{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:53:37Z","timestamp":1787662417394,"version":"build-2736575974"},"reference-count":144,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2022.11197","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T16:56:57Z","timestamp":1644425817000},"source":"Crossref","is-referenced-by-count":10,"title":["Role of melatonin in respiratory diseases (Review)"],"prefix":"10.3892","volume":"23","author":[{"given":"Lijie","family":"Li","sequence":"first","affiliation":[{"name":"Department of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin 130021, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochao","family":"Gang","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin 130021, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin 130021, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin 130021, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"key20220330120704_b1-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0140-6736(19)31147-X","article-title":"Prevalence, risk factors, and management of asthma in China: A national cross-sectional study","volume":"394","author":"Huang","year":"2019","journal-title":"Lancet"},{"key":"key20220330120704_b2-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1001\/jama.291.21.2616","article-title":"The global burden of chronic diseases: Overcoming impediments to prevention and control","volume":"291","author":"Yach","year":"2004","journal-title":"JAMA"},{"key":"key20220330120704_b3-ETM-23-4-11197","first-page":"1","article-title":"Deaths: Final data for 2006","volume":"57","author":"Heron","year":"2009","journal-title":"Natl Vital Stat Rep"},{"key":"key20220330120704_b4-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1111\/j.1600-6143.2006.01274.x","article-title":"Thoracic organ transplantation in the United States, 1995-2004","volume":"6 (5 Pt 2)","author":"Orens","year":"2006","journal-title":"Am J Transplant"},{"key":"key20220330120704_b5-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.healun.2007.06.003","article-title":"Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth official adult lung and heart-lung transplantation report-2007","volume":"26","author":"Trulock","year":"2007","journal-title":"J Heart Lung Transplant"},{"key":"key20220330120704_b6-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1055\/s-0030-1249110","article-title":"Interstitial lung disease and lung transplantation","volume":"31","author":"O'Beirne","year":"2010","journal-title":"Semin Respir Crit Care Med"},{"key":"key20220330120704_b7-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1016\/S0140-6736(11)60052-4","article-title":"Idiopathic pulmonary fibrosis","volume":"378","author":"King","year":"2011","journal-title":"Lancet"},{"issue":"249","key":"key20220330120704_b8-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00249","article-title":"Melatonin synthesis and function: Evolutionary history in animals and plants","volume":"10","author":"Zhao","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"key20220330120704_b9-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/jpi.12364","article-title":"Melatonin biosynthesis in plants: Multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts","volume":"61","author":"Back","year":"2016","journal-title":"J Pineal Res"},{"key":"key20220330120704_b10-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/jpi.12267","article-title":"Melatonin: An ancient molecule that makes oxygen metabolically tolerable","volume":"59","author":"Manchester","year":"2015","journal-title":"J Pineal Res"},{"key":"key20220330120704_b11-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1007\/s00018-008-8001-x","article-title":"Melatonin, hormone of darkness and more: Occurrence, control mechanisms, actions and bioactive metabolites","volume":"65","author":"Hardeland","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"key20220330120704_b12-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"2582","DOI":"10.1073\/pnas.86.8.2582","article-title":"Molecular cloning and analysis of cDNA encoding a plant tryptophan decarboxylase: Comparison with animal dopa decarboxylases","volume":"86","author":"De Luca","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20220330120704_b13-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1271\/bbb.80220","article-title":"Conversion of 5-hydroxytryptophan into serotonin by tryptophan decarboxylase in plants, Escherichia coli, and yeast","volume":"72","author":"Park","year":"2008","journal-title":"Biosci Biotechnol Biochem"},{"key":"key20220330120704_b14-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"18886","DOI":"10.3390\/molecules201018886","article-title":"Melatonin as a potent and inducible endogenous antioxidant: Synthesis and Metabolism","volume":"20","author":"Tan","year":"2015","journal-title":"Molecules"},{"issue":"1312","key":"key20220330120704_b15-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1126\/science.131.3409.1312","article-title":"Enzymatic O-methylation of N-acetylserotonin to melatonin","volume":"131","author":"Axelrod","year":"1960","journal-title":"Science"},{"key":"key20220330120704_b16-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/jpi.12011","article-title":"Molecular