{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T06:15:57Z","timestamp":1793686557453,"version":"4.5.1"},"reference-count":171,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2023.12180","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T08:49:25Z","timestamp":1692953365000},"source":"Crossref","is-referenced-by-count":279,"title":["Knee osteoarthritis: Current status and research progress in treatment (Review)"],"prefix":"10.3892","volume":"26","author":[{"given":"Ruizhi","family":"Geng","sequence":"first","affiliation":[{"name":"Graduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yu","sequence":"additional","affiliation":[{"name":"Graduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Ni","sequence":"additional","affiliation":[{"name":"Graduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqiang","family":"Kang","sequence":"additional","affiliation":[{"name":"Graduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Wei","sequence":"additional","affiliation":[{"name":"Graduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Graduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jin","sequence":"additional","affiliation":[{"name":"Graduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"key20231010100600_b1-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1136\/annrheumdis-2013-203355","article-title":"Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: Influences of age, gender and osteoarthritis affecting other joints","volume":"73","author":"Prieto-Alhambra","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"key20231010100600_b2-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.berh.2010.11.001","article-title":"Osteoarthritis","volume":"24","author":"Busija","year":"2010","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"key20231010100600_b3-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"635","DOI":"10.7326\/0003-4819-133-8-200010170-00016","article-title":"Osteoarthritis: New insights. Part 1: The disease and its risk factors","volume":"133","author":"Felson","year":"2000","journal-title":"Ann Intern Med"},{"key":"key20231010100600_b4-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3238\/arztebl.2010.0152","article-title":"The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee","volume":"107","author":"Michael","year":"2010","journal-title":"Dtsch Arztebl Int"},{"key":"key20231010100600_b5-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1023\/b:abme.0000017541.82498.37","article-title":"A framework for the in vivo pathomechanics of osteoarthritis at the knee","volume":"32","author":"Andriacchi","year":"2004","journal-title":"Ann Biomed Eng"},{"key":"key20231010100600_b6-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1002\/art.21180","article-title":"Impact of persistent hip or knee pain on overall health status in elderly people: A longitudinal population study","volume":"53","author":"Dawson","year":"2005","journal-title":"Arthritis Rheum"},{"key":"key20231010100600_b7-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s00296-008-0809-z","article-title":"Prevalence of rheumatic diseases and disability in China","volume":"29","author":"Xiang","year":"2009","journal-title":"Rheumatol Int"},{"key":"key20231010100600_b8-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1002\/art.39465","article-title":"The prevalence of symptomatic knee osteoarthritis in China: Results from the China Health and retirement longitudinal study","volume":"68","author":"Tang","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"key20231010100600_b9-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.semarthrit.2005.01.013","article-title":"Osteoarthritis: An overview of the disease and its treatment strategies","volume":"35","author":"Sarzi-Puttini","year":"2005","journal-title":"Semin Arthritis Rheum"},{"key":"key20231010100600_b10-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"key20231010100600_b11-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"e721","DOI":"10.5435\/JAAOS-D-21-01233","article-title":"AAOS Clinical practice guideline summary: Management of osteoarthritis of the Knee (Nonarthroplasty), Third edition","volume":"30","author":"Brophy","year":"2022","journal-title":"J Am Acad Orthop Surg"},{"key":"key20231010100600_b12-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1111\/os.13021","article-title":"Osteotomy around the knee: The surgical treatment of osteoarthritis","volume":"13","author":"Peng","year":"2021","journal-title":"Orthop Surg"},{"issue":"2619","key":"key20231010100600_b13-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052619","article-title":"Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee","volume":"22","author":"Jang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"key20231010100600_b14-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.apmr.2021.07.801","article-title":"Cross-sectional analysis of recommendations for the treatment of hip and knee osteoarthritis in clinical guidelines","volume":"103","author":"Bichsel","year":"2022","journal-title":"Arch Phys Med Rehabil"},{"key":"key20231010100600_b15-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1007\/s40121-022-00668-y","article-title":"Descriptive overview of pertussis epidemiology among older adults in Europe during 2010-2020","volume":"11","author":"Bahar","year":"2022","journal-title":"Infect Dis Ther"},{"key":"key20231010100600_b16-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1007\/s00167-016-4068-3","article-title":"Early osteoarthritis of the knee","volume":"24","author":"Madry","year":"2016","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"key20231010100600_b17-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1136\/annrheumdis-2013-204763","article-title":"The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study","volume":"73","author":"Cross","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"key20231010100600_b18-ETM-26-4-12180","first-page":"646","article-title":"Burden of major musculoskeletal conditions","volume":"81","author":"Woolf","year":"2003","journal-title":"Bull World Health Organ"},{"key":"key20231010100600_b19-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"271","DOI":"10.17305\/bjbms.2019.4205","article-title":"The use of cellular matrix in symptomatic knee