{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:19:21Z","timestamp":1790234361013,"version":"4.1.0"},"reference-count":22,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2019.7234","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T10:57:28Z","timestamp":1549277848000},"source":"Crossref","is-referenced-by-count":3,"title":["Effect of the transdifferentiation of BECs into myofibroblasts on the pathogenesis of secondary cholestatic hepatic fibrosis"],"prefix":"10.3892","author":[{"given":"Bing\u2011Feng","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Zhoushan Hospital, Zhoushan, Zhejiang 316000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2011Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Zhoushan Hospital, Zhoushan, Zhejiang 316000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2011Ming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Zhoushan Hospital, Zhoushan, Zhejiang 316000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Zhoushan Hospital, Zhoushan, Zhejiang 316000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Zhoushan Hospital, Zhoushan, Zhejiang 316000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2019,2,4]]},"reference":[{"key":"key20200713120419_b1-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.jhep.2015.11.030","article-title":"Pregnancy and liver disease","volume":"64","author":"Westbrook","year":"2016","journal-title":"J Hepatol"},{"key":"key20200713120419_b2-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1053\/j.gastro.2014.05.001","article-title":"The portal fibroblast: Not just a poor man's stellate cell","volume":"147","author":"Wells","year":"2014","journal-title":"Gastroenterology"},{"key":"key20200713120419_b3-etm-0-0-7234","first-page":"35","article-title":"Melatonin regulation of biliary functions","volume":"3","author":"Glaser","year":"2014","journal-title":"Hepatobiliary Surg Nutr"},{"key":"key20200713120419_b4-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.mayocp.2015.03.017","article-title":"The cholangiopathies","volume":"90","author":"Lazaridis","year":"2015","journal-title":"Mayo Clin Proc"},{"key":"key20200713120419_b5-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.1016\/j.jhep.2015.02.023","article-title":"New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond","volume":"62","author":"Beuers","year":"2015","journal-title":"J Hepatol"},{"key":"key20200713120419_b6-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.2353\/ajpath.2006.050747","article-title":"Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation","volume":"168","author":"Xia","year":"2006","journal-title":"Am J Pathol"},{"key":"key20200713120419_b7-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/S0002-9440(10)65034-1","article-title":"The development and compensation of biliary cirrhosis in interleukin-6-deficient mice","volume":"156","author":"Ezure","year":"2000","journal-title":"Am J Pathol"},{"key":"key20200713120419_b8-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0003-2697(81)90261-X","article-title":"A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues","volume":"112","author":"Jamall","year":"1981","journal-title":"Anal Biochem"},{"key":"key20200713120419_b9-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","article-title":"EMT: 2016","volume":"166","author":"Nieto","year":"2016","journal-title":"Cell"},{"key":"key20200713120419_b10-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1681\/ASN.2014010117","article-title":"Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis","volume":"25","author":"Anders","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"key20200713120419_b11-etm-0-0-7234","first-page":"1409","article-title":"Epithelial mesenchymal transition in the progression of renal disease in dogs","volume":"29","author":"Benali","year":"2014","journal-title":"Histol Histopathol"},{"key":"key20200713120419_b12-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.phrs.2015.04.012","article-title":"Bleomycin in the setting of lung fibrosis induction: From biological mechanisms to counteractions","volume":"97","author":"Della Latta","year":"2015","journal-title":"Pharmacol Res"},{"key":"key20200713120419_b13-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"207","DOI":"10.4254\/wjh.v6.i4.207","article-title":"Mechanisms of fibrogenesis in liver cirrhosis: The molecular aspects of epithelial-mesenchymal transition","volume":"6","author":"Lee","year":"2014","journal-title":"World J Hepatol"},{"key":"key20200713120419_b14-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1002\/hep.21624","article-title":"Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis","volume":"45","author":"Robertson","year":"2007","journal-title":"Hepatology"},{"key":"key20200713120419_b15-etm-0-0-7234","first-page":"3331","article-title":"Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans","volume":"118","author":"Omenetti","year":"2008","journal-title":"J Clin Invest"},{"key":"key20200713120419_b16-etm-0-0-7234","first-page":"250","article-title":"Epithelial-mesenchymal transition of biliary epithelial cells in advanced liver fibrosis","volume":"91","author":"Schulze","year":"2007","journal-title":"Verh Dtsch Ges Pathol"},{"key":"key20200713120419_b17-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"295","DOI":"10.5009\/gnl.2012.6.3.295","article-title":"The crucial role of cholangiocytes in cholangiopathies","volume":"6","author":"Park","year":"2012","journal-title":"Gut Liver"},{"key":"key20200713120419_b18-etm-0-0-7234","first-page":"4076","article-title":"Immunohistochemical study for the origin of ductular reaction in chronic liver disease","volume":"7","author":"Lee","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"key20200713120419_b19-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.2353\/ajpath.2007.070337","article-title":"Cholangiocytes with mesenchymal features contribute to progressive hepatic fibrosis of the polycystic kidney rat","volume":"171","author":"Sato","year":"2007","journal-title":"Am J Pathol"},{"key":"key20200713120419_b20-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1055\/s-2004-815558","article-title":"Isolation and characterization of mouse hepatic stem cells in vitro","volume":"23","author":"Weiss","year":"2003","journal-title":"Semin Liver Dis"},{"key":"key20200713120419_b21-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cca.2005.06.014","article-title":"Mechanisms of liver fibrosis","volume":"364","author":"Tsukada","year":"2006","journal-title":"Clin Chim Acta"},{"key":"key20200713120419_b22-etm-0-0-7234","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/hep.1840070212","article-title":"Characterization of desmin-pvsitive rat liver sinusoidal cells","volume":"7","author":"Tsutsumi","year":"1987","journal-title":"Hepatology"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T11:31:58Z","timestamp":1594639918000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2019.7234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,4]]},"references-count":22,"URL":"https:\/\/doi.org\/10.3892\/etm.2019.7234","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,4]]}}}