{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:58:23Z","timestamp":1793451503836,"version":"4.5.0"},"reference-count":121,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2021.9662","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T14:09:21Z","timestamp":1611151761000},"source":"Crossref","is-referenced-by-count":102,"title":["Challenges of phototherapy for neonatal hyperbilirubinemia (Review)"],"prefix":"10.3892","volume":"21","author":[{"given":"Juan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Health Science Cente, Yangtze University, Jingzhou, Hubei 434023, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genxin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Xiantao First People's Hospital of Yangtze University, Xiantao, Hubei 433000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Second School of Clinical Medicine and Jingzhou Central Hospital, Yangtze University, Jingzhou, Hubei 434023, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Qi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Health Science Center, Yangtze University, Jingzhou, Hubei 434023, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Health Science Center, Yangtze University, Jingzhou, Hubei 434023, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"key":"key20220302133935_b1-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"699","DOI":"10.12968\/hmed.2017.78.12.699","article-title":"Neonatal jaundice: Aetiology, diagnosis and treatment","volume":"78","author":"Mitra","year":"2017","journal-title":"Br J Hosp Med (Lond)"},{"key":"key20220302133935_b2-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1159\/000445708","article-title":"Neonatal jaundice in low- and middle-income countries: Lessons and future directions from the 2015 don ostrow trieste yellow retreat","volume":"110","author":"Greco","year":"2016","journal-title":"Neonatology"},{"key":"key20220302133935_b3-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"4007","DOI":"10.3892\/etm.2019.7432","article-title":"Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice","volume":"17","author":"Zhou","year":"2019","journal-title":"Exp Ther Med"},{"key":"key20220302133935_b4-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1080\/14767058.2017.1369520","article-title":"Probiotics for the management of neonatal hyperbilirubinemia: A systematic review of randomized controlled trials","volume":"32","author":"Deshmukh","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"key":"key20220302133935_b5-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.3889\/oamjms.2018.319","article-title":"Risk factors associated with neonatal jaundice: A cross-sectional study from Iran","volume":"6","author":"Mojtahedi","year":"2018","journal-title":"Open Access Maced J Med Sci"},{"key":"key20220302133935_b6-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.3892\/etm.2018.6340","article-title":"An analysis on treatment effect of blue light phototherapy combined with Bifico in treating neonatal hemolytic jaundice","volume":"16","author":"Jiao","year":"2018","journal-title":"Exp Ther Med"},{"key":"key20220302133935_b7-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"176","DOI":"10.2174\/1573396313666170718150056","article-title":"Update on phototherapy in jaundiced neonates","volume":"13","author":"Ebbesen","year":"2017","journal-title":"Curr Pediatr Rev"},{"key":"key20220302133935_b8-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1001\/jamapediatrics.2020.0559","article-title":"Cycled phototherapy dose-finding study for extremely low-birth-weight infants: A randomized clinical trial","volume":"174","author":"Arnold","year":"2020","journal-title":"JAMA Pediatr"},{"key":"key20220302133935_b9-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1111\/j.1651-2227.2005.tb01818.x","article-title":"Effects of bilirubin and phototherapy on osmotic fragility and haematoporphyrin-induced photohaemolysis of normal erythrocytes and spherocytes","volume":"94","author":"Roll","year":"2005","journal-title":"Acta Paediatr"},{"key":"key20220302133935_b10-etm-0-0-09662","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejmhg.2011.11.003","article-title":"Phototherapy and DNA changes in full term neonates with hyperbilirubinemia","volume":"13","author":"El-Abdin","year":"2012","journal-title":"Egypt J Med Hum Genet"},{"key":"key20220302133935_b11-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"182","DOI":"10.18869\/acadpub.ibj.21.3.182","article-title":"An increased genotoxic risk in lymphocytes from