{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:27:49Z","timestamp":1768289269262,"version":"3.49.0"},"reference-count":33,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2021.10707","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T11:26:20Z","timestamp":1631013980000},"source":"Crossref","is-referenced-by-count":9,"title":["Frequent injections of high\u2011dose human umbilical cord mesenchymal stem cells slightly aggravate arthritis and skeletal muscle cachexia in collagen\u2011induced arthritic mice"],"prefix":"10.3892","volume":"22","author":[{"given":"Lemei","family":"An","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianshu","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liujun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songtao","family":"An","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalong","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Stem Cell Differentiation and Modification, Stem Cell Research Center, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Hao","sequence":"additional","affiliation":[{"name":"Neuroscience Initiative, Advanced Science Research Center at the Graduate Center, City University of New York, NY 10031, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, P.R.\u00a0China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Yue","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Stem Cell Differentiation and Modification, Stem Cell Research Center, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"key20211014132548_b1-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: A review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA"},{"key":"key20211014132548_b2-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1002\/jcsm.12320","article-title":"Prevalence of rheumatoid cachexia in rheumatoid arthritis: A systematic review and meta-analysis","volume":"9","author":"Santo","year":"2018","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"key20211014132548_b3-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/nrd4467","article-title":"Muscle wasting in disease: Molecular mechanisms and promising therapies","volume":"14","author":"Cohen","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"key20211014132548_b4-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/jcsm.12381","article-title":"Myopenia is associated with joint damage in rheumatoid arthritis: A cross-sectional study","volume":"10","author":"Lin","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"key20211014132548_b5-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/jcsm.12280","article-title":"Collagen-induced arthritis as an animal model of rheumatoid cachexia","volume":"9","author":"Alabarse","year":"2018","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"key20211014132548_b6-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1016\/S0140-6736(17)31491-5","article-title":"Novel treatment strategies in rheumatoid arthritis","volume":"389","author":"Burmester","year":"2017","journal-title":"Lancet"},{"issue":"2056","key":"key20211014132548_b7-ETM-0-0-10707","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02056","article-title":"The use of human mesenchymal stem cells as therapeutic agents for the in vivo treatment of immune-related diseases: A systematic review","volume":"9","author":"Leyendecker","year":"2018","journal-title":"Front Immunol"},{"issue":"963689720965896","key":"key20211014132548_b8-ETM-0-0-10707","doi-asserted-by":"publisher","DOI":"10.1177\/0963689720965896","article-title":"Preclinical evaluation of a single intravenous infusion of hUC-MSC (BX-U001) in rheumatoid arthritis","volume":"29","author":"Liu","year":"2020","journal-title":"Cell Transplant"},{"key":"key20211014132548_b9-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41581-018-0023-5","article-title":"Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases","volume":"14","author":"Shi","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"key20211014132548_b10-ETM-0-0-10707","first-page":"288","article-title":"Comparable therapeutic potential of umbilical cord mesenchymal stem cells in collagen-induced arthritis to TNF inhibitor or anti-CD20 treatment","volume":"35","author":"Sun","year":"2017","journal-title":"Clin Exp Rheumatol"},{"issue":"4069032","key":"key20211014132548_b11-ETM-0-0-10707","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4069032","article-title":"Mesenchymal stem cells promote the osteogenesis in collagen-induced arthritic mice through the inhibition of TNF-\u03b1","volume":"2018","author":"Liu","year":"2018","journal-title":"Stem Cells Int"},{"key":"key20211014132548_b12-ETM-0-0-10707","first-page":"1017","article-title":"Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials","volume":"91","author":"Lu","year":"2006","journal-title":"Haematologica"},{"key":"key20211014132548_b13-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/cyto.a.23242","article-title":"Isolation, cultivation, and characterization of human mesenchymal stem cells","volume":"93","author":"Mushahary","year":"2018","journal-title":"Cytometry A"},{"key":"key20211014132548_b14-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"key20211014132548_b15-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/nprot.2007.173","article-title":"Collagen-induced arthritis","volume":"2","author":"Brand","year":"2007","journal-title":"Nat Protoc"},{"key":"key20211014132548_b16-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4939-8802-0_1","article-title":"Collagen-induced arthritis models","volume":"1868","author":"Miyoshi","year":"2018","journal-title":"Methods Mol Biol"},{"key":"key20211014132548_b17-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.ijbiomac.2018.12.146","article-title":"TNF-\u03b1 