{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:06:02Z","timestamp":1792371962411,"version":"4.4.0"},"reference-count":67,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2019.8236","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T07:57:17Z","timestamp":1574409437000},"source":"Crossref","is-referenced-by-count":3,"title":["\u03b23 adrenergic receptor antagonist SR59230A exerts beneficial effects on right ventricular performance in monocrotaline\u2011induced pulmonary arterial hypertension"],"prefix":"10.3892","author":[{"given":"Jiantao","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiemei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"key":"key20200713005350_b1-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1161\/HYPERTENSIONAHA.110.166819","article-title":"Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase","volume":"58","author":"Xu","year":"2011","journal-title":"Hypertension"},{"key":"key20200713005350_b2-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.cjca.2014.10.024","article-title":"Current treatment approaches to pulmonary arterial hypertension","volume":"31","author":"Provencher","year":"2015","journal-title":"Can J Cardiol"},{"key":"key20200713005350_b3-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1183\/09059180.00005412","article-title":"Challenges in the diagnosis and treatment of pulmonary arterial hypertension","volume":"21","author":"Vachiery","year":"2012","journal-title":"Eur Respir Rev"},{"key":"key20200713005350_b4-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.pharmthera.2005.12.002","article-title":"Beta3-adrenoceptors in the cardiovascular system: Putative roles in human pathologies","volume":"111","author":"Rozec","year":"2006","journal-title":"Pharmacol Ther"},{"key":"key20200713005350_b5-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.yjmcc.2010.02.011","article-title":"Beta 3-adrenoreceptor regulation of nitric oxide in the cardiovascular system","volume":"48","author":"Moens","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"key20200713005350_b6-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1172\/JCI118823","article-title":"Functional beta3-adrenoceptor in the human heart","volume":"98","author":"Gauthier","year":"1996","journal-title":"J Clin Invest"},{"key":"key20200713005350_b7-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1016\/j.jacc.2011.12.046","article-title":"Cardioprotective effect of beta-3 adrenergic receptor agonism: Role of neuronal nitric oxide synthase","volume":"59","author":"Niu","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"key20200713005350_b8-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/S0008-6363(03)00359-6","article-title":"Beta3-Adrenergic stimulation produces a decrease of cardiac contractility ex vivo in mice overexpressing the human beta3-adrenergic receptor","volume":"59","author":"Tavernier","year":"2003","journal-title":"Cardiovasc Res"},{"key":"key20200713005350_b9-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1177\/1074248412460123","article-title":"Upregulation of \u03b23-adrenergic receptor expression in the atrium of rats with chronic heart failure","volume":"18","author":"Zhao","year":"2013","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"key20200713005350_b10-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/S0165-6147(00)01562-5","article-title":"Beta3-adrenoceptors in the cardiovascular system","volume":"21","author":"Gauthier","year":"2000","journal-title":"Trends Pharmacol Sci"},{"key":"key20200713005350_b11-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1177\/2042018810390259","article-title":"\u03b2(3) Receptors: Role in cardiometabolic disorders","volume":"2","author":"Bhadada","year":"2011","journal-title":"Ther Adv Endocrinol Metab"},{"key":"key20200713005350_b12-etm-0-0-8236","first-page":"955","article-title":"The use of beta3-adrenergic receptor agonists in the treatment of heart failure","volume":"10","author":"Rasmussen","year":"2009","journal-title":"Curr Opin Investig Drugs"},{"key":"key20200713005350_b13-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"F775","DOI":"10.1152\/ajprenal.00233.2012","article-title":"Nebivolol-induced vasodilation of renal afferent arterioles involves beta3-adrenergic receptor and nitric oxide synthase activation","volume":"303","author":"Feng","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"key20200713005350_b14-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jacc.2005.03.061","article-title":"Characterization of beta3-adrenoceptors in human internal mammary artery and putative involvement in coronary artery bypass management","volume":"46","author":"Rozec","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"key20200713005350_b15-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1472-8206.1995.tb00288.x","article-title":"Pharmacological characteristics and species-related variations of beta 3-adrenergic receptors","volume":"9","author":"Pietri-Rouxel","year":"1995","journal-title":"Fundam Clin Pharmacol"},{"key":"key20200713005350_b16-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1527-3466.2002.tb00079.x","article-title":"Potential use of beta(3)-adrenoceptor antagonists in heart failure