{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:53:32Z","timestamp":1788472412770,"version":"build-2803163510"},"reference-count":34,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2021.10364","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T06:26:21Z","timestamp":1625120781000},"source":"Crossref","is-referenced-by-count":6,"title":["Autophagy\u2011related genes contribute to malignant progression and have a clinical prognostic impact in colon adenocarcinoma"],"prefix":"10.3892","volume":"22","author":[{"given":"Xianyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of General Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runtao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiapeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"issue":"15065","key":"key20210812132821_b1-etm-0-0-10364","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.65","article-title":"Colorectal cancer","volume":"1","author":"Kuipers","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"key20210812132821_b2-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.mayocp.2018.03.010","article-title":"Adenocarcinoma of the colon and microsatellite instability","volume":"93","author":"Erickson","year":"2018","journal-title":"Mayo Clin Proc"},{"key":"key20210812132821_b3-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"S5014","DOI":"10.1002\/cncr.31076","article-title":"Colon cancer survival in the United States by race and stage (2001-2009): Findings from the CONCORD-2 study","volume":"123 (Suppl 24)","author":"White","year":"2017","journal-title":"Cancer"},{"key":"key20210812132821_b4-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.bbapap.2016.11.018","article-title":"Typing of colon and lung adenocarcinoma by high throughput imaging mass spectrometry","volume":"1865","author":"Kriegsmann","year":"2017","journal-title":"Biochim Biophys Acta Proteins Proteom"},{"issue":"12","key":"key20210812132821_b5-etm-0-0-10364","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-1138-4","article-title":"Autophagy and autophagy-related proteins in cancer","volume":"19","author":"Li","year":"2020","journal-title":"Mol Cancer"},{"issue":"2351","key":"key20210812132821_b6-etm-0-0-10364","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112351","article-title":"Autophagy roles in the modulation of DNA repair pathways","volume":"18","author":"Gomes","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"48","key":"key20210812132821_b7-etm-0-0-10364","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0321-5","article-title":"Apoptosis, autophagy, necroptosis, and cancer metastasis","volume":"14","author":"Su","year":"2015","journal-title":"Mol Cancer"},{"key":"key20210812132821_b8-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.lfs.2017.08.029","article-title":"Autophagy: The spotlight for cellular stress responses","volume":"188","author":"Ravanan","year":"2017","journal-title":"Life Sci"},{"key":"key20210812132821_b9-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/978-1-4939-3578-9_6","article-title":"A Practical Guide to The Cancer Genome Atlas (TCGA)","volume":"1418","author":"Wang","year":"2016","journal-title":"Methods Mol Biol"},{"key":"key20210812132821_b10-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","author":"GTEx","year":"2013","journal-title":"Nat Genet"},{"key":"key20210812132821_b11-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1200\/JCO.2014.60.0213","article-title":"Personalizing colon cancer adjuvant therapy: Selecting optimal treatments for individual patients","volume":"33","author":"Dienstmann","year":"2015","journal-title":"J Clin Oncol"},{"issue":"V11150916","key":"key20210812132821_b12-etm-0-0-10364","article-title":"Individualized treatment of colon cancer","volume":"178","author":"Rosen","year":"2016","journal-title":"UgeskrLaeger"},{"issue":"Online","key":"key20210812132821_b13-etm-0-0-10364","article-title":"Colon Cancer","volume":"97","year":"2018","journal-title":"Am Fam Physician"},{"key":"key20210812132821_b14-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"5105","DOI":"10.1038\/onc.2014.458","article-title":"Cell death by autophagy: Emerging molecular mechanisms and implications for cancer therapy","volume":"34","author":"Fulda","year":"2015","journal-title":"Oncogene"},{"issue":"367","key":"key20210812132821_b15-etm-0-0-10364","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020367","article-title":"Role of autophagy and apoptosis in non-small-cell lung cancer","volume":"18","author":"Liu","year":"2017","journal-title":"Int J Mol Sci"},{"key":"key20210812132821_b16-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"270","DOI":"10.5152\/tjg.2018.150318","article-title":"Autophagy and liver cancer","volume":"29","author":"Akkoc","year":"2018","journal-title":"Turk J Gastroenterol"},{"key":"key20210812132821_b17-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.3892\/ijo.2018.4270","article-title":"Role of autophagy in breast cancer and breast cancer stem cells (Review)","volume":"52","author":"Han","year":"2018","journal-title":"Int