{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:59:10Z","timestamp":1788479950054,"version":"build-2803163510"},"reference-count":30,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2022.11329","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T12:41:56Z","timestamp":1650458516000},"source":"Crossref","is-referenced-by-count":16,"title":["Histopathological evaluation of cutaneous malignant melanoma: A retrospective study"],"prefix":"10.3892","volume":"23","author":[{"given":"Daniela-Elena","family":"Mutu","sequence":"first","affiliation":[{"name":"Discipline of Anatomy, Faculty of Medicine, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, Bucharest 020021, Romani"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelaida","family":"Avino","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, \u2018Professor Dr Agrippa Ionescu\u2019 Clinical Emergency Hospital, Bucharest 011356, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andra-Elena","family":"Balcangiu\u2011Stroescu","sequence":"additional","affiliation":[{"name":"Discipline of Physiology, Faculty of Dental Medicine, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, Bucharest 020021, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Mehedin\u021bu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, \u2018Professor Dr Agrippa Ionescu\u2019 Clinical Emergency Hospital, Bucharest 011356, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"B\u0103lan","sequence":"additional","affiliation":[{"name":"Discipline of Physiology, Faculty of Dental Medicine, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, Bucharest 020021, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u0103cr\u0103mioara","family":"Br\u00eendu\u0219e","sequence":"additional","affiliation":[{"name":"Discipline of Public Health and Management, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, Bucharest 020021, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Maria","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Financial and Economic Analysis and Valuation, Faculty of Accounting and Management Information Systems, Bucharest University of Economic Studies, Bucharest 010731, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorin","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Department of Medical Semiology, Discipline of Internal Medicine I and Nephrology, Faculty of Medicine, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, Bucharest 020021, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan-Mihai","family":"Cristea","sequence":"additional","affiliation":[{"name":"Discipline of Anatomy, Faculty of Medicine, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, Bucharest 020021, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lumini\u0163a","family":"Tomescu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, \u2018Professor Dr Agrippa Ionescu\u2019 Clinical Emergency Hospital, Bucharest 011356, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian-Radu","family":"Jecan","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, \u2018Professor Dr Agrippa Ionescu\u2019 Clinical Emergency Hospital, Bucharest 011356, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"R\u0103ducu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, \u2018Professor Dr Agrippa Ionescu\u2019 Clinical Emergency Hospital, Bucharest 011356, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"key20220526110416_b1-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1524-4725.1996.tb00312.x","article-title":"The epidemiology of skin cancer","volume":"22","author":"Gloster","year":"1996","journal-title":"Dermatol Surg"},{"key":"key20220526110416_b2-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1002\/cncr.22273","article-title":"Molecularly targeted therapy for melanoma: Current reality and future options","volume":"107","author":"Becker","year":"2006","journal-title":"Cancer"},{"key":"key20220526110416_b3-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1001\/jama.294.13.1647","article-title":"Clinicopathological features of and risk factors for multiple primary melanomas","volume":"294","author":"Ferrone","year":"2005","journal-title":"JAMA"},{"key":"key20220526110416_b4-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1001\/archderm.139.12.1620","article-title":"Cutaneous melanomas associated with nevi","volume":"139","author":"Bevona","year":"2003","journal-title":"Arch Dermatol"},{"key":"key20220526110416_b5-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"6199","DOI":"10.1200\/JCO.2009.23.4799","article-title":"Final version of 2009 AJCC melanoma staging and classification","volume":"27","author":"Balch","year":"2009","journal-title":"J Clin Oncol"},{"key":"key20220526110416_b6-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1097\/00000658-197812000-00004","article-title":"A multifactorial analysis of melanoma: Prognostic histopathological features comparing Clark's and Breslow's staging methods","volume":"188","author":"Balch","year":"1978","journal-title":"Ann Surg"},{"key":"key20220526110416_b7-ETM-0-0-11329","first-page":"2253","article-title":"Molecular markers in blood as surrogate prognostic indicators of melanoma recurrence","volume":"60","author":"Hoon","year":"2000","journal-title":"Cancer Res"},{"key":"key20220526110416_b8-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jdermsci.2006.05.002","article-title":"Genetic alterations in melanocytic tumors","volume":"43","author":"Takata","year":"2006","journal-title":"J Dermatol Sci"},{"key":"key20220526110416_b9-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"4102","DOI":"10.3892\/ol.2019.10066","article-title":"Current and future applications of confocal laser scanning microscopy imaging in skin oncology","volume":"17","author":"Ilie","year":"2019","journal-title":"Oncol Lett"},{"key":"key20220526110416_b10-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ejcsup.2013.07.012","article-title":"Melanoma epidemiology, biology and prognosis","volume":"11","author":"Ali","year":"2013","journal-title":"EJC Suppl"},{"key":"key20220526110416_b11-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1001\/archderm.141.6.745","article-title":"Early