{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:48:24Z","timestamp":1773280104250,"version":"3.50.1"},"reference-count":39,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2019.7794","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T06:57:44Z","timestamp":1563519464000},"source":"Crossref","is-referenced-by-count":7,"title":["Expression of \u03b2\u2011catenin and MMP\u20118 in gingival crevicular fluid and gingival tissue indicates the disease severity of patients with chronic periodontitis"],"prefix":"10.3892","author":[{"given":"Lilei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Periodontology, Changsha Stomatological Hospital, Changsha, Hunan 410005, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Changsha Stomatological Hospital, Changsha, Hunan 410005, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Changsha Stomatological Hospital, Changsha, Hunan 410005, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Changsha Stomatological Hospital, Changsha, Hunan 410005, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Changsha Stomatological Hospital, Changsha, Hunan 410005, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2019,7,19]]},"reference":[{"key":"key20200713100724_b1-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/prd.12200","article-title":"Periodontitis epidemiology: Is periodontitis under-recognized, over-diagnosed, or both","volume":"75","author":"Papapanou","year":"2017","journal-title":"Periodontol 2000"},{"key":"key20200713100724_b2-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/j.1600-0765.1991.tb01649.x","article-title":"The role of inflammatory mediators in the pathogenesis of periodontal disease","volume":"26","author":"Page","year":"1991","journal-title":"J Periodontal Res"},{"key":"key20200713100724_b3-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.15171\/jlms.2017.s2","article-title":"The effect of photodynamic therapy in the treatment of chronic periodontitis: A review of literature","volume":"8","author":"Meimandi","year":"2017","journal-title":"J Lasers Med Sci"},{"key":"key20200713100724_b4-etm-0-0-7794","first-page":"CD009376","article-title":"Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis","volume":"1","author":"Manresa","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"key20200713100724_b5-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/j.0143-2885.2007.01223.x","article-title":"The effect of chemical inhibition of matrix metalloproteinases on the size of experimentally induced apical periodontitis","volume":"40","author":"Tj\u00e4derhane","year":"2007","journal-title":"Int Endod J"},{"key":"key20200713100724_b6-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.joen.2018.01.010","article-title":"Ovariectomy exacerbates apical periodontitis in rats with an increase in expression of proinflammatory cytokines and matrix metalloproteinases","volume":"44","author":"Romualdo","year":"2018","journal-title":"J Endod"},{"key":"key20200713100724_b7-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1111\/j.1365-2591.2011.01880.x","article-title":"Expression of MMP-8 and MMP-13 in the development of periradicular lesions","volume":"44","author":"Matsui","year":"2011","journal-title":"Int Endod J"},{"key":"key20200713100724_b8-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1080\/07853890600800103","article-title":"Matrix metalloproteinases: Contribution to pathogenesis, diagnosis and treatment of periodontal inflammation","volume":"38","author":"Sorsa","year":"2006","journal-title":"Ann Med"},{"key":"key20200713100724_b9-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1111\/j.1600-051X.1996.tb01814.x","article-title":"Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients","volume":"23","author":"Ingman","year":"1996","journal-title":"J Clin Periodontol"},{"key":"key20200713100724_b10-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/jcpe.12038","article-title":"Salivary biomarkers of oral health: A cross-sectional study","volume":"40","author":"Rathnayake","year":"2013","journal-title":"J Clin Periodontol"},{"key":"key20200713100724_b11-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1111\/jre.12574","article-title":"Interaction between the Wnt\/\u03b2-catenin signaling pathway and the EMMPRIN\/MMP-2, 9 route in periodontitis","volume":"53","author":"Liu","year":"2018","journal-title":"J Periodontal Res"},{"key":"key20200713100724_b12-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"3226","DOI":"10.1016\/j.bbadis.2017.08.031","article-title":"Wnt\/\u03b2-catenin signaling links embryonic lung development and asthmatic airway remodeling","volume":"1863","author":"Hussain","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"key20200713100724_b13-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1038\/emboj.2012.150","article-title":"The many faces and functions of \u03b2-catenin","volume":"31","author":"Valenta","year":"2012","journal-title":"EMBO J"},{"key":"key20200713100724_b14-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1517\/14728222.2014.934813","article-title":"\u03b2-catenin as a regulator and therapeutic target for asthmatic airway remodeling","volume":"18","author":"Kumawat","year":"2014","journal-title":"Expert Opin Ther Targets"},{"key":"key20200713100724_b15-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1177\/0022034510363373","article-title":"Wnt\/beta-catenin signaling in oral tissue development and disease","volume":"89","author":"Liu","year":"2010","journal-title":"J Dent Res"},{"key":"key20200713100724_b16-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.3748\/wjg.v11.i14.2117","article-title":"Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: Relationships with carcinogenesis and metastasis","volume":"11","author":"Li","year":"2005","journal-title":"World J Gastroenterol"},{"key":"key20200713100724_b17-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/jcb.22123","article-title":"Differential role of beta-catenin in VEGF and histamine-induced MMP-2 production in microvascular endothelial cells","volume":"107","author":"Doyle","year":"2009","journal-title":"J Cell Biochem"},{"key":"key20200713100724_b18-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1177\/00220345940730080201","article-title":"Matrix metalloproteinases (MMP-2 and MMP-9) of the oral cavity: Cellular origin and