osteoarthritis","volume":"20","author":"Abbassy","year":"2020","journal-title":"Bosn J Basic Med Sci"},{"key":"key20231010100600_b20-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1002\/1529-0131(200109)44:9<2065::AID-ART356>3.0.CO;2-Z","article-title":"Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: The Beijing Osteoarthritis Study","volume":"44","author":"Zhang","year":"2001","journal-title":"Arthritis Rheum"},{"key":"key20231010100600_b21-ETM-26-4-12180"},{"key":"key20231010100600_b22-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"5103","DOI":"10.7150\/thno.74548","article-title":"Silk fibroin-based biomaterials for cartilage\/osteochondral repair","volume":"12","author":"Zhou","year":"2022","journal-title":"Theranostics"},{"key":"key20231010100600_b23-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.semarthrit.2013.07.003","article-title":"Health economics in the field of osteoarthritis: An Expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)","volume":"43","author":"Hiligsmann","year":"2013","journal-title":"Semin Arthritis Rheum"},{"key":"key20231010100600_b24-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.berh.2005.09.007","article-title":"Osteoarthritis: Epidemiology","volume":"20","author":"Arden","year":"2006","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"key20231010100600_b25-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1093\/rheumatology\/keg400","article-title":"Genetic contribution to cartilage volume in women: A classical twin study","volume":"42","author":"Hunter","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"key20231010100600_b26-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/humu.22915","article-title":"Mutation update for COL2A1 gene variants associated with type II collagenopathies","volume":"37","author":"Barat-Houari","year":"2016","journal-title":"Hum Mutat"},{"key":"key20231010100600_b27-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.bone.2011.11.026","article-title":"Genetic factors in OA pathogenesis","volume":"51","author":"Chapman","year":"2012","journal-title":"Bone"},{"key":"key20231010100600_b28-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jbspin.2011.05.015","article-title":"Body mass index and susceptibility to knee osteoarthritis: A systematic review and meta-analysis","volume":"79","author":"Jiang","year":"2012","journal-title":"Joint Bone Spine"},{"issue":"266","key":"key20231010100600_b29-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-03742-4","article-title":"Prevalence and factors associated with knee osteoarthritis among middle-aged and elderly individuals in rural Tianjin: A population-based cross-sectional study","volume":"18","author":"Ji","year":"2023","journal-title":"J Orthop Surg Res"},{"key":"key20231010100600_b30-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1136\/bmj.332.7542.639","article-title":"Osteoarthritis","volume":"332","author":"Hunter","year":"2006","journal-title":"BMJ"},{"key":"key20231010100600_b31-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/art.1790090610","article-title":"Ethnic differences in self-reported functional status in the rural south: The Johnston County Osteoarthritis Project","volume":"9","author":"Jordan","year":"1996","journal-title":"Arthritis Care Res"},{"key":"key20231010100600_b32-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.joca.2005.04.014","article-title":"A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis","volume":"13","author":"Srikanth","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"key20231010100600_b33-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3892\/ijmm.2020.4460","article-title":"The GSK-3\u03b2\/\u03b2-catenin signaling pathway is involved in HMGB1-induced chondrocyte apoptosis and cartilage matrix degradation","volume":"45","author":"Shu","year":"2020","journal-title":"Int J Mol Med"},{"key":"key20231010100600_b34-ETM-26-4-12180","first-page":"1206","article-title":"High prevalence of knee, but not hip or hand osteoarthritis in Beijing elders: Comparison with data of Caucasian in United States","volume":"83","author":"Xu","year":"2003","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"key20231010100600_b35-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2105\/ajph.84.3.351","article-title":"The effects of specific medical conditions on the functional limitations of elders in the Framingham Study","volume":"84","author":"Guccione","year":"1994","journal-title":"Am J Public Health"},{"key":"key20231010100600_b36-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1177\/0363546509338827","article-title":"Knee osteoarthritis after anterior cruciate ligament injury: A systematic review","volume":"37","author":"\u00d8iestad","year":"2009","journal-title":"Am J Sports Med"},{"key":"key20231010100600_b37-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/JSM.0000000000000894","article-title":"Anterior cruciate ligament injury and knee osteoarthritis: An umbrella systematic review and meta-analysis","volume":"32","author":"Webster","year":"2022","journal-title":"Clin J Sport Med"},{"key":"key20231010100600_b38-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.joca.2005.09.009","article-title":"What health domains and items are important to patients with knee osteoarthritis? A focus group study in a multiethnic urban Asian population","volume":"14","author":"Xie","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"issue":"1273","key":"key20231010100600_b39-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2005.04.004","article-title":"The prevalence of knee pain and symptomatic knee osteoarthritis among veteran traumatic amputees and nonamputees","volume":"86","author":"Stitik","year":"2005","journal-title":"Arch Phys Med Rehabil"},{"key":"key20231010100600_b40-ETM-26-4-12180","first-page":"1484","article-title":"Rheumatic diseases in China: ILAR-China study comparing the prevalence of rheumatic symptoms in northern and southern rural populations","volume":"21","author":"Wigley","year":"1994","journal-title":"J Rheumatol"},{"key":"key20231010100600_b41-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1093\/bmb\/lds012","article-title":"Occupational activities and osteoarthritis of the knee","volume":"102","author":"Palmer","year":"2012","journal-title":"Br Med