713115331_b34-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"a018812","DOI":"10.1101\/cshperspect.a018812","article-title":"Neurogenesis in the adult hippocampus","volume":"7","author":"Kempermann","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"key20200713115331_b35-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1093\/chemse\/19.6.695","article-title":"Rate and pattern of migration of lineally-related olfactory bulb interneurons generated postnatally in the subventricular zone of the rat","volume":"19","author":"Luskin","year":"1994","journal-title":"Chem Senses"},{"key":"key20200713115331_b36-etm-0-0-6848","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0056-15.2015","article-title":"Functional integration of adult-born hippocampal neurons after traumatic brain injury(1,2,3)","volume":"2","author":"Villasana","year":"2015","journal-title":"eNeuro"},{"key":"key20200713115331_b37-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"e552","DOI":"10.1161\/STROKEAHA.110.589010","article-title":"Isolation of locally derived stem\/progenitor cells from the peri-infarct area that do not migrate from the lateral ventricle after cortical stroke","volume":"41","author":"Shimada","year":"2010","journal-title":"Stroke"},{"key":"key20200713115331_b38-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/fnsyn.2013.00004","article-title":"Maturation and integration of adult born hippocampal neurons: Signal convergence onto small rho GTPases","volume":"5","author":"Vadodaria","year":"2013","journal-title":"Front Synaptic Neurosci"},{"key":"key20200713115331_b39-etm-0-0-6848","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1046\/j.1460-9568.2003.03078.x","article-title":"Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family","volume":"19","author":"Savaskan","year":"2004","journal-title":"Eur J Neurosci"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T10:53:37Z","timestamp":1594637617000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2018.6848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,11]]},"references-count":39,"URL":"https:\/\/doi.org\/10.3892\/etm.2018.6848","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,11]]}}}