cloning of rice serotonin N-acetyltransferase, the penultimate gene in plant melatonin biosynthesis","volume":"55","author":"Kang","year":"2013","journal-title":"J Pineal Res"},{"key":"key20220330120704_b17-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"6917","DOI":"10.1093\/jxb\/erv396","article-title":"Melatonin biosynthesis requires N-acetylserotonin methyltransferase activity of caffeic acid O-methyltransferase in rice","volume":"66","author":"Byeon","year":"2015","journal-title":"J Exp Bot"},{"key":"key20220330120704_b18-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/jpi.12289","article-title":"Cloning and functional characterization of the Arabidopsis N-acetylserotonin O-methyltransferase responsible for melatonin synthesis","volume":"60","author":"Byeon","year":"2016","journal-title":"J Pineal Res"},{"key":"key20220330120704_b19-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.1074\/jbc.R600036200","article-title":"Arylalkylamine N-acetyltransferase: \u2018The Timezyme\u2019","volume":"282","author":"Klein","year":"2007","journal-title":"J Biol Chem"},{"issue":"1086","key":"key20220330120704_b20-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01086","article-title":"Promising antineoplastic actions of melatonin","volume":"9","author":"Favero","year":"2018","journal-title":"Front Pharmacol"},{"issue":"843","key":"key20220330120704_b21-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040843","article-title":"Melatonin, a full service anti-cancer agent: Inhibition of initiation, progression and metastasis","volume":"18","author":"Reiter","year":"2017","journal-title":"Int J Mol Sci"},{"key":"key20220330120704_b22-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.2174\/0929867324666170718105557","article-title":"Clinical uses of melatonin in neurological diseases and mental and behavioural disorders","volume":"24","author":"Sanchez-Barcelo","year":"2017","journal-title":"Curr Med Chem"},{"key":"key20220330120704_b23-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/jpi.12137","article-title":"Melatonin, energy metabolism, and obesity: A review","volume":"56","author":"Cipolla-Neto","year":"2014","journal-title":"J Pineal Res"},{"issue":"1835195","key":"key20220330120704_b24-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1835195","article-title":"Melatonin as an Anti-Inflammatory agent modulating inflammasome activation","volume":"2017","author":"Favero","year":"2017","journal-title":"Int J Endocrinol"},{"key":"key20220330120704_b25-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1002\/med.21628","article-title":"Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation","volume":"40","author":"Ma","year":"2020","journal-title":"Med Res Rev"},{"key":"key20220330120704_b26-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1002\/jcp.29036","article-title":"Immunoregulatory role of melatonin in cancer","volume":"235","author":"Moradkhani","year":"2020","journal-title":"J Cell Physiol"},{"key":"key20220330120704_b27-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1002\/jnr.24220","article-title":"The neuroprotective role of melatonin in neurological disorders","volume":"96","author":"Alghamdi","year":"2018","journal-title":"J Neurosci Res"},{"issue":"187","key":"key20220330120704_b28-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.11826","article-title":"Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a\/449a cluster","volume":"23","author":"Ji","year":"2021","journal-title":"Mol Med Rep"},{"key":"key20220330120704_b29-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"4063","DOI":"10.1097\/00001756-199812210-00011","article-title":"Melatonin receptor subtype expression in human cerebellum","volume":"9","author":"Al-Ghoul","year":"1998","journal-title":"Neuroreport"},{"issue":"e12575","key":"key20220330120704_b30-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12575","article-title":"MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations","volume":"67","author":"Klosen","year":"2019","journal-title":"J Pineal Res"},{"key":"key20220330120704_b31-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1007\/BF02527721","article-title":"Effect of melatonin on beta-tubulin and MAP2 expression in NIE-115 cells","volume":"21","author":"Mel\u00e9ndez","year":"1996","journal-title":"Neurochem Res"},{"key":"key20220330120704_b32-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/jpi.12224","article-title":"Anatomical and cellular localization of melatonin MT1 and MT2 receptors in the adult rat brain","volume":"58","author":"Lacoste","year":"2015","journal-title":"J Pineal Res"},{"key":"key20220330120704_b33-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1007\/s00429-017-1439-6","article-title":"Melatonin receptors: distribution in mammalian brain and their respective putative functions","volume":"222","author":"Ng","year":"2017","journal-title":"Brain Struct Funct"},{"issue":"e21161","key":"key20220330120704_b34-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000305R","article-title":"Pharmacological evidence for transactivation within melatonin MT2 and serotonin 5-HT2C receptor heteromers in mouse brain","volume":"35","author":"Gerbier","year":"2021","journal-title":"FASEB