Bull"},{"key":"key20231010100600_b42-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1093\/aje\/152.9.855","article-title":"Factors associated with osteoarthritis of the hip and knee in Hong Kong Chinese: Obesity, joint injury, and occupational activities","volume":"152","author":"Lau","year":"2000","journal-title":"Am J Epidemiol"},{"key":"key20231010100600_b43-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1002\/art.24871","article-title":"The robust association between childhood physical abuse and osteoarthritis in adulthood: Findings from a representative community sample","volume":"61","author":"Fuller-Thomson","year":"2009","journal-title":"Arthritis Rheum"},{"key":"key20231010100600_b44-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1136\/oem.2005.020057","article-title":"Primary osteoarthritis of hip, knee, and hand in relation to occupational exposure","volume":"62","author":"Rossignol","year":"2005","journal-title":"Occup Environ Med"},{"issue":"152013","key":"key20231010100600_b45-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2022.152013","article-title":"Does smoking protect against developing osteoarthritis? Evidence from a genetically informed perspective","volume":"55","author":"Ni","year":"2022","journal-title":"Semin Arthritis Rheum"},{"issue":"1030","key":"key20231010100600_b46-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.3390\/nu10081030","article-title":"Osteoarthritis and the Mediterranean Diet: A systematic review","volume":"10","author":"Morales-Ivorra","year":"2018","journal-title":"Nutrients"},{"key":"key20231010100600_b47-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1136\/aim.25.4.175","article-title":"Analgesic effects of indirect moxibustion on an experimental rat model of osteoarthritis in the knee","volume":"25","author":"Uryu","year":"2007","journal-title":"Acupunct Med"},{"key":"key20231010100600_b48-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1439-0442.2004.00682.x","article-title":"Histopathological evaluation of treatment with chondroitin sulphate for osteoarthritis induced by continuous immobilization in rabbits","volume":"52","author":"Torelli","year":"2005","journal-title":"J Vet Med A Physiol Pathol Clin Med"},{"issue":"674","key":"key20231010100600_b49-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030674","article-title":"Therapeutics in osteoarthritis based on an understanding of its molecular pathogenesis","volume":"19","author":"Kim","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"561459","key":"key20231010100600_b50-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/561459","article-title":"The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis","volume":"2014","author":"Wojdasiewicz","year":"2014","journal-title":"Mediators Inflamm"},{"key":"key20231010100600_b51-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.joca.2013.10.012","article-title":"Oral and topical boswellic acid attenuates mouse osteoarthritis","volume":"22","author":"Wang","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"key20231010100600_b52-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3109\/03008207.2011.628059","article-title":"Immunohistochemical analysis of the effects of estrogen on intraarticular neurogenic inflammation in a rat anterior cruciate ligament transection model of osteoarthritis","volume":"53","author":"Yoshida","year":"2012","journal-title":"Connect Tissue Res"},{"key":"key20231010100600_b53-ETM-26-4-12180","first-page":"S268","article-title":"Free radicals in primary knee osteoarthritis","volume":"92 (Suppl 6)","author":"Sutipornpalangkul","year":"2009","journal-title":"J Med Assoc Thai"},{"key":"key20231010100600_b54-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.matbio.2018.05.008","article-title":"Osteoarthritis as a disease of the cartilage pericellular matrix","volume":"71-72","author":"Guilak","year":"2018","journal-title":"Matrix Biol"},{"key":"key20231010100600_b55-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/art.20740","article-title":"Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints","volume":"52","author":"Aurich","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"56","key":"key20231010100600_b56-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01330-w","article-title":"Osteoarthritis: Pathogenic signaling pathways and therapeutic targets","volume":"8","author":"Yao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"key20231010100600_b57-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1073\/pnas.0806062106","article-title":"Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis","volume":"106","author":"Taniguchi","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20231010100600_b58-ETM-26-4-12180","first-page":"147","article-title":"Apoptosis in osteoarthritis: Morphology, mechanisms, and potential means for therapeutic intervention","volume":"17","author":"Johnson","year":"2008","journal-title":"J Surg Orthop Adv"},{"key":"key20231010100600_b59-ETM-26-4-12180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1016-8478(23)17544-3","article-title":"Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models","volume":"25","author":"Kawaguchi","year":"2008","journal-title":"Mol Cells"},{"key":"key20231010100600_b60-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"3094","DOI":"10.1073\/pnas.95.6.3094","article-title":"Chondrocyte-derived apoptotic bodies and calcification of articular cartilage","volume":"95","author":"Hashimoto","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1001212","key":"key20231010100600_b61-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1001212","article-title":"The role of oxidative stress in the development of knee osteoarthritis: A comprehensive research review","volume":"9","author":"Liu","year":"2022","journal-title":"Front Mol Biosci"},{"key":"key20231010100600_b62-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/cdd.2011.111","article-title":"Hypoxia-inducible factor-2\u03b1 regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction","volume":"19","author":"Ryu","year":"2012","journal-title":"Cell Death Differ"},{"key":"key20231010100600_b63-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11010-015-2420-4","article-title":"MiR-34a promotes Fas-mediated cartilage endplate chondrocyte apoptosis by targeting