{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:31:21Z","timestamp":1788233481900,"version":"build-2803163510"},"reference-count":51,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2021.10319","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T11:49:52Z","timestamp":1623844192000},"source":"Crossref","is-referenced-by-count":8,"title":["Disruption of anchoring junctions in the\u00a0testes of experimental varicocele rats"],"prefix":"10.3892","volume":"22","author":[{"given":"Lihong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350122, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350122, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350122, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"key20210729112245_b1-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/0040-8166(77)90007-6","article-title":"Observations on rat Sertoli ectoplasmic (\u2018junctional\u2019) specializations in their association with germ cells of the rat testis","volume":"9","author":"Russell","year":"1977","journal-title":"Tissue Cell"},{"key":"key20210729112245_b2-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1002\/bies.20099","article-title":"Dynamic cross-talk between cells and the extracellular matrix in the testis","volume":"26","author":"Siu","year":"2004","journal-title":"BioEssays"},{"key":"key20210729112245_b3-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1679\/aohc.63.1","article-title":"Unique and multifunctional adhesion junctions in the testis: Ectoplasmic specializations","volume":"63","author":"Vogl","year":"2000","journal-title":"Arch Histol Cytol"},{"key":"key20210729112245_b4-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.bbamem.2007.11.006","article-title":"Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis","volume":"1778","author":"Wong","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"key20210729112245_b5-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"73","DOI":"10.4161\/spmg.1.1.15452","article-title":"The \u03b21-integrin-p-FAK-p130Cas-DOCK180-RhoA-vinculin is a novel regulatory protein complex at the apical ectoplasmic specialization in adult rat testes","volume":"1","author":"Siu","year":"2011","journal-title":"Spermatogenesis"},{"key":"key20210729112245_b6-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1152\/physrev.00009.2002","article-title":"Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development","volume":"82","author":"Cheng","year":"2002","journal-title":"Physiol Rev"},{"key":"key20210729112245_b7-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"9298","DOI":"10.1073\/pnas.0813113106","article-title":"Focal adhesion kinase is a blood-testis barrier regulator","volume":"106","author":"Siu","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20210729112245_b8-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"977","DOI":"10.14670\/HH-29.977","article-title":"New insights into FAK function and regulation during spermatogenesis","volume":"29","author":"Gungor-Ordueri","year":"2014","journal-title":"Histol Histopathol"},{"key":"key20210729112245_b9-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1002\/bies.950191008","article-title":"Tyrosine phosphorylation and cadherin\/catenin function","volume":"19","author":"Daniel","year":"1997","journal-title":"BioEssays"},{"key":"key20210729112245_b10-etm-0-0-10319","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/j.1939-4640.1999.tb02511.x","article-title":"Adhesion and signaling proteins spatiotemporally associated with spermiation in the rat","volume":"20","author":"Wine","year":"1999","journal-title":"J Androl"},{"key":"key20210729112245_b11-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"E225","DOI":"10.1038\/35046654","article-title":"Signalling by adhesion receptors","volume":"2","author":"Fashena","year":"2000","journal-title":"Nat Cell Biol"},{"key":"key20210729112245_b12-etm-0-0-10319","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/j.1460-2075.1993.tb05658.x","article-title":"p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system","volume":"12","author":"Hamaguchi","year":"1993","journal-title":"EMBO J"},{"key":"key20210729112245_b13-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4161\/spmg.1.1.13971","article-title":"Environmental toxicants and male reproductive function","volume":"1","author":"Cheng","year":"2011","journal-title":"Spermatogenesis"},{"key":"key20210729112245_b14-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"25029","DOI":"10.1074\/jbc.M501049200","article-title":"Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases","volume":"280","author":"Siu","year":"2005","journal-title":"J Biol Chem"},{"key":"key20210729112245_b15-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"3336","DOI":"10.1210\/en.2008-1741","article-title":"An occludin-focal adhesion kinase protein complex at the blood-testis barrier: A study using the cadmium model","volume":"150","author":"Siu","year":"2009","journal-title":"Endocrinology"},{"key":"key20210729112245_b16-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.mvr.2011.08.001","article-title":"Cross talk between focal adhesion kinase and cadherins: Role in regulating endothelial barrier