J"},{"key":"key20220330120704_b35-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"31311","DOI":"10.1074\/jbc.M005141200","article-title":"Identification of the melatonin-binding site MT3 as the quinone reductase 2","volume":"275","author":"Nosjean","year":"2000","journal-title":"J Biol Chem"},{"key":"key20220330120704_b36-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1124\/jpet.118.253260","article-title":"Is there sufficient evidence that the melatonin binding site MT3 Is quinone reductase 2?","volume":"368","author":"Boutin","year":"2019","journal-title":"J Pharmacol Exp Ther"},{"key":"key20220330120704_b37-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ijid.2021.10.012","article-title":"The effect of melatonin on thrombosis, sepsis and mortality rate in COVID-19 Patients","volume":"114","author":"Hasan","year":"2022","journal-title":"Int J Infect Dis"},{"issue":"882","key":"key20220330120704_b38-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-04737-w","article-title":"Evaluation of the efficacy and safety of Melatonin in moderately ill patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial","volume":"21","author":"Ziaei","year":"2020","journal-title":"Trials"},{"key":"key20220330120704_b39-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"key20220330120704_b40-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1134\/S0006297916110018","article-title":"Molecular and cellular mechanisms of inflammation","volume":"81","author":"Kuprash","year":"2016","journal-title":"Biochemistry (Mosc)"},{"key":"key20220330120704_b41-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41573-020-0082-8","article-title":"Kinase inhibition in autoimmunity and inflammation","volume":"20","author":"Zarrin","year":"2021","journal-title":"Nat Rev Drug Discov"},{"issue":"228","key":"key20220330120704_b42-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9659","article-title":"Effects of melatonin on protecting against lung injury (Review)","volume":"21","author":"Wang","year":"2021","journal-title":"Exp Ther Med"},{"issue":"e12525","key":"key20220330120704_b43-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12525","article-title":"Melatonin and inflammation-Story of a double-edged blade","volume":"65","author":"Hardeland","year":"2018","journal-title":"J Pineal Res"},{"key":"key20220330120704_b44-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.5604\/17322693.1221001","article-title":"Immunoregulatory action of melatonin. The mechanism of action and the effect on inflammatory cells","volume":"70","author":"Ma\u0144ka","year":"2016","journal-title":"Postepy Hig Med Dosw (Online)"},{"key":"key20220330120704_b45-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.pneurobio.2015.02.001","article-title":"Melatonin and brain inflammaging","volume":"127","author":"Hardeland","year":"2015","journal-title":"Prog Neurobiol"},{"key":"key20220330120704_b46-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"7037","DOI":"10.1074\/jbc.270.13.7037","article-title":"The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes","volume":"270","author":"Steinhilber","year":"1995","journal-title":"J Biol Chem"},{"key":"key20220330120704_b47-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/s0165-5728(98)00179-9","article-title":"Involvement of nuclear binding sites for melatonin in the regulation of IL-2 and IL-6 production by human blood mononuclear cells","volume":"92","author":"Garcia-Mauri\u00f1o","year":"1998","journal-title":"J Neuroimmunol"},{"key":"key20220330120704_b48-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1034\/j.1600-079x.2000.290301.x","article-title":"Correlation between nuclear melatonin receptor expression and enhanced cytokine production in human lymphocytic and monocytic cell lines","volume":"29","author":"Garc\u00eda-Mauri\u00f1o","year":"2000","journal-title":"J Pineal Res"},{"key":"key20220330120704_b49-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1096\/fj.02-0501fje","article-title":"Melatonin counteracts the inhibitory effect of PGE2 on IL-2 production in human lymphocytes via its mt1 membrane receptor","volume":"17","author":"Carrillo-Vico","year":"2003","journal-title":"FASEB J"},{"key":"key20220330120704_b50-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/jcp.20461","article-title":"Melatonin synthesized by Jurkat human leukemic T cell line is implicated in IL-2 production","volume":"206","author":"Lardone","year":"2006","journal-title":"J Cell Physiol"},{"key":"key20220330120704_b51-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1007\/s10517-016-3242-4","article-title":"Role of melatonin in the regulation of differentiation of T cells producing interleukin-17 (Th17)","volume":"160","author":"Kuklina","year":"2016","journal-title":"Bull Exp Biol Med"},{"key":"key20220330120704_b52-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/s0165-5728(01)00325-3","article-title":"Melatonin modulation of lymphocyte proliferation and Th1\/Th2 cytokine expression","volume":"117","author":"K\u00fchlwein","year":"2001","journal-title":"J Neuroimmunol"},{"key":"key20220330120704_b53-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/s0149-7634(05)80016-8","article-title":"The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances","volume":"17","author":"Hardeland","year":"1993","journal-title":"Neurosci