{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:15:42Z","timestamp":1774271742258,"version":"3.50.1"},"reference-count":38,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2021.11057","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T12:08:29Z","timestamp":1639397309000},"source":"Crossref","is-referenced-by-count":15,"title":["Old and new therapeutic strategies in systemic sclerosis (Review)"],"prefix":"10.3892","volume":"23","author":[{"given":"Carmen","family":"Bobeica","sequence":"first","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u2018Dun\u0103rea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Niculet","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u2018Dun\u0103rea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alin","family":"Tatu","sequence":"additional","affiliation":[{"name":"Multidisciplinary Integrated Center of Dermatological Interface Research MIC-DIR (Centrul Integrat Multidisciplinar de Cercetare de Interfata Dermatologica - CIM-CID), \u2018Dunarea de Jos\u2019 University, 800010 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Craescu","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u2018Dun\u0103rea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Vata","sequence":"additional","affiliation":[{"name":"Clinical Department, Faculty of Medicine and Pharmacy, \u2018Gr. T. Popa\u2019 University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Statescu","sequence":"additional","affiliation":[{"name":"Clinical Department, Faculty of Medicine and Pharmacy, \u2018Gr. T. Popa\u2019 University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Iancu","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u2018Dun\u0103rea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmina","family":"Musat","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u2018Dun\u0103rea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miruna","family":"Draganescu","sequence":"additional","affiliation":[{"name":"Clinical Medicine, Faculty of Medicine and Pharmacy, \u2018Dun\u0103rea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Onisor","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u2018Dun\u0103rea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Lungu","sequence":"additional","affiliation":[{"name":"Clinical Medicine, Faculty of Medicine and Pharmacy, \u2018Dun\u0103rea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Fotea","sequence":"additional","affiliation":[{"name":"Clinical Medicine, Faculty of Medicine and Pharmacy, \u2018Dun\u0103rea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurel","family":"Nechita","sequence":"additional","affiliation":[{"name":"Clinical Medicine, Faculty of Medicine and Pharmacy, \u2018Dun\u0103rea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Stefanescu","sequence":"additional","affiliation":[{"name":"Department of Clinical Surgery, Faculty of Medicine and Pharmacy, \u2018Gr. T. Popa\u2019 University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gheuca\u2011Solovastru","sequence":"additional","affiliation":[{"name":"Clinical Department, Faculty of Medicine and Pharmacy, \u2018Gr. T. Popa\u2019 University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"issue":"4569826","key":"key20220302122010_b1-ETM-0-0-11057","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4569826","article-title":"Systemic sclerosis pathogenesis and emerging therapies, beyond the fibroblast","volume":"2019","author":"Sierra-Sep\u00falveda","year":"2019","journal-title":"Biomed Res Int"},{"key":"key20220302122010_b2-ETM-0-0-11057","first-page":"S3","article-title":"One year in review 2019: Systemic sclerosis","volume":"37 (Suppl 119)","author":"Barsotti","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"key20220302122010_b3-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1007\/s00393-019-00743-9","article-title":"Reality of inpatient vasoactive treatment with prostacyclin derivatives in patients with acral circulation disorders due to systemic sclerosis in Germany","volume":"79","author":"Juche","year":"2020","journal-title":"Z Rheumatol"},{"key":"key20220302122010_b4-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1136\/ard.2008.096677","article-title":"EULAR recommendations for the treatment of systemic sclerosis: A report from the EULAR scleroderma trials and research group (EUSTAR)","volume":"68","author":"Kowal-Bielecka","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"994","key":"key20220302122010_b5-ETM-0-0-11057","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10426","article-title":"Predictive value of immunological markers in systemic sclerosis","volume":"22","author":"Bobeica","year":"2021","journal-title":"Exp Ther Med"},{"key":"key20220302122010_b6-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"55","DOI":"10.7861\/clinmedicine.15-6-s58","article-title":"Advances in pathogenesis and treatment of systemic sclerosis","volume":"16","author":"Denton","year":"2016","journal-title":"Clin Med (Lond)"},{"key":"key20220302122010_b7-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"135","DOI":"10.2169\/internalmedicine.1431-18","article-title":"Intravenous cyclophosphamide for gastric antral vascular ectasia associated with systemic sclerosis refractory to endoscopic treatment: A case report and review of the pertinent literature","volume":"58","author":"Matsumoto","year":"2019","journal-title":"Intern Med"},{"key":"key20220302122010_b8-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1164\/ajrccm.155.2.9032171","article-title":"Immunosuppressive and cytotoxic pharmacotherapy for pulmonary disorders","volume":"155","author":"Lynch","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"key20220302122010_b9-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1080\/14397595.2018.1441658","article-title":"Efficacy and safety of combination therapy with prednisolone and oral tacrolimus for progressive interstitial pneumonia with systemic sclerosis: A retrospective study","volume":"28","author":"Konma","year":"2019","journal-title":"Mod Rheumatol"},{"key":"key20220302122010_b10-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/rheumatology\/kew047","article-title":"Digital ulcers in systemic sclerosis","volume":"56","author":"Hughes","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"key20220302122010_b11-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1007\/s10067-014-2579-1","article-title":"Rituximab for refractory digital infarcts and ulcers in systemic sclerosis","volume":"33","author":"Khor","year":"2014","journal-title":"Clin Rheumatol"},{"key":"key20220302122010_b12-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/art.1780271009","article-title":"Trial of platelet-inhibiting drug in scleroderma. Double-blind study with dipyridamole and aspirin","volume":"27","author":"Beckett","year":"1984","journal-title":"Arthritis Rheum"},{"key":"key20220302122010_b13-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3892\/etm.2020.8572","article-title":"Dynamics of digital ulcers in systemic sclerosis","volume":"20","author":"Bobeic\u0103","year":"2020","journal-title":"Exp Ther Med"},{"key":"key20220302122010_b14-ETM-0-0-11057","first-page":"499","article-title":"Long-term low molecular weight heparin therapy for severe Raynaud's phenomenon: A pilot study","volume":"18","author":"Denton","year":"2000","journal-title":"Clin Exp Rheumatol"},{"issue":"3","key":"key20220302122010_b15-ETM-0-0-11057","article-title":"Systemic sclerosis-scleroderma","volume":"8","author":"Haustein","year":"2002","journal-title":"Dermatol Online J"},{"key":"key20220302122010_b16-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1365-2230.1989.tb00917.x","article-title":"Treatment of peripheral gangrene due to systemic sclerosis with intravenous pentoxifylline","volume":"14","author":"Goodfield","year":"1989","journal-title":"Clin Exp Dermatol"},{"key":"key20220302122010_b17-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/j.1365-2133.1990.tb06294.x","article-title":"Pentoxifylline inhibits the proliferation of human fibroblasts derived from keloid, scleroderma and morphea skin and their production of collagen, glycosaminoglycans and fibronectin","volume":"123","author":"Berman","year":"1990","journal-title":"Br J Dermatol"},{"key":"key20220302122010_b18-ETM-0-0-11057","first-page":"135","article-title":"The challenge of pet therapy in systemic sclerosis: Evidence for an impact on pain, anxiety, neuroticism and social interaction","volume":"36 (Suppl 113)","author":"Fiori","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"key20220302122010_b19-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/imj.12691","article-title":"Prospects for improving outcomes in systemic sclerosis-related pulmonary hypertension","volume":"45","author":"Thakkar","year":"2015","journal-title":"Intern Med J"},{"key":"key20220302122010_b20-ETM-0-0-11057","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0140-6736(01)06250-X","article-title":"Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: A randomized placebo-controlled study","volume":"358","author":"Channick","year":"2001","journal-title":"Lancet"},{"key":"key20220302122010_b21-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1056\/NEJMoa012212","article-title":"Bosentan therapy for pulmonary arterial hypertension","volume":"346","author":"Rubin","year":"2002","journal-title":"N Engl J Med"},{"key":"key20220302122010_b22-ETM-0-0-11057","first-page":"77","article-title":"Psycho-oncology support","volume":"10","author":"Rebegea","year":"2019","journal-title":"BRAIN"},{"key":"key20220302122010_b23-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1097\/01.ASW.0000470155.29821.ed","article-title":"Randomized, controlled study of innovative spray formulation containing ozonated oil and \u03b1-bisabolol in the topical treatment of chronic venous leg ulcers","volume":"28","author":"Solov\u0103stru","year":"2015","journal-title":"Adv Skin Wound Care"},{"key":"key20220302122010_b24-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1093\/rheumatology\/35.4.364","article-title":"Comparison