{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:55:40Z","timestamp":1783029340444,"version":"3.54.6"},"reference-count":23,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2019.7189","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T09:37:26Z","timestamp":1548063446000},"source":"Crossref","is-referenced-by-count":6,"title":["Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice"],"prefix":"10.3892","author":[{"given":"Mingwei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei 441021, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei 441021, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongcao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei 441021, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"key":"key20200713120239_b1-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/nm.4012","article-title":"Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice","volume":"22","author":"Arai","year":"2016","journal-title":"Nat Med"},{"key":"key20200713120239_b2-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.kint.2017.08.014","article-title":"Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia\/reperfusion-induced acute kidney injury","volume":"93","author":"Raup-Konsavage","year":"2018","journal-title":"Kidney Int"},{"key":"key20200713120239_b3-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"F437","DOI":"10.1152\/ajprenal.00254.2016","article-title":"Peptidyl arginine deiminase-4-deficient mice are protected against kidney and liver injury after renal ischemia and reperfusion","volume":"311","author":"Rabadi","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"key20200713120239_b4-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1681\/ASN.2016111210","article-title":"ELABELA and an ELABELA fragment protect against AKI","volume":"28","author":"Chen","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"key20200713120239_b5-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.yexcr.2017.07.038","article-title":"Tisp40 deficiency attenuates renal ischemia reperfusion injury induced apoptosis of tubular epithelial cells","volume":"359","author":"Qin","year":"2017","journal-title":"Exp Cell Res"},{"key":"key20200713120239_b6-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1172\/JCI75417","article-title":"KIM-1-mediated phagocytosis reduces acute injury to the kidney","volume":"125","author":"Yang","year":"2015","journal-title":"J Clin Invest"},{"key":"key20200713120239_b7-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1080\/21691401.2017.1337022","article-title":"An in vitro examination of the antioxidant, cytoprotective and anti-inflammatory properties of chrysin-loaded nanofibrous mats for potential wound healing applications","volume":"46","author":"Deldar","year":"2018","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"key20200713120239_b8-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.ejphar.2017.11.008","article-title":"In vivo cellular and molecular gastroprotective mechanisms of chrysin; Emphasis on oxidative stress, inflammation and angiogenesis","volume":"818","author":"George","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"key20200713120239_b9-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.cbi.2017.11.022","article-title":"Chrysin, a natural and biologically active flavonoid suppresses tumor growth of mouse B16F10 melanoma cells: In vitro and in vivo study","volume":"283","author":"Sassi","year":"2018","journal-title":"Chem Biol Interact"},{"key":"key20200713120239_b10-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"20913","DOI":"10.3390\/ijms151120913","article-title":"Chrysin protects against focal cerebral ischemia\/reperfusion injury in mice through attenuation of oxidative stress and inflammation","volume":"15","author":"Yao","year":"2014","journal-title":"Int J Mol Sci"},{"key":"key20200713120239_b11-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713120239_b12-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3892\/ijmm.2016.2616","article-title":"Brazilin exerts protective effects against renal ischemia-reperfusion injury by inhibiting the NF-\u03baB signaling pathway","volume":"38","author":"Jia","year":"2016","journal-title":"Int J Mol Med"},{"key":"key20200713120239_b13-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"3533","DOI":"10.1681\/ASN.2016121278","article-title":"Renal tubular cell-derived extracellular vesicles accelerate the recovery of established renal ischemia reperfusion injury","volume":"28","author":"Dominguez","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"key20200713120239_b14-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s13287-017-0599-x","article-title":"Bone mesenchymal stem cells ameliorate ischemia\/reperfusion-induced damage in renal epithelial cells via microRNA-223","volume":"8","author":"Yuan","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"key20200713120239_b15-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3390\/molecules23010067","article-title":"Chrysin induces antidiabetic, antidyslipidemic and anti-inflammatory effects in athymic nude diabetic mice","volume":"23","author":"Ramirez-Espinosa","year":"2017","journal-title":"Molecules"},{"key":"key20200713120239_b16-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.fct.2017.10.025","article-title":"Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes","volume":"110","author":"Choi","year":"2017","journal-title":"Food Chem Toxicol"},{"key":"key20200713120239_b17-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"2172981","DOI":"10.1155\/2017\/2172981","article-title":"Chrysin administration protects against oxidative damage in varicocele-induced adult rats","volume":"2017","author":"Missassi","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"key20200713120239_b18-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1002\/jcp.26150","article-title":"Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction","volume":"233","author":"Lim","year":"2018","journal-title":"J Cell Physiol"},{"key":"key20200713120239_b19-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"F926","DOI":"10.1152\/ajprenal.00118.2017","article-title":"UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury","volume":"313","author":"Zhou","year":"2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"key20200713120239_b20-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.surg.2016.07.028","article-title":"ERK phosphorylation plays an important role in the protection afforded by hypothermia against renal ischemia-reperfusion injury","volume":"161","author":"Choi","year":"2017","journal-title":"Surgery"},{"key":"key20200713120239_b21-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s10495-016-1341-3","article-title":"SIRT2-mediated FOXO3a deacetylation drives its nuclear translocation triggering FasL-induced cell apoptosis during renal ischemia reperfusion","volume":"22","author":"Wang","year":"2017","journal-title":"Apoptosis"},{"key":"key20200713120239_b22-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s00011-017-1071-1","article-title":"Effects of sevoflurane on NF-\u043aB and TNF-\u03b1 expression in renal ischemia-reperfusion diabetic rats","volume":"66","author":"Zhang","year":"2017","journal-title":"Inflamm Res"},{"key":"key20200713120239_b23-etm-0-0-7189","doi-asserted-by":"publisher","first-page":"F522","DOI":"10.1152\/ajprenal.00620.2016","article-title":"Arginase-2 mediates renal ischemia-reperfusion injury","volume":"313","author":"Raup-Konsavage","year":"2017","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T11:30:13Z","timestamp":1594639813000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2019.7189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,21]]},"references-count":23,"URL":"https:\/\/doi.org\/10.3892\/etm.2019.7189","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,21]]}}}