regulates microglial activation via the NF-\u03baB signaling pathway in systemic lupus erythematosus with depression","volume":"125","author":"Kong","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"key20211014132548_b18-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/art.20782","article-title":"The non-major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage","volume":"52","author":"Brenner","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"2484678","key":"key20211014132548_b19-ETM-0-0-10707","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2484678","article-title":"Redox status and muscle pathology in rheumatoid arthritis: Insights from various rat hindlimb muscles","volume":"2019","author":"Oyenihi","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"key20211014132548_b20-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"7728","DOI":"10.1021\/acs.nanolett.0c03279","article-title":"Inflammation-targeted celastrol nanodrug attenuates collagen-induced arthritis through NF-\u03baB and Notch1 pathways","volume":"20","author":"An","year":"2020","journal-title":"Nano Lett"},{"key":"key20211014132548_b21-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.3727\/096368915X687949","article-title":"Treatment of collagen-induced arthritis using immune modulatory properties of human mesenchymal stem cells","volume":"25","author":"Park","year":"2016","journal-title":"Cell Transplant"},{"issue":"35933","key":"key20211014132548_b22-ETM-0-0-10707","doi-asserted-by":"publisher","DOI":"10.1038\/srep35933","article-title":"Overexpression of soluble RAGE in mesenchymal stem cells enhances their immunoregulatory potential for cellular therapy in autoimmune arthritis","volume":"6","author":"Park","year":"2016","journal-title":"Sci Rep"},{"issue":"23","key":"key20211014132548_b23-ETM-0-0-10707","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-016-0285-4","article-title":"CD146+ mesenchymal stem cells display greater therapeutic potential than CD146-cells for treating collagen-induced arthritis in mice","volume":"7","author":"Wu","year":"2016","journal-title":"Stem Cell Res Ther"},{"key":"key20211014132548_b24-ETM-0-0-10707","first-page":"484","article-title":"Transplantation of human amnion mesenchymal cells attenuates the disease development in rats with collagen-induced arthritis","volume":"33","author":"Shu","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"key20211014132548_b25-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1097\/01.tp.0000209919.90630.7b","article-title":"Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model","volume":"81","author":"Inoue","year":"2006","journal-title":"Transplantation"},{"issue":"18","key":"key20211014132548_b26-ETM-0-0-10707","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-18","article-title":"The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX\u00ae) in the treatment of inflammatory arthritis","volume":"11","author":"Santos","year":"2013","journal-title":"J Transl Med"},{"key":"key20211014132548_b27-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"7463","DOI":"10.3892\/mmr.2015.4394","article-title":"Human umbilical cord mesenchymal stem cells improve the immune-associated inflammatory and prothrombotic state in collagen type-II-induced arthritic rats","volume":"12","author":"Gu","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20211014132548_b28-ETM-0-0-10707","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/stem.2244","article-title":"The immunosuppressive signature of menstrual blood mesenchymal stem cells entails opposite effects on experimental arthritis and graft versus host diseases","volume":"34","author":"Luz-Crawford","year":"2016","journal-title":"Stem Cells"},{"key":"key20211014132548_b29-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1136\/annrheumdis-2011-200985","article-title":"Mesenchymal stem cells are conditionally therapeutic in preclinical models of rheumatoid arthritis","volume":"71","author":"Papadopoulou","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"key20211014132548_b30-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1089\/scd.2013.0193","article-title":"Mesenchymal stem cells induce an inflammatory response after intravenous infusion","volume":"22","author":"Hoogduijn","year":"2013","journal-title":"Stem Cells Dev"},{"key":"key20211014132548_b31-ETM-0-0-10707","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s13539-013-0102-1","article-title":"Temporal development of muscle atrophy in murine model of arthritis is related to disease severity","volume":"4","author":"Filippin","year":"2013","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"12","key":"key20211014132548_b32-ETM-0-0-10707","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1215-7","article-title":"Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability","volume":"19","author":"Huffman","year":"2017","journal-title":"Arthritis Res Ther"},{"issue":"46","key":"key20211014132548_b33-ETM-0-0-10707","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-016-0305-4","article-title":"Role of VEGF-A in angiogenesis promoted by umbilical cord-derived mesenchymal stromal\/stem cells: In vitro study","volume":"7","author":"Arutyunyan","year":"2016","journal-title":"Stem Cell Res Ther"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T13:23:03Z","timestamp":1634217783000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2021.10707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,7]]},"references-count":33,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,9,7]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2021.10707","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,7]]},"article-number":"1272"}}