{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:27:59Z","timestamp":1779910079653,"version":"3.53.1"},"reference-count":45,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2024.12589","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T10:53:03Z","timestamp":1716547983000},"source":"Crossref","is-referenced-by-count":4,"title":["Impact of premorbid use of beta\u2011blockers on survival outcomes of patients with sepsis: A systematic review and meta\u2011analysis"],"prefix":"10.3892","volume":"28","author":[{"given":"Huan","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou, Zhejiang 313000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmin","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou, Zhejiang 313000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou, Zhejiang 313000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou, Zhejiang 313000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"key20240618110546_b1-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"key20240618110546_b2-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"90","DOI":"10.12669\/pjms.38.1.3992","article-title":"Risk factors and compliance of surviving sepsis campaign: A retrospective cohort study at tertiary care hospital","volume":"38","author":"Yousuf","year":"2022","journal-title":"Pak J Med Sci"},{"key":"key20240618110546_b3-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: Analysis for the global burden of disease study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"issue":"977094","key":"key20240618110546_b4-ETM-28-1-12589","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.977094","article-title":"Prevalence of sepsis among adults in China: A systematic review and meta-analysis","volume":"10","author":"Lei","year":"2022","journal-title":"Front public Health"},{"key":"key20240618110546_b5-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"668","DOI":"10.12669\/pjms.36.4.2031","article-title":"qSOFA score for prediction of sepsis outcome in emergency department","volume":"36","author":"Shahsavarinia","year":"2020","journal-title":"Pak J Med Sci"},{"issue":"1161","key":"key20240618110546_b6-ETM-28-1-12589","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10595","article-title":"Molecular mechanisms in septic shock (Review)","volume":"22","author":"Gorecki","year":"2021","journal-title":"Exp Ther Med"},{"key":"key20240618110546_b7-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.26355\/eurrev_202203_28244","article-title":"Using the lactate-to-albumin ratio to predict mortality in patients with sepsis or septic shock: A systematic review and meta-analysis","volume":"26","author":"Yoon","year":"2022","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"362","key":"key20240618110546_b8-ETM-28-1-12589","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11289","article-title":"Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock","volume":"23","author":"Feng","year":"2022","journal-title":"Exp Ther Med"},{"issue":"230","key":"key20240618110546_b9-ETM-28-1-12589","doi-asserted-by":"publisher","DOI":"10.1186\/cc8026","article-title":"Bench-to-bedside review: Beta-adrenergic modulation in sepsis","volume":"13","author":"de Montmollin","year":"2009","journal-title":"Crit Care"},{"key":"key20240618110546_b10-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/SHK.0000000000000879","article-title":"Non-hemodynamic effects of catecholamines","volume":"48","author":"Hartmann","year":"2017","journal-title":"Shock"},{"key":"key20240618110546_b11-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1177\/08850666211052926","article-title":"Effect of premorbid beta-blockers on mortality in patients with sepsis: A systematic review and meta-analysis","volume":"37","author":"Hasegawa","year":"2022","journal-title":"J Intensive Care Med"},{"key":"key20240618110546_b12-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/S0140-6736(07)61317-8","article-title":"Catecholamine treatment for shock-equally good or bad?","volume":"370","author":"Singer","year":"2007","journal-title":"Lancet"},{"issue":"22","key":"key20240618110546_b13-ETM-28-1-12589","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-017-0215-2","article-title":"Sepsis-induced cardiac dysfunction and \u03b2-adrenergic blockade therapy for sepsis","volume":"5","author":"Suzuki","year":"2017","journal-title":"J Intensive Care"},{"key":"key20240618110546_b14-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1001\/jama.2013.278477","article-title":"Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: A randomized clinical