{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:13:40Z","timestamp":1793294020093,"version":"4.5.0"},"reference-count":24,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2021.10395","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T16:41:26Z","timestamp":1625676086000},"source":"Crossref","is-referenced-by-count":13,"title":["Application of TGF\u2011\u03b21, TIMP\u20111 and TIMP\u20112 small interfering RNAs can alleviate CCl<sub>4<\/sub>\u2011induced hepatic fibrosis in rats by rebalancing Th1\/Th2 cytokines"],"prefix":"10.3892","volume":"22","author":[{"given":"Ying","family":"Xue","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Virus Hepatitis and Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keli","family":"Qian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Virus Hepatitis and Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinchun","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Virus Hepatitis and Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Virus Hepatitis and Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Virus Hepatitis and Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2021,7,7]]},"reference":[{"key":"key20210812132923_b1-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1055\/s-0036-1597816","article-title":"Regression of liver fibrosis","volume":"37","author":"Campana","year":"2017","journal-title":"Semin Liver Dis"},{"key":"key20210812132923_b2-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"key20210812132923_b3-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"7165","DOI":"10.3748\/wjg.v21.i23.7165","article-title":"Activated rat hepatic stellate cells influence Th1\/Th2 profile in vitro","volume":"21","author":"Xing","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"8323747","key":"key20210812132923_b4-etm-0-0-10395","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8323747","article-title":"Regulation of hepatic stellate cells and fibrogenesis by fibroblast growth factors","volume":"2016","author":"Schumacher","year":"2016","journal-title":"Biomed Res Int"},{"key":"key20210812132923_b5-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.bbrc.2011.05.023","article-title":"The antifibrotic effects of TGF-\u03b21 siRNA on hepatic fibrosis in rats","volume":"409","author":"Lang","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"key20210812132923_b6-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3760\/cma.j.cn501113-20190904-00323","article-title":"Effect of tissue inhibitor of metalloproteinase-1 and 2 siRNA on the expression of smad2\/3\/4 protein in hepatic stellate cells","volume":"28","author":"Cheng","year":"2020","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"key20210812132923_b7-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3760\/cma.j.issn.1007-3418.2011.04.014","article-title":"Construction and identification of siRNA eukaryotic expression vectors targeting on TGF\u03b21, TIMP-1 and TIMP-2 genes in vitro","volume":"19","author":"Qian","year":"2011","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"key20210812132923_b8-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20210812132923_b9-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1056\/NEJMc1504848","article-title":"Fibrosis-a common pathway to organ injury and failure","volume":"372","author":"Rockey","year":"2015","journal-title":"N Engl J Med"},{"key":"key20210812132923_b10-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.mam.2018.06.003","article-title":"Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications","volume":"65","author":"Weiskirchen","year":"2019","journal-title":"Mol Aspects Med"},{"issue":"217","key":"key20210812132923_b11-etm-0-0-10395","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01735-2","article-title":"Immunopathology in schistosomiasis is regulated by TLR2, 4- and IFN-\u03b3-activated MSC through modulating Th1\/Th2 responses","volume":"11","author":"Liu","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"key20210812132923_b12-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1111\/wrr.12722","article-title":"Normal and keloid fibroblasts are differentially influenced by IFN-\u03b3 and triamcinolone as well as by their combination","volume":"27","author":"Euler","year":"2019","journal-title":"Wound Repair Regen"},{"key":"key20210812132923_b13-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.jaci.2013.04.033","article-title":"IL-2-inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-\u03b3 in naive CD4+ T cells","volume":"132","author":"Kannan","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"key20210812132923_b14-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"576","DOI":"10.3892\/ijmm.2017.3043","article-title":"1-Methyl-L-tryptophan promotes the apoptosis of hepatic stellate cells arrested by interferon-\u03b3 by increasing the expression of IFN-\u03b3R\u03b2, IRF-1 and FAS","volume":"40","author":"Oh","year":"2017","journal-title":"Int J Mol Med"},{"key":"key20210812132923_b15-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.jconrel.2011.12.023","article-title":"Effects of interferon-gamma liposomes targeted to platelet-derived growth factor receptor-beta on hepatic fibrosis in rats","volume":"159","author":"Li","year":"2012","journal-title":"J Control Release"},{"key":"key20210812132923_b16-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1002\/eji.201847789","article-title":"IL-4 promotes stromal cell expansion and is critical for development of a type-2, but not a type 1 immune response","volume":"49","author":"Cortes-Selva","year":"2019","journal-title":"Eur J Immunol"},{"key":"key20210812132923_b17-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/s1386-6346(00)00133-9","article-title":"Th1 and Th2 cytokines differentially regulate the transformation of Kupffer cells into multinucleated giant cells but similarly enhance the Kupffer cell-induced hepatic stellate cell proliferation","volume":"20","author":"Atsukawa","year":"2001","journal-title":"Hepatol Res"},{"issue":"424S","key":"key20210812132923_b18-etm-0-0-10395","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.3_suppl.424s","article-title":"Interleukin-4 promotes airway remodeling in asthma: Regulation of procollagen I (alpha1) gene by interleukin-4","volume":"123 (Suppl 3)","author":"Bergeron","year":"2003","journal-title":"Chest"},{"key":"key20210812132923_b19-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ebiom.2018.01.028","article-title":"IL-4 Receptor alpha signaling through macrophages differentially regulates liver fibrosis progression and reversal","volume":"29","author":"Weng","year":"2018","journal-title":"EBioMedicine"},{"key":"key20210812132923_b20-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1086\/510313","article-title":"Th2 cytokines are associated with persistent hepatic fibrosis in human Schistosoma japonicum infection","volume":"195","author":"Coutinho","year":"2007","journal-title":"J Infect Dis"},{"key":"key20210812132923_b21-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/nri1412","article-title":"Fibrotic disease and the T(H)1\/T(H)2 paradigm","volume":"4","author":"Wynn","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"key20210812132923_b22-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1080\/08830180802430974","article-title":"Regulatory effect of extracellular signal-regulated kinases (ERK) on type I collagen synthesis in human dermal fibroblasts stimulated by IL-4 and IL-13","volume":"27","author":"Bhogal","year":"2008","journal-title":"Int Rev Immunol"},{"key":"key20210812132923_b23-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"3060","DOI":"10.1681\/ASN.2014070717","article-title":"JAK3\/STAT6 Stimulates bone marrow-derived fibroblast activation in renal fibrosis","volume":"26","author":"Yan","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"key20210812132923_b24-etm-0-0-10395","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/j.1478-3231.2005.01087.x","article-title":"Effect of IL-4 and IL-13 on collagen production in cultured LI90 human hepatic stellate cells","volume":"25","author":"Sugimoto","year":"2005","journal-title":"Liver Int"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T10:38:26Z","timestamp":1628764706000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2021.10395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,7]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,7,7]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2021.10395","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,7]]},"article-number":"963"}}