{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:07:11Z","timestamp":1790478431584,"version":"4.1.0"},"reference-count":144,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2025.12854","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T06:23:00Z","timestamp":1742970180000},"page":"1-12","source":"Crossref","is-referenced-by-count":4,"title":["Anti\u2011atherosclerotic effect of aged garlic extract: Mode of action and therapeutic benefits (Review)"],"prefix":"10.3892","volume":"29","author":[{"given":"Satomi","family":"Miki","sequence":"first","affiliation":[{"name":"Central Research Institute, Wakunaga Pharmaceutical Co., Ltd., Hiroshima 739\u20111195, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Takashima","sequence":"additional","affiliation":[{"name":"Drug Discovery Laboratory, Wananga Pharmaceutical Co., Ltd., Hiroshima 739\u20111195, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ichiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Central Research Institute, Wakunaga Pharmaceutical Co., Ltd., Hiroshima 739\u20111195, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"issue":"114680","key":"key20250417095309_b1-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114680","article-title":"Multiplexed sensing techniques for cardiovascular disease biomarkers-A review","volume":"216","author":"Mani","year":"2022","journal-title":"Biosens Bioelectron"},{"issue":"5245308","key":"key20250417095309_b2-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5245308","article-title":"Mechanistic insights into the oxidized low-density lipoprotein-induced atherosclerosis","volume":"2020","author":"Khatana","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"key20250417095309_b3-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"435","DOI":"10.14348\/molcells.2014.0078","article-title":"Shear stress and atherosclerosis","volume":"37","author":"Heo","year":"2014","journal-title":"Mol Cells"},{"key":"key20250417095309_b4-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s11883-022-00993-0","article-title":"Wall shear stress alteration: A local risk factor of atherosclerosis","volume":"24","author":"J","year":"2022","journal-title":"Curr Atheroscler Rep"},{"issue":"2274","key":"key20250417095309_b5-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.3390\/cells11152274","article-title":"Multifunctional role of S100 protein family in the immune system: An update","volume":"11","author":"Singh","year":"2022","journal-title":"Cells"},{"issue":"828354","key":"key20250417095309_b6-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/828354","article-title":"S100A8 and S100A9: DAMPs at the crossroads between innate immunity, traditional risk factors, and cardiovascular disease","volume":"2013","author":"Schiopu","year":"2013","journal-title":"Mediators Inflamm"},{"key":"key20250417095309_b7-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1161\/ATVBAHA.111.236927","article-title":"S100A8 and S100A9 in cardiovascular biology and disease","volume":"32","author":"Averill","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20250417095309_b8-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1097\/MOL.0000000000000051","article-title":"Hyperlipidemia and cardiovascular disease: Inflammation, dyslipidemia, and atherosclerosis","volume":"25","author":"Tietge","year":"2014","journal-title":"Curr Opin Lipidol"},{"key":"key20250417095309_b9-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1126\/science.822515","article-title":"Hyperlipidemia and atherosclerosis","volume":"193","author":"Ross","year":"1976","journal-title":"Science"},{"key":"key20250417095309_b10-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.cmet.2011.07.015","article-title":"Insulin resistance, hyperglycemia, and atherosclerosis","volume":"14","author":"Bornfeldt","year":"2011","journal-title":"Cell Metab"},{"issue":"1","key":"key20250417095309_b11-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-1-1","article-title":"How hyperglycemia promotes atherosclerosis: Molecular mechanisms","volume":"1","author":"Aronson","year":"2002","journal-title":"Cardiovasc Diabetol"},{"key":"key20250417095309_b12-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.cdtm.2016.05.001","article-title":"Changes of junctions of endothelial cells in coronary sclerosis: A review","volume":"2","author":"Zhang","year":"2016","journal-title":"Chronic Dis Transl Med"},{"issue":"365","key":"key20250417095309_b13-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00365","article-title":"Endothelial barrier and its abnormalities in cardiovascular disease","volume":"6","author":"Chistiakov","year":"2015","journal-title":"Front Physiol"},{"key":"key20250417095309_b14-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/jcmm.12689","article-title":"Macrophage-mediated cholesterol handling in atherosclerosis","volume":"20","author":"Chistiakov","year":"2016","journal-title":"J Cell Mol Med"},{"key":"key20250417095309_b15-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s00109-017-1575-8","article-title":"Mechanisms of foam cell formation in atherosclerosis","volume":"95","author":"Chistiakov","year":"2017","journal-title":"J