relationship to periodontal status","volume":"73","author":"M\u00e4kel\u00e4","year":"1994","journal-title":"J Dent Res"},{"key":"key20200713100724_b19-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1600-0765.2004.00705.x","article-title":"In situ detection of matrix metalloproteinase-9 (MMP-9) in gingival epithelium in human periodontal disease","volume":"39","author":"Smith","year":"2004","journal-title":"J Periodontal Res"},{"key":"key20200713100724_b20-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/odi.12769","article-title":"Associations of oral fluid MMP-8 with periodontitis in Swiss adult subjects","volume":"24","author":"Mauramo","year":"2018","journal-title":"Oral Dis"},{"key":"key20200713100724_b21-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s11684-014-0347-x","article-title":"Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis","volume":"9","author":"Gupta","year":"2015","journal-title":"Front Med"},{"key":"key20200713100724_b22-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1111\/j.1600-0765.2012.01480.x","article-title":"Effect of scaling and root planing on interleukin-1\u03b2, interleukin-8 and MMP-8 levels in gingival crevicular fluid from chronic periodontitis patients","volume":"47","author":"Konopka","year":"2012","journal-title":"J Periodontal Res"},{"key":"key20200713100724_b23-etm-0-0-7794","first-page":"31","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"79","author":"Armitage","year":"2000","journal-title":"Northwest Dent"},{"key":"key20200713100724_b24-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/j.1600-0765.1967.tb01887.x","article-title":"Errors in the clinical assessment of periodontal destruction","volume":"2","author":"Glavind","year":"1967","journal-title":"J Periodontal Res"},{"key":"key20200713100724_b25-etm-0-0-7794","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo","year":"1975","journal-title":"Int Dent J"},{"key":"key20200713100724_b26-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1902\/jop.1984.55.12.684","article-title":"The role of bleeding upon probing in the diagnosis of periodontal disease. A literature review","volume":"55","author":"Greenstein","year":"1984","journal-title":"J Periodontol"},{"key":"key20200713100724_b27-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1600-0765.1986.tb01443.x","article-title":"The use of crevicular fluid prostaglandin E2 levels as a predictor of periodontal attachment loss","volume":"21","author":"Offenbacher","year":"1986","journal-title":"J Periodontal Res"},{"key":"key20200713100724_b28-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1177\/00220345960750010801","article-title":"Interleukin (IL)-1 beta, IL-6, tumor necrosis factor-alpha, epidermal growth factor, and beta 2-microglobulin levels are elevated in gingival crevicular fluid during human orthodontic tooth movement","volume":"75","author":"Uematsu","year":"1996","journal-title":"J Dent Res"},{"key":"key20200713100724_b29-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1590\/S1517-83822011000300047","article-title":"Expression of HMGB1 and HMGN2 in gingival tissues, GCF and PICF of periodontitis patients and peri-implantitis","volume":"42","author":"Xie","year":"2011","journal-title":"Braz J Microbiol"},{"key":"key20200713100724_b30-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.ijom.2010.01.014","article-title":"Proinflammatory cytokines (IL-1beta and TNF-alpha) and chemokines (IL-8 and MIP-1alpha) as markers of peri-implant tissue condition","volume":"39","author":"Petkovi\u0107","year":"2010","journal-title":"Int J Oral Maxillofac Surg"},{"key":"key20200713100724_b31-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"key20200713100724_b32-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1196\/annals.1384.028","article-title":"Oral fluid-based biomarkers of alveolar bone loss in periodontitis","volume":"1098","author":"Kinney","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"key20200713100724_b33-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.phrs.2010.10.005","article-title":"Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines","volume":"63","author":"Sorsa","year":"2011","journal-title":"Pharmacol Res"},{"key":"key20200713100724_b34-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"e9642","DOI":"10.1097\/MD.0000000000009642","article-title":"Salivary matrix metalloproteinase (MMP)-8 as a biomarker for periodontitis: A PRISMA-compliant systematic review and meta-analysis","volume":"97","author":"Zhang","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"key20200713100724_b35-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.oraloncology.2014.06.005","article-title":"\u03b2-catenin in oral cancer: An update on current knowledge","volume":"50","author":"Gonz\u00e1lez-Moles","year":"2014","journal-title":"Oral Oncol"},{"key":"key20200713100724_b36-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: Components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev Cell"},{"key":"key20200713100724_b37-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1111\/jcpe.12245","article-title":"Involvement of the Wnt-\u03b2-catenin signalling antagonists, sclerostin and dickkopf-related protein 1, in chronic periodontitis","volume":"41","author":"Napimoga","year":"2014","journal-title":"J Clin Periodontol"},{"key":"key20200713100724_b38-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.archoralbio.2017.11.012","article-title":"Dickkopf-1 may regulate bone coupling by attenuating wnt\/\u03b2-catenin signaling in chronic apical periodontitis","volume":"86","author":"Tan","year":"2018","journal-title":"Arch Oral Biol"},{"key":"key20200713100724_b39-etm-0-0-7794","doi-asserted-by":"publisher","first-page":"15594","DOI":"10.18632\/oncotarget.3709","article-title":"PBK\/TOPK enhances aggressive phenotype in prostate cancer via \u03b2-catenin-TCF\/LEF-mediated matrix metalloproteinases production and invasion","volume":"6","author":"Brown-Clay","year":"2015","journal-title":"Oncotarget"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T09:07:46Z","timestamp":1594631266000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2019.7794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,19]]},"references-count":39,"URL":"https:\/\/doi.org\/10.3892\/etm.2019.7794","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,19]]}}}