phototherapy-treated hyperbilirubinemic neonates","volume":"21","author":"Mesbah-Namin","year":"2017","journal-title":"Iran Biomed J"},{"issue":"e20151354","key":"key20220302133935_b12-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1354","article-title":"Retrospective cohort study of phototherapy and childhood cancer in northern california","volume":"137","author":"Newman","year":"2016","journal-title":"Pediatrics"},{"key":"key20220302133935_b13-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1056\/NEJMoa0803024","article-title":"Aggressive vs conservative phototherapy for infants with extremely low birth weight","volume":"359","author":"Morris","year":"2008","journal-title":"N Engl J Med"},{"issue":"24","key":"key20220302133935_b14-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics9010024","article-title":"Clinicopathological spectrum of bilirubin encephalopathy\/kernicterus","volume":"9","author":"Das","year":"2019","journal-title":"Diagnostics (Basel)"},{"issue":"64","key":"key20220302133935_b15-etm-0-0-09662","article-title":"Severe neonatal hyperbilirubinemia leading to exchange transfusion","volume":"28","author":"Alizadeh Taheri","year":"2014","journal-title":"Med J Islam Repub Iran"},{"key":"key20220302133935_b16-etm-0-0-09662","author":"Ansong-Assoku"},{"key":"key20220302133935_b17-etm-0-0-09662","author":"Kalakonda"},{"key":"key20220302133935_b18-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.adnc.2006.08.004","article-title":"Fundamentals of phototherapy for neonatal jaundice","volume":"6","author":"Stokowski","year":"2006","journal-title":"Adv Neonatal Care"},{"key":"key20220302133935_b19-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s12519-018-0217-8","article-title":"Effect of metoclopramide administration to mothers on neonatal bilirubin and maternal prolactin: A randomized, controlled, clinical trial","volume":"15","author":"Tabrizi","year":"2019","journal-title":"World J Pediatr"},{"key":"key20220302133935_b20-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/S2352-4642(18)30139-1","article-title":"Neonatal hyperbilirubinaemia: A global perspective","volume":"2","author":"Olusanya","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"key":"key20220302133935_b21-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1152\/physrev.00004.2019","article-title":"Molecular physiology and pathophysiology of bilirubin handling by the blood, liver, intestine, and brain in the newborn","volume":"100","author":"Hansen","year":"2020","journal-title":"Physiol Rev"},{"key":"key20220302133935_b22-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1159\/000209851","article-title":"UGT1A1 haplotype mutation among Asians in Singapore","volume":"96","author":"Zhou","year":"2009","journal-title":"Neonatology"},{"issue":"11","key":"key20220302133935_b23-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.7748\/ncyp.28.6.11.s15","article-title":"Neonatal jaundice","volume":"28","author":"Allen","year":"2016","journal-title":"Nurs Child Young People"},{"key":"key20220302133935_b24-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.jpeds.2014.12.003","article-title":"Unbound unconjugated hyperbilirubinemia is associated with central apnea in premature infants","volume":"166","author":"Amin","year":"2015","journal-title":"J Pediatr"},{"key":"key20220302133935_b25-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s12098-018-2633-0","article-title":"Prediction of neonatal hyperbilirubinemia using 1st day serum bilirubin levels","volume":"86","author":"Spoorthi","year":"2019","journal-title":"Indian J Pediatr"},{"issue":"e000408","key":"key20220302133935_b26-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.1080\/20469047.2019.1707397","article-title":"Management of neonatal jaundice in low- and lower-middle-income countries","volume":"3","author":"Mir","year":"2019","journal-title":"BMJ Paediatr Open"},{"issue":"e190858","key":"key20220302133935_b27-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.0858","article-title":"Rates of extreme neonatal hyperbilirubinemia and kernicterus in children and adherence to national guidelines for screening, diagnosis, and treatment in Sweden","volume":"2","author":"Alk\u00e9n","year":"2019","journal-title":"JAMA Netw Open"},{"key":"key20220302133935_b28-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1080\/24694193.2017.1386975","article-title":"Sensitivity, specificity, and accuracy of kramer examination of neonatal jaundice: Comparison with total bilirubin serum","volume":"40","author":"Aprillia","year":"2017","journal-title":"Compr