Mol Med (Berl)"},{"key":"key20250417095309_b16-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"C7","DOI":"10.1016\/j.jacc.2005.09.068","article-title":"Pathogenesis of atherosclerosis","volume":"47 (8 Suppl)","author":"Falk","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"key20250417095309_b17-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/s1568-1637(02)00049-1","article-title":"Garlic and aging: New insights into an old remedy","volume":"2","author":"Rahman","year":"2003","journal-title":"Ageing Res Rev"},{"key":"key20250417095309_b18-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.3892\/etm.2019.8393","article-title":"Chemistry of aged garlic: Diversity of constituents in aged garlic extract and their production mechanisms via the combination of chemical and enzymatic reactions","volume":"19","author":"Kodera","year":"2020","journal-title":"Exp Ther Med"},{"key":"key20250417095309_b19-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"782S","DOI":"10.1093\/jn\/136.3.782S","article-title":"Aged garlic extract and its constituents inhibit platelet aggregation through multiple mechanisms","volume":"136 (3 Suppl)","author":"Allison","year":"2006","journal-title":"J Nutr"},{"key":"key20250417095309_b20-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"1109S","DOI":"10.1093\/jn\/131.3.1109S","article-title":"Effects of garlic preparations on the gastrointestinal mucosa","volume":"131 (3S)","author":"Hoshino","year":"2001","journal-title":"J Nutr"},{"key":"key20250417095309_b21-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2131\/jts.9.61","article-title":"Chronic toxicity test of garlic extract in rats","volume":"9","author":"Sumiyoshi","year":"1984","journal-title":"J Toxicol Sci"},{"key":"key20250417095309_b22-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/s0021-9150(97)00078-6","article-title":"The effect of the aged garlic extract, \u2018Kyolic\u2019, on the development of experimental atherosclerosis","volume":"132","author":"Efendy","year":"1997","journal-title":"Atherosclerosis"},{"key":"key20250417095309_b23-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"750S","DOI":"10.1093\/jn\/136.3.750S","article-title":"Aged garlic extract improves homocysteine-induced endothelial dysfunction in macro- and microcirculation","volume":"136 (3 Suppl)","author":"Weiss","year":"2006","journal-title":"J Nutr"},{"key":"key20250417095309_b24-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.3892\/etm.2019.8371","article-title":"Aged garlic extract reduces low attenuation plaque in coronary arteries of patients with diabetes: A randomized, double-blind, placebo-controlled study","volume":"19","author":"Shaikh","year":"2020","journal-title":"Exp Ther Med"},{"issue":"285795","key":"key20250417095309_b25-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/285795","article-title":"Aged garlic extract improves adiponectin levels in subjects with metabolic syndrome: A double-blind, placebo-controlled, randomized, crossover study","volume":"2013","author":"G\u00f3mez-Arbel\u00e1ez","year":"2013","journal-title":"Mediators Inflamm"},{"key":"key20250417095309_b26-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"427S","DOI":"10.3945\/jn.114.202424","article-title":"Aged garlic extract reduces low attenuation plaque in coronary arteries of patients with metabolic syndrome in a prospective randomized double-blind study","volume":"146","author":"Matsumoto","year":"2016","journal-title":"J Nutr"},{"issue":"132","key":"key20250417095309_b27-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-02932-5","article-title":"The effect of aged garlic extract on the atherosclerotic process-a randomized double-blind placebo-controlled trial","volume":"20","author":"Wlosinska","year":"2020","journal-title":"BMC Complement Med Ther"},{"key":"key20250417095309_b28-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1002\/ptr.1663","article-title":"Aged garlic extract improves endothelial function in men with coronary artery disease","volume":"19","author":"Williams","year":"2005","journal-title":"Phytother Res"},{"key":"key20250417095309_b29-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"741S","DOI":"10.1093\/jn\/136.3.741S","article-title":"Aged garlic extract retards progression of coronary artery calcification","volume":"136 (3 Suppl)","author":"Budoff","year":"2006","journal-title":"J Nutr"},{"issue":"A1472","key":"key20250417095309_b30-ETM-29-5-12854","article-title":"The effects of aged garlic extract on coronary artery calcification progression and blood pressure","volume":"65","author":"Hom","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"key20250417095309_b31-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.ypmed.2004.04.012","article-title":"Inhibiting progression of coronary calcification using aged garlic extract in patients receiving statin therapy: A preliminary study","volume":"39","author":"Budoff","year":"2004","journal-title":"Prev Med"},{"key":"key20250417095309_b32-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1097\/MCA.0000000000000587","article-title":"Randomized trial evaluating the effect of aged garlic extract