{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:14:57Z","timestamp":1782926097666,"version":"3.54.5"},"reference-count":35,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2018.6880","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T07:38:37Z","timestamp":1539934717000},"source":"Crossref","is-referenced-by-count":8,"title":["Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis"],"prefix":"10.3892","author":[{"given":"Shengjian","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2011Head and Neck Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2011Head and Neck Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2011Head and Neck Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2011Head and Neck Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2011Head and Neck Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youzhen","family":"Wei","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2011Head and Neck Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,10,19]]},"reference":[{"key":"key20200713115418_b1-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jaci.2003.09.047","article-title":"Allergic rhinitis: A disease remodeling the upper airways?","volume":"113","author":"Bousquet","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"key20200713115418_b2-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1111\/j.1399-3038.2010.01000.x","article-title":"Allergic rhinitis is an extremely common problem, but prevalence rates widely vary between countries","volume":"21","author":"Warner","year":"2010","journal-title":"Pediatr Allergy Immunol"},{"key":"key20200713115418_b3-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1159\/000176306","article-title":"Prevalence of self-reported allergic rhinitis in eleven major cities in China","volume":"149","author":"Zhang","year":"2009","journal-title":"Int Arch Allergy Immunol"},{"key":"key20200713115418_b4-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"105","DOI":"10.4168\/aair.2014.6.2.105","article-title":"Prevalence of allergic rhinitis in china","volume":"6","author":"Zhang","year":"2014","journal-title":"Allergy Asthma Immunol Res"},{"key":"key20200713115418_b5-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"300","DOI":"10.4168\/aair.2018.10.4.300","article-title":"Chinese society of allergy guidelines for diagnosis and treatment of allergic rhinitis","volume":"10","author":"Cheng","year":"2018","journal-title":"Allergy Asthma Immunol Res"},{"key":"key20200713115418_b6-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.anai.2015.07.022","article-title":"Oxidative stress in schoolchildren with allergic rhinitis: Propensity score matching case-control study","volume":"115","author":"Sim","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"key20200713115418_b7-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.aller.2010.07.006","article-title":"Oxidative stress status and plasma trace elements in patients with asthma or allergic rhinitis","volume":"39","author":"Sagdic","year":"2011","journal-title":"Allergol Immunopathol (Madr)"},{"key":"key20200713115418_b8-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12950-016-0148-x","article-title":"Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via reducing oxidative stress","volume":"14","author":"Yu","year":"2017","journal-title":"J Inflamm (Lond)"},{"key":"key20200713115418_b9-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nm1577","article-title":"Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals","volume":"13","author":"Ohsawa","year":"2007","journal-title":"Nat Med"},{"key":"key20200713115418_b10-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.bbrc.2008.08.020","article-title":"Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30\/GNL knockout mice","volume":"375","author":"Sato","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713115418_b11-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.healun.2012.11.007","article-title":"Hydrogen inhalation decreases lung graft injury in brain-dead donor rats","volume":"32","author":"Zhou","year":"2013","journal-title":"J Heart Lung Transplant"},{"key":"key20200713115418_b12-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.bbrc.2007.07.088","article-title":"Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia\/reperfusion through reducing oxidative stress","volume":"361","author":"Fukuda","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713115418_b13-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1111\/j.1600-6143.2008.02359.x","article-title":"Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury","volume":"8","author":"Buchholz","year":"2008","journal-title":"Am J Transplant"},{"key":"key20200713115418_b14-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00280-008-0924-2","article-title":"Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice","volume":"64","author":"Nakashima-Kamimura","year":"2009","journal-title":"Cancer Chemother Pharmacol"},{"key":"key20200713115418_b15-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.bbrc.2009.09.047","article-title":"Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells","volume":"389","author":"Itoh","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713115418_b16-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1097\/SHK.0b013e3181def9aa","article-title":"Hydrogen gas improves survival rate and organ damage in zymosan-induced generalized inflammation model","volume":"34","author":"Xie","year":"2010","journal-title":"Shock"},{"key":"key20200713115418_b17-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40733-018-0040-y","article-title":"Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice","volume":"4","author":"Zhang","year":"2018","journal-title":"Asthma