{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:40:24Z","timestamp":1791643224896,"version":"4.3.4"},"reference-count":68,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2022.11545","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T06:44:35Z","timestamp":1659422675000},"source":"Crossref","is-referenced-by-count":24,"title":["Riboflavin ameliorates mitochondrial dysfunction via the AMPK\/PGC1\u03b1\/HO\u20111 signaling pathway and attenuates carbon tetrachloride\u2011induced liver fibrosis in rats"],"prefix":"10.3892","volume":"24","author":[{"given":"Ning","family":"Tang","sequence":"first","affiliation":[{"name":"Emergency Intensive Care Unit, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241002, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Physiology, Wannan Medical College, Wuhu, Anhui 241002, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Experimental Center for Function Subjects, Wannan Medical College, Wuhu, Anhui 241002, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Experimental Center for Function Subjects, Wannan Medical College, Wuhu, Anhui 241002, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Wannan Medical College, Wuhu, Anhui 241002, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Wannan Medical College, Wuhu, Anhui 241002, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"issue":"101600","key":"key20220930135154_b1-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101600","article-title":"Curcumin blunts epithelial-mesenchymal transition of hepatocytes to alleviate hepatic fibrosis through regulating oxidative stress and autophagy","volume":"36","author":"Kong","year":"2020","journal-title":"Redox Biol"},{"issue":"145","key":"key20220930135154_b2-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0145-y","article-title":"Liver cirrhosis mortality in 187 countries between 1980 and 2010: A systematic analysis","volume":"12","author":"Mokdad","year":"2014","journal-title":"BMC Med"},{"key":"key20220930135154_b3-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s12072-019-09997-6","article-title":"TAF and TDF attenuate liver fibrosis through NS5ATP9, TGF\u03b21\/Smad3, and NF-\u03baB\/NLRP3 inflammasome signaling pathways","volume":"14","author":"Zhao","year":"2020","journal-title":"Hepatol Int"},{"key":"key20220930135154_b4-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.jhep.2011.09.024","article-title":"Clinical evidence for the regression of liver fibrosis","volume":"56","author":"Ellis","year":"2012","journal-title":"J Hepatol"},{"key":"key20220930135154_b5-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1136\/gutjnl-2013-305908","article-title":"Molecular targets for antifibrotic therapy in liver disease: Using magic bullets for crossfire rather than a one-sided shotgun attack","volume":"63","author":"Hellerbrand","year":"2014","journal-title":"Gut"},{"key":"key20220930135154_b6-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J Pathol"},{"key":"key20220930135154_b7-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1055\/s-2007-1007117","article-title":"Epidemiology of primary liver cancer","volume":"19","author":"Bosch","year":"1999","journal-title":"Semin Liver Dis"},{"key":"key20220930135154_b8-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/S0140-6736(14)62401-6","article-title":"Hepatitis C","volume":"385","author":"Webster","year":"2015","journal-title":"Lancet"},{"key":"key20220930135154_b9-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.biopha.2016.11.097","article-title":"Dicranostiga leptopodu (Maxim.) Fedde extracts attenuated CCl4-induced acute liver damage in mice through increasing anti-oxidative enzyme activity to improve mitochondrial function","volume":"85","author":"Tang","year":"2017","journal-title":"Biomed Pharmacother"},{"issue":"e13033","key":"key20220930135154_b10-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13033","article-title":"Cholix toxin, an eukaryotic elongation factor 2 ADP-ribosyltransferase, interacts with Prohibitins and induces apoptosis with mitochondrial dysfunction in human hepatocytes","volume":"21","author":"Yahiro","year":"2019","journal-title":"Cell Microbiol"},{"key":"key20220930135154_b11-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"issue":"125099","key":"key20220930135154_b12-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.125099","article-title":"Mitochondrial respiratory chain damage and mitochondrial fusion disorder are involved in liver dysfunction of fluoride-induced mice","volume":"241","author":"Wang","year":"2020","journal-title":"Chemosphere"},{"key":"key20220930135154_b13-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"879","DOI":"10.2174\/138945011795528877","article-title":"Mitochondria in chronic liver disease","volume":"12","author":"Grattagliano","year":"2011","journal-title":"Curr Drug Targets"},{"key":"key20220930135154_b14-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"key":"key20220930135154_b15-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1056\/NEJMra052270","article-title":"Drug-related hepatotoxicity","volume":"354","author":"Navarro","year":"2006","journal-title":"N Engl J Med"},{"key":"key20220930135154_b16-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jep.2015.01.044","article-title":"Hepatoprotective