Bcl-2","volume":"406","author":"Chen","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"key20231010100600_b64-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH746>3.0.CO;2-K","article-title":"Apoptosis in rheumatoid arthritis-expression of Fas, Fas-L, p53, and Bcl-2 in rheumatoid synovial tissues","volume":"193","author":"Chou","year":"2001","journal-title":"J Pathol"},{"key":"key20231010100600_b65-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/jcb.10611","article-title":"Regulation of nitric oxide and bcl-2 expression by shear stress in human osteoarthritic chondrocytes in vitro","volume":"90","author":"Lee","year":"2003","journal-title":"J Cell Biochem"},{"key":"key20231010100600_b66-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/jcmm.13322","article-title":"Rosmarinic acid down-regulates NO and PGE2 expression via MAPK pathway in rat chondrocytes","volume":"22","author":"Chen","year":"2018","journal-title":"J Cell Mol Med"},{"key":"key20231010100600_b67-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","article-title":"Osteoarthritis: An update with relevance for clinical practice","volume":"377","author":"Bijlsma","year":"2011","journal-title":"Lancet"},{"issue":"251","key":"key20231010100600_b68-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020251","article-title":"Osteoarthritic subchondral bone release exosomes that promote cartilage degeneration","volume":"10","author":"Wu","year":"2021","journal-title":"Cells"},{"key":"key20231010100600_b69-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/ncprheum0505","article-title":"Bone, not cartilage, should be the major focus in osteoarthritis","volume":"3","author":"Mansell","year":"2007","journal-title":"Nat Clin Pract Rheumatol"},{"issue":"6694","key":"key20231010100600_b70-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-10600-6","article-title":"Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints","volume":"12","author":"Ajami","year":"2022","journal-title":"Sci Rep"},{"key":"key20231010100600_b71-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1002\/acr.22693","article-title":"Prognosis of pain and physical functioning in patients with knee osteoarthritis: A systematic review and meta-analysis","volume":"68","author":"de Rooij","year":"2016","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"key20231010100600_b72-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s15006-018-0023-1","article-title":"Knee pain-symptoms, diagnosis and therapy of osteoarthritis","volume":"160","author":"Emmert","year":"2018","journal-title":"MMW Fortschr Med"},{"key":"key20231010100600_b73-ETM-26-4-12180","first-page":"49","article-title":"Osteoarthritis: Diagnosis and treatment","volume":"85","author":"Sinusas","year":"2012","journal-title":"Am Fam Physician"},{"key":"key20231010100600_b74-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/acr.24131","article-title":"2019 American college of Rheumatology\/Arthritis foundation guideline for the management of osteoarthritis of the hand, hip, and knee","volume":"72","author":"Kolasinski","year":"2020","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"key20231010100600_b75-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1136\/ard.2008.087775","article-title":"The synovitis of \u2018Non-Inflammatory\u2019 orthopaedic arthropathies: A quantitative histological and immunohistochemical analysis","volume":"67","author":"Pessler","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"key20231010100600_b76-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.joca.2010.05.017","article-title":"Changes of human menisci in osteoarthritic knee joints","volume":"18","author":"Katsuragawa","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"key20231010100600_b77-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.gaitpost.2011.02.006","article-title":"Torsion deformity and joint loading for medial knee osteoarthritis","volume":"33","author":"Krackow","year":"2011","journal-title":"Gait Posture"},{"issue":"736","key":"key20231010100600_b78-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.8478","article-title":"I have arthritis of the knees: What Should I Do?","volume":"179","author":"Incze","year":"2019","journal-title":"JAMA Intern Med"},{"issue":"23094990211049587","key":"key20231010100600_b79-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1177\/23094990211049587","article-title":"West Lake staging: A new staging system orchestrated by X-ray and MRI on knee osteoarthritis","volume":"29","author":"Huang","year":"2021","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"key20231010100600_b80-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.rcl.2022.03.004","article-title":"Imaging of osteoarthritis of the knee","volume":"60","author":"Sukerkar","year":"2022","journal-title":"Radiol Clin North Am"},{"key":"key20231010100600_b81-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1177\/1947603519855776","article-title":"The value of SPECT\/CT for knee osteoarthritis: A systematic review","volume":"12","author":"Zarringam","year":"2021","journal-title":"Cartilage"},{"key":"key20231010100600_b82-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"S861","DOI":"10.1007\/s00198-012-2169-5","article-title":"CT imaging for the investigation of subchondral bone in knee osteoarthritis","volume":"23 (Suppl 8)","author":"Bousson","year":"2012","journal-title":"Osteoporos Int"},{"key":"key20231010100600_b83-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/s1063-4584(96)80016-1","article-title":"Cartilage swelling and loss in a spontaneous model of osteoarthritis visualized by magnetic resonance imaging","volume":"4","author":"Watson","year":"1996","journal-title":"Osteoarthritis Cartilage"},{"issue":"198","key":"key20231010100600_b84-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-198","article-title":"Semiquantitative assessment of subchondral bone marrow edema-like lesions and subchondral cysts of the knee at 3T MRI: A comparison between intermediate-weighted fat-suppressed spin echo and Dual Echo Steady State sequences","volume":"12","author":"Hayashi","year":"2011","journal-title":"BMC Musculoskelet Disord"},{"key":"key20231010100600_b85-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"76","DOI":"10.22203\/ecm.v013a08","article-title":"Quantitative magnetic resonance imaging of articular cartilage in