{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:23:24Z","timestamp":1774578204400,"version":"3.50.1"},"reference-count":31,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2024.12557","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T11:38:17Z","timestamp":1714390697000},"source":"Crossref","is-referenced-by-count":3,"title":["Changes in the intestinal microbiota of multiple myeloma patients living in high\u2011altitude and cold regions analyzed using 16s rRNA high\u2011throughput sequencing"],"prefix":"10.3892","volume":"27","author":[{"given":"Xiaofei","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuyang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huixin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Qiqihar MingZhu Hospital, Qiqihar, Heilongjiang 161000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Kou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haipeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"key20240520085319_b1-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/S0140-6736(21)00135-5","article-title":"Multiple myeloma","volume":"397","author":"van de Donk","year":"2021","journal-title":"Lancet"},{"key":"key20240520085319_b2-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/nrc.2017.63","article-title":"Evolutionary biology of high-risk multiple myeloma","volume":"17","author":"Pawlyn","year":"2017","journal-title":"Nat Rev Cancer"},{"key":"key20240520085319_b3-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1001\/jamaoncol.2018.2128","article-title":"Global Burden of multiple myeloma","volume":"4","author":"Cowan","year":"2018","journal-title":"JAMA Oncol"},{"issue":"606","key":"key20240520085319_b4-ETM-27-6-12557","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08280-y","article-title":"Measuring the global, regional, and national burden of multiple myeloma from 1990 to 2019","volume":"21","author":"Zhou","year":"2021","journal-title":"BMC Cancer"},{"key":"key20240520085319_b5-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1016\/S1470-2045(20)30756-7","article-title":"Treatment of relapsed and refractory multiple myeloma: Recommendations from the international myeloma working group","volume":"22","author":"Moreau","year":"2021","journal-title":"Lancet Oncol"},{"key":"key20240520085319_b6-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1038\/leu.2015.356","article-title":"Management of relapsed multiple myeloma: Recommendations of the international myeloma working group","volume":"30","author":"Laubach","year":"2016","journal-title":"Leukemia"},{"key":"key20240520085319_b7-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nri.2016.42","article-title":"Gut microbiota, metabolites and host immunity","volume":"16","author":"Rooks","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"key20240520085319_b8-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","article-title":"An insight into gut microbiota and its functionalities","volume":"76","author":"Adak","year":"2019","journal-title":"Cell Mol Life Sci"},{"issue":"741376","key":"key20240520085319_b9-ETM-27-6-12557","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.741376","article-title":"The role of the gut microbiome in pathogenesis, biology, and treatment of plasma cell dyscrasias","volume":"11","author":"Jasi\u0144ski","year":"2021","journal-title":"Front Oncol"},{"key":"key20240520085319_b10-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1136\/gutjnl-2018-316723","article-title":"Human gut microbiome: Hopes, threats and promises","volume":"67","author":"Cani","year":"2018","journal-title":"Gut"},{"key":"key20240520085319_b11-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/cncr.33400","article-title":"Clinical effects and applications of the gut microbiome in hematologic malignancies","volume":"127","author":"D'Angelo","year":"2021","journal-title":"Cancer"},{"key":"key20240520085319_b12-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1084\/jem.20161590","article-title":"Antibody-secreting plasma cells persist for decades in human intestine","volume":"214","author":"Landsverk","year":"2017","journal-title":"J Exp Med"},{"key":"key20240520085319_b13-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/SPC.0000000000000266","article-title":"Proteasome inhibitor-induced gastrointestinal toxicity","volume":"11","author":"Stansborough","year":"2017","journal-title":"Curr Opin Support Palliat Care"},{"key":"key20240520085319_b14-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1200\/JCO.2016.70.3348","article-title":"Intestinal microbiota and relapse after hematopoietic-cell transplantation","volume":"35","author":"Peled","year":"2017","journal-title":"J Clin Oncol"},{"key":"key20240520085319_b15-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/bjh.16205","article-title":"Pre- and post-serial metagenomic analysis of gut microbiota as a prognostic factor in patients undergoing haematopoietic stem cell transplantation","volume":"188","author":"Kusakabe","year":"2020","journal-title":"Br J Haematol"},{"key":"key20240520085319_b16-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1080\/10428194.2022.2131410","article-title":"Perturbation of the gut microbiome and association with outcomes following autologous stem