Child Adolesc Nurs"},{"key":"key20220302133935_b29-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1136\/archdischild-2019-317024","article-title":"Blue LED phototherapy in preterm infants: Effects on an oxidative marker of DNA damage","volume":"105","author":"van der Schoor","year":"2020","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"key20220302133935_b30-etm-0-0-09662","first-page":"7","article-title":"Bilirubin induced encephalopathy","volume":"14","author":"Karimzadeh","year":"2020","journal-title":"Iran J Child Neurol"},{"key":"key20220302133935_b31-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"F202","DOI":"10.1136\/archdischild-2017-314622","article-title":"Learning from claims: Hyperbilirubinaemia and kernicterus","volume":"104","author":"Rennie","year":"2019","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"key20220302133935_b32-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"199","DOI":"10.2174\/1573396313666170815100214","article-title":"The Neurological sequelae of neonatal hyperbilirubinemia: Definitions, diagnosis and treatment of the kernicterus spectrum disorders (KSDs)","volume":"13","author":"Le Pichon","year":"2017","journal-title":"Curr Pediatr Rev"},{"key":"key20220302133935_b33-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1111\/apa.13470","article-title":"Haemolytic and nonhaemolytic neonatal jaundice have different risk factor profiles","volume":"105","author":"Lee","year":"2016","journal-title":"Acta Paediatr"},{"issue":"15","key":"key20220302133935_b34-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.7748\/ns.30.44.15.s17","article-title":"Neonatal jaundice","volume":"30","author":"Dean","year":"2016","journal-title":"Nurs Stand"},{"issue":"e000105","key":"key20220302133935_b35-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2017-000105","article-title":"Burden of severe neonatal jaundice: A systematic review and meta-analysis","volume":"1","author":"Slusher","year":"2017","journal-title":"BMJ Paediatr Open"},{"key":"key20220302133935_b36-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1159\/000495518","article-title":"The neonatal acute bilirubin encephalopathy registry (NABER): Background, aims, and protocol","volume":"115","author":"Bahr","year":"2019","journal-title":"Neonatology"},{"key":"key20220302133935_b37-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3892\/br.2018.1166","article-title":"Phototherapy is associated with the decrease in serum globulin levels in neonatal hyperbilirubinemia","volume":"10","author":"Zheng","year":"2019","journal-title":"Biomed Rep"},{"issue":"0319","key":"key20220302133935_b38-etm-0-0-09662","article-title":"Neonatal jaundice: Phototherapy","volume":"2015","author":"Woodgate","year":"2015","journal-title":"BMJ Clin Evid"},{"key":"key20220302133935_b39-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1053\/j.semperi.2011.02.014","article-title":"A global need for affordable neonatal jaundice technologies","volume":"35","author":"Slusher","year":"2011","journal-title":"Semin Perinatol"},{"key":"key20220302133935_b40-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/cts.12401","article-title":"A pilot metabolic profiling study of patients with neonatal jaundice and response to phototherapy","volume":"9","author":"Cai","year":"2016","journal-title":"Clin Transl Sci"},{"key":"key20220302133935_b41-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.earlhumdev.2013.09.013","article-title":"Effects of phototherapy using different light sources on oxidant and antioxidant status of neonates with jaundice","volume":"89","author":"Kale","year":"2013","journal-title":"Early Hum Dev"},{"key":"key20220302133935_b42-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.pedneo.2018.03.004","article-title":"Phototherapy for neonatal hyperbilirubinemia and childhood eczema, rhinitis and wheeze","volume":"60","author":"Tham","year":"2019","journal-title":"Pediatr Neonatol"},{"key":"key20220302133935_b43-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1210\/en.2017-03230","article-title":"How UV light touches the brain and endocrine system through skin, and why","volume":"159","author":"Slominski","year":"2018","journal-title":"Endocrinology"},{"key":"key20220302133935_b44-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/jpc.12984","article-title":"Phototherapy in transport for neonates with unconjugated hyperbilirubinaemia","volume":"52","author":"Waterham","year":"2016","journal-title":"J Paediatr Child