therapy","volume":"20","author":"Moniotte","year":"2002","journal-title":"Cardiovasc Drug Rev"},{"key":"key20200713005350_b17-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s00210-005-1082-2","article-title":"Role of beta2-adrenoceptors (beta-AR), but not beta1-, beta3-AR and endothelial nitric oxide, in beta-AR-mediated relaxation of rat intrapulmonary artery","volume":"372","author":"Pourageaud","year":"2005","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"key20200713005350_b18-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/PL00007650","article-title":"Atypical adrenoceptor-mediated relaxation of canine pulmonary artery through a cyclic adenosine monophosphate-dependent pathway","volume":"177","author":"Tagaya","year":"1999","journal-title":"Lung"},{"key":"key20200713005350_b19-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"3230","DOI":"10.1038\/ncomms4230","article-title":"A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages","volume":"5","author":"Yu","year":"2014","journal-title":"Nat Commun"},{"key":"key20200713005350_b20-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00395-016-0567-0","article-title":"Beta-3 adrenergic agonists reduce pulmonary vascular resistance and improve right ventricular performance in a porcine model of chronic pulmonary hypertension","volume":"111","author":"Garc\u00eda-A\u00edvarez","year":"2016","journal-title":"Basic Res Cardiol"},{"key":"key20200713005350_b21-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.jacc.2014.11.050","article-title":"Nebivolol for improving endothelial dysfunction, pulmonary vascular remodeling and right heart function in pulmonary hypertension","volume":"65","author":"Perros","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"key20200713005350_b22-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/sj.bjp.0705065","article-title":"The preferential beta3-adrenoceptor agonist BRL 37344 increases force via beta1-\/beta2-adrenoceptors and induces endothelial nitric oxide synthase via beta3-adrenoceptors in human atrial myocardium","volume":"138","author":"Pott","year":"2003","journal-title":"Br J Pharmacol"},{"key":"key20200713005350_b23-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1124\/jpet.107.125757","article-title":"GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog","volume":"323","author":"Hicks","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"key20200713005350_b24-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1139\/cjpp-2015-0431","article-title":"Nebivolol has a beneficial effect in monocrotaline-induced pulmonary hypertension","volume":"94","author":"Pankey","year":"2016","journal-title":"Can J Physiol Pharmacol"},{"key":"key20200713005350_b25-etm-0-0-8236","first-page":"675","article-title":"Effect of beta3-adrenoceptor antagonist on the cardiac function and expression of endothelial nitric oxide synthase in a rat model of heart failure","volume":"19","author":"Gan","year":"2007","journal-title":"Zhongguo Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"key20200713005350_b26-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"4528906","DOI":"10.1155\/2016\/4528906","article-title":"Targeting Pin1 protects mouse cardiomyocytes from high-dose alcohol-induced apoptosis","volume":"2016","author":"Wang","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"key20200713005350_b27-etm-0-0-8236","volume-title":"Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"key20200713005350_b28-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713005350_b29-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1080\/10937409809524557","article-title":"Chronic pulmonary hypertension-the monocrotaline model and involvement of the hemostatic system","volume":"1","author":"Schultze","year":"1998","journal-title":"J Toxicol Environ Health B Crit Rev"},{"key":"key20200713005350_b30-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"685-713","DOI":"10.1016\/j.echo.2010.05.010","article-title":"Guidelines for the echocardiographic assessment of the right heart in adults: A report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology and the Canadian Society of Echocardiography","volume":"23","author":"Rudski","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"key20200713005350_b31-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1164\/rccm.201003-0335OC","article-title":"Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats","volume":"182","author":"Bogaard","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"key20200713005350_b32-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.tips.2011.02.010","article-title":"Evolution of \u03b2-blockers: From anti-anginal drugs to ligand-directed signalling","volume":"32","author":"Baker","year":"2011","journal-title":"Trends Pharmacol Sci"},{"key":"key20200713005350_b33-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S1054-3589(10)59005-7","article-title":"Beta3-adrenergic receptors in cardiac and vascular tissues emerging concepts and therapeutic perspectives","volume":"59","author":"Dessy","year":"2010","journal-title":"Adv Pharmacol"},{"key":"key20200713005350_b34-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1146\/annurev.pharmtox.37.1.421","article-title":"Structure and function