{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:51:12Z","timestamp":1787061072578,"version":"build-2736575974"},"reference-count":49,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2021.10611","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T04:22:59Z","timestamp":1628828579000},"source":"Crossref","is-referenced-by-count":5,"title":["Cyclophosphamide inhibits the progression of Meniere's disease by reducing the generation of circulating immune complex"],"prefix":"10.3892","volume":"22","author":[{"given":"Shu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liang","sequence":"additional","affiliation":[{"name":"Computer Information and Network Management Center, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boqian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"key20210903112756_b1-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s001060050717","article-title":"Electrocochleography and phase audiometry in diagnosis of Meniere disease","volume":"49","author":"Anft","year":"2001","journal-title":"HNO"},{"key":"key20210903112756_b2-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/cei.13083","article-title":"RNA-sequencing study of peripheral blood mononuclear cells in sporadic Meniere's disease patients: Possible contribution of immunologic dysfunction to the development of this disorder","volume":"192","author":"Sun","year":"2018","journal-title":"Clin Exp Immunol"},{"key":"key20210903112756_b3-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1017\/S0022215120000626","article-title":"Magnetic resonance imaging of Meniere's disease: Early clinical experience in a UK centre","volume":"134","author":"Pai","year":"2020","journal-title":"J Laryngol Otol"},{"key":"key20210903112756_b4-etm-0-0-10611","first-page":"1317","article-title":"Observations on the pathology of Meniere's syndrome: (Section of otology)","volume":"31","author":"Hallpike","year":"1938","journal-title":"Proc R Soc Med"},{"key":"key20210903112756_b5-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.semarthrit.2017.11.008","article-title":"Autoimmune arthritis in Meniere's disease: A systematic review of the literature","volume":"48","author":"Caulley","year":"2018","journal-title":"Semin Arthritis Rheum"},{"key":"key20210903112756_b6-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.autrev.2012.01.004","article-title":"Meniere's disease might be an autoimmune condition?","volume":"11","author":"Greco","year":"2012","journal-title":"Autoimmun Rev"},{"key":"key20210903112756_b7-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"2738","DOI":"10.1002\/lary.28647","article-title":"Is endolymphatic sac surgery beneficial for Meniere's disease?","volume":"130","author":"Cooper","year":"2020","journal-title":"Laryngoscope"},{"key":"key20210903112756_b8-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1258\/002221503321192548","article-title":"Autoimmune sensorineural hearing loss: Is it still a clinical diagnosis?","volume":"117","author":"Mathews","year":"2003","journal-title":"J Laryngol Otol"},{"key":"key20210903112756_b9-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1288\/00005537-199309000-00014","article-title":"Immunoperoxidase study of the endolymphatic sac in Meniere's disease","volume":"103","author":"Dornhoffer","year":"1993","journal-title":"Laryngoscope"},{"issue":"e26759","key":"key20210903112756_b10-etm-0-0-10611","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026759","article-title":"High prevalence of systemic autoimmune diseases in patients with Meniere's disease","volume":"6","author":"Gazquez","year":"2011","journal-title":"PLoS One"},{"key":"key20210903112756_b11-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"450","DOI":"10.3109\/00016488409132920","article-title":"Endolymphatic hydrops and III type allergic reaction","volume":"97","author":"Harada","year":"1984","journal-title":"Acta Otolaryngol"},{"issue":"2","key":"key20210903112756_b12-etm-0-0-10611","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-2","article-title":"Polymorphisms of CD16A and CD32 Fc\u03b3 receptors and circulating immune complexes in Meniere's disease: A case-control study","volume":"12","author":"Lopez-Escamez","year":"2011","journal-title":"BMC Med Genet"},{"key":"key20210903112756_b13-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1288\/00005537-199103000-00001","article-title":"Meniere's disease: An immune complex-mediated illness?","volume":"101","author":"Derebery","year":"1991","journal-title":"Laryngoscope"},{"key":"key20210903112756_b14-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1177\/000348949009900707","article-title":"Immunoglobulin E and circulating immune complexes in endolymphatic hydrops","volume":"99","author":"Hsu","year":"1990","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"e111039","key":"key20210903112756_b15-etm-0-0-10611","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111039","article-title":"Autoimmunity