{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:46:54Z","timestamp":1774446414636,"version":"3.50.1"},"reference-count":28,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2023.12295","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T13:08:29Z","timestamp":1699621709000},"source":"Crossref","is-referenced-by-count":2,"title":["Butorphanol inhibits ferroptosis to attenuate PC12 cell injury by blocking JNK\/p38 signaling"],"prefix":"10.3892","volume":"27","author":[{"given":"Lulu","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"She","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibin","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"issue":"692286","key":"key20240115121015_b1-ETM-27-1-12295","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.692286","article-title":"Butorphanol promotes macrophage phenotypic transition to inhibit inflammatory lung injury via \u03ba receptors","volume":"12","author":"Luan","year":"2021","journal-title":"Front Immunol"},{"key":"key20240115121015_b2-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"82","DOI":"10.4103\/0259-1162.173612","article-title":"Postoperative pain relief with epidural buprenorphine versus epidural butorphanol in laparoscopic hysterectomies: A comparative study","volume":"10","author":"Jose","year":"2016","journal-title":"Anesth Essays Res"},{"key":"key20240115121015_b3-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.3892\/mmr.2020.11290","article-title":"Butorphanol protects PC12 cells against OGD\/R-induced inflammation and apoptosis","volume":"22","author":"Yang","year":"2020","journal-title":"Mol Med Rep"},{"key":"key20240115121015_b4-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"10973","DOI":"10.2147\/OTT.S244928","article-title":"Butorphanol inhibits the malignant biological behaviors of ovarian cancer cells via down-regulating the expression of TMEFF1","volume":"13","author":"Wang","year":"2020","journal-title":"Onco Targets Ther"},{"issue":"a028035","key":"key20240115121015_b5-ETM-27-1-12295","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028035","article-title":"Pathology of neurodegenerative diseases","volume":"9","author":"Dugger","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"88","key":"key20240115121015_b6-ETM-27-1-12295","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: Past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis"},{"issue":"8765","key":"key20240115121015_b7-ETM-27-1-12295","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228765","article-title":"Ferroptosis mechanisms involved in neurodegenerative diseases","volume":"21","author":"Reichert","year":"2020","journal-title":"Int J Mol Sci"},{"key":"key20240115121015_b8-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.3892\/ijmm.2015.2175","article-title":"Protective effects of semen crotonis pulveratum on trinitrobenzene sulphonic acid-induced colitis in rats and H2O2-induced intestinal cell apoptosis in vitro","volume":"35","author":"Wang","year":"2015","journal-title":"Int J Mol Med"},{"key":"key20240115121015_b9-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1007\/s10616-014-9823-z","article-title":"X\/XO or H2O2 induced IPEC-J2 cell as a new in vitro model for studying apoptosis in post-weaning piglets","volume":"68","author":"Cai","year":"2016","journal-title":"Cytotechnology"},{"key":"key20240115121015_b10-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1177\/1073858411404531","article-title":"H2O2: A dynamic neuromodulator","volume":"17","author":"Rice","year":"2011","journal-title":"Neuroscientist"},{"issue":"5624","key":"key20240115121015_b11-ETM-27-1-12295","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165624","article-title":"Involvement of p38 MAPK in synaptic function and dysfunction","volume":"21","author":"Falcicchia","year":"2020","journal-title":"Int J Mol Sci"},{"key":"key20240115121015_b12-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/aps.2016.160","article-title":"BX-795 inhibits HSV-1 and HSV-2 replication by blocking the JNK\/p38 pathways without interfering with PDK1 activity in host cells","volume":"38","author":"Su","year":"2017","journal-title":"Acta Pharmacol Sin"},{"key":"key20240115121015_b13-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/ni.3665","article-title":"A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging","volume":"18","author":"Lanna","year":"2017","journal-title":"Nat Immunol"},{"key":"key20240115121015_b14-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/1440-1681.12918","article-title":"PI3K\/AKT\/JNK\/p38 signalling pathway-mediated neural apoptosis in the prefrontal cortex of mice is involved in the antidepressant-like