{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T21:07:20Z","timestamp":1781903240361,"version":"3.54.5"},"reference-count":58,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2022.11273","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T12:20:02Z","timestamp":1647951602000},"source":"Crossref","is-referenced-by-count":9,"title":["LINC01605 knockdown induces apoptosis in human Tenon's capsule fibroblasts by inhibiting autophagy"],"prefix":"10.3892","volume":"23","author":[{"given":"Qifei","family":"Shang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Fuyang People's Hospital, Hangzhou, Zhejiang 311400, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Fuyang People's Hospital, Hangzhou, Zhejiang 311400, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangzhu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Fuyang People's Hospital, Hangzhou, Zhejiang 311400, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"key20220428103046_b1-ETM-23-5-11273","first-page":"508","article-title":"Glaucoma treatment","volume":"66","author":"Bluwol","year":"2016","journal-title":"Rev Prat"},{"key":"key20220428103046_b2-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: A review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"key20220428103046_b3-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"495","DOI":"10.4103\/ijo.IJO_1130_17","article-title":"Simplifying \u2018target\u2019 intraocular pressure for different stages of primary open-angle glaucoma and primary angle-closure glaucoma","volume":"66","author":"Sihota","year":"2018","journal-title":"Indian J Ophthalmol"},{"issue":"23","key":"key20220428103046_b4-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.9.11.23","article-title":"Injected versus sponge-applied mitomycin C (MMC) during modified trabeculectomy in New Zealand white rabbit model","volume":"9","author":"Swogger","year":"2020","journal-title":"Transl Vis Sci Technol"},{"key":"key20220428103046_b5-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.ajo.2012.02.024","article-title":"The changing face of primary open-angle glaucoma in the United States: Demographic and geographic changes from 2011 to 2050","volume":"154","author":"Vajaranant","year":"2012","journal-title":"Am J Ophthalmol"},{"issue":"204","key":"key20220428103046_b6-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.11843","article-title":"Knockdown of FAM225B inhibits the progression of the hypertrophic scar following glaucoma surgery by inhibiting autophagy","volume":"23","author":"Ma","year":"2021","journal-title":"Mol Med Rep"},{"issue":"602","key":"key20220428103046_b7-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00602","article-title":"Tetramethylpyrazine induces apoptosis and inhibits proliferation of hypertrophic scar-derived fibroblasts via inhibiting the phosphorylation of AKT","volume":"11","author":"Wu","year":"2020","journal-title":"Front Pharmacol"},{"issue":"711","key":"key20220428103046_b8-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030711","article-title":"Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids","volume":"19","author":"Lee","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"eaat2039","key":"key20220428103046_b9-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat2039","article-title":"Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-\u03b2\/Smad3 pathway","volume":"10","author":"Wang","year":"2018","journal-title":"Sci Transl Med"},{"issue":"15129","key":"key20220428103046_b10-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15129","article-title":"The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion","volume":"8","author":"Jiang","year":"2017","journal-title":"Nat Commun"},{"key":"key20220428103046_b11-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.3892\/etm.2019.8345","article-title":"Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients","volume":"19","author":"Zheng","year":"2020","journal-title":"Exp Ther Med"},{"issue":"e000131","key":"key20220428103046_b12-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2017-000131","article-title":"LncRNAs in genetic basis of glaucoma","volume":"3","author":"Ciss\u00e9","year":"2018","journal-title":"BMJ Open Ophthalmol"},{"key":"key20220428103046_b13-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.bbrc.2017.11.027","article-title":"LncRNA COL1A2-AS1 inhibits the scar fibroblasts proliferation via regulating miR-21\/Smad7 pathway","volume":"495","author":"Nong","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"key20220428103046_b14-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1159\/000452548","article-title":"The long non-coding RNA LncRNA8975-1 is upregulated in hypertrophic scar fibroblasts and controls collagen expression","volume":"40","author":"Li","year":"2016","journal-title":"Cell Physiol Biochem"},{"issue":"20587384211016724","key":"key20220428103046_b15-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1177\/20587384211016724","article-title":"Blockade of LINC01605-enriched exosome generation in M2 macrophages impairs M2 macrophage-induced proliferation, migration, and invasion of human dermal fibroblasts","volume":"35","author":"Zhu","year":"2021","journal-title":"Int J Immunopathol Pharmacol"},{"key":"key20220428103046_b16-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.26355\/eurrev_201805_15047","article-title":"Tacrolimus inhibits proliferation and induces apoptosis by decreasing survivin in scar fibroblasts after glaucoma surgery","volume":"22","author":"Wang","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"8","key":"key20220428103046_b17-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.13.8","article-title":"The effect of age on increasing susceptibility to retinal nerve fiber layer loss in glaucoma","volume":"61","author":"Jammal","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20220428103046_b18-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1089\/acm.2020.0109","article-title":"Physical