Health"},{"key":"key20220302133935_b45-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/jp.2017.167","article-title":"Double versus single intensive phototherapy with LEDs in treatment of neonatal hyperbilirubinemia","volume":"38","author":"Donneborg","year":"2018","journal-title":"J Perinatol"},{"key":"key20220302133935_b46-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/pr.2016.115","article-title":"Bilirubin isomer distribution in jaundiced neonates during phototherapy with LED light centered at 497 nm (turquoise) vs 459 nm (blue)","volume":"80","author":"Ebbesen","year":"2016","journal-title":"Pediatr Res"},{"key":"key20220302133935_b47-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1111\/ped.13332","article-title":"Phototherapy for neonatal hyperbilirubinemia","volume":"59","author":"Itoh","year":"2017","journal-title":"Pediatr Int"},{"key":"key20220302133935_b48-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1055\/s-0038-1667379","article-title":"Side effects of phototherapy on neonates","volume":"36","author":"Faulhaber","year":"2019","journal-title":"Am J Perinatol"},{"key":"key20220302133935_b49-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"453","DOI":"10.29271\/jcpsp.2019.05.453","article-title":"Effect of phototherapy on neutrophil VCS parameters and white blood cells","volume":"29","author":"Altuntas","year":"2019","journal-title":"J Coll Physicians Surg Pak"},{"key":"key20220302133935_b50-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/jp.2015.166","article-title":"Jaundice, phototherapy and DNA damage in full-term neonates","volume":"36","author":"Ramy","year":"2016","journal-title":"J Perinatol"},{"issue":"e20151353","key":"key20220302133935_b51-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1353","article-title":"Neonatal phototherapy and infantile cancer","volume":"137","author":"Wickremasinghe","year":"2016","journal-title":"Pediatrics"},{"key":"key20220302133935_b52-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jbmt.2017.08.005","article-title":"The effect of tactile-kinesthetic stimulation on growth indices of healthy neonates","volume":"22","author":"Abedi","year":"2018","journal-title":"J Bodyw Mov Ther"},{"key":"key20220302133935_b53-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.infbeh.2015.10.009","article-title":"Effects of baby massage on neonatal jaundice in healthy Iranian infants: A pilot study","volume":"42","author":"Dalili","year":"2016","journal-title":"Infant Behav Dev"},{"key":"key20220302133935_b54-etm-0-0-09662","first-page":"31","article-title":"The effect of moderate non-hemolytic jaundice and phototherapy on newborn behavior","volume":"32","author":"Ju","year":"1991","journal-title":"Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi"},{"key":"key20220302133935_b55-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3325\/cmj.2011.52.594","article-title":"The impact of sleep deprivation and nighttime light exposure on clock gene expression in humans","volume":"52","author":"Kavcic","year":"2011","journal-title":"Croat Med J"},{"key":"key20220302133935_b56-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1203\/01.pdr.0000183663.98446.05","article-title":"The effect of blue light exposure on the expression of circadian genes: Bmal1 and cryptochrome 1 in peripheral blood mononuclear cells of jaundiced neonates","volume":"58","author":"Chen","year":"2005","journal-title":"Pediatr Res"},{"key":"key20220302133935_b57-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s40261-019-00793-6","article-title":"Melatonin and multiple sclerosis: From plausible neuropharmacological mechanisms of action to experimental and clinical evidence","volume":"39","author":"Yeganeh Salehpour","year":"2019","journal-title":"Clin Drug Investig"},{"issue":"317","key":"key20220302133935_b58-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1556-7","article-title":"Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care","volume":"10","author":"Tarocco","year":"2019","journal-title":"Cell Death Dis"},{"key":"key20220302133935_b59-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1055\/s-2001-18698","article-title":"Transepidermal water loss and skin hydration in preterm infants during phototherapy","volume":"18","author":"Maayan-Metzger","year":"2001","journal-title":"Am J Perinatol"},{"key":"key20220302133935_b60-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s13312-010-0020-7","article-title":"Light emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: A multi center randomized controlled