trial","volume":"310","author":"Morelli","year":"2013","journal-title":"JAMA"},{"key":"key20240618110546_b15-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1016\/j.chest.2021.01.009","article-title":"Effect of ultrashort-acting \u03b2-blockers on mortality in patients with sepsis with persistent tachycardia despite initial resuscitation: A systematic review and meta-analysis of randomized controlled trials","volume":"159","author":"Hasegawa","year":"2021","journal-title":"Chest"},{"issue":"6516","key":"key20240618110546_b16-ETM-28-1-12589","doi-asserted-by":"publisher","DOI":"10.51894\/001c.6516","article-title":"Cardiovascular factors associated with septic shock mortality risks","volume":"3","author":"Arnautovic","year":"2018","journal-title":"Spartan Med Res J"},{"issue":"413","key":"key20240618110546_b17-ETM-28-1-12589","article-title":"1351: Effect of preadmission beta-blocker use on outcomes of patients admitted with septic shock","volume":"44","author":"Sharma","year":"2016","journal-title":"Crit Care Med"},{"issue":"40","key":"key20240618110546_b18-ETM-28-1-12589","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-021-00553-9","article-title":"Premorbid \u03b21-selective (but not non-selective) \u03b2-blocker exposure reduces intensive care unit mortality among septic patients","volume":"9","author":"Kuo","year":"2021","journal-title":"J Intensive Care"},{"issue":"298","key":"key20240618110546_b19-ETM-28-1-12589","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2562-y","article-title":"The association between premorbid beta blocker exposure and mortality in sepsis-a systematic review","volume":"23","author":"Tan","year":"2019","journal-title":"Crit Care"},{"issue":"105906","key":"key20240618110546_b20-ETM-28-1-12589","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"88","author":"Page","year":"2021","journal-title":"Int J Surg"},{"key":"key20240618110546_b21-ETM-28-1-12589","author":"Wells"},{"key":"key20240618110546_b22-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1177\/1060028017726552","article-title":"Effects of chronic antihypertensives on vasopressor dosing in septic shock","volume":"52","author":"DeMott","year":"2018","journal-title":"Ann Pharmacother"},{"key":"key20240618110546_b23-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/SHK.0000000000001382","article-title":"Preadmission antihypertensive drug use and sepsis outcome: Impact of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs)","volume":"53","author":"Hsieh","year":"2020","journal-title":"Shock"},{"key":"key20240618110546_b24-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"e921","DOI":"10.1093\/cid\/ciab034","article-title":"\u03b2-Blockers, tachycardia, and survival following sepsis: An observational cohort study","volume":"73","author":"Guz","year":"2021","journal-title":"Clin Infect Dis"},{"key":"key20240618110546_b25-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/1742-6723.13584","article-title":"Is lactate lower in septic patients who are prescribed beta blockers? Retrospective cohort study of an intensive care population","volume":"33","author":"Pham","year":"2021","journal-title":"Emerg Med Australas"},{"key":"key20240618110546_b26-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1097\/CCM.0000000000005034","article-title":"Association between premorbid beta-blocker exposure and sepsis outcomes-the beta-blockers in european and Australian\/American septic patients (BEAST) study","volume":"49","author":"Tan","year":"2021","journal-title":"Crit Care Med"},{"issue":"1843","key":"key20240618110546_b27-ETM-28-1-12589","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58121843","article-title":"Association between pre-existing long-term \u03b2-blocker therapy and the outcomes of sepsis-associated coagulopathy: A retrospective study","volume":"58","author":"Ma","year":"2022","journal-title":"Medicina (Kaunas)"},{"issue":"e46169","key":"key20240618110546_b28-ETM-28-1-12589","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.46169","article-title":"Exploring the impact of prior beta-blocker and calcium channel blocker usage on clinical outcomes in critically Ill patients with sepsis: An observational study","volume":"15","author":"Kumar","year":"2023","journal-title":"Cureus"},{"key":"key20240618110546_b29-ETM-28-1-12589","author":"Charles"},{"key":"key20240618110546_b30-ETM-28-1-12589","author":"Alsolamy"},{"issue":"A6655","key":"key20240618110546_b31-ETM-28-1-12589","article-title":"Long- term use of beta blockers is protective in severe sepsis and septic shock","volume":"189","author":"Al-Qadi","year":"2014","journal-title":"Am J Resp Crit Care