of the beta 3-adrenergic receptor","volume":"37","author":"Strosberg","year":"1997","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"key20200713005350_b35-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1161\/hh1901.098042","article-title":"Upregulation of functional beta(3)-adrenergic receptor in the failing canine myocardium","volume":"89","author":"Cheng","year":"2001","journal-title":"Circ Res"},{"key":"key20200713005350_b36-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"H2425","DOI":"10.1152\/ajpheart.01045.2003","article-title":"Endogenous beta3-adrenoreceptor activation contributes to left ventricular and cardiomyocyte dysfunction in heart failure","volume":"286","author":"Morimoto","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key20200713005350_b37-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1097\/00029330-200712020-00018","article-title":"Chronic blocking of beta 3-adrenoceptor ameliorates cardiac function in rat model of heart failure","volume":"120","author":"Gan","year":"2007","journal-title":"Chin Med J (Engl)"},{"key":"key20200713005350_b38-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.phrs.2009.01.002","article-title":"The beta3-adrenoceptor as a therapeutic target: Current perspectives","volume":"59","author":"Ursino","year":"2009","journal-title":"Pharmacol Res"},{"key":"key20200713005350_b39-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s00210-006-0056-3","article-title":"Agonist effects of zinterol at the mouse and human beta(3)-adrenoceptor","volume":"373","author":"Hutchinson","year":"2006","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"key20200713005350_b40-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1124\/mol.107.035337","article-title":"Ligand-directed signaling at the beta3-adrenoceptor produced by 3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapt-1-ylamino]-2S-2-propanol oxalate (SR59230A) relative to receptor agonists","volume":"72","author":"Sato","year":"2007","journal-title":"Mol Pharmacol"},{"key":"key20200713005350_b41-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00210-006-0127-5","article-title":"Tools to study beta3-adrenoceptors","volume":"374","author":"Vrydag","year":"2007","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"key20200713005350_b42-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1378\/chest.11-0793","article-title":"Inflammation in pulmonary arterial hypertension","volume":"141","author":"Price","year":"2012","journal-title":"Chest"},{"key":"key20200713005350_b43-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1161\/CIRCRESAHA.108.182014","article-title":"Interleukin-6 overexpression induces pulmonary hypertension","volume":"104","author":"Steiner","year":"2009","journal-title":"Circ Res"},{"key":"key20200713005350_b44-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.bbalip.2010.04.012","article-title":"Beta3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK","volume":"1801","author":"Mottillo","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"key20200713005350_b45-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1016\/j.molimm.2009.04.008","article-title":"Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes","volume":"46","author":"Tchivileva","year":"2009","journal-title":"Mol Immunol"},{"key":"key20200713005350_b46-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"5864","DOI":"10.1210\/jcem.86.12.8104","article-title":"Beta-adrenergic regulation of IL-6 release from adipose tissue: In vivo and in vitro studies","volume":"86","author":"Mohamed-Ali","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key20200713005350_b47-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1161\/CIRCULATIONAHA.107.653584","article-title":"Right ventricular function in cardiovascular disease, part II: Pathophysiology, clinical importance and management of right ventricular failure","volume":"117","author":"Haddad","year":"2008","journal-title":"Circulation"},{"key":"key20200713005350_b48-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"609","DOI":"10.3389\/fphys.2018.00609","article-title":"Inflammatory mediators drive adverse right ventricular remodeling and dysfunction and serve as potential biomarkers","volume":"9","author":"Sydykov","year":"2018","journal-title":"Front Physiol"},{"key":"key20200713005350_b49-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1164\/rccm.201304-0686PP","article-title":"Nitric oxide deficiency and endothelial dysfunction in pulmonary arterial hypertension","volume":"188","author":"Klinger","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"key20200713005350_b50-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1161\/01.RES.76.2.215","article-title":"Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy and growth retardation in the hypoxic newborn rat","volume":"76","author":"Roberts","year":"1995","journal-title":"Circ Res"},{"key":"key20200713005350_b51-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1161\/01.RES.81.1.34","article-title":"Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene","volume":"81","author":"Steudel","year":"1997","journal-title":"Circ Res"},{"key":"key20200713005350_b52-etm-0-0-8236","first-page":"L472","article-title":"Relative