effects of lignans extract from Herpetospermum caudigerum against CCl(4)-induced acute liver injury in mice","volume":"164","author":"Shen","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"key20220930135154_b17-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"11282","DOI":"10.1073\/pnas.1511016112","article-title":"Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration","volume":"112","author":"Khiati","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20220930135154_b18-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.7150\/thno.29620","article-title":"P66Shc contributes to liver fibrosis through the regulation of mitochondrial reactive oxygen species","volume":"9","author":"Zhao","year":"2019","journal-title":"Theranostics"},{"issue":"304","key":"key20220930135154_b19-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55060304","article-title":"Hepatoprotective effect of melatonin in toxic liver injury in rats","volume":"55","author":"Oleshchuk","year":"2019","journal-title":"Medicina (Kaunas)"},{"key":"key20220930135154_b20-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.2353\/ajpath.2009.090332","article-title":"Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice","volume":"175","author":"Mitchell","year":"2009","journal-title":"Am J Pathol"},{"issue":"5807","key":"key20220930135154_b21-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19668-y","article-title":"AdipoR1\/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis","volume":"11","author":"Xu","year":"2020","journal-title":"Nat Commun"},{"key":"key20220930135154_b22-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1039\/c2fo10246c","article-title":"Riboflavin as a photosensitizer. Effects on human health and food quality","volume":"3","author":"Cardoso","year":"2012","journal-title":"Food Funct"},{"key":"key20220930135154_b23-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1110\/ps.12801","article-title":"Sequence-structure analysis of FAD-containing proteins","volume":"10","author":"Dym","year":"2001","journal-title":"Protein Sci"},{"issue":"950","key":"key20220930135154_b24-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030950","article-title":"Riboflavin: The health benefits of a forgotten natural vitamin","volume":"21","author":"Suwannasom","year":"2020","journal-title":"Int J Mol Sci"},{"key":"key20220930135154_b25-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.abb.2015.08.013","article-title":"Ameliorative effect of riboflavin on hyperglycemia, oxidative stress and DNA damage in type-2 diabetic mice: Mechanistic and therapeutic strategies","volume":"584","author":"Alam","year":"2015","journal-title":"Arch Biochem Biophys"},{"key":"key20220930135154_b26-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1016\/j.fct.2010.04.033","article-title":"Riboflavin protects mice against liposaccharide-induced shock through expression of heat shock protein 25","volume":"48","author":"Shih","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"key20220930135154_b27-ETM-24-4-11545","first-page":"413","article-title":"The relative effectiveness of iron and iron with riboflavin in correcting a microcytic anaemia in men and children in rural Gambia","volume":"37","author":"Powers","year":"1983","journal-title":"Hum Nutr Clin Nutr"},{"key":"key20220930135154_b28-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.fct.2014.02.013","article-title":"Riboflavin (vitamin B-2) reduces hepatocellular injury following liver ischaemia and reperfusion in mice","volume":"67","author":"Sanches","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"key20220930135154_b29-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1093\/jn\/105.5.562","article-title":"Riboflavin and mouse hepatic cell structure and function. Mitochondrial oxidative metabolism in severe deficiency states","volume":"105","author":"Hoppel","year":"1975","journal-title":"J Nutr"},{"key":"key20220930135154_b30-ETM-24-4-11545"},{"key":"key20220930135154_b31-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1124\/mol.118.111831","article-title":"Celecoxib does not protect against fibrosis and inflammation in a carbon tetrachloride-induced model of liver injury","volume":"94","author":"Harris","year":"2018","journal-title":"Mol Pharmacol"},{"key":"key20220930135154_b32-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1136\/bmj.1.5950.150-b","article-title":"Letter: Diagnostic test for multiple sclerosis","volume":"1","author":"Crawford","year":"1975","journal-title":"Br Med J"},{"issue":"e96043","key":"key20220930135154_b33-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096043","article-title":"Pathological changes in pulmonary circulation in carbon tetrachloride (CCl4)-induced cirrhotic mice","volume":"9","author":"Das","year":"2014","journal-title":"PLoS One"},{"key":"key20220930135154_b34-ETM-24-4-11545","first-page":"1058","article-title":"Molecular mechanism for alkyl sulfide-modulated carbon tetrachloride-induced hepatotoxicity: The role of cytochrome P450 2E1, P450 2B and glutathione S-transferase expression","volume":"277","author":"Kim","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"key20220930135154_b35-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.chroma.2015.08.014","article-title":"Development