Med"},{"key":"key20240618110546_b32-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1097\/CCM.0b013e31825b9509","article-title":"Previous prescription of \u03b2-blockers is associated with reduced mortality among patients hospitalized in intensive care units for sepsis","volume":"40","author":"Macchia","year":"2012","journal-title":"Crit Care Med"},{"key":"key20240618110546_b33-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1097\/CCM.0000000000001308","article-title":"Long-term \u03b2-blocker therapy decreases blood lactate concentration in severely septic patients","volume":"43","author":"Contenti","year":"2015","journal-title":"Crit Care Med"},{"key":"key20240618110546_b34-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.amjsurg.2017.06.007","article-title":"Outpatient beta-blockers and survival from sepsis: Results from a national cohort of Medicare beneficiaries","volume":"214","author":"Singer","year":"2017","journal-title":"Am J Surg"},{"key":"key20240618110546_b35-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.1016\/j.ajem.2019.12.046","article-title":"Beta-blockers' effect on levels of Lactate in patients with suspected sepsis-The BeLLa study","volume":"38","author":"Chan","year":"2020","journal-title":"Am J Emerg Med"},{"issue":"395","key":"key20240618110546_b36-ETM-28-1-12589","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7180.395","article-title":"Clinicians and epidemiologists view crude death rates differently","volume":"318","author":"Nakayama","year":"1999","journal-title":"BMJ"},{"key":"key20240618110546_b37-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3238\/arztebl.2016.0159","article-title":"Hospital incidence and mortality rates of sepsis","volume":"113","author":"Fleischmann","year":"2016","journal-title":"Dtsch Arztebl Int"},{"key":"key20240618110546_b38-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1080\/23744235.2021.2017475","article-title":"Epidemiology of sepsis and risk factors for mortality in intensive care unit: A hospital based prospective study in South India","volume":"54","author":"Garg","year":"2022","journal-title":"Infect Dis (Lond)"},{"issue":"17","key":"key20240618110546_b39-ETM-28-1-12589","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01809-8","article-title":"Risk factor analysis and nomogram for predicting in-hospital mortality in ICU patients with sepsis and lung infection","volume":"22","author":"Ren","year":"2022","journal-title":"BMC Pulm Med"},{"key":"key20240618110546_b40-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s40261-019-00762-z","article-title":"Benefits of beta-blockade in sepsis and septic shock: A systematic review","volume":"39","author":"Lee","year":"2019","journal-title":"Clin Drug Investig"},{"key":"key20240618110546_b41-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1001\/jama.2023.20134","article-title":"Landiolol and organ failure in patients with septic shock: The STRESS-L randomized clinical trial","volume":"330","author":"Whitehouse","year":"2023","journal-title":"JAMA"},{"key":"key20240618110546_b42-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1093\/bja\/aex231","article-title":"Continuing chronic beta-blockade in the acute phase of severe sepsis and septic shock is associated with decreased mortality rates up to 90 days","volume":"119","author":"Fuchs","year":"2017","journal-title":"Br J Anaesth"},{"key":"key20240618110546_b43-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1177\/0885066609340519","article-title":"Sympathetic overstimulation during critical illness: Adverse effects of adrenergic stress","volume":"24","author":"D\u00fcnser","year":"2009","journal-title":"J Intensive Care Med"},{"key":"key20240618110546_b44-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/S0140-6736(07)61344-0","article-title":"Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: A randomised trial","volume":"370","author":"Annane","year":"2007","journal-title":"Lancet"},{"key":"key20240618110546_b45-ETM-28-1-12589","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1056\/NEJMoa010342","article-title":"Reversal of catabolism by beta-blockade after severe burns","volume":"345","author":"Herndon","year":"2001","journal-title":"N Engl J Med"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T08:13:13Z","timestamp":1718698393000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2024.12589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,24]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,5,24]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2024.12589","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,24]]},"article-number":"300"}}