{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T06:32:20Z","timestamp":1778394740577,"version":"3.51.4"},"reference-count":45,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2021.10553","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T11:33:16Z","timestamp":1628076796000},"source":"Crossref","is-referenced-by-count":11,"title":["Resveratrol reduces the progression of titanium particle\u2011induced osteolysis via the Wnt\/\u03b2\u2011catenin signaling pathway<i>in\u00a0vivo<\/i>and<i>in\u00a0vitro<\/i>"],"prefix":"10.3892","volume":"22","author":[{"given":"Xi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouxuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianxiang","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Geng","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qunhua","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"key20210903112558_b1-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.arth.2004.03.024","article-title":"Particle bioreactivity and wear-mediated osteolysis","volume":"19","author":"Wang","year":"2004","journal-title":"J Arthroplasty"},{"key":"key20210903112558_b2-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"4251","DOI":"10.1016\/j.biomaterials.2012.03.005","article-title":"The effect of TNFa secreted from macrophages activated by titanium particles on osteogenic activity regulated by WNT\/BMP signaling in osteoprogenitor cells","volume":"33","author":"Lee","year":"2012","journal-title":"Biomaterials"},{"key":"key20210903112558_b3-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.11.046","article-title":"Inhibition of titanium-particle-induced inflammatory osteolysis after local administration of dopamine and suppression of osteoclastogenesis via D2-like receptor signaling pathway","volume":"80","author":"Yang","year":"2016","journal-title":"Biomaterials"},{"key":"key20210903112558_b4-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1016\/j.actbio.2012.03.042","article-title":"Revision joint replacement, wear particles, and macrophage polarization","volume":"8","author":"Rao","year":"2012","journal-title":"Acta Biomater"},{"key":"key20210903112558_b5-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"201","DOI":"10.2106\/00004623-200102000-00007","article-title":"The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts","volume":"83","author":"Vermes","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"key20210903112558_b6-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"4912","DOI":"10.1016\/j.actbio.2014.07.025","article-title":"Strontium ranelate inhibits titanium-particle-induced osteolysis by restraining inflammatory osteoclastogenesis in vivo","volume":"10","author":"Liu","year":"2014","journal-title":"Acta Biomaterialia"},{"key":"key20210903112558_b7-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3892\/ijmm.2013.1416","article-title":"Adenovirus-mediated small interfering RNA targeting tumor necrosis factor-\u03b1 inhibits titanium particle-induced osteoclastogenesis and bone resorption","volume":"32","author":"Guo","year":"2013","journal-title":"Int J Mol Med"},{"key":"key20210903112558_b8-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"829","DOI":"10.3727\/096368915X689622","article-title":"Clinical trials with mesenchymal stem cells: An update","volume":"25","author":"Squillaro","year":"2016","journal-title":"Cell Transplant"},{"key":"key20210903112558_b9-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1007\/s00198-015-3109-y","article-title":"The position of strontium ranelate in today's management of osteoporosis","volume":"26","author":"Reginster","year":"2015","journal-title":"Osteoporos Int"},{"key":"key20210903112558_b10-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.1902\/jop.2016.160227","article-title":"Investigating the effects of systemically administered strontium ranelate on alveolar bone loss histomorphometrically and histopathologically on experimental periodontitis in rats","volume":"88","author":"Karakan","year":"2017","journal-title":"J Periodontol"},{"key":"key20210903112558_b11-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature05354","article-title":"Resveratrol improves health and survival of mice on a high-calorie diet","volume":"444","author":"Baur","year":"2006","journal-title":"Nature"},{"key":"key20210903112558_b12-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: The in vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"key20210903112558_b13-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.cmet.2012.11.007","article-title":"Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria","volume":"16","author":"Liu","year":"2012","journal-title":"Cell