as a candidate for the etiopathogenesis of Meniere's disease: Detection of autoimmune reactions and diagnostic biomarker candidate","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"key":"key20210903112756_b16-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1080\/21645515.2019.1710413","article-title":"Targeting the IL-9 pathway in cancer immunotherapy","volume":"16","author":"Zheng","year":"2020","journal-title":"Hum Vaccin Immunother"},{"issue":"1534","key":"key20210903112756_b17-etm-0-0-10611","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101534","article-title":"Natural killer cell therapy: A new treatment paradigm for solid tumors","volume":"11","author":"Oh","year":"2019","journal-title":"Cancers (Basel)"},{"key":"key20210903112756_b18-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.otc.2010.05.004","article-title":"Allergy and its relation to Meniere's disease","volume":"43","author":"Derebery","year":"2010","journal-title":"Otolaryngol Clin North Am"},{"key":"key20210903112756_b19-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1080\/07315724.2017.1364181","article-title":"Delayed immunomodulatory effect of cow milk-free diet in Meniere's Disease","volume":"37","author":"Di Berardino","year":"2018","journal-title":"J Am Coll Nutr"},{"key":"key20210903112756_b20-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/ajd.12406","article-title":"Cyclophosphamide in dermatology","volume":"58","author":"Kim","year":"2017","journal-title":"Australas J Dermatol"},{"key":"key20210903112756_b21-etm-0-0-10611","first-page":"4862","article-title":"Augmentation of the human immune response by cyclophosphamide","volume":"42","author":"Berd","year":"1982","journal-title":"Cancer Res"},{"key":"key20210903112756_b22-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/nrclinonc.2009.146","article-title":"Cyclophosphamide and cancer: Golden anniversary","volume":"6","author":"Emadi","year":"2009","journal-title":"Nat Rev Clin Oncol"},{"key":"key20210903112756_b23-etm-0-0-10611","author":"Tsuchida"},{"key":"key20210903112756_b24-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3760\/cma.j.issn.1673-0860.2017.03.002","article-title":"Guideline of diagnosis and treatment of Meniere disease (2017)","volume":"52","year":"2017","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"issue":"3651","key":"key20210903112756_b25-etm-0-0-10611","doi-asserted-by":"publisher","DOI":"10.3390\/s18113651","article-title":"New method for pure-tone audiometry using electrooculogram: A proof-of-concept study","volume":"18","author":"Kim","year":"2018","journal-title":"Sensors (Basel)"},{"key":"key20210903112756_b26-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/00016480902729827","article-title":"Grading of endolymphatic hydrops using magnetic resonance imaging","volume":"560","author":"Nakashima","year":"2009","journal-title":"Acta Otolaryngol Suppl"},{"key":"key20210903112756_b27-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1212\/01.WNL.0000161876.20552.AA","article-title":"Characteristics and clinical applications of vestibular-evoked myogenic potentials","volume":"64","author":"Welgampola","year":"2005","journal-title":"Neurology"},{"key":"key20210903112756_b28-etm-0-0-10611","first-page":"596","article-title":"Analysis of the main components of inner ear antigens inducing autoimmune Meniere's disease in guinea pigs","volume":"43","author":"Lu","year":"2008","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"issue":"286","key":"key20210903112756_b29-etm-0-0-10611","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1998.tb10161.x","article-title":"Revised australian code of practice for the care and use of animals for scientific purposes","volume":"76","author":"Perry","year":"1998","journal-title":"Aust Vet J"},{"issue":"e000326","key":"key20210903112756_b30-etm-0-0-10611","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2019-000326","article-title":"Measuring plasma C4D to monitor immune complexes in lupus nephritis","volume":"6","author":"Kraaij","year":"2019","journal-title":"Lupus Sci Med"},{"key":"key20210903112756_b31-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.ebiom.2018.10.038","article-title":"Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trials","volume":"37","author":"Gupta","year":"2018","journal-title":"EBioMedicine"},{"issue":"0505","key":"key20210903112756_b32-etm-0-0-10611","article-title":"Meniere's disease","volume":"2015","author":"Wright","year":"2015","journal-title":"BMJ Clin Evid"},{"key":"key20210903112756_b33-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/00005537-200203000-00019","article-title":"Augmentation of vestibular evoked myogenic potentials: An indication for distended saccular hydrops","volume":"112","author":"Young","year":"2002","journal-title":"Laryngoscope"},{"key":"key20210903112756_b34-etm-0-0-10611","first-page":"964","article-title":"Electrocochleography in the diagnosis