effect of pioglitazone","volume":"45","author":"Li","year":"2018","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"key20240115121015_b15-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.3892\/or.2016.4687","article-title":"Selective suppression of Notch1 inhibits proliferation of renal cell carcinoma cells through JNK\/p38 pathway","volume":"35","author":"Wu","year":"2016","journal-title":"Oncol Rep"},{"key":"key20240115121015_b16-ETM-27-1-12295","first-page":"730","article-title":"HMGB1 regulates erastin-induced ferroptosis via RAS-JNK\/p38 signaling in HL-60\/NRASQ61L cells","volume":"9","author":"Ye","year":"2019","journal-title":"Am J Cancer Res"},{"issue":"125179","key":"key20240115121015_b17-ETM-27-1-12295","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.125179","article-title":"Combined exposure of alumina nanoparticles and chronic stress exacerbates hippocampal neuronal ferroptosis via activating IFN-\u03b3\/ASK1\/JNK signaling pathway in rats","volume":"411","author":"Zhang","year":"2021","journal-title":"J Hazard Mater"},{"key":"key20240115121015_b18-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s10571-014-0089-y","article-title":"Investigating the protective effect of lithium against high glucose-induced neurotoxicity in PC12 cells: Involvements of ROS, JNK and P38 MAPKs, and apoptotic mitochondria pathway","volume":"34","author":"Aminzadeh","year":"2014","journal-title":"Cell Mol Neurobiol"},{"key":"key20240115121015_b19-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s00117-018-0363-y","article-title":"Neurodegenerative diseases","volume":"58","author":"Reith","year":"2018","journal-title":"Radiologe"},{"key":"key20240115121015_b20-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"S125","DOI":"10.3233\/JAD-132738","article-title":"Apoptosis and oxidative stress in neurodegenerative diseases","volume":"42 (Suppl 3)","author":"Radi","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"key20240115121015_b21-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/ca.23792","article-title":"Apoptosis and its therapeutic implications in neurodegenerative diseases","volume":"35","author":"Erekat","year":"2022","journal-title":"Clin Anat"},{"issue":"1583","key":"key20240115121015_b22-ETM-27-1-12295","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24081583","article-title":"Oxidative stress: A key modulator in neurodegenerative diseases","volume":"24","author":"Singh","year":"2019","journal-title":"Molecules"},{"issue":"574","key":"key20240115121015_b23-ETM-27-1-12295","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18935-1","article-title":"Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells","volume":"8","author":"Wu","year":"2018","journal-title":"Sci Rep"},{"key":"key20240115121015_b24-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1538\/expanim.14-0073","article-title":"Effect of midazolam and butorphanol premedication on inhalant isoflurane anesthesia in mice","volume":"64","author":"Tsukamoto","year":"2015","journal-title":"Exp Anim"},{"issue":"565","key":"key20240115121015_b25-ETM-27-1-12295","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9997","article-title":"Butylphthalide inhibits nerve cell apoptosis in cerebral infarction rats via the JNK\/p38 MAPK signaling pathway","volume":"21","author":"Bu","year":"2021","journal-title":"Exp Ther Med"},{"key":"key20240115121015_b26-ETM-27-1-12295","first-page":"1876","article-title":"Peroxiredoxin 1 inhibits lipopolysaccharide-induced oxidative stress in lung tissue by regulating P38\/JNK signaling pathway","volume":"21","author":"Lv","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"key20240115121015_b27-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mrfmmm.2010.12.017","article-title":"Icariin inhibits hydrogen peroxide-induced toxicity through inhibition of phosphorylation of JNK\/p38 MAPK and p53 activity","volume":"708","author":"Li","year":"2011","journal-title":"Mutat Res"},{"key":"key20240115121015_b28-ETM-27-1-12295","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.26355\/eurrev_201803_14601","article-title":"Butorphanol attenuates myocardial ischemia reperfusion injury through inhibiting mitochondria-mediated apoptosis in mice","volume":"22","author":"Huang","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T10:10:23Z","timestamp":1705313423000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2023.12295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,10]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,11,10]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2023.12295","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,10]]},"article-number":"8"}}