{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:06:34Z","timestamp":1785881194246,"version":"3.56.0"},"reference-count":33,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2021.10525","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T07:15:13Z","timestamp":1627888513000},"source":"Crossref","is-referenced-by-count":6,"title":["Osteogenic ability using porous hydroxyapatite scaffold\u2011based delivery of human placenta\u2011derived mesenchymal stem cells"],"prefix":"10.3892","volume":"22","author":[{"given":"Xiaohua","family":"Ren","sequence":"first","affiliation":[{"name":"Stomatology Department, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Chengdu Biology and Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, Sichuan 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Stomatology Department, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shuangliu Hospital of Traditional Chinese Medicine, Chengdu, Sichuan 610000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Southwest Medical University, Luzhou, Sichuan 646000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Tian","sequence":"additional","affiliation":[{"name":"Stomatology Department, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Chengdu Biology and Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, Sichuan 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandong","family":"Mu","sequence":"additional","affiliation":[{"name":"Stomatology Department, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"key20210903112500_b1-etm-0-0-10525","first-page":"87","article-title":"Repair of critical bone defects with injectable platelet rich plasma\/bone marrow-derived stromal cells composite: Experimental study in rabbits","volume":"14","author":"Cheng","year":"2008","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"key20210903112500_b2-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/0278-2391(84)90389-6","article-title":"A comparison of particulate allogeneic and particulate autogenous bone grafts into maxillary alveolar clefts in dogs","volume":"42","author":"Marx","year":"1984","journal-title":"J Oral Maxillofac Surg"},{"key":"key20210903112500_b3-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"S77","DOI":"10.1016\/j.injury.2011.06.014","article-title":"What should be the characteristics of the ideal bone graft substitute? Combining scaffolds with growth factors and\/or stem cells","volume":"42 (Suppl 2)","author":"Janicki","year":"2011","journal-title":"Injury"},{"key":"key20210903112500_b4-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s12593-012-0076-9","article-title":"Carpal tunnel syndrome due to hydroxyapatite crystal deposition disease","volume":"5","author":"Suresh","year":"2013","journal-title":"J Hand Microsurg"},{"key":"key20210903112500_b5-etm-0-0-10525","doi-asserted-by":"crossref","first-page":"21656","DOI":"10.1016\/j.ceramint.2018.08.249","article-title":"Enhancement of osteogenesis using a novel porous hydroxyapatite scaffold in vivo and vitro","volume":"44","author":"Xiaohua","year":"2018","journal-title":"Ceram Int"},{"key":"key20210903112500_b6-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nrg2484","article-title":"RNA-Seq: A revolutionary tool for transcriptomics","volume":"10","author":"Wang","year":"2009","journal-title":"Nat Rev Genet"},{"key":"key20210903112500_b7-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.exer.2016.11.021","article-title":"Transcriptome analysis of adult and fetal trabecular meshwork, cornea, and ciliary body tissues by RNA sequencing","volume":"167","author":"Carnes","year":"2018","journal-title":"Exp Eye Res"},{"key":"key20210903112500_b8-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/nmeth.1223","article-title":"Stem cell transcriptome profiling via massive-scale mRNA sequencing","volume":"5","author":"Cloonan","year":"2008","journal-title":"Nat Methods"},{"key":"key20210903112500_b9-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/nmeth.1226","article-title":"Mapping and quantifying mammalian transcriptomes by RNA-Seq","volume":"5","author":"Mortazavi","year":"2008","journal-title":"Nat Methods"},{"key":"key20210903112500_b10-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat Biotechnol"},{"key":"key20210903112500_b11-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/nbt.1633","article-title":"Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs","volume":"28","author":"Guttman","year":"2010","journal-title":"Nat Biotechnol"},{"issue":"e55769","key":"key20210903112500_b12-etm-0-0-10525","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055769","article-title":"High throughput transcriptome profiling of lithium stimulated human mesenchymal stem cells reveals priming towards osteoblastic lineage","volume":"8","author":"Satija","year":"2013","journal-title":"PLoS One"},{"key":"key20210903112500_b13-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"key20210903112500_b14-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"829","DOI":"10.3727\/096368915X689622","article-title":"Clinical trials with mesenchymal stem cells: An Update","volume":"25","author":"Squillaro","year":"2016","journal-title":"Cell Transplant"},{"key":"key20210903112500_b15-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"19328","DOI":"10.18632\/oncotarget.25039","article-title":"Stress and stem cells: adult Muse cells tolerate extensive genotoxic stimuli better than mesenchymal stromal cells","volume":"9","author":"Alessio","year":"2018","journal-title":"Oncotarget"},{"key":"key20210903112500_b16-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s12011-017-1199-4","article-title":"Zinc