with supplements versus placebo on adipose tissue surrogates for coronary atherosclerosis progression","volume":"29","author":"Zeb","year":"2018","journal-title":"Coron Artery Dis"},{"key":"key20250417095309_b33-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1016\/j.ijcard.2013.01.182","article-title":"Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis","volume":"168","author":"Ahmadi","year":"2013","journal-title":"Int J Cardiol"},{"key":"key20250417095309_b34-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.nut.2012.03.016","article-title":"Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: The FAITH randomized clinical trial","volume":"29","author":"Larijani","year":"2013","journal-title":"Nutrition"},{"key":"key20250417095309_b35-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"185","DOI":"10.4103\/0975-3583.98883","article-title":"Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial","volume":"3","author":"Zeb","year":"2012","journal-title":"J Cardiovasc Dis Res"},{"key":"key20250417095309_b36-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ypmed.2009.06.018","article-title":"Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: A randomized clinical trial","volume":"49","author":"Budoff","year":"2009","journal-title":"Prev Med"},{"key":"key20250417095309_b37-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"745S","DOI":"10.1093\/jn\/136.3.745S","article-title":"Homocysteine-lowering action is another potential cardiovascular protective factor of aged garlic extract","volume":"136 (3 Suppl)","author":"Yeh","year":"2006","journal-title":"J Nutr"},{"issue":"22469","key":"key20250417095309_b38-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-01866-3","article-title":"S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R\/STAT3 signaling","volume":"11","author":"Miki","year":"2021","journal-title":"Sci Rep"},{"issue":"1700308","key":"key20250417095309_b39-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700308","article-title":"Aged garlic extract suppresses inflammation in apolipoprotein E-knockout mice","volume":"61","author":"Morihara","year":"2017","journal-title":"Mol Nutr Food Res"},{"key":"key20250417095309_b40-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"460S","DOI":"10.3945\/jn.114.206953","article-title":"Aged garlic extract suppresses the development of atherosclerosis in apolipoprotein E-knockout mice","volume":"146","author":"Morihara","year":"2016","journal-title":"J Nutr"},{"issue":"239","key":"key20250417095309_b41-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01502-8","article-title":"Inflammation and aging: Signaling pathways and intervention therapies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"865827","key":"key20250417095309_b42-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.865827","article-title":"The inflamm-aging model identifies key risk factors in atherosclerosis","volume":"13","author":"He","year":"2022","journal-title":"Front Genet"},{"issue":"466","key":"key20250417095309_b43-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.112921.2","article-title":"Accelerated atherosclerosis in rheumatoid arthritis: A systematic review","volume":"11","author":"Raj","year":"2022","journal-title":"F1000Res"},{"key":"key20250417095309_b44-ETM-29-5-12854","first-page":"460","article-title":"Rheumatoid Arthritis and Atherosclerosis","volume":"21","author":"Adawi","year":"2019","journal-title":"IMAJ"},{"issue":"105212","key":"key20250417095309_b45-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105212","article-title":"Emerging roles of neutrophil-borne S100A8\/A9 in cardiovascular inflammation","volume":"161","author":"Sreejit","year":"2020","journal-title":"Pharmacol Res"},{"issue":"e27","key":"key20250417095309_b46-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.4110\/in.2018.18.e27","article-title":"Damage-associated molecular patterns in inflammatory diseases","volume":"18","author":"Roh","year":"2018","journal-title":"Immune Netw"},{"issue":"6636875","key":"key20250417095309_b47-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6636875","article-title":"Aged garlic extract reduces IL-6: A double-blind placebo-controlled trial in females with a low risk of cardiovascular disease","volume":"2021","author":"Wlosinska","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"key20250417095309_b48-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.clnesp.2017.11.010","article-title":"Aged garlic extract supplementation modifies inflammation and immunity of adults with obesity: A randomized, double-blind, placebo-controlled clinical trial","volume":"24","author":"Xu","year":"2018","journal-title":"Clin Nutr ESPEN"},{"key":"key20250417095309_b49-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3892\/ijmm.2014.2036","article-title":"Diallyl trisulfide exerts anti-inflammatory effects in lipopolysaccharide-stimulated RAW 264.7 macrophages by suppressing the Toll-like receptor 4\/nuclear factor-\u03baB pathway","volume":"35","author":"Lee","year":"2015","journal-title":"Int J Mol Med"},{"key":"key20250417095309_b50-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"134","DOI":"10.15430\/JCP.2018.23.3.134","article-title":"Diallyl