of methotrexate with placebo in the treatment of systemic sclerosis: A 24-week randomized double-blind trial, followed by a 24-week observational trial","volume":"35","author":"van den Hoogen","year":"1996","journal-title":"Br J Rheumatol"},{"key":"key20220302122010_b25-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1097\/00005382-200310000-00004","article-title":"Methotrexate induced pulmonary injury: Serial CT findings","volume":"18","author":"Arakawa","year":"2003","journal-title":"J Thorac Imaging"},{"key":"key20220302122010_b26-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1002\/1529-0131(199809)41:9<1613::AID-ART11>3.0.CO;2-O","article-title":"Case-control study of corticosteroids and other drugs that either precipitate or protect from the development of renal scleroderma crisis","volume":"41","author":"Steen","year":"1998","journal-title":"Arthritis Rheum"},{"key":"key20220302122010_b27-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"352","DOI":"10.7326\/0003-4819-113-5-352","article-title":"Outcome of renal crisis in systemic sclerosis: Relation to availability of angiotensin converting enzyme (ACE) inhibitors","volume":"113","author":"Steen","year":"1990","journal-title":"Ann Intern Med"},{"key":"key20220302122010_b28-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"600","DOI":"10.7326\/0003-4819-133-8-200010170-00010","article-title":"Long-term outcomes of renal scleroderma crisis","volume":"133","author":"Steen","year":"2000","journal-title":"Ann Intern Med"},{"issue":"59","key":"key20220302122010_b29-ETM-0-0-11057","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-020-2141-2","article-title":"ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis-a EUSTAR analysis","volume":"22","author":"B\u00fctikofer","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"key20220302122010_b30-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1136\/ard.2009.114264","article-title":"Causes and risk factors of death in systemic sclerosis: A study from the EULAR scleroderma trials and research (EUSTAR) database","volume":"69","author":"Tyndal","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"key20220302122010_b31-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1159\/000103892","article-title":"Small intestinal bacterial overgrowth: Diagnosis and treatment","volume":"25","author":"Gasbarrini","year":"2007","journal-title":"Dig Dis"},{"key":"key20220302122010_b32-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"530","DOI":"10.5966\/sctm.2015-0227","article-title":"Concise review: Endothelial progenitor cells in regenerative medicine: Applications and challenges","volume":"5","author":"Chong","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"key20220302122010_b33-ETM-0-0-11057","first-page":"411","article-title":"Introduction to next generation of endothelial progenitor cell therapy: A promise in vascular medicine","volume":"7","author":"Sukmawati","year":"2015","journal-title":"Am J Transl Res"},{"key":"key20220302122010_b34-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"124","DOI":"10.4183\/aeb.2017.124","article-title":"Multiple autoimmune syndrome type III-thyroiditis, vitiligo and alopecia areata","volume":"13","author":"Tatu","year":"2017","journal-title":"Acta Endocrinol (Buchar)"},{"key":"key20220302122010_b35-ETM-0-0-11057","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.37358\/RC.18.9.6575","article-title":"Statins. A review on structural perspectives, adverse reactions and relations with son-melanoma skin cancer","volume":"69","author":"Nwabudike","year":"2018","journal-title":"Rev Chim (Buchar)"},{"key":"key20220302122010_b36-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.3892\/etm.2018.6977","article-title":"New insights in vitiligo treatments using bioactive compounds from Piper nigrum","volume":"17","author":"Mih\u0103il\u0103","year":"2019","journal-title":"Exp Ther Med"},{"key":"key20220302122010_b37-ETM-0-0-11057","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1080\/14397595.2019.1640343","article-title":"Comparative efficacy and safety of immunosuppressive therapies for systemic sclerosis related interstitial lung disease: A Bayesian network analysis","volume":"30","author":"Zheng","year":"2020","journal-title":"Mod Rheumatol"},{"issue":"575","key":"key20220302122010_b38-ETM-0-0-11057","article-title":"Eficacia del micofenolato asociado a metotrexato como tratamiento de mantenimiento de la enfermedad pulmonary intersticial asociada a la sclerosis sist\u00e9mica","volume":"47","author":"Gonzalez-Nieto","year":"2011","journal-title":"Arch Bronconeumol"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T10:21:39Z","timestamp":1646216499000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2021.11057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,13]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,12,13]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2021.11057","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,13]]},"article-number":"134"}}