sulphate mediates the stimulation of cell proliferation of rat adipose tissue-derived mesenchymal stem cells under high intensity of EMF exposure","volume":"184","author":"Fathi","year":"2017","journal-title":"Biol Trace Elem Res"},{"key":"key20210903112500_b17-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.tice.2019.01.006","article-title":"Immunophenotypic characterization, multi-lineage differentiation and aging of zebrafish heart and liver tissue-derived mesenchymal stem cells as a novel approach in stem cell-based therapy","volume":"57","author":"Fathi","year":"2019","journal-title":"Tissue Cell"},{"key":"key20210903112500_b18-etm-0-0-10525","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s13770-013-1094-9","article-title":"Comparison of bone regeneration rate in flat and long bone defects: Calvarial and tibial bone","volume":"10","author":"Lim","year":"2013","journal-title":"Tissue Eng Regene Med"},{"issue":"2422","key":"key20210903112500_b19-etm-0-0-10525","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112422","article-title":"Enhancement of bone marrow-derived mesenchymal stem cell osteogenesis and new bone formation in rats by obtusilactone A","volume":"18","author":"Lin","year":"2017","journal-title":"Int J Mol Sci"},{"key":"key20210903112500_b20-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2002","journal-title":"Methods"},{"issue":"32771","key":"key20210903112500_b21-etm-0-0-10525","doi-asserted-by":"publisher","DOI":"10.1038\/srep32771","article-title":"Functional differences between AMPK alpha1 and alpha2 subunits in osteogenesis, osteoblast-associated induction of osteoclastogenesis, and adipogenesis","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"key":"key20210903112500_b22-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s10142-019-00677-0","article-title":"Transcriptome analysis reveals molecular mechanisms of sclerotial development in the rice sheath blight pathogen Rhizoctonia solani AG1-IA","volume":"19","author":"Shu","year":"2015","journal-title":"Funct Integr Genomics"},{"issue":"121","key":"key20210903112500_b23-etm-0-0-10525","doi-asserted-by":"publisher","DOI":"10.1177\/0885328216637978","article-title":"Periodontal regeneration with stem cells-seeded collagen-hydroxyapatite scaffold","volume":"31","author":"Liu","year":"2016","journal-title":"J Biomater Appl"},{"key":"key20210903112500_b24-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1302\/0301-620X.92B2.22602","article-title":"The use of silk fibroin\/hydroxyapatite composite co-cultured with rabbit bone-marrow stromal cells in the healing of a segmental bone defect","volume":"92","author":"Wang","year":"2010","journal-title":"Bone Joint Surg Br"},{"key":"key20210903112500_b25-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/jbm.a.32186","article-title":"Human umbilical cord mesenchymal stem cells: Osteogenesis in vivo as seed cells for bone tissue engineering","volume":"91A","author":"Diao","year":"2010","journal-title":"J Biomed Mater Res Part A"},{"key":"key20210903112500_b26-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1177\/0885328216637978","article-title":"Periodontal regeneration with stem cells-seeded collagen-hydroxyapatite scaffold","volume":"31","author":"Liu","year":"2016","journal-title":"J Biomater Appl"},{"issue":"e15224","key":"key20210903112500_b27-etm-0-0-10525","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015224","article-title":"Integrated profiling of microRNAs and mRNAs: microRNAs located on Xq27.3 associate with clear cell renal cell carcinoma","volume":"5","author":"Zhou","year":"2010","journal-title":"PLoS One"},{"key":"key20210903112500_b28-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1634\/stemcells.2006-0686","article-title":"Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis","volume":"25","author":"Hung","year":"2007","journal-title":"Stem Cells"},{"key":"key20210903112500_b29-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/j.cellsig.2016.06.004","article-title":"AMPK promotes osteogenesis and inhibits adipogenesis through AMPK-Gfi1-OPN axis","volume":"28","author":"Wang","year":"2016","journal-title":"Cell Signal"},{"key":"key20210903112500_b30-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"349","DOI":"10.4103\/2230-8210.95662","article-title":"Osteoanabolics","volume":"6","author":"Gupta","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"key20210903112500_b31-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s12011-015-0459-4","article-title":"Role of magnesium transporter subtype 1 (MagT1) in the osteogenic differentiation of rat bone marrow stem cells","volume":"171","author":"Zheng","year":"2016","journal-title":"Biol Trace Elem Res"},{"key":"key20210903112500_b32-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1128\/MCB.23.3.1004-1013.2003","article-title":"Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ","volume":"23","author":"Cui","year":"2003","journal-title":"Mol Cell Biol"},{"key":"key20210903112500_b33-etm-0-0-10525","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.bone.2009.11.003","article-title":"Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation","volume":"46","author":"Kwun","year":"2010","journal-title":"Bone"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T18:40:28Z","timestamp":1630953628000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2021.10525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,2]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,8,2]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2021.10525","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,2]]},"article-number":"1091"}}