{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:39:50Z","timestamp":1778632790884,"version":"3.51.4"},"reference-count":34,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2020.8664","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T08:41:32Z","timestamp":1586940092000},"source":"Crossref","is-referenced-by-count":5,"title":["Botulinum toxin in low urinary tract disorders \u2011 over 30 years of practice (Review)"],"prefix":"10.3892","author":[{"given":"Arsenie","family":"Spinu","sequence":"first","affiliation":[{"name":"\u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidiu","family":"Bratu","sequence":"additional","affiliation":[{"name":"\u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camelia","family":"Diaconu","sequence":"additional","affiliation":[{"name":"\u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Stanescu","sequence":"additional","affiliation":[{"name":"\u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Bungau","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Oradea, Faculty of Medicine and Pharmacy, 410028 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidiu","family":"Fratila","sequence":"additional","affiliation":[{"name":"Department of Medical Disciplines, University of Oradea, Faculty of Medicine and Pharmacy, 410087 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Bohiltea","sequence":"additional","affiliation":[{"name":"\u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Mischianu","sequence":"additional","affiliation":[{"name":"\u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"key20200713004437_b1-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/s0022-5347(17)42717-0","article-title":"Effects of botulinum A toxin on detrusor-sphincter dyssynergia in spinal cord injury patients","volume":"139","author":"Dykstra","year":"1988","journal-title":"J Urol"},{"key":"key20200713004437_b2-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.coph.2004.12.006","article-title":"Botulinal neurotoxins: Revival of an old killer","volume":"5","author":"Montecucco","year":"2005","journal-title":"Curr Opin Pharmacol"},{"key":"key20200713004437_b3-etm-0-0-8664","first-page":"734","article-title":"Botulinum toxin injection of eye muscles to correct strabismus","volume":"79","author":"Scott","year":"1981","journal-title":"Trans Am Ophthalmol Soc"},{"key":"key20200713004437_b4-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/nau.10052","article-title":"The standardisation of terminology of lower urinary tract function: Report from the Standardisation Sub-committee of the International Continence Society","volume":"21","author":"Abrams","year":"2002","journal-title":"Neurourol Urodyn"},{"key":"key20200713004437_b5-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1016\/j.eururo.2006.09.019","article-title":"Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: Results of the EPIC study","volume":"50","author":"Irwin","year":"2006","journal-title":"Eur Urol"},{"key":"key20200713004437_b6-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2147\/rru.s4166","article-title":"Social, economic, and health utility considerations in the treatment of overactive bladder","volume":"2","author":"Sacco","year":"2010","journal-title":"Open Access J Urol"},{"key":"key20200713004437_b7-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1111\/j.1464-410X.2003.04714.x","article-title":"Botulinum toxin and its applications in the lower urinary tract","volume":"93","author":"Harper","year":"2004","journal-title":"BJU Int"},{"key":"key20200713004437_b8-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"721.e1","DOI":"10.1016\/j.urology.2011.03.070","article-title":"Effect of botulinum toxin on expression of nerve growth factor and transient receptor potential vanilloid 1 in urothelium and detrusor muscle of rats with bladder outlet obstruction-induced detrusor overactivity","volume":"78","author":"Ha","year":"2011","journal-title":"Urology"},{"key":"key20200713004437_b9-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ucl.2004.09.005","article-title":"Injectable neuromodulatory agents: Botulinum toxin therapy","volume":"32","author":"Frenkl","year":"2005","journal-title":"Urol Clin North Am"},{"key":"key20200713004437_b10-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.eururo.2012.03.031","article-title":"Botulinum neurotoxin serotype A suppresses neurotransmitter release from afferent as well as efferent nerves in the urinary bladder","volume":"62","author":"Ikeda","year":"2012","journal-title":"Eur Urol"},{"key":"key20200713004437_b11-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1002\/mds.870120627","article-title":"DYSBOT: A single-blind, randomized parallel study to determine whether any differences can be detected in the efficacy and tolerability of two formulations of botulinum toxin type A - Dysport and Botox - assuming a ratio of 4:1","volume":"12","author":"Sampaio","year":"1997","journal-title":"Mov Disord"},{"key":"key20200713004437_b12-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1136\/jnnp.64.1.6","article-title":"A double blind, randomised, parallel group study to investigate the dose equivalence of Dysport and Botox in the treatment of cervical dystonia","volume":"64","author":"Odergren","year":"1998","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key20200713004437_b13-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1136\/jnnp.72.4.430","article-title":"Respective potencies of Botox and Dysport: A double blind, randomised, crossover study in cervical dystonia","volume":"72","author":"Ranoux","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key20200713004437_b14-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1111\/bju.13945","article-title":"Comparative assessment of the efficacy of onabotulinum toxin A and oral therapies (anticholinergics and mirabegron) for overactive bladder: A systematic review and network meta-analysis","volume":"120","author":"Drake","year":"2017","journal-title":"BJU Int"},{"issue":"eAO4207","key":"key20200713004437_b15-etm-0-0-8664","doi-asserted-by":"publisher","DOI":"10.1590\/S1679-45082018AO4207","article-title":"Intradetrusor onabotulinum toxin A injections are significantly more efficacious than oral oxybutynin for treatment of neurogenic detrusor overactivity: Results of