{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:10:51Z","timestamp":1770837051384,"version":"3.50.1"},"reference-count":40,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2021.10739","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T08:19:50Z","timestamp":1631780390000},"source":"Crossref","is-referenced-by-count":9,"title":["Exosomes derived from PC\u20113 cells suppress osteoclast differentiation by downregulating miR\u2011148a and blocking the PI3K\/AKT\/mTOR pathway"],"prefix":"10.3892","volume":"22","author":[{"given":"Gaoqiang","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, The Affiliated Yuebei People's Hospital of Shantou University Medical College, Shaoguan, Guangdong 512025, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konghe","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The Affiliated Yuebei People's Hospital of Shantou University Medical College, Shaoguan, Guangdong 512025, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujun","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingming","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanlin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songjia","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Southern Medical University, Guangzhou, Guangdong 510250, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"key20211014132653_b1-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1177\/1557988318798279","article-title":"Global trends and prostate cancer: A review of incidence, detection, and mortality as influenced by race, ethnicity, and geographic location","volume":"12","author":"Taitt","year":"2018","journal-title":"Am J Mens Health"},{"key":"key20211014132653_b2-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"key20211014132653_b3-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/00042307-200501000-00006","article-title":"Epidemiology of male osteoporosis and prostate cancer","volume":"15","author":"Gilbert","year":"2005","journal-title":"Curr Opin Urol"},{"key":"key20211014132653_b4-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nrclinonc.2011.67","article-title":"Bone metastasis in prostate cancer: Emerging therapeutic strategies","volume":"8","author":"Sturge","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"issue":"2587","key":"key20211014132653_b5-ETM-0-0-10739","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102587","article-title":"Prostate cancer and bone metastases: The underlying mechanisms","volume":"20","author":"Wong","year":"2019","journal-title":"Int J Mol Sci"},{"key":"key20211014132653_b6-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/prca.201400114","article-title":"Exosomes in bodily fluids are a highly stable resource of disease biomarkers","volume":"9","author":"Boukouris","year":"2015","journal-title":"Proteomics Clin Appl"},{"issue":"4","key":"key20211014132653_b7-ETM-0-0-10739","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-7-4","article-title":"Can urinary exosomes act as treatment response markers in prostate cancer?","volume":"7","author":"Mitchell","year":"2009","journal-title":"J Transl Med"},{"key":"key20211014132653_b8-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"5157","DOI":"10.1021\/pr8004887","article-title":"Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes","volume":"7","author":"Conde-Vancells","year":"2008","journal-title":"J Proteome Res"},{"key":"key20211014132653_b9-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: Composition, biogenesis and function","volume":"2","author":"Th\u00e9ry","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"key20211014132653_b10-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.gpb.2015.02.001","article-title":"Exosome and exosomal microRNA: Trafficking, sorting, and function","volume":"13","author":"Zhang","year":"2015","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"key20211014132653_b11-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/nature10661","article-title":"A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells","volume":"481","author":"Png","year":"2011","journal-title":"Nature"},{"key":"key20211014132653_b12-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"S52","DOI":"10.1080\/21691401.2018.1489263","article-title":"Detection of exosome miRNAs using molecular beacons for diagnosing prostate cancer","volume":"46 (Sup3)","author":"Lee","year":"2018","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"key20211014132653_b13-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-7046-9_1","article-title":"MicroRNAs, long noncoding RNAs, and their functions in human disease","volume":"1617","author":"Xue","year":"2017","journal-title":"Methods Mol Biol"},{"issue":"5395","key":"key20211014132653_b14-ETM-0-0-10739","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07810-w","article-title":"Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis","volume":"9","author":"Zeng","year":"2018","journal-title":"Nat Commun"},{"key":"key20211014132653_b15-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"4929","DOI":"10.1038\/onc.2017.105","article-title":"Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1","volume":"36","author":"Hsu","year":"2017","journal-title":"Oncogene"},{"key":"key20211014132653_b16-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/s0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"key20211014132653_b17-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20211014132653_b18-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.cell.2007.04.040","article-title":"A mammalian microRNA expression atlas based on small RNA library sequencing","volume":"129","author":"Landgraf","year":"2007","journal-title":"Cell"},{"key":"key20211014132653_b19-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1007\/s00018-019-03162-w","article-title":"Deregulated miRNAs in osteoporosis: Effects in bone metastasis","volume":"76","author":"Bellavia","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"key20211014132653_b20-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1002\/jbmr.2175","article-title":"Five freely circulating miRNAs and bone tissue miRNAs Are associated with osteoporotic fractures","volume":"29","author":"Seeliger","year":"2014","journal-title":"J