Biobehav Rev"},{"key":"key20220330120704_b54-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/j.1600-079x.1993.tb00498.x","article-title":"Melatonin, hydroxyl radical-mediated oxidative damage, and aging: A hypothesis","volume":"14","author":"Poeggeler","year":"1993","journal-title":"J Pineal Res"},{"key":"key20220330120704_b55-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1006\/frne.1995.1014","article-title":"Functional pleiotropy of the neurohormone melatonin: Antioxidant protection and neuroendocrine regulation","volume":"16","author":"Reiter","year":"1995","journal-title":"Front Neuroendocrinol"},{"key":"key20220330120704_b56-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/978-1-4615-0135-0_62","article-title":"Melatonin: Detoxification of oxygen and nitrogen-based toxic reactants","volume":"527","author":"Reiter","year":"2003","journal-title":"Adv Exp Med Biol"},{"issue":"1135","key":"key20220330120704_b57-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031135","article-title":"Importance of melatonin in assisted reproductive technology and ovarian aging","volume":"21","author":"Tamura","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"17","key":"key20220330120704_b58-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-018-0168-5","article-title":"Melatonin ameliorates H2O2-induced oxidative stress through modulation of Erk\/Akt\/NFkB pathway","volume":"51","author":"Moniruzzaman","year":"2018","journal-title":"Biol Res"},{"key":"key20220330120704_b59-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1600-079x.1996.tb00292.x","article-title":"Adjuvant therapy with the pineal hormone melatonin in patients with lymph node relapse due to malignant melanoma","volume":"21","author":"Lissoni","year":"1996","journal-title":"J Pineal Res"},{"key":"key20220330120704_b60-ETM-23-4-11197","first-page":"4693","article-title":"Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events","volume":"59","author":"Blask","year":"1999","journal-title":"Cancer Res"},{"key":"key20220330120704_b61-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1177\/1534735409352320","article-title":"Circadian stage-dependent inhibition of human breast cancer metabolism and growth by the nocturnal melatonin signal: Consequences of its disruption by light at night in rats and women","volume":"8","author":"Blask","year":"2009","journal-title":"Integr Cancer Ther"},{"key":"key20220330120704_b62-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1600-079X.2011.00888.x","article-title":"Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night","volume":"51","author":"Blask","year":"2011","journal-title":"J Pineal Res"},{"key":"key20220330120704_b63-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1006\/taap.1997.8151","article-title":"Potent protective effect of melatonin on chromium(VI)-induced DNA single-strand breaks, cytotoxicity, and lipid peroxidation in primary cultures of rat hepatocytes","volume":"144","author":"Susa","year":"1997","journal-title":"Toxicol Appl Pharmacol"},{"key":"key20220330120704_b64-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0304-3835(93)90076-l","article-title":"The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo","volume":"70","author":"Tan","year":"1993","journal-title":"Cancer Lett"},{"key":"key20220330120704_b65-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1600-079X.2004.00162.x","article-title":"Prophylactic use of melatonin protects against focal cerebral ischemia in mice: Role of endothelin converting enzyme-1","volume":"37","author":"Kilic","year":"2004","journal-title":"J Pineal Res"},{"key":"key20220330120704_b66-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/jpi.12131","article-title":"Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-\u03ba\u03b2","volume":"56","author":"Le\u00f3n","year":"2014","journal-title":"J Pineal Res"},{"key":"key20220330120704_b67-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: A review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol Pathol"},{"key":"key20220330120704_b68-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1590\/1519-6984.228437","article-title":"Apoptosis (programmed cell death) and its signals-A review","volume":"81","author":"Obeng","year":"2021","journal-title":"Braz J Biol"},{"key":"key20220330120704_b69-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.neulet.2005.01.003","article-title":"Melatonin attenuates amyloid beta25-35-induced apoptosis in mouse microglial BV2 cells","volume":"380","author":"Jang","year":"2005","journal-title":"Neurosci Lett"},{"key":"key20220330120704_b70-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1034\/j.1600-079x.2002.02899.x","article-title":"Melatonin suppresses NO-induced apoptosis via induction of Bcl-2 expression in PGT-beta immortalized pineal cells","volume":"33","author":"Yoo","year":"2002","journal-title":"J Pineal Res"},{"key":"key20220330120704_b71-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1600-079X.2009.00682.x","article-title":"Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: Therapeutic implications for prostate