{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:45:00Z","timestamp":1785840300729,"version":"3.56.0"},"reference-count":16,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2021.10501","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T09:43:31Z","timestamp":1627379011000},"source":"Crossref","is-referenced-by-count":18,"title":["Involvement of COL5A2 and TGF\u2011\u03b21 in pathological scarring"],"prefix":"10.3892","volume":"22","author":[{"given":"Roxana","family":"Ilie\u0219","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, \u2018Iuliu Ha\u021bieganu\u2019 University of Medicine and Pharmacy, 400349 Cluj\u2011Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casian","family":"Aioanei","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, \u2018Iuliu Ha\u021bieganu\u2019 University of Medicine and Pharmacy, 400349 Cluj\u2011Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"C\u0103tan\u0103","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, \u2018Iuliu Ha\u021bieganu\u2019 University of Medicine and Pharmacy, 400349 Cluj\u2011Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salomea-Ruth","family":"Halmagyi","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, \u2018Iuliu Ha\u021bieganu\u2019 University of Medicine and Pharmacy, 400349 Cluj\u2011Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Lukacs","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynecology, \u2018Iuliu Ha\u021bieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj\u2011Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reka-Eniko","family":"Tokes","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynecology, \u2018Iuliu Ha\u021bieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj\u2011Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Rotar","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynecology, \u2018Iuliu Ha\u021bieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj\u2011Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioan","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, \u2018Iuliu Ha\u021bieganu\u2019 University of Medicine and Pharmacy, 400349 Cluj\u2011Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"key20210903112405_b1-etm-0-0-10501","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/j.1524-475X.2010.00611.x","article-title":"Importance of housekeeping gene selection for accurate reverse transcription-quantitative polymerase chain reaction in a wound healing model","volume":"18","author":"Turabelidze","year":"2010","journal-title":"Wound Repair Regen"},{"key":"key20210903112405_b2-etm-0-0-10501","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1089\/wound.2013.0485","article-title":"Extracellular matrix reorganization during wound healing and its impact on abnormal scarring","volume":"4","author":"Xue","year":"2015","journal-title":"Adv Wound Care (New Rochelle)"},{"issue":"4","key":"key20210903112405_b3-etm-0-0-10501","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-7-4","article-title":"Wnt signaling induces epithelial differentiation during cutaneous wound healing","volume":"7","author":"Fathke","year":"2006","journal-title":"BMC Cell Biol"},{"key":"key20210903112405_b4-etm-0-0-10501","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/1947-2714.92892","article-title":"Collagen IV in normal skin and in pathological processes","volume":"4","author":"Abreu-Velez","year":"2012","journal-title":"N Am J Med Sci"},{"key":"key20210903112405_b5-etm-0-0-10501","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1097\/GIM.0b013e3181eed412","article-title":"Clinical and genetic aspects of Ehlers-Danlos syndrome, classic type","volume":"12","author":"Malfait","year":"2010","journal-title":"Genet Med"},{"key":"key20210903112405_b6-etm-0-0-10501","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1016\/j.ajpath.2017.06.006","article-title":"Deficits in Col5a2 expression result in novel skin and adipose abnormalities and predisposition to aortic aneurysms and dissections","volume":"187","author":"Park","year":"2017","journal-title":"Am J Pathol"},{"issue":"83","key":"key20210903112405_b7-etm-0-0-10501","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00083","article-title":"Current therapeutic approach to hypertrophic scars","volume":"4","author":"Mokos","year":"2017","journal-title":"Front Med (Lausanne)"},{"key":"key20210903112405_b8-etm-0-0-10501","doi-asserted-by":"publisher","first-page":"916","DOI":"10.3892\/etm.2019.7513","article-title":"Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions","volume":"18","author":"Ilie","year":"2019","journal-title":"Exp Ther Med"},{"key":"key20210903112405_b9-etm-0-0-10501","first-page":"18","article-title":"The role of the TGF-\u03b2 family in wound healing, burns and scarring: A review","volume":"2","author":"Penn","year":"2012","journal-title":"Int J Burns Trauma"},{"key":"key20210903112405_b10-etm-0-0-10501","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1111\/bjd.17851","article-title":"Atrophic acne scar: A process from altered metabolism of elastic fibres and collagen fibres based on transforming growth factor-\u03b21 signalling","volume":"181","author":"Moon","year":"2019","journal-title":"Br J Dermatol"},{"key":"key20210903112405_b11-etm-0-0-10501","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1111\/bjd.14812","article-title":"The SCAR (Scar Cosmesis Assessment and Rating) scale: Development and validation of a new outcome measure for postoperative scar assessment","volume":"175","author":"Kantor","year":"2016","journal-title":"Br J Dermatol"},{"key":"key20210903112405_b12-etm-0-0-10501","doi-asserted-by":"publisher","first-page":"565","DOI":"10.6061\/clinics\/2014(08)11","article-title":"Update on hypertrophic scar treatment","volume":"69","author":"Rabello","year":"2014","journal-title":"Clinics (Sao Paulo)"},{"key":"key20210903112405_b13-etm-0-0-10501","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.burns.2009.03.008","article-title":"Longitudinal changes in plasma Transforming growth factor beta-1 and post-burn scarring in children","volume":"36","author":"Rorison","year":"2010","journal-title":"Burns"},{"key":"key20210903112405_b14-etm-0-0-10501","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1111\/j.1524-475X.2007.00261.x","article-title":"Increased TGF-\u03b2-producing CD4+ T lymphocytes in postburn patients and their potential interaction with dermal fibroblasts in hypertrophic scarring","volume":"15","author":"Wang","year":"2007","journal-title":"Wound Repair Regen"},{"key":"key20210903112405_b15-etm-0-0-10501","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1242\/jcs.108.3.985","article-title":"Neutralisation of TGF-\u03b2 1 and TGF-\u03b2 2 or exogenous addition of TGF-\u03b2 3 to cutaneous rat wounds reduces scarring","volume":"108","author":"Shah","year":"1995","journal-title":"J Cell Sci"},{"key":"key20210903112405_b16-etm-0-0-10501","doi-asserted-by":"publisher","first-page":"8125","DOI":"10.1073\/pnas.0602581103","article-title":"Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility","volume":"103","author":"Mao","year":"2006","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T16:42:46Z","timestamp":1630946566000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2021.10501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,27]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,7,27]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2021.10501","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,27]]},"article-number":"1067"}}