management of scar tissue: A systematic review and meta-analysis","volume":"26","author":"Deflorin","year":"2020","journal-title":"J Altern Complement Med"},{"key":"key20220428103046_b19-ETM-23-5-11273","first-page":"2123","article-title":"TGF-beta-induced interleukin-6 participates in transdifferentiation of human Tenon's fibroblasts to myofibroblasts","volume":"15","author":"Seong","year":"2009","journal-title":"Mol Vis"},{"key":"key20220428103046_b20-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.2147\/OPTH.S245915","article-title":"The pro-fibrotic behavior of human Tenon's capsule fibroblasts in medically treated glaucoma patients","volume":"14","author":"Trelford","year":"2020","journal-title":"Clin Ophthalmol"},{"key":"key20220428103046_b21-ETM-23-5-11273","first-page":"4799","article-title":"TGF-\u03b22 stimulates Tenon's capsule fibroblast proliferation in patients with glaucoma via suppression of miR-29b expression regulated by Nrf2","volume":"8","author":"Ran","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"key20220428103046_b22-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.3892\/ol.2013.1498","article-title":"Inhibition of autophagy by 3-MA enhances endoplasmic reticulum stress-induced apoptosis in human nasopharyngeal carcinoma cells","volume":"6","author":"Song","year":"2013","journal-title":"Oncol Lett"},{"key":"key20220428103046_b23-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.3892\/mmr.2015.3145","article-title":"CD44v6 promotes \u03b2-catenin and TGF-\u03b2 expression, inducing aggression in ovarian cancer cells","volume":"11","author":"Wang","year":"2015","journal-title":"Mol Med Rep"},{"issue":"e12429","key":"key20220428103046_b24-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.12429","article-title":"Genome-wide identification and expression analysis of ethylene responsive factor family transcription factors in Juglans regia","volume":"9","author":"Wang","year":"2021","journal-title":"PeerJ"},{"key":"key20220428103046_b25-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.exer.2018.02.018","article-title":"Fibrocyte migration, differentiation and apoptosis during the corneal wound healing response to injury","volume":"170","author":"Lassance","year":"2018","journal-title":"Exp Eye Res"},{"key":"key20220428103046_b26-ETM-23-5-11273","author":"Battaglia"},{"issue":"011001","key":"key20220428103046_b27-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/abbcc2","article-title":"The vimentin cytoskeleton: When polymer physics meets cell biology","volume":"18","author":"Patteson","year":"2020","journal-title":"Phys Biol"},{"issue":"105878","key":"key20220428103046_b28-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2020.105878","article-title":"Keratin intermediate filaments in the colon: Guardians of epithelial homeostasis","volume":"129","author":"Polari","year":"2020","journal-title":"Int J Biochem Cell Biol"},{"issue":"120235","key":"key20220428103046_b29-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120235","article-title":"Targeting cIAPs attenuates CCl(4)-induced liver fibrosis by increasing MMP9 expression derived from neutrophils","volume":"289","author":"Wu","year":"2022","journal-title":"Life Sci"},{"key":"key20220428103046_b30-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1007\/s12265-020-10089-2","article-title":"Lefty1 ameliorates post-infarction fibrosis by suppressing p-Smad2 and p-ERK1\/2 signaling pathways","volume":"14","author":"Li","year":"2021","journal-title":"J Cardiovasc Transl Res"},{"key":"key20220428103046_b31-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1016\/j.jhep.2015.07.033","article-title":"Activation of Slit2-Robo1 signaling promotes liver fibrosis","volume":"63","author":"Chang","year":"2015","journal-title":"J Hepatol"},{"issue":"489","key":"key20220428103046_b32-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1728-5","article-title":"Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis"},{"key":"key20220428103046_b33-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"8839","DOI":"10.1002\/jcp.29727","article-title":"SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK\/mTOR pathway and promoting GPX4 levels","volume":"235","author":"Han","year":"2020","journal-title":"J Cell Physiol"},{"issue":"6093","key":"key20220428103046_b34-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20236093","article-title":"Quercetin suppresses the progression of atherosclerosis by regulating MST1-mediated autophagy in ox-LDL-Induced RAW264.7 macrophage foam cells","volume":"20","author":"Cao","year":"2019","journal-title":"Int J Mol Sci"},{"key":"key20220428103046_b35-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1080\/15548627.2017.1359449","article-title":"Autophagy protects auditory hair cells against neomycin-induced damage","volume":"13","author":"He","year":"2017","journal-title":"Autophagy"},{"issue":"6694214","key":"key20220428103046_b36-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6694214","article-title":"Bergenin attenuates hepatic fibrosis by regulating autophagy mediated by the PPAR-\u03b3\/TGF-\u03b2 pathway","volume":"2020","author":"Xia","year":"2020","journal-title":"PPAR Res"},{"key":"key20220428103046_b37-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"973","DOI":"10.2147\/DDDT.S280322","article-title":"Dihydroartemisinin Inhibits TGF-\u03b2-induced fibrosis in human tenon fibroblasts via inducing autophagy","volume":"15","author":"Wang","year":"2021","journal-title":"Drug Des Devel Ther"},{"key":"key20220428103046_b38-ETM-23-5-11273"},{"key":"key20220428103046_b39-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"3250","DOI":"10.1096\/fj.07-8218com","article-title":"Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis","volume":"21","author":"Aarabi","year":"2007","journal-title":"FASEB