osteoarthritis","volume":"13","author":"Blumenkrantz","year":"2007","journal-title":"Eur Cell Mater"},{"key":"key20231010100600_b86-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1055\/s-2004-861764","article-title":"Cartilage MRI T2 relaxation time mapping: Overview and applications","volume":"8","author":"Mosher","year":"2004","journal-title":"Semin Musculoskelet Radiol"},{"key":"key20231010100600_b87-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.joca.2006.06.002","article-title":"T(2) relaxation time mapping reveals age- and species-related diversity of collagen network architecture in articular cartilage","volume":"14","author":"Nissi","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"key20231010100600_b88-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1148\/radiology.205.2.9356643","article-title":"Spatial variation of T2 in human articular cartilage","volume":"205","author":"Dardzinski","year":"1997","journal-title":"Radiology"},{"key":"key20231010100600_b89-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1136\/annrheumdis-2013-204157","article-title":"Early T2 changes predict onset of radiographic knee osteoarthritis: Data from the osteoarthritis initiative","volume":"74","author":"Liebl","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"key20231010100600_b90-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.berh.2005.08.003","article-title":"Is MRI useful in osteoarthritis?","volume":"20","author":"Conaghan","year":"2006","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"2584291","key":"key20231010100600_b91-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2584291","article-title":"Back propagation neural network-based ultrasound image for diagnosis of cartilage lesions in knee osteoarthritis","volume":"2021","author":"Zhao","year":"2021","journal-title":"J Healthc Eng"},{"key":"key20231010100600_b92-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1136\/ard.51.8.938","article-title":"Scintigraphic assessment of osteoarthritis of the knee joint","volume":"51","author":"McCrae","year":"1992","journal-title":"Ann Rheum Dis"},{"key":"key20231010100600_b93-ETM-26-4-12180","first-page":"697","article-title":"Cross-sectional association of 10 molecular markers of bone, cartilage, and synovium with disease activity and radiological joint damage in patients with hip osteoarthritis: The ECHODIAH cohort","volume":"32","author":"Garnero","year":"2005","journal-title":"J Rheumatol"},{"key":"key20231010100600_b94-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1093\/rheumatology\/32.4.274","article-title":"Insulin-like growth factor-1: A prognostic factor of knee osteoarthritis","volume":"32","author":"Schouten","year":"1993","journal-title":"Br J Rheumatol"},{"key":"key20231010100600_b95-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1002\/art.1780371211","article-title":"Serum levels of collagenase, stromelysin-1, and TIMP-1. Age- and sex-related differences in normal subjects and relationship to the extent of joint involvement and serum levels of antigenic keratan sulfate in patients with osteoarthritis","volume":"37","author":"Manicourt","year":"1994","journal-title":"Arthritis Rheum"},{"key":"key20231010100600_b96-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1136\/ard.2004.028886","article-title":"EULAR evidence based recommendations for the management of hip osteoarthritis: Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)","volume":"64","author":"Zhang","year":"2005","journal-title":"Ann Rheum Dis"},{"issue":"794062","key":"key20231010100600_b97-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.794062","article-title":"Benefits and mechanisms of exercise training for knee osteoarthritis","volume":"12","author":"Zeng","year":"2021","journal-title":"Front Physiol"},{"key":"key20231010100600_b98-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/BOR.0000000000000478","article-title":"Exercise in the management of knee and hip osteoarthritis","volume":"30","author":"Wellsandt","year":"2018","journal-title":"Curr Opin Rheumatol"},{"key":"key20231010100600_b99-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1177\/0269215515610039","article-title":"The effects of resistance exercise in patients with knee osteoarthritis: A systematic review and meta-analysis","volume":"30","author":"Li","year":"2016","journal-title":"Clin Rehabil"},{"key":"key20231010100600_b100-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1756-185X.2011.01612.x","article-title":"Physiotherapy management of knee osteoarthritis","volume":"14","author":"Page","year":"2011","journal-title":"Int J Rheum Dis"},{"key":"key20231010100600_b101-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/msc.1492","article-title":"A clinical practice guideline for physical therapy in patients with hip or knee osteoarthritis","volume":"18","author":"van Doormaal","year":"2020","journal-title":"Musculoskeletal Care"},{"key":"key20231010100600_b102-ETM-26-4-12180","first-page":"268","article-title":"Physiotherapy in hip and knee osteoarthritis: Development of a practice guideline concerning initial assessment, treatment and evaluation","volume":"36","author":"Peter","year":"2011","journal-title":"Acta Reumatol Port"},{"key":"key20231010100600_b103-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1136\/annrheumdis-2018-213826","article-title":"2018 update of the EULAR recommendations for the management of hand osteoarthritis","volume":"78","author":"Kloppenburg","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"key20231010100600_b104-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1136\/annrheumdis-2018-213585","article-title":"2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis","volume":"77","author":"Rausch Osthoff","year":"2018","journal-title":"Ann Rheum Dis"},{"issue":"e000734","key":"key20231010100600_b105-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2018-000734","article-title":"Efficacy and safety of non-pharmacological, pharmacological and surgical treatment for hand osteoarthritis: A systematic literature review informing the 2018 update of the EULAR recommendations for the management of hand osteoarthritis","volume":"4","author":"Kroon","year":"2018","journal-title":"RMD Open"},{"key":"key20231010100600_b106-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/s11655-010-0512-2","article-title":"Progress