{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:07:13Z","timestamp":1768072033830,"version":"3.49.0"},"reference-count":61,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2021.9655","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T09:46:26Z","timestamp":1610963186000},"source":"Crossref","is-referenced-by-count":19,"title":["Inhibition of the mevalonate pathway improves myocardial fibrosis"],"prefix":"10.3892","volume":"21","author":[{"given":"Huifeng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"key20220302133921_b1-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/343425a0","article-title":"Regulation of the mevalonate pathway","volume":"343","author":"Goldstein","year":"1990","journal-title":"Nature"},{"key":"key20220302133921_b2-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"77","DOI":"10.2174\/1874467209666160112123205","article-title":"Mevalonate Pathway and Human Cancers","volume":"10","author":"Bathaie","year":"2017","journal-title":"Curr Mol Pharmacol"},{"key":"key20220302133921_b3-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.pharmthera.2014.02.007","article-title":"Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease","volume":"143","author":"Yeganeh","year":"2014","journal-title":"Pharmacol Ther"},{"key":"key20220302133921_b4-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1056\/NEJMoa1806747","article-title":"Mendelian Randomization Study of ACLY and Cardiovascular Disease","volume":"380","author":"Ference","year":"2019","journal-title":"N Engl J Med"},{"key":"key20220302133921_b5-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11883-011-0215-y","article-title":"Treatment of familial hypercholesterolemia: Is there a need beyond statin therapy?","volume":"14","author":"Raper","year":"2012","journal-title":"Curr Atheroscler Rep"},{"key":"key20220302133921_b6-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1161\/CIRCRESAHA.116.308537","article-title":"Pleiotropic effects of statins on the cardiovascular system","volume":"120","author":"Oesterle","year":"2017","journal-title":"Circ Res"},{"key":"key20220302133921_b7-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1055\/s-2004-869599","article-title":"Anti-inflammatory properties of statins","volume":"4","author":"Steffens","year":"2004","journal-title":"Semin Vasc Med"},{"key":"key20220302133921_b8-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/nri1839","article-title":"Statin therapy and autoimmune disease: From protein prenylation to immunomodulation","volume":"6","author":"Greenwood","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"key20220302133921_b9-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1161\/CIRCRESAHA.118.312782","article-title":"Statin toxicity","volume":"124","author":"Ward","year":"2019","journal-title":"Circ Res"},{"key":"key20220302133921_b10-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"544","DOI":"10.18553\/jmcp.2019.25.5.544","article-title":"Quantifying unmet need in statin-treated hyperlipidemia patients and the potential benefit of further LDL-C reduction through an EHR-based retrospective cohort study","volume":"25","author":"Schleyer","year":"2019","journal-title":"J Manag Care Spec Pharm"},{"key":"key20220302133921_b11-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"23","DOI":"10.14797\/mdcj-15-1-23","article-title":"Statins: Then and now","volume":"15","author":"Toth","year":"2019","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"key20220302133921_b12-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1253\/circj.CJ-14-0865","article-title":"Prognostic impact of statin use in patients with heart failure and preserved ejection fraction","volume":"79","author":"Nochioka","year":"2015","journal-title":"Circ J"},{"key":"key20220302133921_b13-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1056\/NEJMoa0706201","article-title":"CORONA Group: Rosuvastatin in older patients with systolic heart failure","volume":"357","author":"Kjekshus","year":"2007","journal-title":"N Engl J Med"},{"key":"key20220302133921_b14-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.amjcard.2013.12.023","article-title":"Meta-analysis of the effect of statins on mortality in patients with preserved ejection fraction","volume":"113","author":"Liu","year":"2014","journal-title":"Am J Cardiol"},{"key":"key20220302133921_b15-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.gene.2018.07.069","article-title":"RNA-seq analyses the effect of high-salt diet in hypertension","volume":"677","author":"Xu","year":"2018","journal-title":"Gene"},{"key":"key20220302133921_b16-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"3340","DOI":"10.1016\/j.ijcard.2013.04.038","article-title":"Effect