trisulfide suppresses the production of lipopolysaccharide-induced inflammatory mediators in BV2 microglia by decreasing the NF-\u03baB pathway activity associated with toll-like Receptor 4 and CXCL12\/CXCR4 pathway blockade","volume":"23","author":"Lee","year":"2018","journal-title":"J Cancer Prev"},{"issue":"14148","key":"key20250417095309_b51-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32431-0","article-title":"Anti-inflammatory action of cysteine derivative S-1-propenylcysteine by inducing MyD88 degradation","volume":"8","author":"Suzuki","year":"2018","journal-title":"Sci Rep"},{"key":"key20250417095309_b52-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.3892\/etm.2019.8392","article-title":"Regulation of immune response by S-1-propenylcysteine through autophagy-mediated protein degradation","volume":"19","author":"Suzuki","year":"2020","journal-title":"Exp Ther Med"},{"key":"key20250417095309_b53-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1615\/JEnvironPatholToxicolOncol.2018027078","article-title":"Antiarthritic activity of diallyl disulfide against freund's adjuvant-induced arthritic rat model","volume":"37","author":"Chen","year":"2018","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"key20250417095309_b54-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1136\/ard-2022-223626","article-title":"L-arginine metabolism inhibits arthritis and inflammatory bone loss","volume":"83","author":"Cao","year":"2024","journal-title":"Ann Rheum Dis"},{"issue":"212","key":"key20250417095309_b55-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2306212","article-title":"Mechanism of hypercholesterolemia-induced atherosclerosis","volume":"23","author":"Prasad","year":"2022","journal-title":"Rev Cardiovasc Med"},{"key":"key20250417095309_b56-ETM-29-5-12854","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1001\/jama.1990.03450230080033","article-title":"A single cholesterol measurement underestimates the risk of coronary heart disease. An empirical example from the lipid research clinics mortality follow-up study","volume":"264","author":"Davis","year":"1990","journal-title":"JAMA"},{"issue":"1107","key":"key20250417095309_b57-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081107","article-title":"Antioxidant activity of \u01b3-oryzanol: A complex network of interactions","volume":"17","author":"Minatel","year":"2016","journal-title":"Int J Mol Sci"},{"key":"key20250417095309_b58-ETM-29-5-12854","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s13765-017-0285-9","article-title":"Crosstalk between reactive oxygen species and pro-inflammatory markers in developing various chronic diseases: A review","volume":"60","author":"Ranneh","year":"2017","journal-title":"Appl Biol Chem"},{"key":"key20250417095309_b59-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"989S","DOI":"10.1093\/jn\/131.3.989S","article-title":"Cholesterol-lowering effect of garlic extracts and organosulfur compounds: Human and animal studies","volume":"131 (3S)","author":"Yeh","year":"2001","journal-title":"J Nutr"},{"key":"key20250417095309_b60-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1093\/ajcn\/64.6.866","article-title":"A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids","volume":"64","author":"Steiner","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"key20250417095309_b61-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"765S","DOI":"10.1093\/jn\/136.3.765S","article-title":"Suppression of LDL oxidation by garlic compounds is a possible mechanism of cardiovascular health benefit","volume":"136 (3 Suppl)","author":"Lau","year":"2006","journal-title":"J Nutr"},{"issue":"959285","key":"key20250417095309_b62-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.959285","article-title":"Hypertension as a risk factor for atherosclerosis: Cardiovascular risk assessment","volume":"9","author":"Poznyak","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"key20250417095309_b63-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur Heart J"},{"issue":"382802","key":"key20250417095309_b64-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/382802","article-title":"Hypertension management in the high cardiovascular risk population","volume":"2013","author":"Maraj","year":"2013","journal-title":"Int J Hypertens"},{"key":"key20250417095309_b65-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/ejcn.2012.178","article-title":"Aged garlic extract reduces blood pressure in hypertensives: A dose-response trial","volume":"67","author":"Ried","year":"2013","journal-title":"Eur J Clin Nutr"},{"key":"key20250417095309_b66-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2147\/IBPC.S93335","article-title":"The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: The AGE at heart trial","volume":"9","author":"Ried","year":"2016","journal-title":"Integr Blood Press Control"},{"issue":"122","key":"key20250417095309_b67-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2018.00122","article-title":"The effect of kyolic aged garlic extract on gut microbiota, inflammation, and cardiovascular markers in