trial","volume":"47","author":"Kumar","year":"2010","journal-title":"Indian Pediatr"},{"key":"key20220302133935_b61-etm-0-0-09662","author":"Asghar"},{"key":"key20220302133935_b62-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.12669\/pjms.326.10849","article-title":"Hypocalcemia in jaundiced neonates receiving phototherapy","volume":"32","author":"Khan","year":"2016","journal-title":"Pak J Med Sci"},{"key":"key20220302133935_b63-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.14661\/1387","article-title":"Prevalence of hypocalcemia after phototherapy among neonates who underwent phototherapy in Koodakan Hospital in Bandar Abbas in 2013","volume":"7","author":"Gheshmi","year":"2015","journal-title":"Electron Physician"},{"issue":"176","key":"key20220302133935_b64-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9175.190992","article-title":"The effect of head covering in prevention of phototherapy-induced hypocalcemia in icterus newborns with gestational age less than 35 weeks","volume":"5","author":"Barekatain","year":"2016","journal-title":"Adv Biomed Res"},{"key":"key20220302133935_b65-etm-0-0-09662","first-page":"121","article-title":"Effect of head covering on phototherapy-induced hypocalcaemia in icterus newborns; a randomized controlled trial","volume":"2","author":"Kargar","year":"2014","journal-title":"Int J Community Based Nurs Midwifery"},{"key":"key20220302133935_b66-etm-0-0-09662","first-page":"357","article-title":"Effect of phototherapy on serum level of calcium, magnesium and vitamin D in infants with hyperbilirubinemia","volume":"13","author":"Shahriarpanah","year":"2018","journal-title":"Iran J Pathol"},{"key":"key20220302133935_b67-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/S0377-1237(11)60078-6","article-title":"Incidence of thrombocytopenia following phototherapy in hyperbilirubinemic neonates","volume":"67","author":"Khera","year":"2011","journal-title":"Med J Armed Forces India"},{"key":"key20220302133935_b68-etm-0-0-09662","first-page":"46","article-title":"Phototherapy-induced purpuric eruption in a neonate","volume":"8","author":"LaRusso","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"key20220302133935_b69-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1111\/pde.12083","article-title":"Phototherapy and skin rashes","volume":"30","author":"Jeffrey Maisels","year":"2013","journal-title":"Pediatr Dermatol"},{"key":"key20220302133935_b70-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jpeds.2017.05.005","article-title":"Bronze baby syndrome","volume":"188","author":"Le","year":"2017","journal-title":"J Pediatr"},{"issue":"624","key":"key20220302133935_b71-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-013-0161-6","article-title":"Bronze baby syndrome","volume":"50","author":"Kar","year":"2013","journal-title":"Indian Pediatr"},{"key":"key20220302133935_b72-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.4103\/0975-7406.155766","article-title":"Antioxidant status in neonatal jaundice before and after phototherapy","volume":"7 (Suppl 1)","author":"Ayyappan","year":"2015","journal-title":"J Pharm Bioallied Sci"},{"key":"key20220302133935_b73-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"335","DOI":"10.25011\/cim.v33i5.14359","article-title":"Comparison of total oxidant\/antioxidant status in unconjugated hyperbilirubinemia of newborn before and after conventional and LED phototherapy: A prospective randomized controlled trial","volume":"33","author":"Demirel","year":"2010","journal-title":"Clin Invest Med"},{"issue":"181","key":"key20220302133935_b74-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010181","article-title":"Detection of reactive oxygen and nitrogen species by electron paramagnetic resonance (EPR) technique","volume":"22","author":"Suzen","year":"2017","journal-title":"Molecules"},{"key":"key20220302133935_b75-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.earlhumdev.2015.03.009","article-title":"Hyperbilirubinemia and phototherapy in newborns: Effects on cardiac autonomic control","volume":"91","author":"Uhrikova","year":"2015","journal-title":"Early Hum Dev"},{"key":"key20220302133935_b76-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1080\/08035259950168540","article-title":"Cardiac output and ductal reopening during phototherapy in preterm infants","volume":"88","author":"Benders","year":"1999","journal-title":"Acta Paediatr"},{"key":"key20220302133935_b77-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"40L","DOI":"10.1016\/s0002-9149(02)02963-6","article-title":"Endothelial