Bone Miner Res"},{"key":"key20211014132653_b21-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"S519","DOI":"10.1007\/s00508-016-1141-3","article-title":"MiR-148a the epigenetic regulator of bone homeostasis is increased in plasma of osteoporotic postmenopausal women","volume":"128 (Suppl 7)","author":"Bedene","year":"2016","journal-title":"Wien Klin Wochenschr"},{"issue":"15861","key":"key20211014132653_b22-ETM-0-0-10739","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16113-x","article-title":"miRNAs in bone tissue correlate to bone mineral density and circulating miRNAs are gender independent in osteoporotic patients","volume":"7","author":"Kelch","year":"2017","journal-title":"Sci Rep"},{"key":"key20211014132653_b23-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1002\/jbmr.1845","article-title":"miR-148a regulates osteoclastogenesis by targeting V-maf musculoaponeurotic fibrosarcoma oncogene homolog B","volume":"28","author":"Cheng","year":"2013","journal-title":"J Bone Miner Res"},{"key":"key20211014132653_b24-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.2741\/4443","article-title":"The PI3K\/AKT pathway in the pathogenesis of prostate cancer","volume":"21","author":"Chen","year":"2016","journal-title":"Front Biosci (Landmark Ed)"},{"key":"key20211014132653_b25-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1146\/annurev-med-062913-051343","article-title":"The PI3K\/AKT pathway as a target for cancer treatment","volume":"67","author":"Mayer","year":"2016","journal-title":"Annu Rev Med"},{"key":"key20211014132653_b26-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"378","DOI":"10.4103\/1008-682X.122876","article-title":"PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance","volume":"16","author":"Edlind","year":"2014","journal-title":"Asian J Androl"},{"key":"key20211014132653_b27-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s12013-014-0433-3","article-title":"Effect of PI3K\/Akt signaling pathway on the process of prostate cancer metastasis to bone","volume":"72","author":"Zhu","year":"2015","journal-title":"Cell Biochem Biophys"},{"key":"key20211014132653_b28-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1002\/phar.2173","article-title":"Current and investigational agents targeting the phosphoinositide 3-kinase pathway","volume":"38","author":"Tang","year":"2018","journal-title":"Pharmacotherapy"},{"issue":"Unit 3.22","key":"key20211014132653_b29-ETM-0-0-10739","doi-asserted-by":"publisher","DOI":"10.1002\/0471143030.cb0322s30","article-title":"Isolation and characterization of exosomes from cell culture supernatants and biological fluids","volume":"3","author":"Th\u00e9ry","year":"2006","journal-title":"Curr Protoc Cell Biol Chapter"},{"key":"key20211014132653_b30-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers","volume":"10","author":"Skog","year":"2008","journal-title":"Nat Cell Biol"},{"key":"key20211014132653_b31-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/iju.13594","article-title":"Extracellular vesicles: Toward a clinical application in urological cancer treatment","volume":"25","author":"Urabe","year":"2018","journal-title":"Int J Urol"},{"key":"key20211014132653_b32-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"key20211014132653_b33-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s11307-017-1101-y","article-title":"[68Ga]PSMA-HBED-CC uptake in osteolytic, osteoblastic, and bone marrow metastases of prostate cancer patients","volume":"19","author":"Janssen","year":"2017","journal-title":"Mol Imaging Biol"},{"key":"key20211014132653_b34-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s12094-014-1247-x","article-title":"Differences of osteoblastic bone metastases and osteolytic bone metastases in clinical features and molecular characteristics","volume":"17","author":"Fang","year":"2015","journal-title":"Clin Transl Oncol"},{"key":"key20211014132653_b35-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1080\/13685538.2018.1424130","article-title":"PI3K pathway and Bcl-2 family. Clinicopathological features in prostate cancer","volume":"21","author":"Torrealba","year":"2018","journal-title":"Aging Male"},{"key":"key20211014132653_b36-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"920","DOI":"10.3892\/mmr.2018.9026","article-title":"Regulatory effects of miRNA-181a on FasL expression in bone marrow mesenchymal stem cells and its effect on CD4+T lymphocyte apoptosis in estrogen deficiency-induced osteoporosis","volume":"18","author":"Shao","year":"2018","journal-title":"Mol Med Rep"},{"key":"key20211014132653_b37-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.omtn.2019.08.010","article-title":"Exosomes derived from miR-143-overexpressing MSCs inhibit cell migration and invasion in human prostate cancer by downregulating TFF3","volume":"18","author":"Che","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"key20211014132653_b38-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1002\/jbmr.3618","article-title":"Understanding the bone in cancer metastasis","volume":"33","author":"Fornetti","year":"2018","journal-title":"J Bone Miner Res"},{"key":"key20211014132653_b39-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"13772","DOI":"10.18632\/oncotarget.3830","article-title":"Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation","volume":"6","author":"Raimondi","year":"2015","journal-title":"Oncotarget"},{"key":"key20211014132653_b40-ETM-0-0-10739","doi-asserted-by":"publisher","first-page":"307","DOI":"10.34172\/apb.2020.037","article-title":"Interleukin-6, -8, and TGF-\u03b2 secreted from mesenchymal stem cells show functional role in reduction of telomerase activity of leukemia cell via Wnt5a\/\u03b2-catenin and P53 pathways","volume":"10","author":"Fathi","year":"2020","journal-title":"Adv Pharm Bull"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T13:58:20Z","timestamp":1634219900000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2021.10739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,16]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,9,16]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2021.10739","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,16]]},"article-number":"1304"}}