{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:18:49Z","timestamp":1773127129938,"version":"3.50.1"},"reference-count":21,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2023.12237","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T12:24:10Z","timestamp":1696249450000},"source":"Crossref","is-referenced-by-count":9,"title":["Trehalose delays postmenopausal osteoporosis by enhancing AKT\/TFEB pathway\u2011dependent autophagy flow in rats"],"prefix":"10.3892","volume":"26","author":[{"given":"Yongli","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Huzhou Central Hospital, Huzhou Basic and Clinical Translation of Orthopedics Key Laboratory, Huzhou, Zhejiang 313300, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingcun","family":"Li","sequence":"additional","affiliation":[{"name":"Public Health Section, Huzhou Central Hospital, Huzhou Basic and Clinical Translation of Orthopedics Key Laboratory, Huzhou, Zhejiang 313300, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Huzhou Central Hospital, Huzhou Basic and Clinical Translation of Orthopedics Key Laboratory, Huzhou, Zhejiang 313300, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Huzhou Central Hospital, Huzhou Basic and Clinical Translation of Orthopedics Key Laboratory, Huzhou, Zhejiang 313300, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"key20231026123253_b1-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ecl.2021.03.009","article-title":"Postmenopausal osteoporosis: Latest guidelines","volume":"50","author":"Arceo-Mendoza","year":"2021","journal-title":"Endocrinol Metab Clin North Am"},{"key":"key20231026123253_b2-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.mcna.2022.10.013","article-title":"Osteoporosis","volume":"107","author":"Gopinath","year":"2023","journal-title":"Med Clin North Am"},{"key":"key20231026123253_b3-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"182","DOI":"10.7326\/M22-0684","article-title":"Effectiveness and safety of treatments to prevent fractures in people with low bone mass or primary osteoporosis: A living systematic review and network meta-analysis for the American college of physicians","volume":"176","author":"Ayers","year":"2023","journal-title":"Ann Intern Med"},{"issue":"e1003180","key":"key20231026123253_b4-ETM-26-5-12237","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003180","article-title":"Incidence of and trends in hip fracture among adults in urban China: A nationwide retrospective cohort study","volume":"17","author":"Zhang","year":"2020","journal-title":"PLoS Med"},{"key":"key20231026123253_b5-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.cell.2014.11.006","article-title":"Metabolic control of autophagy","volume":"159","author":"Galluzzi","year":"2014","journal-title":"Cell"},{"issue":"140","key":"key20231026123253_b6-ETM-26-5-12237","doi-asserted-by":"publisher","DOI":"10.1186\/scrt530","article-title":"Human mesenchymal stem cells\/multipotent stromal cells consume accumulated autophagosomes early in differentiation","volume":"5","author":"Nuschke","year":"2014","journal-title":"Stem Cell Res Ther"},{"key":"key20231026123253_b7-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"12913","DOI":"10.1073\/pnas.0913058107","article-title":"Neighbor of Brcal gene (Nbrl) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity","volume":"107","author":"Whitehouse","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20231026123253_b8-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1016\/j.celrep.2014.11.031","article-title":"p62 is required for stem cell\/progenitor retention through inhibition of IKK\/NF-kappaB\/Cc14 signaling at the bone marrow macrophage-osteoblast niche","volume":"9","author":"Chang","year":"2014","journal-title":"Cell Rep"},{"key":"key20231026123253_b9-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1007\/s12035-015-9173-7","article-title":"Treatment with trehalose prevents behavioral and neurochemical deficits produced in an AAV \u03b1-Synuclein rat model of Parkinson's disease","volume":"53","author":"He","year":"2016","journal-title":"Mol Neurobiol"},{"key":"key20231026123253_b10-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1021\/acschemneuro.1c00144","article-title":"Neuroprotective effects of trehalose and sodium butyrate on preformed fibrillar form of \u03b1-synuclein-induced rat model of Parkinson's disease","volume":"12","author":"Kakoty","year":"2021","journal-title":"ACS Chem Neurosci"},{"key":"key20231026123253_b11-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1007\/s12035-015-9173-7","article-title":"Treatment with trehalose prevents behavioral and neurochemical deficits produced in an AAV \u03b1-synuclein rat model of Parkinson's disease","volume":"53","author":"Qing","year":"2016","journal-title":"Mol Neurobiol"},{"key":"key20231026123253_b12-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nature21388","article-title":"Autophagy maintains the metabolism and function of young and old stem cells","volume":"543","author":"Ho","year":"2017","journal-title":"Nature"},{"key":"key20231026123253_b13-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"9280","DOI":"10.7150\/thno.46566","article-title":"TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress","volume":"10","author":"Zhou","year":"2020","journal-title":"Theranostics"},{"key":"key20231026123253_b14-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.humpath.2016.10.024","article-title":"Sclerosing TFEB rearrangement renal cell carcinoma: A recurring histologic pattern","volume":"62","author":"Williamson","year":"2016","journal-title":"Hum Pathol"},{"issue":"3153","key":"key20231026123253_b15-ETM-26-5-12237","doi-asserted-by":"publisher","DOI":"10.3390\/cells11193153","article-title":"TFEB; Beyond its role as an autophagy and lysosomes regulator","volume":"11","author":"Franco-Ju\u00e1rez","year":"2022","journal-title":"Cells"},{"issue":"333","key":"key20231026123253_b16-ETM-26-5-12237","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020333","article-title":"TFEB biology and agonists at a glance","volume":"10","author":"Chen","year":"2021","journal-title":"Cells"},{"key":"key20231026123253_b17-ETM-26-5-12237","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0271-5317(00)00155-X","article-title":"Disaccharide-trehalose inhibits bone resorption in ovariectomized mice","volume":"20","author":"Nishizaki","year":"2000","journal-title":"Nutr Res"},{"key":"key20231026123253_b18-ETM-26-5-12237","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0271-5317(00)80029-9","article-title":"Trehalose suppresses osteoclast differentiation in ovariectomized mice: Correlation with decreased in vitro interleukin-6 production by bone marrow cells","volume":"20","author":"Yoshizane","year":"2000","journal-title":"Nutr Res"},{"key":"key20231026123253_b19-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ejphar.2015.03.028","article-title":"Animal models for osteoporosis","volume":"759","author":"Komori","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"key20231026123253_b20-ETM-26-5-12237","doi-asserted-by":"publisher","first-page":"8402","DOI":"10.1096\/fj.201902528RRR","article-title":"Trehalose reduces bone loss in experimental biliary cirrhosis rats via ERK phosphorylation regulation by enhancing autophagosome formation","volume":"34","author":"Xu","year":"2020","journal-title":"FASEB J"},{"issue":"e202002085","key":"key20231026123253_b21-ETM-26-5-12237","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202002085","article-title":"Autophagosome biogenesis: From membrane growth to closure","volume":"219","author":"Melia","year":"2020","journal-title":"J Cell Biol"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T09:33:00Z","timestamp":1698312780000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2023.12237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,2]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,10,2]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2023.12237","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,2]]},"article-number":"538"}}