of farnesyltransferase inhibition on cardiac remodeling in spontaneously hypertensive rats","volume":"168","author":"Li","year":"2013","journal-title":"Int J Cardiol"},{"issue":"39186","key":"key20220302133921_b17-etm-0-0-09655","doi-asserted-by":"publisher","DOI":"10.1038\/srep39186","article-title":"Inhibition of farnesyl pyrophosphate synthase improves pressure overload induced chronic cardiac remodeling","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci Rep"},{"key":"key20220302133921_b18-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1093\/cvr\/cvs347","article-title":"Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice","volume":"97","author":"Yang","year":"2013","journal-title":"Cardiovasc Res"},{"issue":"216","key":"key20220302133921_b19-etm-0-0-09655","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-1153-x","article-title":"Comparative efficacy between atorvastatin and rosuvastatin in the prevention of cardiovascular disease recurrence","volume":"18","author":"Perez-Calahorra","year":"2019","journal-title":"Lipids Health Dis"},{"key":"key20220302133921_b20-etm-0-0-09655","first-page":"70","article-title":"Rosuvastatin: Role in Secondary Prevention of Cardiovascular Disease","volume":"66","author":"Wander","year":"2018","journal-title":"J Assoc Physicians India"},{"key":"key20220302133921_b21-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.3892\/mmr.2016.5025","article-title":"Farnesyl pyrophosphate synthase inhibitor, ibandronate, improves endothelial function in spontaneously hypertensive rats","volume":"13","author":"Han","year":"2016","journal-title":"Mol Med Rep"},{"key":"key20220302133921_b22-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/hr.2013.96","article-title":"Inhibition of farnesyl pyrophosphate synthase prevents norepinephrine-induced fibrotic responses in vascular smooth muscle cells from spontaneously hypertensive rats","volume":"37","author":"Du","year":"2014","journal-title":"Hypertens Res"},{"key":"key20220302133921_b23-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.ejphar.2013.01.027","article-title":"Cardiovascular effects of a novel selective Rho kinase inhibitor, 2-(1H-indazole-5-yl)amino-4-methoxy-6-piperazino triazine (DW1865)","volume":"702","author":"Oh","year":"2013","journal-title":"Eur J Pharmacol"},{"issue":"1083","key":"key20220302133921_b24-etm-0-0-09655","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01083","article-title":"Fasudil, a Rho-kinase inhibitor, exerts cardioprotective function in animal models of myocardial ischemia\/reperfusion injury: a meta-analysis and review of preclinical evidence and possible mechanisms","volume":"9","author":"Huang","year":"2018","journal-title":"Front Pharmacol"},{"issue":"12889","key":"key20220302133921_b25-etm-0-0-09655","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49285-9","article-title":"An improved method of maintaining primary murine cardiac fibroblasts in two-dimensional cell culture","volume":"9","author":"Landry","year":"2019","journal-title":"Sci Rep"},{"key":"key20220302133921_b26-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1161\/CIRCRESAHA.116.309202","article-title":"A simplified, Langendorff-free method for concomitant isolation of viable cardiac myocytes and nonmyocytes from the adult mouse heart","volume":"119","author":"Ackers-Johnson","year":"2016","journal-title":"Circ Res"},{"key":"key20220302133921_b27-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) \u03bcethod","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20220302133921_b28-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"207","DOI":"10.5551\/jat.RV17030","article-title":"Diagnosis and management of statin intolerance","volume":"26","author":"Alonso","year":"2019","journal-title":"J Atheroscler Thromb"},{"key":"key20220302133921_b29-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1007\/s40265-016-0613-0","article-title":"Unmet \u03bdeeds in LDL-C lowering: when statins won't do!","volume":"76","author":"Kr\u00e4henb\u00fchl","year":"2016","journal-title":"Drugs"},{"key":"key20220302133921_b30-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1158\/1541-7786.MCR-19-0756","article-title":"Targeting the mevalonate pathway to overcome acquired anti-HER2 treatment resistance in breast cancer","volume":"17","author":"Sethunath","year":"2019","journal-title":"Mol Cancer Res"},{"key":"key20220302133921_b31-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.molmet.2019.04.003","article-title":"An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer","volume":"25","author":"Longo","year":"2019","journal-title":"Mol