function. From vascular biology to clinical applications","volume":"90","author":"Behrendt","year":"2002","journal-title":"Am J Cardiol"},{"key":"key20220302133935_b78-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12519-008-0006-x","article-title":"Effect of phototherapy on blood endothelin and nitric oxide levels: Clinical significance in preterm infants","volume":"4","author":"Liu","year":"2008","journal-title":"World J Pediatr"},{"key":"key20220302133935_b79-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s004310051082","article-title":"Haemodynamic consequences of phototherapy in term infants","volume":"158","author":"Benders","year":"1999","journal-title":"Eur J Pediatr"},{"key":"key20220302133935_b80-etm-0-0-09662","first-page":"376","article-title":"Association of patent ductus arteriosus and phototherapy in infants weighing less than 1000 g","volume":"13","author":"Barefield","year":"1993","journal-title":"J Perinatol"},{"key":"key20220302133935_b81-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1097\/HJH.0b013e32832bff54","article-title":"Light-induced vs bradykinin-induced relaxation of coronary arteries: Do S-nitrosothiols act as endothelium-derived hyperpolarizing factors?","volume":"27","author":"Batenburg","year":"2009","journal-title":"J Hypertens"},{"issue":"CD009816","key":"key20220302133935_b82-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009816.pub2","article-title":"Chest shielding for prevention of a haemodynamically significant patent ductus arteriosus in preterm infants receiving phototherapy","author":"Bhola","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"key20220302133935_b83-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1542\/peds.2009-3506","article-title":"Patent ductus arteriosus of the preterm infant","volume":"125","author":"Hamrick","year":"2010","journal-title":"Pediatrics"},{"key":"key20220302133935_b84-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1055\/s-0036-1592079","article-title":"Meta-analysis of the effect of chest shielding on preventing patent ductus arteriosus in premature infants","volume":"34","author":"Mannan","year":"2017","journal-title":"Am J Perinatol"},{"key":"key20220302133935_b85-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1080\/08035250600771458","article-title":"Patent ductus arteriosus in extremely preterm infants receiving phototherapy: Does shielding the chest make a difference? A randomized, controlled trial","volume":"95","author":"Travadi","year":"2006","journal-title":"Acta Paediatr"},{"key":"key20220302133935_b86-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"774","DOI":"10.3109\/10715762.2013.829570","article-title":"Blue LED light exposure develops intracellular reactive oxygen species, lipid peroxidation, and subsequent cellular injuries in cultured bovine retinal pigment epithelial cells","volume":"47","author":"Nakanishi-Ueda","year":"2013","journal-title":"Free Radic Res"},{"key":"key20220302133935_b87-etm-0-0-09662","first-page":"497","article-title":"Rhodopsin-mediated blue-light damage to the rat retina: Effect of photoreversal of bleaching","volume":"42","author":"Grimm","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"68","key":"key20220302133935_b88-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.3390\/cells8010068","article-title":"Retinal neuron is more sensitive to blue light-induced damage than glia cell due to DNA double-strand breaks","volume":"8","author":"Chen","year":"2019","journal-title":"Cells"},{"key":"key20220302133935_b89-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.jcma.2017.08.003","article-title":"Ocular findings on follow-up in children who received phototherapy for neonatal jaundice","volume":"80","author":"Kara","year":"2017","journal-title":"J Chin Med Assoc"},{"key":"key20220302133935_b90-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1159\/000489819","article-title":"5-Oxo-ETE from nasal epithelial cells upregulates eosinophil cation protein by eosinophils in nasal polyps in vitro","volume":"177","author":"Lin","year":"2018","journal-title":"Int Arch Allergy Immunol"},{"key":"key20220302133935_b91-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3109\/15513815.2014.883456","article-title":"The effects of phototherapy on eosinophil and eosinophilic cationic protein in newborns with hyperbilirubinemia","volume":"33","author":"Beken","year":"2014","journal-title":"Fetal Pediatr Pathol"},{"key":"key20220302133935_b92-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"e733","DOI":"10.1111\/j.1399-3038.2010.01038.x","article-title":"Confirmed