Metab"},{"issue":"e35712","key":"key20210903112558_b14-etm-0-0-10553","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035712","article-title":"Resveratrol mediated modulation of Sirt-1\/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation","volume":"7","author":"Shakibaei","year":"2012","journal-title":"PLoS One"},{"key":"key20210903112558_b15-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1016\/j.cellsig.2010.06.016","article-title":"Dishevelled-DEP domain interacting protein (DDIP) inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4\/beta-catenin complex","volume":"22","author":"Zhang","year":"2010","journal-title":"Cell Signal"},{"issue":"19","key":"key20210903112558_b16-etm-0-0-10553","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-018-0216-4","article-title":"Lncrna kcnq1ot1 promotes osteogenic differentiation to relieve osteolysis via wnt\/\u03b2-catenin activation","volume":"8","author":"Gao","year":"2018","journal-title":"Cell Biosci"},{"key":"key20210903112558_b17-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/j.cell.2009.01.015","article-title":"Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration","volume":"136","author":"Goessling","year":"2009","journal-title":"Cell"},{"key":"key20210903112558_b18-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"68","DOI":"10.4161\/org.4.2.5851","article-title":"Wnt signal transduction pathways","volume":"4","author":"Komiya","year":"2008","journal-title":"Organogenesis"},{"issue":"176","key":"key20210903112558_b19-etm-0-0-10553","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0231-0","article-title":"Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis","volume":"9","author":"Jing","year":"2018","journal-title":"Cell Death Dis"},{"key":"key20210903112558_b20-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1002\/jcp.24218","article-title":"The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines","volume":"228","author":"Lucero","year":"2013","journal-title":"J Cell Physiol"},{"key":"key20210903112558_b21-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/s0092-8674(00)80258-5","article-title":"Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts","volume":"89","author":"Komori","year":"1997","journal-title":"Cell"},{"key":"key20210903112558_b22-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/emmm.201201606","article-title":"SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating beta-catenin","volume":"5","author":"Simic","year":"2013","journal-title":"EMBO Mol Med"},{"key":"key20210903112558_b23-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/jor.20342","article-title":"Murine model of prosthesis failure for the long term study of aseptic loosening","volume":"25","author":"Yang","year":"2007","journal-title":"J Orthop Res"},{"key":"key20210903112558_b24-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1016\/j.biomaterials.2009.11.069","article-title":"Protection against titanium particle induced osteolysis by cannabinoid receptor 2 selective antagonist","volume":"31","author":"Geng","year":"2010","journal-title":"Biomaterials"},{"key":"key20210903112558_b25-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0736-0266(03)00156-6","article-title":"NF-kB signaling blockade abolishes implant particle-induced osteoclastogenesis","volume":"22","author":"Clohisy","year":"2004","journal-title":"J Orthop Res"},{"key":"key20210903112558_b26-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.orthres.2003.08.013","article-title":"The effectiveness of polyethylene versus titanium particles in inducing osteolysis in vivo","volume":"22","author":"von Knoch","year":"2004","journal-title":"J Orthop Res"},{"key":"key20210903112558_b27-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.3892\/etm.2019.7311","article-title":"Therapeutic effect of resveratrol on mice with depression","volume":"17","author":"Gu","year":"2019","journal-title":"Exp Ther Med"},{"issue":"99","key":"key20210903112558_b28-etm-0-0-10553","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8040099","article-title":"Natural antioxidant resveratrol suppresses uterine fibroid cell growth and extracellular matrix formation in vitro and in vivo","volume":"8","author":"Chen","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"key20210903112558_b29-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1139\/cjpp-2019-0188","article-title":"Effects of resveratrol postconditioning on cerebral ischemia in mice: Role of the sirtuin-1 pathway","volume":"97","author":"Grewal","year":"2019","journal-title":"Can J Physiol Pharmacol"},{"key":"key20210903112558_b30-etm-0-0-10553","first-page":"S83","article-title":"Ten-year results of the first 100 genesis II total knee replacement procedures","volume":"30 (Suppl 