{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:02:10Z","timestamp":1785542530476,"version":"3.56.0"},"reference-count":34,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2022.11220","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T05:57:37Z","timestamp":1645077457000},"source":"Crossref","is-referenced-by-count":15,"title":["S100A9 blockade improves the functional recovery after spinal cord injury via mediating neutrophil infiltration"],"prefix":"10.3892","volume":"23","author":[{"given":"Feng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Imaging, General Hospital of Heilongjiang General Administration of Agriculture and Reclamation, Harbin, Heilongjiang 150000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, General Hospital of Heilongjiang General Administration of Agriculture and Reclamation, Harbin, Heilongjiang 150000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianli","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"key20220330120746_b1-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/s41582-019-0280-3","article-title":"The translational landscape in spinal cord injury: Focus on neuroplasticity and regeneration","volume":"15","author":"Hutson","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"key20220330120746_b2-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1001\/jama.2016.13645","article-title":"US county-level trends in mortality rates for major causes of death, 1980-2014","volume":"316","author":"Dwyer-Lindgren","year":"2016","journal-title":"JAMA"},{"key":"key20220330120746_b3-ETM-23-4-11220"},{"key":"key20220330120746_b4-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1093\/neuros\/nyw080","article-title":"Traumatic spinal cord injury-repair and regeneration","volume":"80 (Suppl 3)","author":"Ahuja","year":"2017","journal-title":"Neurosurgery"},{"key":"key20220330120746_b5-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.expneurol.2014.03.003","article-title":"Lymphocytes and autoimmunity after spinal cord injury","volume":"258","author":"Jones","year":"2014","journal-title":"Exp Neurol"},{"key":"key20220330120746_b6-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/s0014-4886(03)00361-3","article-title":"Differences in cytokine gene expression profile between acute and secondary injury in adult rat spinal cord","volume":"184","author":"Nakamura","year":"2003","journal-title":"Exp Neurol"},{"key":"key20220330120746_b7-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1172\/JCI62423","article-title":"Alarmins: Awaiting a clinical response","volume":"122","author":"Chan","year":"2012","journal-title":"J Clin Invest"},{"key":"key20220330120746_b8-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.pharmthera.2016.07.015","article-title":"S100A8\/A9: From basic science to clinical application","volume":"167","author":"Pruenster","year":"2016","journal-title":"Pharmacol Ther"},{"key":"key20220330120746_b9-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1161\/CIRCULATIONAHA.118.039262","article-title":"S100a8\/a9 signaling causes mitochondrial dysfunction and cardiomyocyte death in response to ischemic\/reperfusion injury","volume":"140","author":"Li","year":"2019","journal-title":"Circulation"},{"key":"key20220330120746_b10-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1093\/eurheartj\/ehz461","article-title":"Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction","volume":"40","author":"Marinkovi\u0107","year":"2019","journal-title":"Eur Heart J"},{"issue":"283","key":"key20220330120746_b11-ETM-23-4-11220","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1658-2","article-title":"Lentivirus-mediated downregulation of \u03b1-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury","volume":"16","author":"Zeng","year":"2019","journal-title":"J Neuroinflammation"},{"issue":"45","key":"key20220330120746_b12-ETM-23-4-11220","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01641-y","article-title":"S100A9 blockade prevents lipopolysaccharide-induced lung injury via suppressing the NLRP3 pathway","volume":"22","author":"Zhao","year":"2021","journal-title":"Respir Res"},{"key":"key20220330120746_b13-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/neu.1995.12.1","article-title":"A sensitive and reliable locomotor rating scale for open field testing in rats","volume":"12","author":"Basso","year":"1995","journal-title":"J Neurotrauma"},{"key":"key20220330120746_b14-ETM-23-4-11220","author":"Bryan"},{"key":"key20220330120746_b15-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"882","key":"key20220330120746_b16-ETM-23-4-11220","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0847-8","article-title":"Human menstrual blood-derived stem cells promote functional recovery in a rat spinal cord hemisection model","volume":"9","author":"Wu","year":"2018","journal-title":"Cell Death Dis"},{"key":"key20220330120746_b17-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s13402-018-0392-6","article-title":"TLR4 and RAGE conversely mediate pro-inflammatory S100A8\/9-mediated inhibition of proliferation-linked signaling in myeloproliferative neoplasms","volume":"41","author":"Kova\u010di\u0107","year":"2018","journal-title":"Cell Oncol (Dordr)"},{"key":"key20220330120746_b18-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"S187","DOI":"10.1074\/mcp.M116.064840","article-title":"Global characterization of protein secretion from human