detection of thick melanomas in the United States: Beware of the nodular subtype","volume":"141","author":"Demierre","year":"2005","journal-title":"Arch Dermatol"},{"key":"key20220526110416_b12-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1002\/1097-0142(19940715)74:2<782::aid-cncr2820740236>3.0.co;2-g","article-title":"The national cancer data base. Report on melanoma","volume":"74","author":"Urist","year":"1994","journal-title":"Cancer"},{"key":"key20220526110416_b13-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1002\/(sici)1097-0142(19990715)86:2<288::aid-cncr13>3.0.co;2-s","article-title":"Classification of cutaneous malignant melanoma: A reassessment of histopathologic criteria for the distinction of different types","volume":"86","author":"Weyers","year":"1999","journal-title":"Cancer"},{"key":"key20220526110416_b14-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1158\/1078-0432.CCR-06-1820","article-title":"Gene expression signatures for tumor progression, tumor subtype, and tumor thickness in laser-microdissected melanoma tissues","volume":"13","author":"Jaeger","year":"2007","journal-title":"Clin Cancer Res"},{"key":"key20220526110416_b15-ETM-0-0-11329","first-page":"131","article-title":"Plantar lentiginous melanoma: A distinctive variant of human cutaneous malignant melanoma. Am J Surg","volume":"1","author":"Arrington","year":"1977","journal-title":"Pathol"},{"key":"key20220526110416_b16-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1002\/1097-0142(19801201)46:11<2492::aid-cncr2820461130>3.0.co;2-j","article-title":"Melanomas of the palm, sole, and nailbed: A clinicopathologic study","volume":"46","author":"Feibleman","year":"1980","journal-title":"Cancer"},{"key":"key20220526110416_b17-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1440-0960.1991.tb00679.x","article-title":"Lentinginous dysplastic naevi in the elderly: A potential precursor for malignant melanoma","volume":"32","author":"Kossard","year":"1991","journal-title":"Australas J Dermatol"},{"key":"key20220526110416_b18-ETM-0-0-11329","doi-asserted-by":"crossref","first-page":"993","DOI":"10.37358\/RC.19.3.7047","article-title":"Treatment of high blood pressure in patients with chronic renal disease","volume":"70","author":"Mandita","year":"2019","journal-title":"Rev Chim"},{"key":"key20220526110416_b19-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1046\/j.1365-2559.2000.00894.x","article-title":"Morphological and immunophenotypic variations in malignant melanoma","volume":"36","author":"Banerjee","year":"2000","journal-title":"Histopathology"},{"key":"key20220526110416_b20-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.bbrc.2004.07.096","article-title":"S100 proteins in mouse and man: From evolution to function and pathology (including an update of the nomenclature)","volume":"322","author":"Marenholz","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"key20220526110416_b21-ETM-0-0-11329","first-page":"198","article-title":"S100 protein family and its application in clinical practice","volume":"12","author":"Sedaghat","year":"2008","journal-title":"Hippokratia"},{"key":"key20220526110416_b22-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ygeno.2004.02.002","article-title":"Probing the S100 protein family through genomic and functional analysis","volume":"84","author":"Ravasi","year":"2004","journal-title":"Genomics"},{"issue":"10","key":"key20220526110416_b23-ETM-0-0-11329","article-title":"Evaluation of Kindlin-1 and Ki-67 immunohistochemical expression in primary cutaneous malignant melanoma: A clinical series","volume":"39","author":"El Halal Schuch","year":"2019","journal-title":"Appl Cancer Res"},{"key":"key20220526110416_b24-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1002\/cyto.a.23685","article-title":"Image analysis in digital pathology: Combining automated assessment of Ki67 staining quality with calculation of Ki67 cell proliferation index","volume":"95","author":"Bengtsson","year":"2019","journal-title":"Cytometry A"},{"key":"key20220526110416_b25-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cca.2019.01.011","article-title":"Ki-67 protein as a tumour proliferation marker","volume":"491","author":"Menon","year":"2019","journal-title":"Clin Chim Acta"},{"key":"key20220526110416_b26-ETM-0-0-11329","first-page":"357","article-title":"Use of monoclonal antibodies in detection of melanoma-associated antigens in intact human tumors","volume":"107","author":"Thompson","year":"1982","journal-title":"Am J Pathol"},{"key":"key20220526110416_b27-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1097\/00000478-199008000-00006","article-title":"Antibody HMB-45 identifies the cells of blue nevi. An immunohistochemical study on paraffin sections","volume":"14","author":"Sun","year":"1990","journal-title":"Am J Surg Pathol"},{"key":"key20220526110416_b28-ETM-0-0-11329","first-page":"740","article-title":"Tyrosinase, melan-A, and KBA62 as markers for the immunohistochemical identification of metastatic amelanotic melanomas on paraffin sections","volume":"11","author":"Kaufmann","year":"1998","journal-title":"Mod Pathol"},{"key":"key20220526110416_b29-ETM-0-0-11329","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/1570164611310030006","article-title":"Cellomics as integrative omics for cancer","volume":"10","author":"Boda","year":"2013","journal-title":"Curr Proteomics"},{"key":"key20220526110416_b30-ETM-0-0-11329","doi-asserted-by":"publisher","first-page":"4188","DOI":"10.3892\/ol.2019.10068","article-title":"Development of QSAR machine learning-based models to forecast the effect of substances on malignant melanoma cells","volume":"17","author":"Ancuceanu","year":"2019","journal-title":"Oncol Lett"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T08:04:30Z","timestamp":1653552270000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2022.11329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,4,20]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2022.11329","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,20]]},"article-number":"402"}}