on integrated Chinese and Western medicine in the treatment of osteoarthritis","volume":"16","author":"Wang","year":"2010","journal-title":"Chin J Integr Med"},{"issue":"e21877","key":"key20231010100600_b107-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021877","article-title":"Chinese herbal medicine Yanghe decoction for knee osteoarthritis: A protocol for systematic review and meta-analysis","volume":"99","author":"Xu","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"109708","key":"key20231010100600_b108-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109708","article-title":"Jiawei Yanghe decoction ameliorates cartilage degradation in vitro and vivo via Wnt\/\u03b2-catenin signaling pathway","volume":"122","author":"Xia","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"key20231010100600_b109-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1053\/berh.2001.0175","article-title":"Pharmacological therapy of osteoarthritis","volume":"15","author":"Hochberg","year":"2001","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"key20231010100600_b110-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.semarthrit.2013.11.012","article-title":"A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.S. bone and joint initiative","volume":"43","author":"Nelson","year":"2014","journal-title":"Semin Arthritis Rheum"},{"issue":"114147","key":"key20231010100600_b111-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114147","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective","volume":"180","author":"Bindu","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"key20231010100600_b112-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"52","DOI":"10.2174\/187152312803476255","article-title":"Clinical pharmacology of non-steroidal anti-inflammatory drugs: A review","volume":"11","author":"Bacchi","year":"2012","journal-title":"Antiinflamm Antiallergy Agents Med Chem"},{"key":"key20231010100600_b113-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"4S","DOI":"10.1016\/s0002-9343(00)00627-6","article-title":"Nonsteroidal anti-inflammatory drug prescribing: Past, present, and future","volume":"110 (Suppl)","author":"Jones","year":"2001","journal-title":"Am J Med"},{"issue":"CD009865","key":"key20231010100600_b114-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009865.pub2","article-title":"Celecoxib for osteoarthritis","volume":"5","author":"Puljak","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"key20231010100600_b115-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.joca.2005.02.004","article-title":"Selective COX-2 inhibition is favorable to human early and late-stage osteoarthritic cartilage: A human in vitro study","volume":"13","author":"Mastbergen","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"key20231010100600_b116-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1056\/NEJMoa050405","article-title":"Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention","volume":"352","author":"Solomon","year":"2005","journal-title":"N Engl J Med"},{"issue":"422","key":"key20231010100600_b117-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-03891-6","article-title":"Clinical examination, ultrasound assessment and aspiration of knee effusion in primary knee osteoarthritis patients","volume":"18","author":"Elsawy","year":"2023","journal-title":"J Orthop Surg Res"},{"key":"key20231010100600_b118-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.joca.2015.12.010","article-title":"Changes in ultrasound assessed markers of inflammation following intra-articular steroid injection combined with exercise in knee osteoarthritis: Exploratory outcome from a randomized trial","volume":"24","author":"Henricsdotter","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"key20231010100600_b119-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"424","DOI":"10.12200\/j.issn.1003-0034.2021.05.006","article-title":"Intra-articular injection of compound betamethasone and hyaluronic acid for the treatment of moderate-severe knee osteoarthritis: A randomized controlled trial","volume":"34","author":"Wang","year":"2021","journal-title":"Zhongguo Gu Shang"},{"key":"key20231010100600_b120-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1056\/NEJMoa1905877","article-title":"Physical therapy versus glucocorticoid injection for osteoarthritis of the knee","volume":"382","author":"Deyle","year":"2020","journal-title":"N Engl J Med"},{"issue":"6","key":"key20231010100600_b121-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06993-4","article-title":"Efficacy and safety of GLucocorticoid injections into InfrapaTellar faT pad in patients with knee ostEoarthRitiS: Protocol for the GLITTERS randomized controlled trial","volume":"24","author":"Zhang","year":"2023","journal-title":"Trials"},{"issue":"812","key":"key20231010100600_b122-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-022-05767-y","article-title":"Effect of hyaluronic acid on cytokines and immune cells change in patients of knee osteoarthritis","volume":"23","author":"Jin","year":"2022","journal-title":"BMC Musculoskelet Disord"},{"key":"key20231010100600_b123-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1007\/s00296-019-04290-z","article-title":"Modifiable risk factors in knee osteoarthritis: Treatment implications","volume":"39","author":"Georgiev","year":"2019","journal-title":"Rheumatol Int"},{"issue":"6078","key":"key20231010100600_b124-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076078","article-title":"Comparative efficacy of intra-articular injection, physical therapy, and combined treatments on pain, function, and sarcopenia indices in knee osteoarthritis: A network meta-analysis of randomized controlled trials","volume":"24","author":"Liao","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"204","key":"key20231010100600_b125-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1186\/ar4493","article-title":"Biology of platelet-rich plasma and its clinical application in cartilage repair","volume":"16","author":"Xie","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"key20231010100600_b126-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s00167-016-4110-5","article-title":"Choice of intra-articular injection in treatment of knee osteoarthritis: Platelet-rich