cancer","volume":"47","author":"Joo","year":"2009","journal-title":"J Pineal Res"},{"key":"key20220330120704_b72-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1600-079x.1998.tb00380.x","article-title":"Inhibition of cell proliferation: A mechanism likely to mediate the prevention of neuronal cell death by melatonin","volume":"25","author":"Mayo","year":"1998","journal-title":"J Pineal Res"},{"key":"key20220330120704_b73-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1002\/jmv.26250","article-title":"Discharged COVID-19 patients testing positive again for SARS-CoV-2 RNA: A minireview of published studies from China","volume":"93","author":"Han","year":"2021","journal-title":"J Med Virol"},{"key":"key20220330120704_b74-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"key20220330120704_b75-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2214\/AJR.20.23034","article-title":"Coronavirus disease 2019 (COVID-19): A systematic review of imaging findings in 919 patients","volume":"215","author":"Salehi","year":"2020","journal-title":"AJR Am J Roentgenol"},{"key":"key20220330120704_b76-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1080\/17512433.2020.1814141","article-title":"Melatonin as a putative protection against myocardial injury in COVID-19 infection","volume":"13","author":"Simko","year":"2020","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"4410","key":"key20220330120704_b77-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25194410","article-title":"Targeting host defense system and rescuing compromised mitochondria to increase tolerance against pathogens by melatonin may impact outcome of deadly virus infection pertinent to COVID-19","volume":"25","author":"Tan","year":"2020","journal-title":"Molecules"},{"key":"key20220330120704_b78-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.eprac.2021.06.001","article-title":"Melatonin in early treatment for COVID-19: A narrative review of current evidence and possible efficacy","volume":"27","author":"Cross","year":"2021","journal-title":"Endocr Pract"},{"issue":"e3000970","key":"key20220330120704_b79-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000970","article-title":"A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19","volume":"18","author":"Zhou","year":"2020","journal-title":"PLoS Biol"},{"issue":"226","key":"key20220330120704_b80-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00226","article-title":"Therapeutic algorithm for use of melatonin in patients with COVID-19","volume":"7","author":"Reiter","year":"2020","journal-title":"Front Med (Lausanne)"},{"issue":"117583","key":"key20220330120704_b81-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117583","article-title":"COVID-19: Melatonin as a potential adjuvant treatment","volume":"250","author":"Zhang","year":"2020","journal-title":"Life Sci"},{"key":"key20220330120704_b82-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s41782-020-00111-7","article-title":"Elderly as a high-risk group during COVID-19 pandemic: Effect of circadian misalignment, sleep dysregulation and melatonin administration","author":"Cardinali","year":"2020","journal-title":"Sleep Vigil"},{"key":"key20220330120704_b83-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1600-079X.2009.00733.x","article-title":"Inhibitory effect of melatonin on lung oxidative stress induced by respiratory syncytial virus infection in mice","volume":"48","author":"Huang","year":"2010","journal-title":"J Pineal Res"},{"key":"key20220330120704_b84-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/08830185.2020.1756284","article-title":"Can melatonin reduce the severity of COVID-19 pandemic?","volume":"39","author":"Shneider","year":"2020","journal-title":"Int Rev Immunol"},{"issue":"521783","key":"key20220330120704_b85-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/521783","article-title":"The Angiotensin-melatonin axis","volume":"2013","author":"Campos","year":"2013","journal-title":"Int J Hypertens"},{"key":"key20220330120704_b86-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/jpi.12162","article-title":"Melatonin: A well-documented antioxidant with conditional pro-oxidant actions","volume":"57","author":"Zhang","year":"2014","journal-title":"J Pineal Res"},{"key":"key20220330120704_b87-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"5204","DOI":"10.1016\/j.ygeno.2020.09.028","article-title":"Mutations on COVID-19 diagnostic targets","volume":"112","author":"Wang","year":"2020","journal-title":"Genomics"},{"issue":"e124","key":"key20220330120704_b88-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2021.36.e124","article-title":"Will mutations in the spike protein of SARS-CoV-2 lead to the failure of COVID-19 Vaccines?","volume":"36","author":"Jia","year":"2021","journal-title":"J Korean Med Sci"},{"issue":"173375","key":"key20220330120704_b89-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173375","article-title":"Virology, pathogenesis, diagnosis and in-line treatment of COVID-19","volume":"883","author":"Samudrala","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"key20220330120704_b90-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1183\/09059180.00003609","article-title":"Epidemiology of COPD","volume":"18","author":"Raherison","year":"2009","journal-title":"Eur