Res Pract"},{"key":"key20200713115418_b18-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.aller.2016.10.007","article-title":"Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model","volume":"45","author":"Zhao","year":"2017","journal-title":"Allergol Immunopathol (Madr)"},{"key":"key20200713115418_b19-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1002\/alr.21579","article-title":"Dexamethasone suppresses allergic rhinitis and amplifies CD4(+) Foxp3(+) regulatory T cells in vitro","volume":"5","author":"Wang","year":"2015","journal-title":"Int Forum Allergy Rhinol"},{"key":"key20200713115418_b20-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1007\/s10753-016-0440-1","article-title":"Hydrogen gas inhalation attenuates seawater instillation-induced acute lung injury via the Nrf2 pathway in rabbits","volume":"39","author":"Diao","year":"2016","journal-title":"Inflammation"},{"key":"key20200713115418_b21-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.neuroscience.2016.08.021","article-title":"Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats-a possible new hydrogen resource for clinical use","volume":"335","author":"Cui","year":"2016","journal-title":"Neuroscience"},{"key":"key20200713115418_b22-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1097\/WNR.0000000000000824","article-title":"Molecular hydrogen inhalation attenuates postoperative cognitive impairment in rats","volume":"28","author":"Xin","year":"2017","journal-title":"Neuroreport"},{"key":"key20200713115418_b23-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.intimp.2015.03.032","article-title":"Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma","volume":"26","author":"Al-Harbi","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"key20200713115418_b24-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.intimp.2016.07.009","article-title":"Increased glutathione levels contribute to the beneficial effects of hydrogen sulfide and inducible nitric oxide inhibition in allergic lung inflammation","volume":"39","author":"Campos","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"key20200713115418_b25-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1164\/rccm.201107-1281OC","article-title":"Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma","volume":"185","author":"Sutcliffe","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"key20200713115418_b26-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1164\/ajrccm\/145.2_Pt_1.317","article-title":"Enhanced superoxide production by alveolar macrophages and air-space cells, airway inflammation, and alveolar macrophage density changes after segmental antigen bronchoprovocation in allergic subjects","volume":"145","author":"Calhoun","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"key20200713115418_b27-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1183\/09031936.94.07091585","article-title":"Enhancement of reactive oxygen species formation in stable and unstable asthmatic patients","volume":"7","author":"Vachier","year":"1994","journal-title":"Eur Respir J"},{"issue":"vi","key":"key20200713115418_b28-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.otc.2007.11.005","article-title":"Asthma and rhinitis: Comorbidities","volume":"41","author":"Ryan","year":"2008","journal-title":"Otolaryngol Clin North Am"},{"key":"key20200713115418_b29-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1146\/annurev.med.60.041807.123524","article-title":"Immunomodulation of allergic disease","volume":"60","author":"Broide","year":"2009","journal-title":"Annu Rev Med"},{"key":"key20200713115418_b30-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1034\/j.1600-065X.2001.790118.x","article-title":"IL-5-induced airway eosinophilia-the key to asthma?","volume":"179","author":"Hamelmann","year":"2001","journal-title":"Immunol Rev"},{"key":"key20200713115418_b31-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1177\/0194599810396133","article-title":"Peroxisome proliferator-activated receptor-gamma agonist induces regulatory T cells in a murine model of allergic rhinitis","volume":"144","author":"Wang","year":"2011","journal-title":"Otolaryngol Head Neck Surg"},{"key":"key20200713115418_b32-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.annepidem.2007.11.001","article-title":"Obesity and adult asthma: Potential effect modification by gender, but not by hay fever","volume":"18","author":"Loerbroks","year":"2008","journal-title":"Ann Epidemiol"},{"key":"key20200713115418_b33-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"418705","DOI":"10.1155\/2014\/418705","article-title":"Effects of Hyeonggaeyeongyo-tang in ovalbumin-induced allergic rhinitis model","volume":"2014","author":"Hong","year":"2014","journal-title":"Mediators Inflamm"},{"key":"key20200713115418_b34-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1172\/JCI200421146","article-title":"Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice","volume":"114","author":"Rangasamy","year":"2004","journal-title":"J Clin Invest"},{"key":"key20200713115418_b35-etm-0-0-6880","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.brainres.2014.09.030","article-title":"Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis","volume":"1589","author":"Liu","year":"2014","journal-title":"Brain Res"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T10:57:49Z","timestamp":1594637869000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2018.6880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,19]]},"references-count":35,"URL":"https:\/\/doi.org\/10.3892\/etm.2018.6880","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,19]]}}}