association between neonatal phototherapy or neonatal icterus and risk of childhood asthma","volume":"21","author":"Aspberg","year":"2010","journal-title":"Pediatr Allergy Immunol"},{"issue":"5674","key":"key20220302133935_b93-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225674","article-title":"Excitatory amino acid transporters (EAATs): Glutamate transport and beyond","volume":"20","author":"Magi","year":"2019","journal-title":"Int J Mol Sci"},{"key":"key20220302133935_b94-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"5171","DOI":"10.1073\/pnas.0813132106","article-title":"Bilirubin and glutathione have complementary antioxidant and cytoprotective roles","volume":"106","author":"Sedlak","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20220302133935_b95-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"153","DOI":"10.9758\/cpn.2017.15.2.153","article-title":"Relationship between serum bilirubin levels and metabolic syndrome in patients with schizophrenia spectrum disorders","volume":"15","author":"Karadag","year":"2017","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"key20220302133935_b96-etm-0-0-09662","doi-asserted-by":"crossref","first-page":"8","DOI":"10.59566\/IJBS.2010.6008","article-title":"Is there a role of early neonatal events in susceptibility to allergy?","volume":"6","author":"Gloria-Bottini","year":"2010","journal-title":"Int J Biomed Sci"},{"key":"key20220302133935_b97-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"3078","DOI":"10.4161\/cc.6.24.5022","article-title":"Bilirubin inhibits tumor cell growth via activation of ERK","volume":"6","author":"Ollinger","year":"2007","journal-title":"Cell Cycle"},{"issue":"1801243","key":"key20220302133935_b98-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1801243","article-title":"Bilirubin-induced oxidative stress leads to DNA damage in the cerebellum of hyperbilirubinemic neonatal mice and activates DNA double-strand break repair pathways in human cells","volume":"2018","author":"Rawat","year":"2018","journal-title":"Oxid Med Cell Longev"},{"issue":"15045","key":"key20220302133935_b99-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.1038\/srep15045","article-title":"Unconjugated bilirubin exerts pro-apoptotic effect on platelets via p38-MAPK activation","volume":"5","author":"NaveenKumar","year":"2015","journal-title":"Sci Rep"},{"key":"key20220302133935_b100-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2223\/JPED.1765","article-title":"Phototherapy causes DNA damage in peripheral mononuclear leukocytes in term infants","volume":"84","author":"Aycicek","year":"2008","journal-title":"J Pediatr (Rio J)"},{"key":"key20220302133935_b101-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jphotobiol.2014.09.012","article-title":"Effects of blue light phototherapy on DNA integrity in preterm newborns","volume":"141","author":"G\u00f3mez-Meda","year":"2014","journal-title":"J Photochem Photobiol B"},{"key":"key20220302133935_b102-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.mrgentox.2007.06.013","article-title":"Phototherapy increases DNA damage in lymphocytes of hyperbilirubinemic neonates","volume":"654","author":"Tatli","year":"2008","journal-title":"Mutat Res"},{"key":"key20220302133935_b103-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/01480545.2019.1710182","article-title":"Effects of hyperbilirubinemia on markers of genotoxicity and total oxidant and antioxidant status in newborns","author":"Bulut","year":"2020","journal-title":"Drug Chem Toxicol"},{"key":"key20220302133935_b104-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"80","DOI":"10.2174\/1389450114666140106101412","article-title":"Targeting tumor suppressor p53 for cancer therapy: Strategies, challenges and opportunities","volume":"15","author":"Hong","year":"2014","journal-title":"Curr Drug Targets"},{"issue":"154","key":"key20220302133935_b105-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10060154","article-title":"Treating p53 mutant aggregation-associated cancer","volume":"10","author":"Kanapathipillai","year":"2018","journal-title":"Cancers (Basel)"},{"key":"key20220302133935_b106-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00431-014-2418-z","article-title":"Influence of hyperbilirubinemia and phototherapy on markers of genotoxicity and apoptosis in full-term infants","volume":"174","author":"Yahia","year":"2015","journal-title":"Eur J Pediatr"},{"key":"key20220302133935_b107-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1136\/ebmed-2016-110528","article-title":"Whether