Respir Rev"},{"key":"key20220330120704_b91-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1111\/resp.12642","article-title":"COPD and its comorbidities: Impact, measurement and mechanisms","volume":"20","author":"Negewo","year":"2015","journal-title":"Respirology"},{"key":"key20220330120704_b92-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1164\/rccm.201204-0596PP","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"187","author":"Vestbo","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"key20220330120704_b93-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S0140-6736(07)61377-4","article-title":"International variation in the prevalence of COPD (the BOLD Study): A population-based prevalence study","volume":"370","author":"Buist","year":"2007","journal-title":"Lancet"},{"key":"key20220330120704_b94-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.rmed.2011.10.013","article-title":"Direct medical costs of COPD-an excess cost approach based on two population-based studies","volume":"106","author":"Menn","year":"2012","journal-title":"Respir Med"},{"issue":"112001","key":"key20220330120704_b95-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112001","article-title":"Roles of melatonin in the field of reproductive medicine","volume":"144","author":"Yong","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"668002","key":"key20220330120704_b96-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.668002","article-title":"An integrative transcriptomic and metabolomic study revealed that melatonin plays a protective role in chronic lung inflammation by reducing necroptosis","volume":"12","author":"Mao","year":"2021","journal-title":"Front Immunol"},{"key":"key20220330120704_b97-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1111\/jcmm.14816","article-title":"Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke","volume":"24","author":"Shin","year":"2020","journal-title":"J Cell Mol Med"},{"key":"key20220330120704_b98-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"95692","DOI":"10.18632\/oncotarget.21680","article-title":"Melatonin suppresses fibrotic responses induced by cigarette smoke via downregulation of TGF-\u03b21","volume":"8","author":"Shin","year":"2017","journal-title":"Oncotarget"},{"issue":"111588","key":"key20220330120704_b99-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111588","article-title":"Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice","volume":"144","author":"Mahalanobish","year":"2020","journal-title":"Food Chem Toxicol"},{"key":"key20220330120704_b100-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/jpi.12192","article-title":"Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling","volume":"58","author":"Shin","year":"2015","journal-title":"J Pineal Res"},{"issue":"1125","key":"key20220330120704_b101-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061125","article-title":"Melatonin attenuates pulmonary hypertension in chronically hypoxic rats","volume":"18","author":"Hung","year":"2017","journal-title":"Int J Mol Sci"},{"key":"key20220330120704_b102-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1111\/j.1600-079X.2011.00950.x","article-title":"Melatonin suppresses acrolein-induced IL-8 production in human pulmonary fibroblasts","volume":"52","author":"Kim","year":"2012","journal-title":"J Pineal Res"},{"key":"key20220330120704_b103-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.lfs.2012.08.030","article-title":"The non-neuronal cholinergic system as novel drug target in the airways","volume":"91","author":"Pieper","year":"2012","journal-title":"Life Sci"},{"key":"key20220330120704_b104-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: An overview","author":"Ferlay","year":"2021","journal-title":"Int J Cancer"},{"key":"key20220330120704_b105-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/hex.12433","article-title":"Lung cancer screening: What do long-term smokers know and believe?","volume":"20","author":"Carter-Harris","year":"2017","journal-title":"Health Expect"},{"key":"key20220330120704_b106-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.lungcan.2019.11.017","article-title":"Long-term cancer risk associated with lung nodules observed on low-dose screening CT scans","volume":"139","author":"Pinsky","year":"2020","journal-title":"Lung Cancer"},{"key":"key20220330120704_b107-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.bbcan.2015.08.002","article-title":"Lung cancer: Biology and treatment options","volume":"1856","author":"Lemjabbar-Alaoui","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"key20220330120704_b108-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.1111\/resp.13870","article-title":"Radiotherapy treatment for lung cancer: Current status and future directions","volume":"25 (Suppl 2)","author":"Vinod","year":"2020","journal-title":"Respirology"},{"key":"key20220330120704_b109-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1034\/j.1600-079x.2003.00032.x","article-title":"Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: A randomized trial","volume":"35","author":"Lissoni","year":"2003","journal-title":"J Pineal