J Oncol"},{"key":"key20210812132821_b18-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"192","DOI":"10.4161\/auto.26927","article-title":"Autophagy-mediated regulation of macrophages and its applications for cancer","volume":"10","author":"Chen","year":"2014","journal-title":"Autophagy"},{"issue":"52","key":"key20210812132821_b19-etm-0-0-10364","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-017-0219-2","article-title":"Autophagy and multidrug resistance in cancer","volume":"36","author":"Li","year":"2017","journal-title":"Chin J Cancer"},{"key":"key20210812132821_b20-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1182\/blood-2016-07-692707","article-title":"Autophagy, a key mechanism of oncogenesis and resistance in leukemia","volume":"129","author":"Auberger","year":"2017","journal-title":"Blood"},{"key":"key20210812132821_b21-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/CAD.0000000000000572","article-title":"Autophagy and doxorubicin resistance in cancer","volume":"29","author":"Chen","year":"2018","journal-title":"Anticancer Drugs"},{"key":"key20210812132821_b22-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.bcp.2017.11.021","article-title":"Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization","volume":"147","author":"Bhat","year":"2018","journal-title":"Biochem Pharmacol"},{"key":"key20210812132821_b23-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.clinbiochem.2015.04.022","article-title":"Bioinformatics analysis of circulating cell-free DNA sequencing data","volume":"48","author":"Chan","year":"2015","journal-title":"ClinBiochem"},{"key":"key20210812132821_b24-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"5037","DOI":"10.1158\/1078-0432.CCR-15-0490","article-title":"Autophagy, metabolism, and cancer","volume":"21","author":"White","year":"2015","journal-title":"Clin Cancer Res"},{"key":"key20210812132821_b25-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1101\/sqb.2016.81.030981","article-title":"Autophagy, metabolism, and cancer","volume":"81","author":"Guo","year":"2016","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"key20210812132821_b26-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.rmr.2013.10.651","article-title":"Hepatic involvement in hereditary alpha-1-antitrypsin deficiency)","volume":"31","author":"Lachaux","year":"2014","journal-title":"Rev Mal Respir"},{"key":"key20210812132821_b27-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s40139-017-0147-5","article-title":"Liver disease in alpha-1 antitrypsin deficiency: Current approaches and future directions","volume":"5","author":"Mitchell","year":"2017","journal-title":"Curr Pathobiol Rep"},{"key":"key20210812132821_b28-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"5043","DOI":"10.1200\/JCO.2006.06.7330","article-title":"Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers","volume":"24","author":"Griffith","year":"2006","journal-title":"J Clin Oncol"},{"issue":"e0184959","key":"key20210812132821_b29-etm-0-0-10364","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184959","article-title":"Correlation of DAPK1 methylation and the risk of gastrointestinal cancer: A systematic review and meta-analysis","volume":"12","author":"Yuan","year":"2017","journal-title":"PLoS One"},{"issue":"46","key":"key20210812132821_b30-etm-0-0-10364","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2016.00046","article-title":"Death Associated Protein Kinase 1 (DAPK1): A regulator of apoptosis and autophagy","volume":"9","author":"Singh","year":"2016","journal-title":"Front Mol Neurosci"},{"key":"key20210812132821_b31-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1159\/000485286","article-title":"Ablation of ATG4B suppressed autophagy and activated AMPK for cell cycle arrest in cancer cells","volume":"44","author":"Liu","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"key20210812132821_b32-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/15548627.2018.1517073","article-title":"Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo","volume":"15","author":"Fu","year":"2019","journal-title":"Autophagy"},{"key":"key20210812132821_b33-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/s41417-019-0143-5","article-title":"Identification of genes of four malignant tumors and a novel prediction model development based on PPI data and support vector machines","volume":"27","author":"Li","year":"2020","journal-title":"Cancer Gene Ther"},{"key":"key20210812132821_b34-etm-0-0-10364","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1136\/gutjnl-2017-314983","article-title":"SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer","volume":"68","author":"Wan","year":"2019","journal-title":"Gut"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T10:31:51Z","timestamp":1628764311000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2021.10364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,7,1]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2021.10364","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,1]]},"article-number":"932"}}