plasma, hyaluronic acid or ozone options","volume":"25","author":"Duymus","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"100165","key":"key20231010100600_b127-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocarto.2021.100165","article-title":"Current use of analgesics and the risk of falls in people with knee osteoarthritis: A population-based cohort study using primary care and hospital records","volume":"3","author":"Taqi","year":"2021","journal-title":"Osteoarthr Cartil Open"},{"key":"key20231010100600_b128-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ejphar.2013.10.053","article-title":"Mechanisms and clinical uses of capsaicin","volume":"720","author":"Sharma","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"key20231010100600_b129-ETM-26-4-12180","first-page":"942","article-title":"Comparative study between three analgesic agents for the pain management during extracorporeal shock wave lithotripsy","volume":"10","author":"Liu","year":"2013","journal-title":"Urol J"},{"issue":"1015941","key":"key20231010100600_b130-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1015941","article-title":"Safety and efficacy of compound methyl salicylate liniment for topical pain: A multicenter real-world study in China","volume":"13","author":"Guo","year":"2022","journal-title":"Front Pharmacol"},{"issue":"e12","key":"key20231010100600_b131-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203546","article-title":"Response to comments in: Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study by Clockaerts et al","volume":"72","author":"Riddle","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"62","key":"key20231010100600_b132-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-62","article-title":"Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytes","volume":"11","author":"Sondergaard","year":"2010","journal-title":"BMC Musculoskelet Disord"},{"key":"key20231010100600_b133-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.3346\/jkms.2012.27.11.1405","article-title":"Inhalation therapy of calcitonin relieves osteoarthritis of the knee","volume":"27","author":"Armagan","year":"2012","journal-title":"J Korean Med Sci"},{"key":"key20231010100600_b134-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0361-9230(95)02037-3","article-title":"Biphasic changes in behavioral, endocrine, and sympathetic systems in adjuvant arthritis in Lewis rats","volume":"39","author":"Tanaka","year":"1996","journal-title":"Brain Res Bull"},{"key":"key20231010100600_b135-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1136\/ard.2009.120469","article-title":"Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT","volume":"69","author":"Sawitzke","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"key20231010100600_b136-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1136\/ard.2003.011742","article-title":"EULAR Recommendations 2003: An evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)","volume":"62","author":"Jordan","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"key20231010100600_b137-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s10719-016-9665-3","article-title":"Chondroitin sulphate: A focus on osteoarthritis","volume":"33","author":"Bishnoi","year":"2016","journal-title":"Glycoconj J"},{"key":"key20231010100600_b138-ETM-26-4-12180","author":"Fidelix"},{"key":"key20231010100600_b139-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0140-6736(00)03610-2","article-title":"Long-term effects of glucosamine sulphate on osteoarthritis progression: A randomised, placebo-controlled clinical trial","volume":"357","author":"Reginster","year":"2001","journal-title":"Lancet"},{"key":"key20231010100600_b140-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: A disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum"},{"key":"key20231010100600_b141-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s000110050742","article-title":"Effects of tetracyclines on the production of matrix metalloproteinases and plasminogen activators as well as of their natural inhibitors, tissue inhibitor of metalloproteinases-1 and plasminogen activator inhibitor-1","volume":"50","author":"Sadowski","year":"2001","journal-title":"Inflamm Res"},{"key":"key20231010100600_b142-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.bcp.2019.02.033","article-title":"Inhibition of MMPs and ADAM\/ADAMTS","volume":"165","author":"Malemud","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"key20231010100600_b143-ETM-26-4-12180","first-page":"32","article-title":"Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis","volume":"16","author":"Rosenbaum","year":"2010","journal-title":"Altern Ther Health Med"},{"issue":"121437","key":"key20231010100600_b144-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121437","article-title":"Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy","volume":"283","author":"Gui","year":"2022","journal-title":"Biomaterials"},{"issue":"1607","key":"key20231010100600_b145-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.3390\/nu14081607","article-title":"A Meta-analysis of the impact of nutritional supplementation on osteoarthritis symptoms","volume":"14","author":"Mathieu","year":"2022","journal-title":"Nutrients"},{"key":"key20231010100600_b146-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/j.bioactmat.2020.10.016","article-title":"Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice","volume":"6","author":"Yao","year":"2021","journal-title":"Bioact Mater"},{"key":"key20231010100600_b147-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.7860\/JCDR\/2013\/5802.3333","article-title":"Oxidative stress, vitamin e, and antioxidant capacity in knee osteoarthritis","volume":"7","author":"Suantawee","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"key20231010100600_b148-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1177\/1759720X11424458","article-title":"Efficacy of vitamin E in knee osteoarthritis management of North Indian geriatric population","volume":"4","author":"Bhattacharya","year":"2012","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"key20231010100600_b149-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.joca.2006.03.014","article-title":"Calcitonin is involved in cartilage homeostasis: Is calcitonin a treatment for