of Meniere's disease","volume":"28","author":"Mao","year":"2014","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"issue":"301","key":"key20210903112756_b35-etm-0-0-10611","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00301","article-title":"Tone burst electrocochleography for the diagnosis of clinically certain Meniere's disease","volume":"11","author":"Hornibrook","year":"2017","journal-title":"Front Neurosci"},{"key":"key20210903112756_b36-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1097\/MLG.0b013e3181453a3c","article-title":"Treatment of Meniere's disease by low-dosage intratympanic gentamicin application: Effect on otolith function","volume":"117","author":"Helling","year":"2007","journal-title":"Laryngoscope"},{"key":"key20210903112756_b37-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1097\/MAO.0b013e31825d9a95","article-title":"In vivo visualized endolymphatic hydrops and inner ear functions in patients with electrocochleographically confirmed Meniere's disease","volume":"33","author":"Gurkov","year":"2012","journal-title":"Otol Neurotol"},{"key":"key20210903112756_b38-etm-0-0-10611","first-page":"S105","article-title":"Physiological and pathological aspects of circulating immune complex","volume":"68 (Suppl 6)","author":"Tamai","year":"2010","journal-title":"Nihon Rinsho"},{"key":"key20210903112756_b39-etm-0-0-10611","first-page":"281","article-title":"Immune deposits and immune complex disease","volume":"4","author":"Salvidio","year":"1986","journal-title":"Clin Exp Rheumatol"},{"key":"key20210903112756_b40-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00405-006-0147-2","article-title":"Non-specific immunological determinations in Meniere's disease: Any role in clinical practice?","volume":"264","author":"Savastano","year":"2007","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"key20210903112756_b41-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1177\/000348940211100704","article-title":"Induction of endolymphatic hydrops by directly infused monoclonal antibody against type II collagen CB11 peptide","volume":"111","author":"Matsuoka","year":"2002","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"e39086","key":"key20210903112756_b42-etm-0-0-10611","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039086","article-title":"Betahistine exerts a dose-dependent effect on cochlear stria vascularis blood flow in guinea pigs in vivo","volume":"7","author":"Ihler","year":"2012","journal-title":"PLoS One"},{"key":"key20210903112756_b43-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1097\/mao.0b013e31815aea05","article-title":"Long-term vertigo control in patients after intratympanic gentamicin instillation for Meniere's disease","volume":"28","author":"Bodmer","year":"2007","journal-title":"Otol Neurotol"},{"key":"key20210903112756_b44-etm-0-0-10611","first-page":"6016","article-title":"Intratympanic dexamethasone injections for refractory Meniere' s disease","volume":"8","author":"Ren","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"key20210903112756_b45-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1002\/lary.25057","article-title":"Transitory effect on endolymphatic hydrops of the intratympanic steroids for Meniere's disease","volume":"125","author":"Martin-Sanz","year":"2015","journal-title":"Laryngoscope"},{"key":"key20210903112756_b46-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.otorri.2017.08.008","article-title":"Immune-mediated inner ear disease: Diagnostic and therapeutic approaches","volume":"70","author":"Peneda","year":"2019","journal-title":"Acta Otorrinolaringol Esp"},{"key":"key20210903112756_b47-etm-0-0-10611","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3760\/cma.j.issn.1673-0860.2018.12.017","article-title":"Recent immunology research of Meniere's disease","volume":"53","author":"Guo","year":"2018","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"issue":"2058738418808680","key":"key20210903112756_b48-etm-0-0-10611","doi-asserted-by":"publisher","DOI":"10.1177\/2058738418808680","article-title":"Autoimmune inner ear disease (AIED): A diagnostic challenge","volume":"32","author":"Ciorba","year":"2018","journal-title":"Int J Immunopathol Pharmacol"},{"key":"key20210903112756_b49-etm-0-0-10611","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/014556130007900207","article-title":"Low-dose oral methotrexate management of patients with bilateral Meniere's disease","volume":"79","author":"Kilpatrick","year":"2000","journal-title":"Ear Nose Throat J"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T15:22:43Z","timestamp":1630941763000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2021.10611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":49,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,8,13]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2021.10611","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,13]]},"article-number":"1177"}}