of a mitochondria-based centrifugal ultrafiltration\/liquid chromatography\/mass spectrometry method for screening mitochondria-targeted bioactive constituents from complex matrixes: Herbal medicines as a case study","volume":"1413","author":"Yang","year":"2015","journal-title":"J Chromatogr A"},{"issue":"176","key":"key20220930135154_b36-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2595-4","article-title":"The extract from Agkistrodon halys venom protects against lipopolysaccharide (LPS)-induced myocardial injury","volume":"19","author":"Wang","year":"2019","journal-title":"BMC Complement Altern Med"},{"issue":"e16533","key":"key20220930135154_b37-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016533","article-title":"Evaluation of hepatic fibrosis by ultrasonic acoustic structure quantification","volume":"98","author":"Cheng","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"key20220930135154_b38-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.3748\/wjg.v16.i22.2771","article-title":"Protective effect of recombinant human IL-1Ra on CCl4-induced acute liver injury in mice","volume":"16","author":"Zhu","year":"2010","journal-title":"World J Gastroenterol"},{"key":"key20220930135154_b39-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"12250","DOI":"10.3390\/molecules200712250","article-title":"Protective effect of procyanidin B2 against CCl4-induced acute liver injury in mice","volume":"20","author":"Yang","year":"2015","journal-title":"Molecules"},{"key":"key20220930135154_b40-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1016\/j.cellsig.2013.07.007","article-title":"Induction of renal fibrotic genes by TGF-beta1 requires EGFR activation, p53 and reactive oxygen species","volume":"25","author":"Samarakoon","year":"2013","journal-title":"Cell Signal"},{"key":"key20220930135154_b41-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1084\/jem.192.7.1001","article-title":"Reactive oxygen species (ROS)-induced ROS release: A new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes","volume":"192","author":"Zorov","year":"2000","journal-title":"J Exp Med"},{"key":"key20220930135154_b42-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/bja\/aer093","article-title":"Oxidative stress and mitochondrial dysfunction in sepsis","volume":"107","author":"Galley","year":"2011","journal-title":"Br J Anaesth"},{"key":"key20220930135154_b43-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s00204-013-1034-4","article-title":"Oxidative stress: The mitochondria-dependent and mitochondria-independent pathways of apoptosis","volume":"87","author":"Sinha","year":"2013","journal-title":"Arch Toxicol"},{"key":"key20220930135154_b44-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/s0168-8278(00)80362-1","article-title":"Relationship between hepatic mitochondrial functions in vivo and in vitro in rats with carbon tetrachloride-induced liver cirrhosis","volume":"33","author":"Krahenbuhl","year":"2000","journal-title":"J Hepatol"},{"key":"key20220930135154_b45-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"G298","DOI":"10.1152\/ajpgi.00135.2019","article-title":"Mitochondria-targeted antioxidant mitoquinone attenuates liver inflammation and fibrosis in cirrhotic rats","volume":"318","author":"Turkseven","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1252","key":"key20220930135154_b46-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9121252","article-title":"Mitochondrial abnormalities in induced pluripotent stem cells-derived motor neurons from patients with riboflavin transporter deficiency","volume":"9","author":"Colasuonno","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"key20220930135154_b47-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","article-title":"A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine","volume":"39","author":"Wallace","year":"2005","journal-title":"Annu Rev Genet"},{"key":"key20220930135154_b48-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1096\/fasebj.14.2.312","article-title":"Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals","volume":"14","author":"Barja","year":"2000","journal-title":"FASEB J"},{"key":"key20220930135154_b49-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.bbabio.2005.11.009","article-title":"Riboflavin enhances the assembly of mitochondrial cytochrome c oxidase in C. elegans NADH-ubiquinone oxidoreductase mutants","volume":"1757","author":"Grad","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"key20220930135154_b50-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.cmet.2007.01.008","article-title":"Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis","volume":"5","author":"Reznick","year":"2007","journal-title":"Cell Metab"},{"key":"key20220930135154_b51-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1161\/CIRCULATIONAHA.108.784298","article-title":"Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction","volume":"118","author":"Schulz","year":"2008","journal-title":"Circulation"},{"key":"key20220930135154_b52-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/jpi.12319","article-title":"Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis","volume":"60","author":"Kang","year":"2016","journal-title":"J Pineal