OA?","volume":"14","author":"Karsdal","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"key20231010100600_b150-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1002\/jcb.30309","article-title":"Therapeutic effects of statins on osteoarthritis: A review","volume":"123","author":"Saberianpour","year":"2022","journal-title":"J Cell Biochem"},{"key":"key20231010100600_b151-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/s0195-5616(97)50087-8","article-title":"Surgical treatment of osteoarthritis","volume":"27","author":"Cook","year":"1997","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"key20231010100600_b152-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/s00167-011-1780-x","article-title":"Surgical treatment for early osteoarthritis. Part I: Cartilage repair procedures","volume":"20","author":"Gomoll","year":"2012","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"key20231010100600_b153-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/JSA.0b013e318270d1bd","article-title":"Treatment of OA of the knee in the middle-aged athlete: The role of arthroscopy","volume":"21","author":"Krych","year":"2013","journal-title":"Sports Med Arthrosc Rev"},{"key":"key20231010100600_b154-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/j.arthro.2020.04.001","article-title":"Editorial commentary: Cartilage restoration-what is currently available?","volume":"36","author":"Gobbi","year":"2020","journal-title":"Arthroscopy"},{"key":"key20231010100600_b155-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"129","DOI":"10.4055\/cios.2017.9.2.129","article-title":"Rotational acetabular osteotomy","volume":"9","author":"Yasunaga","year":"2017","journal-title":"Clin Orthop Surg"},{"key":"key20231010100600_b156-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"701","DOI":"10.2214\/AJR.21.26659","article-title":"High Tibial osteotomy: An update for radiologists","volume":"218","author":"Li","year":"2022","journal-title":"AJR Am J Roentgenol"},{"key":"key20231010100600_b157-ETM-26-4-12180","first-page":"4771","article-title":"An implementation study of periarticular knee osteotomy in the treatment of knee osteoarthritis","volume":"13","author":"Han","year":"2021","journal-title":"Am J Transl Res"},{"issue":"3717","key":"key20231010100600_b158-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113817","article-title":"Effects of Sarcopenic obesity and its confounders on knee range of motion outcome after total knee replacement in older adults with knee osteoarthritis: A retrospective study","volume":"13","author":"Liao","year":"2021","journal-title":"Nutrients"},{"issue":"e10828","key":"key20231010100600_b159-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010828","article-title":"Function scores of different surgeries in the treatment of knee osteoarthritis: A PRISMA-compliant systematic review and network-meta analysis","volume":"97","author":"Liu","year":"2018","journal-title":"Medicine (Baltimore)"},{"issue":"258","key":"key20231010100600_b160-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-022-03142-0","article-title":"The effects of total knee arthroplasty on knee proprioception of patients with knee osteoarthritis: A meta-analysis","volume":"17","author":"Xue","year":"2022","journal-title":"J Orthop Surg Res"},{"issue":"56","key":"key20231010100600_b161-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01601-z","article-title":"Progress in the treatment of knee osteoarthritis with high Tibial osteotomy: A systematic review","volume":"10","author":"He","year":"2021","journal-title":"Syst Rev"},{"issue":"425","key":"key20231010100600_b162-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-016-1286-2","article-title":"Identification of clinical phenotypes in knee osteoarthritis: A systematic review of the literature","volume":"17","author":"Dell'Isola","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"key20231010100600_b163-ETM-26-4-12180","doi-asserted-by":"publisher","first-page":"835","DOI":"10.3892\/etm.2014.1516","article-title":"Needle-knife therapy improves the clinical symptoms of knee osteoarthritis by inhibiting the expression of inflammatory cytokines","volume":"7","author":"Lin","year":"2014","journal-title":"Exp Ther Med"},{"key":"key20231010100600_b164-ETM-26-4-12180","author":"Du"},{"key":"key20231010100600_b165-ETM-26-4-12180","author":"Dai"},{"issue":"1949","key":"key20231010100600_b166-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15071949","article-title":"Fabrication of injectable Kartogenin-conjugated composite hydrogel with a sustained drug release for cartilage repair","volume":"15","author":"Li","year":"2023","journal-title":"Pharmaceutics"},{"key":"key20231010100600_b167-ETM-26-4-12180","author":"Deng"},{"key":"key20231010100600_b168-ETM-26-4-12180","author":"Liu"},{"issue":"12282","key":"key20231010100600_b169-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512282","article-title":"Polynucleotides suppress inflammation and stimulate matrix synthesis in an in vitro Cell-based osteoarthritis model","volume":"24","author":"Kuppa","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"110726","key":"key20231010100600_b170-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110726","article-title":"An in vitro and in vivo study: Valencene protects cartilage and alleviates the progression of osteoarthritis by anti-oxidative stress and anti-inflammatory effects","volume":"123","author":"Chen","year":"2023","journal-title":"Int Immunopharmacol"},{"issue":"258","key":"key20231010100600_b171-ETM-26-4-12180","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02036-5","article-title":"Conversion of senescent cartilage into a pro-chondrogenic microenvironment with antibody-functionalized copper sulfate nanoparticles for efficient osteoarthritis therapy","volume":"21","author":"Wang","year":"2023","journal-title":"J Nanobiotechnology"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T17:36:59Z","timestamp":1729964219000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2023.12180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,25]]},"references-count":171,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,8,25]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2023.12180","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,25]]},"article-number":"481"}}