a randomized, controlled, 24-week trial","volume":"16","author":"Ferreira","year":"2018","journal-title":"Einstein (Sao Paulo)"},{"key":"key20200713004437_b16-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.eururo.2007.04.026","article-title":"Botulinum toxin A improves the quality of life of patients with neurogenic urinary incontinence","volume":"52","author":"Schurch","year":"2007","journal-title":"Eur Urol"},{"key":"key20200713004437_b17-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.eururo.2007.10.013","article-title":"Botulinum toxin A (Botox) intradetrusor injections in adults with neurogenic detrusor overactivity\/neurogenic overactive bladder: A systematic literature review","volume":"53","author":"Karsenty","year":"2008","journal-title":"Eur Urol"},{"key":"key20200713004437_b18-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"963","DOI":"10.4103\/0366-6999.154318","article-title":"Efficacy and safety of onabotulinum toxin A in treating neurogenic detrusor overactivity: A systematic review and meta-analysis","volume":"128","author":"Zhou","year":"2015","journal-title":"Chin Med J (Engl)"},{"key":"key20200713004437_b19-etm-0-0-8664","first-page":"419","article-title":"The effects of soy isoflavones and hormonal replacing therapy on the incidence and evolution of postmenopausal female urinary incontinence","volume":"64","author":"Bumbu","year":"2016","journal-title":"Farmacia"},{"key":"key20200713004437_b20-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1111\/bju.13976","article-title":"Intradetrusor onabotulinum toxin A injections for refractory neurogenic detrusor overactivity incontinence: Do we need urodynamic investigation for outcome assessment?","volume":"120","author":"Koschorke","year":"2017","journal-title":"BJU Int"},{"key":"key20200713004437_b21-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1590\/S1677-5538.IBJU.2015.02.05","article-title":"Onabotulinum toxin A for neurogenic detrusor overactivity and dose differences: A systematic review","volume":"41","author":"Zhang","year":"2015","journal-title":"Int Braz J Urol"},{"key":"key20200713004437_b22-etm-0-0-8664","author":"Duthie"},{"key":"key20200713004437_b23-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1111\/bju.13795","article-title":"Positive outcomes with first onabotulinum toxin A treatment persist in the long term with repeat treatments in patients with neurogenic detrusor overactivity","volume":"119","author":"Denys","year":"2017","journal-title":"BJU Int"},{"key":"key20200713004437_b24-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/01.ju.0000162035.73977.1c","article-title":"Botox Detrusor Hyperreflexia Study Team: Botulinum toxin type A is a safe and effective treatment for neurogenic urinary incontinence: Results of a single treatment, randomized, placebo controlled 6-month study","volume":"174","author":"Schurch","year":"2005","journal-title":"J Urol"},{"key":"key20200713004437_b25-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/sc.2015.143","article-title":"Combined detrusor-trigone BTX-A injections for urinary incontinence secondary to neurogenic detrusor overactivity","volume":"54","author":"Hui","year":"2016","journal-title":"Spinal Cord"},{"key":"key20200713004437_b26-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1016\/j.juro.2010.08.028","article-title":"Botulinum toxin-A injections into neurogenic overactive bladder - to include or exclude the trigone? A prospective, randomized, controlled trial","volume":"184","author":"Abdel-Meguid","year":"2010","journal-title":"J Urol"},{"issue":"e0159307","key":"key20200713004437_b27-etm-0-0-8664","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159307","article-title":"Efficacy and safety of onabotulinum toxin A in patients with neurogenic detrusor overactivity: A systematic review and meta-analysis of randomized controlled trials","volume":"11","author":"Cheng","year":"2016","journal-title":"PLoS One"},{"key":"key20200713004437_b28-etm-0-0-8664","doi-asserted-by":"publisher","first-page":"226","DOI":"10.5213\/inj.1938030.015","article-title":"Outcomes of intradetrusor onabotulinum toxin A therapy in overactive bladder refractory to sacral neuromodulation","volume":"23","author":"Trinh","year":"2019","journal-title":"Int Neurourol J"},{"key":"key20200713004437_b29-etm-0-0-8664","doi-asserted-by":"crossref","first-page":"645","DOI":"10.37358\/RC.18.3.6167","article-title":"The use of ELISA and PCR in identifying correlations between viral infections and benign prostatic hypertrophy","volume":"69","author":"Spinu","year":"2018","journal-title":"Rev Chim Buchar"},{"key":"key20200713004437_b30-etm-0-0-8664","first-page":"445","article-title":"Giant condyloma acuminatum - Buschke-Lowenstein disease - a literature review","volume":"109","author":"Spinu","year":"2014","journal-title":"Chirurgia (Bucur)"},{"issue":"260","key":"key20200713004437_b31-etm-0-0-8664","doi-asserted-by":"publisher","DOI":"10.3390\/toxins10070260","article-title":"Novel applications of onabotulinum toxin A in lower urinary tract dysfunction","volume":"10","author":"Jhang","year":"2018","journal-title":"Toxins (Basel)"},{"key":"key20200713004437_b32-etm-0-0-8664","first-page":"4180","article-title":"Heart failure with preserved ejection fraction and atrial fibrillation: A review","volume":"69","author":"Manea","year":"2018","journal-title":"Rev Chim Buchar"},{"key":"key20200713004437_b33-etm-0-0-8664","first-page":"76","article-title":"Liver abnormalities in patients with heart failure","volume":"53","author":"Draghici","year":"2018","journal-title":"Arch Balk Med Union"},{"issue":"91","key":"key20200713004437_b34-etm-0-0-8664","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8040091","article-title":"Intravesical onabotulinum toxin A injection for overactive bladder patients with frailty, medical comorbidities or prior lower urinary tract surgery","volume":"8","author":"Liao","year":"2016","journal-title":"Toxins (Basel)"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T23:44:45Z","timestamp":1594597485000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2020.8664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,15]]},"references-count":34,"URL":"https:\/\/doi.org\/10.3892\/etm.2020.8664","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,15]]}}}