Metab"},{"key":"key20220302133921_b32-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.jacl.2017.02.016","article-title":"Effects of atorvastatin treatment on left ventricular diastolic function in peritoneal dialysis patients-The ALEVENT clinical trial","volume":"11","author":"Wu","year":"2017","journal-title":"J Clin Lipidol"},{"key":"key20220302133921_b33-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.atherosclerosis.2012.03.030","article-title":"Diastolic function parameters are improved by the addition of simvastatin to enalapril-based treatment in hypertensive individuals","volume":"222","author":"Beck","year":"2012","journal-title":"Atherosclerosis"},{"key":"key20220302133921_b34-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1097\/HJH.0000000000000184","article-title":"Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats","volume":"32","author":"Akahori","year":"2014","journal-title":"J Hypertens"},{"key":"key20220302133921_b35-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s11745-017-4246-1","article-title":"Inhibition of angiotensin II-induced cardiac fibrosis by atorvastatin in adiponectin knockout mice","volume":"52","author":"Choi","year":"2017","journal-title":"Lipids"},{"key":"key20220302133921_b36-etm-0-0-09655","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1001\/archinte.1996.00440020046007","article-title":"Congestive heart failure with normal left ventricular systolic function. Clinical approaches to the diagnosis and treatment of diastolic heart failure","volume":"156","author":"Vasan","year":"1996","journal-title":"Arch Intern Med"},{"key":"key20220302133921_b37-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.ijcard.2016.03.186","article-title":"The effect of statins on mortality in heart failure with preserved ejection fraction: A meta-analysis of propensity score analyses","volume":"214","author":"Fukuta","year":"2016","journal-title":"Int J Cardiol"},{"issue":"1301","key":"key20220302133921_b38-etm-0-0-09655","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc073536","article-title":"Rosuvastatin in older patients with systolic heart failure","volume":"358","author":"Florkowski","year":"2008","journal-title":"N Engl J Med"},{"key":"key20220302133921_b39-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1074\/jbc.TM118.002812","article-title":"Roles of the endoplasmic reticulum-resident, collagen-specific molecular chaperone Hsp47 in vertebrate cells and human disease","volume":"294","author":"Ito","year":"2019","journal-title":"J Biol Chem"},{"key":"key20220302133921_b40-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/labinvest.3700271","article-title":"Expression of HSP47, a collagen-specific chaperone, in normal and diseased human liver","volume":"85","author":"Brown","year":"2005","journal-title":"Lab Invest"},{"key":"key20220302133921_b41-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1046\/j.1523-1755.2003.00169.x","article-title":"Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress peritoneal fibrosis in rats","volume":"64","author":"Nishino","year":"2003","journal-title":"Kidney Int"},{"key":"key20220302133921_b42-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.ejphar.2007.02.057","article-title":"Introduction of antisense oligonucleotides to heat shock protein 47 prevents pulmonary fibrosis in lipopolysaccharide-induced pneumopathy of the rat","volume":"564","author":"Hagiwara","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"key20220302133921_b43-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2741\/1513","article-title":"Hsp47 a novel collagen binding serpin chaperone, autoantigen and therapeutic target","volume":"10","author":"Sauk","year":"2005","journal-title":"Front Biosci"},{"key":"key20220302133921_b44-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1517\/13543776.2011.593511","article-title":"Farnesyl pyrophosphate synthase modulators: A patent review (2006-2010)","volume":"21","author":"Sun","year":"2011","journal-title":"Expert Opin Ther Pat"},{"key":"key20220302133921_b45-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.nbt.2012.07.001","article-title":"Farnesyl pyrophosphate synthase: A key enzyme in isoprenoid biosynthetic pathway and potential molecular target for drug development","volume":"30","author":"Dhar","year":"2013","journal-title":"N Biotechnol"},{"key":"key20220302133921_b46-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1074\/jbc.M109.016741","article-title":"Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor","volume":"285","author":"Vukelic","year":"2010","journal-title":"J Biol Chem"},{"key":"key20220302133921_b47-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.bbalip.2010.03.014","article-title":"Isoprenoids, small