function","volume":"83","author":"Quadri","year":"2012","journal-title":"Microvasc Res"},{"key":"key20210729112245_b17-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"19623","DOI":"10.1073\/pnas.1111414108","article-title":"P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin\/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK)","volume":"108","author":"Su","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20210729112245_b18-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1210\/en.2013-1657","article-title":"Perfluorooctanesulfonate (PFOS) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via p-FAK-Tyr(407): An in vitro study","volume":"155","author":"Wan","year":"2014","journal-title":"Endocrinology"},{"key":"key20210729112245_b19-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"12562","DOI":"10.1073\/pnas.1202316109","article-title":"Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat","volume":"109","author":"Lie","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20210729112245_b20-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.1128\/MCB.15.5.2819","article-title":"Identification of Tyr-397 as the primary site of tyrosine phosphorylation and pp60src association in the focal adhesion kinase, pp125FAK","volume":"15","author":"Eide","year":"1995","journal-title":"Mol Cell Biol"},{"key":"key20210729112245_b21-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1242\/jcs.00373","article-title":"Focal adhesion kinase: The first ten years","volume":"116","author":"Parsons","year":"2003","journal-title":"J Cell Sci"},{"key":"key20210729112245_b22-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/s0094-0143(02)00075-7","article-title":"Varicocele: Current concepts in pathophysiology, diagnosis, and treatment","volume":"29","author":"Fretz","year":"2002","journal-title":"Urol Clin North Am"},{"issue":"5","key":"key20210729112245_b23-etm-0-0-10319","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7179.1","article-title":"Varicocele - a case for early intervention","volume":"5","author":"Bach","year":"2016","journal-title":"F1000 Res"},{"key":"key20210729112245_b24-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/aja.2010.111","article-title":"Effects of varicocele on testosterone, apoptosis and expression of StAR mRNA in rat Leydig cells","volume":"13","author":"Luo","year":"2011","journal-title":"Asian J Androl"},{"key":"key20210729112245_b25-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"276","DOI":"10.4103\/1008-682X.167724","article-title":"The varicocele: Diagnostic dilemmas, therapeutic challenges and future perspectives","volume":"18","author":"Chiba","year":"2016","journal-title":"Asian J Androl"},{"key":"key20210729112245_b26-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1172\/jci110252","article-title":"Influence of surgically induced varicocele on testicular blood flow, temperature, and histology in adult rats and dogs","volume":"68","author":"Saypol","year":"1981","journal-title":"J Clin Invest"},{"key":"key20210729112245_b27-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"659","DOI":"10.4103\/1008-682X.153539","article-title":"Varicocele and testicular function","volume":"17","author":"Pastuszak","year":"2015","journal-title":"Asian J Androl"},{"key":"key20210729112245_b28-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1046\/j.1464-410x.2000.00853.x","article-title":"The role of adrenomedullin in varicocele and impotence","volume":"86","author":"Ozbek","year":"2000","journal-title":"BJU Int"},{"issue":"6585430","key":"key20210729112245_b29-etm-0-0-10319","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6585430","article-title":"Adverse effects of subchronic dose of aspirin on reproductive profile of male rats","volume":"2016","author":"Vyas","year":"2016","journal-title":"J Pharm (Cairo)"},{"key":"key20210729112245_b30-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1111\/andr.12066","article-title":"A detailed protocol for a rapid analysis of testicular cell populations using flow cytometry","volume":"3","author":"Rotgers","year":"2015","journal-title":"Andrology"},{"key":"key20210729112245_b31-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.semcdb.2016.04.009","article-title":"Spermatogenesis in humans and its affecting factors","volume":"59","author":"Neto","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"key20210729112245_b32-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ucl.2008.02.001","article-title":"Evolving approach to the varicocele","volume":"35","author":"Khera","year":"2008","journal-title":"Urol Clin North Am"},{"key":"key20210729112245_b33-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1210\/en.2002-0211","article-title":"TGF-beta3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: An in vivo study","volume":"144","author":"Lui","year":"2003","journal-title":"Endocrinology"},{"key":"key20210729112245_b34-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1677\/joe.1.06781","article-title":"Tumor necrosis factor {alpha} reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes","volume":"190","author":"Li","year":"2006","journal-title":"J