cell transplantation in patients with multiple myeloma","volume":"64","author":"D'Angelo","year":"2023","journal-title":"Leuk Lymphoma"},{"key":"key20240520085319_b17-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International myeloma working group updated criteria for the diagnosis of multiple myeloma","volume":"15","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol"},{"key":"key20240520085319_b18-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/imr.13016","article-title":"Memory B cells and plasma cells: The differentiative continuum of humoral immunity","volume":"303","author":"Cancro","year":"2021","journal-title":"Immunol Rev"},{"key":"key20240520085319_b19-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.1111\/febs.16068","article-title":"The immunity-malignancy equilibrium in multiple myeloma: Lessons from oncogenic events in plasma cells","volume":"289","author":"Perini","year":"2022","journal-title":"FEBS J"},{"key":"key20240520085319_b20-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1159\/000500976","article-title":"The human microbiota in multiple myeloma and proteasome inhibitors","volume":"143","author":"Alkharabsheh","year":"2020","journal-title":"Acta Haematol"},{"key":"key20240520085319_b21-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nrclinonc.2017.197","article-title":"The bone-marrow niche in MDS and MGUS: Implications for AML and MM","volume":"15","author":"Ghobrial","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"key20240520085319_b22-ETM-27-6-12557","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1182\/blood-2019-130643","article-title":"Analysis of intestinal microbiome in multiple myeloma reveals progressive dysbiosis compared to MGUS and healthy individuals","volume":"134","author":"Pepeljugoski","year":"2019","journal-title":"Blood"},{"key":"key20240520085319_b23-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"8269","DOI":"10.12659\/MSM.919988","article-title":"Fecal microbiota taxonomic shifts in chinese multiple myeloma patients analyzed by quantitative polimerase chain reaction (QPCR) and 16S rRNA high-throughput sequencing","volume":"25","author":"Zhang","year":"2019","journal-title":"Med Sci Monit"},{"issue":"4832","key":"key20240520085319_b24-ETM-27-6-12557","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07305-8","article-title":"Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression","volume":"9","author":"Calcinotto","year":"2018","journal-title":"Nat Commun"},{"key":"key20240520085319_b25-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1080\/10428194.2018.1543883","article-title":"Is complement C1q a potential marker for tumor burden and immunodeficiency in multiple myeloma?","volume":"60","author":"Yang","year":"2019","journal-title":"Leukemia Lymphoma"},{"issue":"11795549221079171","key":"key20240520085319_b26-ETM-27-6-12557","doi-asserted-by":"publisher","DOI":"10.1177\/11795549221079171","article-title":"Complement 4 aids in the prediction of newly diagnosed multiple myeloma outcome in patients","volume":"16","author":"Zhang","year":"2022","journal-title":"Clin Med Insights Oncol"},{"issue":"69","key":"key20240520085319_b27-ETM-27-6-12557","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2023.230210","article-title":"Values of immunoglobulin and complements for evaluating treatment outcomes of patients with multiple myeloma","volume":"1","author":"Liu","year":"2023","journal-title":"Clin Lab Nov"},{"issue":"74","key":"key20240520085319_b28-ETM-27-6-12557","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00854-5","article-title":"Alterations of gut microbiome accelerate multiple myeloma progression by increasing the relative abundances of nitrogen-recycling bacteria","volume":"8","author":"Jian","year":"2020","journal-title":"Microbiome"},{"key":"key20240520085319_b29-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1182\/bloodadvances.2019032276","article-title":"Minimal residual disease negativity in multiple myeloma is associated with intestinal microbiota composition","volume":"3","author":"Pianko","year":"2019","journal-title":"Blood Adv"},{"key":"key20240520085319_b30-ETM-27-6-12557","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1016\/j.bbmt.2019.04.007","article-title":"Gastrointestinal microbiome and mycobiome changes during autologous transplantation for multiple myeloma: Results of a prospective pilot study","volume":"25","author":"El Jurdi","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"issue":"5313","key":"key20240520085319_b31-ETM-27-6-12557","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32960-3","article-title":"CAR-T cell therapy-related cytokine release syndrome and therapeutic response is modulated by the gut microbiome in hematologic malignancies","volume":"13","author":"Hu","year":"2022","journal-title":"Nat Commun"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T05:54:21Z","timestamp":1716184461000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2024.12557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,29]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,4,29]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2024.12557","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,29]]},"article-number":"269"}}