macrophages following non-canonical caspase-4\/5 inflammasome activation","volume":"16 (Suppl 1)","author":"Lorey","year":"2017","journal-title":"Mol Cell Proteomics"},{"key":"key20220330120746_b19-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/S1474-4422(14)70144-9","article-title":"Restoring function after spinal cord injury: Towards clinical translation of experimental strategies","volume":"13","author":"Ramer","year":"2014","journal-title":"Lancet Neurol"},{"key":"key20220330120746_b20-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/B978-0-444-52137-8.00030-9","article-title":"Harmful and beneficial effects of inflammation after spinal cord injury: Potential therapeutic implications","volume":"109","author":"David","year":"2012","journal-title":"Handb Clin Neurol"},{"key":"key20220330120746_b21-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s13311-018-0631-6","article-title":"Spinal cord injury scarring and inflammation: Therapies targeting glial and inflammatory responses","volume":"15","author":"Orr","year":"2018","journal-title":"Neurotherapeutics"},{"issue":"2","key":"key20220330120746_b22-ETM-23-4-11220","doi-asserted-by":"publisher","DOI":"10.25259\/SNI_568_2019","article-title":"Current advancements in the management of spinal cord injury: A comprehensive review of literature","volume":"11","author":"Shah","year":"2020","journal-title":"Surg Neurol Int"},{"key":"key20220330120746_b23-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/s0003-9993(99)90249-6","article-title":"Neurologic recovery after traumatic spinal cord injury: Data from the model spinal cord injury systems","volume":"80","author":"Marino","year":"1999","journal-title":"Arch Phys Med Rehabil"},{"key":"key20220330120746_b24-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1016\/j.apmr.2004.03.015","article-title":"Late neurologic recovery after traumatic spinal cord injury","volume":"85","author":"Kirshblum","year":"2004","journal-title":"Arch Phys Med Rehabil"},{"key":"key20220330120746_b25-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s00401-012-1076-3","article-title":"The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury","volume":"125","author":"Enzmann","year":"2013","journal-title":"Acta Neuropathol"},{"key":"key20220330120746_b26-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.expneurol.2008.09.006","article-title":"An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury","volume":"214","author":"Bao","year":"2008","journal-title":"Exp Neurol"},{"key":"key20220330120746_b27-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1111\/j.1471-4159.2007.04643.x","article-title":"Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF-alpha","volume":"102","author":"Nguyen","year":"2007","journal-title":"J Neurochem"},{"key":"key20220330120746_b28-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.cmet.2013.04.001","article-title":"Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis","volume":"17","author":"Nagareddy","year":"2013","journal-title":"Cell Metab"},{"key":"key20220330120746_b29-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1161\/ATVBAHA.113.302432","article-title":"Plasma S100A8\/A9 correlates with blood neutrophil counts, traditional risk factors, and cardiovascular disease in middle-aged healthy individuals","volume":"34","author":"Cotoi","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20220330120746_b30-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1161\/CIRCRESAHA.120.315865","article-title":"S100A9 links inflammation and repair in myocardial infarction","volume":"127","author":"Marinkovi\u0107","year":"2020","journal-title":"Circ Res"},{"key":"key20220330120746_b31-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1172\/JCI89867","article-title":"Autoinhibitory regulation of S100A8\/S100A9 alarmin activity locally restricts sterile inflammation","volume":"128","author":"Vogl","year":"2018","journal-title":"J Clin Invest"},{"key":"key20220330120746_b32-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.3727\/096368916X690836","article-title":"Cell transplantation and neuroengineering approach for spinal cord injury treatment: A summary of current laboratory findings and review of literature","volume":"25","author":"Lin","year":"2016","journal-title":"Cell Transplant"},{"key":"key20220330120746_b33-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"5107","DOI":"10.1016\/j.biomaterials.2013.03.062","article-title":"Promotion of neuronal differentiation of neural progenitor cells by using EGFR antibody functionalized collagen scaffolds for spinal cord injury repair","volume":"34","author":"Li","year":"2013","journal-title":"Biomaterials"},{"key":"key20220330120746_b34-ETM-23-4-11220","doi-asserted-by":"publisher","first-page":"4930","DOI":"10.1182\/blood-2013-02-486217","article-title":"Mast cell and macrophage chemokines CXCL1\/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation","volume":"121","author":"De Filippo","year":"2013","journal-title":"Blood"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T09:32:31Z","timestamp":1648632751000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2022.11220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,17]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,2,17]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2022.11220","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,17]]},"article-number":"291"}}