Res"},{"key":"key20220930135154_b53-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"7199","DOI":"10.3390\/ijms12107199","article-title":"Roles of oxidative stress, apoptosis, PGC-1alpha and mitochondrial biogenesis in cerebral ischemia","volume":"12","author":"Chen","year":"2011","journal-title":"Int J Mol Sci"},{"key":"key20220930135154_b54-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"12017","DOI":"10.1073\/pnas.0705070104","article-title":"AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha","volume":"104","author":"Jager","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20220930135154_b55-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1089\/scd.2016.0072","article-title":"Epoxyeicosatrienoic acids regulate adipocyte differentiation of mouse 3T3 cells, via PGC-1alpha activation, which is required for HO-1 expression and increased mitochondrial function","volume":"25","author":"Waldman","year":"2016","journal-title":"Stem Cells Dev"},{"issue":"108186","key":"key20220930135154_b56-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2019.108186","article-title":"Heme oxygenase-1\/carbon monoxide as modulators of autophagy and inflammation","volume":"678","author":"Ryter","year":"2019","journal-title":"Arch Biochem Biophys"},{"key":"key20220930135154_b57-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.nbd.2015.04.012","article-title":"Exogenous induction of HO-1 alleviates vincristine-induced neuropathic pain by reducing spinal glial activation in mice","volume":"79","author":"Shen","year":"2015","journal-title":"Neurobiol Dis"},{"key":"key20220930135154_b58-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1039\/c5fo01622c","article-title":"Sea cucumber peptides exert anti-inflammatory activity through suppressing NF-kappaB and MAPK and inducing HO-1 in RAW264.7 macrophages","volume":"7","author":"Song","year":"2016","journal-title":"Food Funct"},{"key":"key20220930135154_b59-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/jnc.13115","article-title":"Neuroprotective effects of Argon are mediated via an ERK-1\/2 dependent regulation of heme-oxygenase-1 in retinal ganglion cells","volume":"134","author":"Ulbrich","year":"2015","journal-title":"J Neurochem"},{"issue":"e21","key":"key20220930135154_b60-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.4081\/hi.2011.e21","article-title":"Riboflavin alleviates cardiac failure in type I diabetic cardiomyopathy","volume":"6","author":"Wang","year":"2011","journal-title":"Heart Int"},{"key":"key20220930135154_b61-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/s0024-3205(03)00383-7","article-title":"The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells","volume":"73","author":"Li","year":"2003","journal-title":"Life Sci"},{"issue":"792639","key":"key20220930135154_b62-ETM-24-4-11545","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/792639","article-title":"Mitogen-activated protein kinases and reactive oxygen species: How can ROS activate MAPK pathways?","volume":"2011","author":"Son","year":"2011","journal-title":"J Signal Transduct"},{"key":"key20220930135154_b63-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.tox.2012.10.008","article-title":"Chloroacetic acid induced neuronal cells death through oxidative stress-mediated p38-MAPK activation pathway regulated mitochondria-dependent apoptotic signals","volume":"303","author":"Chen","year":"2013","journal-title":"Toxicology"},{"key":"key20220930135154_b64-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1161\/01.ATV.0000066132.32063.F2","article-title":"Role of JNK, p38, and ERK in platelet-derived growth factor-induced vascular proliferation, migration, and gene expression","volume":"23","author":"Zhan","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20220930135154_b65-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1016\/j.jacc.2010.07.033","article-title":"Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy","volume":"56","author":"Rajesh","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"key20220930135154_b66-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/s0014-5793(02)03276-3","article-title":"p38 MAPK mediates the regulation of alpha1(I) procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells(1)","volume":"528","author":"Varela-Rey","year":"2002","journal-title":"FEBS Lett"},{"key":"key20220930135154_b67-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1002\/hep.510300406","article-title":"Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat","volume":"30","author":"Marra","year":"1999","journal-title":"Hepatology"},{"key":"key20220930135154_b68-ETM-24-4-11545","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.tox.2011.01.009","article-title":"\u03b1-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-\u03b2","volume":"282","author":"Foo","year":"2011","journal-title":"Toxicology"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T10:54:59Z","timestamp":1664535299000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2022.11545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,2]]},"references-count":68,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,8,2]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2022.11545","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,2]]},"article-number":"608"}}