contributions of endothelial, inducible and neuronal NOS to tone in the murine pulmonary circulation","volume":"277","author":"Fagan","year":"1999","journal-title":"Am J Physiol"},{"key":"key20200713005350_b53-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1097\/01.anes.0000278909.40408.24","article-title":"Altered contractile response due to increased beta3-adrenoceptor stimulation in diabetic cardiomyopathy: The role of nitric oxide synthase 1-derived nitric oxide","volume":"107","author":"Amour","year":"2007","journal-title":"Anesthesiology"},{"key":"key20200713005350_b54-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1161\/HYPERTENSIONAHA.107.094458","article-title":"Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation","volume":"50","author":"Maffei","year":"2007","journal-title":"Hypertension"},{"key":"key20200713005350_b55-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1093\/cvr\/cvr270","article-title":"eNOS uncoupling in pulmonary hypertension","volume":"92","author":"d'Uscio","year":"2011","journal-title":"Cardiovasc Res"},{"key":"key20200713005350_b56-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.cardfail.2008.08.006","article-title":"Effects of the beta3-adrenergic agonist BRL 37344 on endothelial nitric oxide synthase phosphorylation and force of contraction in human failing myocardium","volume":"15","author":"Napp","year":"2009","journal-title":"J Card Fail"},{"key":"key20200713005350_b57-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1038\/sj.bjp.0702878","article-title":"Mechanisms underlying the impairment of endothelium-dependent relaxation in the pulmonary artery of monocrotaline-induced pulmonary hypertensive rats","volume":"128","author":"Nakazawa","year":"1999","journal-title":"Br J Pharmacol"},{"key":"key20200713005350_b58-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"e23439","DOI":"10.1371\/journal.pone.0023439","article-title":"Pulmonary oxidative stress is increased in cyclooxygenase-2 knockdown mice with mild pulmonary hypertension induced by monocrotaline","volume":"6","author":"Seta","year":"2011","journal-title":"PLoS One"},{"key":"key20200713005350_b59-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.2174\/13816128113196660748","article-title":"eNOS uncoupling in cardiovascular diseases-the role of oxidative stress and inflammation","volume":"20","author":"Karbach","year":"2014","journal-title":"Curr Pharm Des"},{"key":"key20200713005350_b60-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"316","DOI":"10.4330\/wjc.v2.i10.316","article-title":"Contribution of oxidative stress to pulmonary arterial hypertension","volume":"2","author":"Demarco","year":"2010","journal-title":"World J Cardiol"},{"key":"key20200713005350_b61-etm-0-0-8236","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12312","article-title":"Tetrahydrobiopterin (BH4): Targeting endothelial nitric oxide synthase as a potential therapy for pulmonary hypertension","volume":"36","author":"Francis","year":"2018","journal-title":"Cardiovasc Ther"},{"key":"key20200713005350_b62-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/1465-9921-12-119","article-title":"Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension","volume":"12","author":"Dorfm\u00fcller","year":"2011","journal-title":"Respir Res"},{"key":"key20200713005350_b63-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"L11","DOI":"10.1152\/ajplung.00023.2005","article-title":"Pulmonary vascular iNOS induction participates in the onset of chronic hypoxic pulmonary hypertension","volume":"290","author":"Hampl","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key20200713005350_b64-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10067-018-3978-5","article-title":"Urantide improves the structure and function of right ventricle as determined by echocardiography in monocrotaline-induced pulmonary hypertension rat model","volume":"38","author":"Wang","year":"2018","journal-title":"Clin Rheumatol"},{"key":"key20200713005350_b65-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1536\/ihj.14-367","article-title":"Evaluation of right ventricle by speckle tracking and conventional echocardiography in rats with right ventricular heart failure","volume":"56","author":"Kimura","year":"2015","journal-title":"Int Heart J"},{"key":"key20200713005350_b66-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/sj.bjp.0705983","article-title":"Mechanisms of beta 3-adrenoceptor-induced eNOS activation in right atrial and left ventricular human myocardium","volume":"143","author":"Brixius","year":"2004","journal-title":"Br J Pharmacol"},{"key":"key20200713005350_b67-etm-0-0-8236","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1139\/y06-033","article-title":"Beta3-adrenergic eNOS stimulation in left ventricular murine myocardium","volume":"84","author":"Brixius","year":"2006","journal-title":"Can J Physiol Pharmacol"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T23:53:58Z","timestamp":1594598038000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2019.8236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,22]]},"references-count":67,"URL":"https:\/\/doi.org\/10.3892\/etm.2019.8236","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,22]]}}}