Res"},{"key":"key20220330120704_b110-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1600-079X.2007.00463.x","article-title":"Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture","volume":"43","author":"Garc\u00eda-Navarro","year":"2007","journal-title":"J Pineal Res"},{"key":"key20220330120704_b111-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1600-079X.2006.00406.x","article-title":"Signaling mechanisms of melatonin in antiproliferation of hormone-refractory 22Rv1 human prostate cancer cells: Implications for prostate cancer chemoprevention","volume":"42","author":"Tam","year":"2007","journal-title":"J Pineal Res"},{"key":"key20220330120704_b112-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"789","DOI":"10.14670\/HH-24.789","article-title":"Melatonin modulates microfilament phenotypes in epithelial cells: Implications for adhesion and inhibition of cancer cell migration","volume":"24","author":"Ben\u00edtez-King","year":"2009","journal-title":"Histol Histopathol"},{"key":"key20220330120704_b113-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/s0024-3205(99)00262-3","article-title":"Melatonin increases p53 and p21WAF1 expression in MCF-7 human breast cancer cells in vitro","volume":"65","author":"Mediavilla","year":"1999","journal-title":"Life Sci"},{"issue":"e101132","key":"key20220330120704_b114-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101132","article-title":"Melatonin inhibits the migration of human lung adenocarcinoma A549 cell lines involving JNK\/MAPK pathway","volume":"9","author":"Zhou","year":"2014","journal-title":"PloS One"},{"key":"key20220330120704_b115-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1081\/cbi-100106083","article-title":"Circadian rhythms of basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), cortisol, and melatonin in women with breast cancer","volume":"18","author":"Haus","year":"2001","journal-title":"Chronobiol Int"},{"key":"key20220330120704_b116-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/jpi.12261","article-title":"HDAC1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways","volume":"59","author":"Fan","year":"2015","journal-title":"J Pineal Res"},{"key":"key20220330120704_b117-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1600-079X.2012.00973.x","article-title":"Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells","volume":"53","author":"Wang","year":"2012","journal-title":"J Pineal Res"},{"key":"key20220330120704_b118-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.18632\/oncotarget.6407","article-title":"Melatonin inhibits AP-2\u03b2\/hTERT, NF-\u03baB\/COX-2 and Akt\/ERK and activates caspase\/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells","volume":"7","author":"Lu","year":"2016","journal-title":"Oncotarget"},{"key":"key20220330120704_b119-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1096\/fj.03-0694fje","article-title":"Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and\/or paracrine substance","volume":"18","author":"Carrillo-Vico","year":"2004","journal-title":"FASEB J"},{"key":"key20220330120704_b120-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1211\/002235702760345374","article-title":"Melatonin: Reducing the toxicity and increasing the efficacy of drugs","volume":"54","author":"Reiter","year":"2002","journal-title":"J Pharm Pharmacol"},{"key":"key20220330120704_b121-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1056\/NEJMra1300575","article-title":"Fibrosis-a common pathway to organ injury and failure","volume":"372","author":"Rockey","year":"2015","journal-title":"N Engl J Med"},{"key":"key20220330120704_b122-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"C1098","DOI":"10.1152\/ajpcell.00171.2013","article-title":"Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle","volume":"305","author":"Birbrair","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"key20220330120704_b123-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1600-079X.2008.00588.x","article-title":"Regulatory influence of melatonin on collagen accumulation in the infarcted heart scar","volume":"45","author":"Drobnik","year":"2008","journal-title":"J Pineal Res"},{"key":"key20220330120704_b124-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"4223","DOI":"10.1074\/jbc.M110709200","article-title":"Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen","volume":"277","author":"Di Lullo","year":"2002","journal-title":"J Biol Chem"},{"key":"key20220330120704_b125-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.1600-079X.2007.00541.x","article-title":"Melatonin accelerates the process of wound repair in full-thickness incisional wounds","volume":"44","author":"Pugazhenthi","year":"2008","journal-title":"J Pineal Res"},{"issue":"110827","key":"key20220330120704_b126-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110827","article-title":"Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3\u03b2\/Nrf2 pathway","volume":"132","author":"Ding","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"key20220330120704_b127-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1600-079X.2005.00272.x","article-title":"Preventive effect of melatonin on bleomycin-induced lung fibrosis in rats","volume":"40","author":"Yildirim","year":"2006","journal-title":"J Pineal