neonatal phototherapy increases the risk of cancer in children is a disturbing unresolved issue","volume":"22","author":"Tyson","year":"2017","journal-title":"Evid Based Med"},{"key":"key20220302133935_b108-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1002\/ijc.32158","article-title":"Neonatal phototherapy and future risk of childhood cancer","volume":"145","author":"Auger","year":"2019","journal-title":"Int J Cancer"},{"key":"key20220302133935_b109-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1136\/adc.2009.179275","article-title":"Risk of skin cancer after neonatal phototherapy: Retrospective cohort study","volume":"95","author":"Brewster","year":"2010","journal-title":"Arch Dis Child"},{"key":"key20220302133935_b110-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1001\/archderm.142.12.1599","article-title":"Effect of neonatal phototherapy on melanocytic nevus count in children","volume":"142","author":"Matichard","year":"2006","journal-title":"Arch Dermatol"},{"key":"key20220302133935_b111-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1111\/apa.14727","article-title":"Increased risk of hemangioma after exposure to neonatal phototherapy in infants with predisposing risk factors","volume":"108","author":"Auger","year":"2019","journal-title":"Acta Paediatr"},{"key":"key20220302133935_b112-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"202","DOI":"10.5152\/TurkPediatriArs.2017.5143","article-title":"The effect of phototherapy on sister chromatid exchange with different light density in newborn hyperbilirubinemia","volume":"52","author":"Kanmaz","year":"2017","journal-title":"Turk Pediatri Ars"},{"key":"key20220302133935_b113-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1053\/j.semperi.2014.08.008","article-title":"Phototherapy in ELBW newborns: Does it work? Is it safe? The evidence from randomized clinical trials","volume":"38","author":"Arnold","year":"2014","journal-title":"Semin Perinatol"},{"key":"key20220302133935_b114-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/jp.2012.80","article-title":"Let there be light-but should there be less?","volume":"32","author":"Hansen","year":"2012","journal-title":"J Perinatol"},{"key":"key20220302133935_b115-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.clp.2016.01.004","article-title":"A pharmacologic view of phototherapy","volume":"43","author":"Lamola","year":"2016","journal-title":"Clin Perinatol"},{"key":"key20220302133935_b116-etm-0-0-09662","first-page":"1883","article-title":"Photodegradation of riboflavin in neonates","volume":"46","author":"Sisson","year":"1987","journal-title":"Fed Proc"},{"issue":"F564","key":"key20220302133935_b117-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.057646","article-title":"Is mesenteric blood flow compromised during phototherapy in preterm neonates?","volume":"89","author":"Kadalraja","year":"2004","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"key20220302133935_b118-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/14767050500233076","article-title":"Is phototherapy a risk factor for ileus in high-risk neonates?","volume":"18","author":"Raghavan","year":"2005","journal-title":"J Matern Fetal Neonatal Med"},{"key":"key20220302133935_b119-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/01.NAJ.0000552612.04276.7c","article-title":"Increased seizure risk after phototherapy for jaundice","volume":"119","author":"Rosenberg","year":"2019","journal-title":"Am J Nurs"},{"issue":"e20180648","key":"key20220302133935_b120-etm-0-0-09662","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-0648","article-title":"Childhood seizures after phototherapy","volume":"142","author":"Newman","year":"2018","journal-title":"Pediatrics"},{"key":"key20220302133935_b121-etm-0-0-09662","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/ped.13821","article-title":"Green light-emitting diode phototherapy for neonatal hyperbilirubinemia: Randomized controlled trial","volume":"61","author":"Kuboi","year":"2019","journal-title":"Pediatr Int"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T06:36:29Z","timestamp":1697610989000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2021.9662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,20]]},"references-count":121,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,1,20]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2021.9662","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,20]]},"article-number":"231"}}