GTPases and Alzheimer's disease","volume":"1801","author":"Hooff","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"key20220302133921_b48-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1111\/j.1745-7254.2008.00855.x","article-title":"Tissue-specific effects of atorvastatin on 3-hydroxy-3-methylglutarylcoenzyme A reductase expression and activity in spontaneously hypertensive rats","volume":"29","author":"Chen","year":"2008","journal-title":"Acta Pharmacol Sin"},{"key":"key20220302133921_b49-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1159\/000356610","article-title":"Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fraction","volume":"32","author":"Chen","year":"2013","journal-title":"Cell Physiol Biochem"},{"key":"key20220302133921_b50-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/13543776.2019.1608180","article-title":"A patent review of bisphosphonates in treating bone disease","volume":"29","author":"Holstein","year":"2019","journal-title":"Expert Opin Ther Pat"},{"key":"key20220302133921_b51-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1002\/jbmr.3448","article-title":"Association of alendronate and risk of cardiovascular events in patients with hip fracture","volume":"33","author":"Sing","year":"2018","journal-title":"J Bone Miner Res"},{"key":"key20220302133921_b52-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1159\/000445619","article-title":"Alteration of RhoA prenylation ameliorates cardiac and vascular remodeling in spontaneously hypertensive rats","volume":"39","author":"Yang","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"key20220302133921_b53-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/s0735-1097(03)00926-4","article-title":"Beneficial pleiotropic vascular effects of rosuvastatin in two hypertensive models","volume":"42","author":"Susic","year":"2003","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"key20220302133921_b54-etm-0-0-09655","doi-asserted-by":"publisher","DOI":"10.4161\/21541248.2014.968004","article-title":"Toward understanding RhoGTPase specificity: Structure, function and local activation","volume":"5","author":"Schaefer","year":"2014","journal-title":"Small GTPases"},{"issue":"33","key":"key20220302133921_b55-etm-0-0-09655","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-2-33","article-title":"Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke","volume":"2","author":"Vesterinen","year":"2013","journal-title":"Syst Rev"},{"issue":"193","key":"key20220302133921_b56-etm-0-0-09655","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-016-0372-6","article-title":"RhoA\/rock signaling mediates peroxynitrite-induced functional impairment of Rat coronary vessels","volume":"16","author":"Sun","year":"2016","journal-title":"BMC Cardiovasc Disord"},{"key":"key20220302133921_b57-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1517\/14728222.2012.671811","article-title":"Targeting RhoA\/ROCK pathway in pulmonary arterial hypertension","volume":"16","author":"Antoniu","year":"2012","journal-title":"Expert Opin Ther Targets"},{"key":"key20220302133921_b58-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1152\/physrev.00021.2012","article-title":"Small G proteins in the cardiovascular system: Physiological and pathological aspects","volume":"93","author":"Loirand","year":"2013","journal-title":"Physiol Rev"},{"key":"key20220302133921_b59-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1172\/JCI6842","article-title":"Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure","volume":"103","author":"Sah","year":"1999","journal-title":"J Clin Invest"},{"key":"key20220302133921_b60-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1253\/circj.CJ-16-0433","article-title":"Rho kinases and cardiac remodeling","volume":"80","author":"Shimizu","year":"2016","journal-title":"Circ J"},{"key":"key20220302133921_b61-etm-0-0-09655","doi-asserted-by":"publisher","first-page":"843","DOI":"10.2174\/1567201813666160808100937","article-title":"Current therapeutic drugs against cerebral vasospasm after subarachnoid hemorrhage: a comprehensive review of basic and clinical studies","volume":"14","author":"Hasegawa","year":"2017","journal-title":"Curr Drug Deliv"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T11:42:41Z","timestamp":1646221361000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2021.9655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,18]]},"references-count":61,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,1,18]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2021.9655","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,18]]},"article-number":"224"}}