Res"},{"key":"key20220330120704_b128-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1600-079X.2005.00229.x","article-title":"Melatonin limits lung injury in bleomycin treated mice","volume":"39","author":"Genovese","year":"2005","journal-title":"J Pineal Res"},{"key":"key20220330120704_b129-ETM-23-4-11197","first-page":"327","article-title":"Melatonin alleviates bleomycin-induced pulmonary fibrosis in mice","volume":"29","author":"Karimfar","year":"2015","journal-title":"J Biol Regul Homeost Agents"},{"key":"key20220330120704_b130-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.lfs.2018.03.032","article-title":"Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin","volume":"201","author":"Hosseinzadeh","year":"2018","journal-title":"Life Sci"},{"key":"key20220330120704_b131-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.mvr.2013.02.008","article-title":"Antiangiogenic effects of melatonin in endothelial cell cultures","volume":"87","author":"Alvarez-Garc\u00eda","year":"2013","journal-title":"Microvasc Res"},{"key":"key20220330120704_b132-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/jpi.12007","article-title":"Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells","volume":"54","author":"Alvarez-Garc\u00eda","year":"2013","journal-title":"J Pineal Res"},{"issue":"639531","key":"key20220330120704_b133-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/639531","article-title":"The beneficial effect of melatonin in brain endothelial cells against oxygen-glucose deprivation followed by reperfusion-induced injury","volume":"2014","author":"Song","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"key20220330120704_b134-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.trsl.2014.10.003","article-title":"Melatonin limits the expression of profibrogenic genes and ameliorates the progression of hepatic fibrosis in mice","volume":"165","author":"Crespo","year":"2015","journal-title":"Transl Res"},{"key":"key20220330120704_b135-ETM-23-4-11197","first-page":"567","article-title":"Protective effects of melatonin against thioacetamide-induced liver fibrosis in rats","volume":"66","author":"Czechowska","year":"2015","journal-title":"J Physiol Pharmacol"},{"key":"key20220330120704_b136-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/jpi.12020","article-title":"Melatonin treatment improves adipose-derived mesenchymal stem cell therapy for acute lung ischemia-reperfusion injury","volume":"54","author":"Yip","year":"2013","journal-title":"J Pineal Res"},{"key":"key20220330120704_b137-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1034\/j.1399-3003.2000.15d19.x","article-title":"Endothelin-1 production is associated with eosinophilic rather than neutrophilic airway inflammation","volume":"15","author":"Finsnes","year":"2000","journal-title":"Eur Respir J"},{"key":"key20220330120704_b138-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"920","DOI":"10.3892\/mmr.2016.5313","article-title":"Melatonin protects podocytes from angiotensin II-induced injury in an in vitro diabetic nephropathy model","volume":"14","author":"Ji","year":"2016","journal-title":"Mol Med Rep"},{"issue":"6211","key":"key20220330120704_b139-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126211","article-title":"Role of JAK\/STAT in interstitial lung diseases; Molecular and cellular mechanisms","volume":"22","author":"Montero","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"15561","key":"key20220330120704_b140-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1038\/srep15561","article-title":"Chronic activation of the renin-angiotensin system induces lung fibrosis","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep"},{"key":"key20220330120704_b141-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"L887","DOI":"10.1152\/ajplung.00432.2005","article-title":"Extravascular sources of lung angiotensin peptide synthesis in idiopathic pulmonary fibrosis","volume":"291","author":"Li","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"875910","key":"key20220330120704_b142-ETM-23-4-11197","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/875910","article-title":"Angiotensinogen gene transcription in pulmonary fibrosis","volume":"2012","author":"Uhal","year":"2012","journal-title":"Int J Pept"},{"key":"key20220330120704_b143-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s40261-015-0368-5","article-title":"The safety of melatonin in humans","volume":"36","author":"Andersen","year":"2016","journal-title":"Clin Drug Investig"},{"key":"key20220330120704_b144-ETM-23-4-11197","doi-asserted-by":"publisher","first-page":"467","DOI":"10.2174\/1568026616666160824120338","article-title":"Melatonin and respiratory diseases: A review","volume":"17","author":"Habtemariam","year":"2017","journal-title":"Curr Top Med Chem"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T09:25:30Z","timestamp":1648632330000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2022.11197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,9]]},"references-count":144,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,2,9]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2022.11197","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,9]]},"article-number":"271"}}