8)","author":"Bourne","year":"2007","journal-title":"Orthopedics"},{"key":"key20210903112558_b31-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3760\/cma.j.issn.0253-3766.2018.05.002","article-title":"Proliferation and apoptosis of lung cancer cells regulated by gultaredoxin 3","volume":"40","author":"Zhu","year":"2018","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"key20210903112558_b32-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20210903112558_b33-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"23771","DOI":"10.1074\/jbc.M111.251116","article-title":"An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts","volume":"286","author":"Rybchyn","year":"2011","journal-title":"J Biol Chem"},{"key":"key20210903112558_b34-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.phrs.2012.10.010","article-title":"Negative regulation of inflammation by SIRT1","volume":"67","author":"Xie","year":"2013","journal-title":"Pharmacol Res"},{"key":"key20210903112558_b35-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1093\/cvr\/cvr022","article-title":"Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53","volume":"90","author":"Zhang","year":"2011","journal-title":"Cardiocasc Res"},{"key":"key20210903112558_b36-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1101\/gad.13.19.2570","article-title":"The SIR2\/3\/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms","volume":"13","author":"Kaeberlein","year":"1999","journal-title":"Genes Dev"},{"key":"key20210903112558_b37-etm-0-0-10553","doi-asserted-by":"crossref","first-page":"166","DOI":"10.14712\/fb2012058040166","article-title":"Resveratrol inhibits proliferation of primary rat hepatocytes in G0\/G1 by inhibiting DNA synthesis","volume":"58","author":"Rubiolo","year":"2012","journal-title":"Folia Biol (Praha)"},{"key":"key20210903112558_b38-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/odi.12785","article-title":"Resveratrol suppresses the alveolar bone resorption induced by artificial trauma from occlusion in mice","volume":"24","author":"Matsuda","year":"2018","journal-title":"Oral Dis"},{"key":"key20210903112558_b39-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"481","DOI":"10.3109\/00016357.2013.865787","article-title":"Effects of resveratrol and irradiation upon oral squamous cell carcinoma cells","volume":"72","author":"Atienzar","year":"2014","journal-title":"Acta Odontol Scand"},{"key":"key20210903112558_b40-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3892\/ijmm.2014.1978","article-title":"Electromagnetic fields and nanomagnetic particles increase the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells","volume":"35","author":"Kim","year":"2015","journal-title":"Int J Mol Med"},{"key":"key20210903112558_b41-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"17917","DOI":"10.1007\/s11356-015-5018-1","article-title":"The short-term toxic effects of TiO2 nanoparticles toward bacteria through viability, cellular respiration, and lipid peroxidation","volume":"22","author":"Erdem","year":"2015","journal-title":"Environ Sci Pollut Res Int"},{"key":"key20210903112558_b42-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"3617","DOI":"10.2147\/IJN.S124661","article-title":"The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-\u03baB deacetylation in aseptic loosening","volume":"12","author":"Deng","year":"2017","journal-title":"Int J Nanomedicine"},{"key":"key20210903112558_b43-etm-0-0-10553","doi-asserted-by":"publisher","first-page":"5871","DOI":"10.3390\/nu6125871","article-title":"Effects of resveratrol supplementation on bone growth in young rats and microarchitecture and remodeling in ageing rats","volume":"6","author":"Lee","year":"2014","journal-title":"Nutrients"},{"issue":"e0178520","key":"key20210903112558_b44-etm-0-0-10553","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178520","article-title":"SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2","volume":"12","author":"Zainabadi","year":"2017","journal-title":"PLoS One"},{"issue":"jcs229351","key":"key20210903112558_b45-etm-0-0-10553","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.229351","article-title":"Catabolic activity of osteoblast lineage cells contributes to osteoclastic bone resorption in vitro","volume":"132","author":"Pirapaharan","year":"2019","journal-title":"J Cell Sci"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T20:43:56Z","timestamp":1725569036000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2021.10553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,4]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,8,4]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2021.10553","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,4]]},"article-number":"1119"}}