Endocrinol"},{"key":"key20210729112245_b35-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1016\/j.biocel.2009.05.016","article-title":"Disruption of the blood-testis barrier integrity by bisphenol A in vitro: Is this a suitable model for studying blood-testis barrier dynamics?","volume":"41","author":"Li","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"key20210729112245_b36-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1002\/jemt.20756","article-title":"Changes in MAPK pathway in neonatal and adult testis following fetal estrogen exposure and effects on rat testicular cells","volume":"72","author":"Thuillier","year":"2009","journal-title":"Microsc Res Tech"},{"key":"key20210729112245_b37-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1210\/en.2004-1464","article-title":"Blood-testis barrier dynamics are regulated by {alpha}2-macroglobulin via the c-Jun N-terminal protein kinase pathway","volume":"146","author":"Wong","year":"2005","journal-title":"Endocrinology"},{"key":"key20210729112245_b38-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1242\/jcs.00900","article-title":"Regulation of blood-testis barrier dynamics: An in vivo study","volume":"117","author":"Wong","year":"2004","journal-title":"J Cell Sci"},{"key":"key20210729112245_b39-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/978-1-4939-6424-6_16","article-title":"Quantifying tensile force and ERK phosphorylation on actin stress fibers","volume":"1487","author":"Hirata","year":"2017","journal-title":"Methods Mol Biol"},{"issue":"ra47","key":"key20210729112245_b40-etm-0-0-10319","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaa8859","article-title":"ERK reinforces actin polymerization to power persistent edge protrusion during motility","volume":"8","author":"Mendoza","year":"2015","journal-title":"Sci Signal"},{"issue":"e08314","key":"key20210729112245_b41-etm-0-0-10319","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.08314","article-title":"Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration","volume":"4","author":"Logue","year":"2015","journal-title":"eLife"},{"key":"key20210729112245_b42-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1083\/jcb.137.2.481","article-title":"Regulation of cell motility by mitogen-activated protein kinase","volume":"137","author":"Klemke","year":"1997","journal-title":"J Cell Biol"},{"key":"key20210729112245_b43-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"D102","DOI":"10.2741\/cary","article-title":"Focal adhesion kinase in integrin mediated signaling. Frontiers in bioscience","volume":"4","author":"Cary","year":"1999","journal-title":"Front Biosci"},{"key":"key20210729112245_b44-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1242\/jcs.00609","article-title":"The phosphoinositide (PI) 3-kinase family","volume":"116","author":"Foster","year":"2003","journal-title":"J Cell Sci"},{"key":"key20210729112245_b45-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/jcp.10167","article-title":"Emerging functions of p21-activated kinases in human cancer cells","volume":"193","author":"Kumar","year":"2002","journal-title":"J Cell Physiol"},{"key":"key20210729112245_b46-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.ceb.2009.05.006","article-title":"Focal adhesion kinase: Switching between GAPs and GEFs in the regulation of cell motility","volume":"21","author":"Tomar","year":"2009","journal-title":"Curr Opin Cell Biol"},{"key":"key20210729112245_b47-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1242\/jcs.045112","article-title":"Cellular functions of FAK kinases: Insight into molecular mechanisms and novel functions","volume":"123","author":"Schaller","year":"2010","journal-title":"J Cell Sci"},{"key":"key20210729112245_b48-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nrm2026","article-title":"The ARP2\/3 complex: An actin nucleator comes of age","volume":"7","author":"Goley","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20210729112245_b49-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"9565","DOI":"10.1074\/jbc.M310739200","article-title":"Focal adhesion kinase regulation of N-WASP subcellular localization and function","volume":"279","author":"Wu","year":"2004","journal-title":"J Biol Chem"},{"key":"key20210729112245_b50-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1038\/ncb1626","article-title":"Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2\/3 complex","volume":"9","author":"Serrels","year":"2007","journal-title":"Nat Cell Biol"},{"key":"key20210729112245_b51-etm-0-0-10319","doi-asserted-by":"publisher","first-page":"8950","DOI":"10.1073\/pnas.0711264105","article-title":"An autocrine axis in the testis that coordinates spermiation and blood-testis barrier restructuring during spermatogenesis","volume":"105","author":"Yan","year":"2008","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T23:22:08Z","timestamp":1699140128000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2021.10319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,16]]},"references-count":51,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,6,16]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2021.10319","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,16]]},"article-number":"887"}}