J"},{"key":"key20220428103046_b40-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"22046","DOI":"10.18632\/aging.104044","article-title":"MiR-205 inhibits the development of hypertrophic scars by targeting THBS1","volume":"12","author":"Jiang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"key20220428103046_b41-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.biopha.2018.10.161","article-title":"Puerarin attenuates neurological deficits via Bcl-2\/Bax\/cleaved caspase-3 and Sirt3\/SOD2 apoptotic pathways in subarachnoid hemorrhage mice","volume":"109","author":"Zhang","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"key20220428103046_b42-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.rvsc.2016.02.004","article-title":"Evaluation of apoptosis-associated protein (Bcl-2, Bax, cleaved caspase-3 and p53) expression in canine mammary tumors: An immunohistochemical and prognostic study","volume":"105","author":"Dolka","year":"2016","journal-title":"Res Vet Sci"},{"key":"key20220428103046_b43-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/iub.1704","article-title":"Ligustrazine suppresses neuron apoptosis via the Bax\/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia","volume":"70","author":"Zhao","year":"2018","journal-title":"IUBMB Life"},{"key":"key20220428103046_b44-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/978-1-59745-157-4_4","article-title":"LC3 and autophagy","volume":"445","author":"Tanida","year":"2008","journal-title":"Methods Mol Biol"},{"key":"key20220428103046_b45-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"3961","DOI":"10.1096\/fj.201600698R","article-title":"LC3\/GABARAP family proteins: Autophagy-(un)related functions","volume":"30","author":"Schaaf","year":"2016","journal-title":"FASEB J"},{"key":"key20220428103046_b46-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1016\/j.biocel.2004.05.009","article-title":"LC3 conjugation system in mammalian autophagy","volume":"36","author":"Tanida","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"issue":"10147","key":"key20220428103046_b47-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46657-z","article-title":"LC3-positive structures are prominent in autophagy-deficient cells","volume":"9","author":"Runwal","year":"2019","journal-title":"Sci Rep"},{"key":"key20220428103046_b48-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/nrm2239","article-title":"Self-eating and self-killing: Crosstalk between autophagy and apoptosis","volume":"8","author":"Maiuri","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20220428103046_b49-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/jpi.12264","article-title":"Melatonin and endoplasmic reticulum stress: Relation to autophagy and apoptosis","volume":"59","author":"Fern\u00e1ndez","year":"2015","journal-title":"J Pineal Res"},{"issue":"104522","key":"key20220428103046_b50-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2020.104522","article-title":"MiR-302a-3p aggravates myocardial ischemia-reperfusion injury by suppressing mitophagy via targeting FOXO3","volume":"117","author":"Lv","year":"2020","journal-title":"Exp Mol Pathol"},{"key":"key20220428103046_b51-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s10495-015-1198-x","article-title":"Anti-tumor activities of luteolin and silibinin in glioblastoma cells: Overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo","volume":"21","author":"Chakrabarti","year":"2016","journal-title":"Apoptosis"},{"key":"key20220428103046_b52-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/exd.13410","article-title":"Inactivation of Beclin-1-dependent autophagy promotes ursolic acid-induced apoptosis in hypertrophic scar fibroblasts","volume":"27","author":"Cao","year":"2018","journal-title":"Exp Dermatol"},{"key":"key20220428103046_b53-ETM-23-5-11273","author":"Deng"},{"key":"key20220428103046_b54-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1111\/jphp.13077","article-title":"Mangiferin attenuates bleomycin-induced pulmonary fibrosis in mice through inhibiting TLR4\/p65 and TGF-\u03b21\/Smad2\/3 pathway","volume":"71","author":"Jia","year":"2019","journal-title":"J Pharm Pharmacol"},{"key":"key20220428103046_b55-ETM-23-5-11273","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/tox.22878","article-title":"TGF-\u03b21 mediated Smad signaling pathway and EMT in hepatic fibrosis induced by Nano NiO in vivo and in vitro","volume":"35","author":"Zhang","year":"2020","journal-title":"Environ Toxicol"},{"issue":"78","key":"key20220428103046_b56-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1356-0","article-title":"Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-\u03b2 and NLRP3 inflammasome signaling pathway","volume":"10","author":"Nam","year":"2019","journal-title":"Cell Death Dis"},{"issue":"9289","key":"key20220428103046_b57-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09673-5","article-title":"Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-\u03b21\/Smads and PI3K\/Akt pathways","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"issue":"6175091","key":"key20220428103046_b58-ETM-23-5-11273","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6175091","article-title":"Isorhamnetin inhibits liver fibrosis by reducing autophagy and inhibiting extracellular matrix formation via the TGF-\u03b21\/Smad3 and TGF-\u03b21\/p38 MAPK pathways","volume":"2019","author":"Liu","year":"2019","journal-title":"Mediators Inflamm"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T07:30:54Z","timestamp":1651131054000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2022.11273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,22]]},"references-count":58,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,3,22]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2022.11273","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,22]]},"article-number":"343"}}