hypertensives: The GarGIC trial","volume":"5","author":"Ried","year":"2018","journal-title":"Front Nutr"},{"key":"key20250417095309_b68-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jchromb.2017.01.029","article-title":"Metabolomic study on the antihypertensive effect of S-1-propenylcysteine in spontaneously hypertensive rats using liquid chromatography coupled with quadrupole-orbitrap mass spectrometry","volume":"1046","author":"Matsutomo","year":"2017","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"key20250417095309_b69-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jpba.2019.01.043","article-title":"Metabolomic study reveals the acute hypotensive effect of S-1-propenylcysteine accompanied by alteration of the plasma histidine level in spontaneously hypertensive rats","volume":"168","author":"Matsutomo","year":"2019","journal-title":"J Pharm Biomed Anal"},{"key":"key20250417095309_b70-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/jphp.12865","article-title":"Effects of S-1-propenylcysteine, a sulfur compound in aged garlic extract, on blood pressure and peripheral circulation in spontaneously hypertensive rats","volume":"70","author":"Ushijima","year":"2018","journal-title":"J Pharm Pharmacol"},{"key":"key20250417095309_b71-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"F1691","DOI":"10.1152\/ajprenal.00235.2007","article-title":"Renoprotective and antihypertensive effects of S-allylcysteine in 5\/6 nephrectomized rats","volume":"293","author":"Cruz","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"issue":"507","key":"key20250417095309_b72-ETM-29-5-12854","article-title":"Pakistan veterinary journal S-allylcysteine supplementation effects on vascular and bone health in ovariectomized wistar rats","volume":"41","author":"Halim","year":"2021","journal-title":"Pakistan Vet J"},{"key":"key20250417095309_b73-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41569-022-00770-1","article-title":"Vascular endothelial cell development and diversity","volume":"20","author":"Trimm","year":"2023","journal-title":"Nat Rev Cardiol"},{"issue":"430","key":"key20250417095309_b74-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00430","article-title":"C-reactive protein in atherothrombosis and angiogenesis","volume":"9","author":"Badimon","year":"2018","journal-title":"Front Immunol"},{"key":"key20250417095309_b75-ETM-29-5-12854","doi-asserted-by":"crossref","first-page":"e419","DOI":"10.1016\/j.crvasa.2015.08.002","article-title":"Monocyte adhesion to the endothelium is an initial stage of atherosclerosis development","volume":"58","author":"\u010cejkov\u00e1","year":"2016","journal-title":"Cor Vasa"},{"key":"key20250417095309_b76-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/s0092-8674(01)00238-0","article-title":"Atherosclerosis. The road ahead","volume":"104","author":"Glass","year":"2001","journal-title":"Cell"},{"key":"key20250417095309_b77-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.atherosclerosis.2012.05.010","article-title":"Inflammatory Ly-6C(hi) monocytes play an important role in the development of severe transplant arteriosclerosis in hyperlipidemic recipients","volume":"223","author":"Schiopu","year":"2012","journal-title":"Atherosclerosis"},{"key":"key20250417095309_b78-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/nrcardio.2009.228","article-title":"Monocytes in atherosclerosis: Subsets and functions","volume":"7","author":"Woollard","year":"2010","journal-title":"Nat Rev Cardiol"},{"key":"key20250417095309_b79-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1161\/ATVBAHA.114.303565","article-title":"Monocyte fate in atherosclerosis","volume":"35","author":"Hilgendorf","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20250417095309_b80-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"621","DOI":"10.4049\/jimmunol.2000935","article-title":"Enhanced proliferation of Ly6C+ monocytes\/macrophages contributes to chronic inflammation in skin wounds of diabetic mice","volume":"206","author":"Pang","year":"2021","journal-title":"J Immunol"},{"key":"key20250417095309_b81-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1078\/0944-7113-00005","article-title":"S-allyl cysteine reduces oxidant load in cells involved in the atherogenic process","volume":"8","author":"Ho","year":"2001","journal-title":"Phytomedicine"},{"key":"key20250417095309_b82-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1081\/ddc-100102217","article-title":"S-allylcysteine attenuates oxidative stress in endothelial cells","volume":"25","author":"Ide","year":"1999","journal-title":"Drug Dev Ind Pharm"},{"key":"key20250417095309_b83-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"1020S","DOI":"10.1093\/jn\/131.3.1020S","article-title":"Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-kappa b activation","volume":"131 (3S)","author":"Ide","year":"2001","journal-title":"J Nutr"},{"key":"key20250417095309_b84-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1111\/j.2042-7158.1997.tb06134.x","article-title":"Garlic compounds protect vascular endothelial cells from oxidized low density lipoprotein-induced injury","volume":"49","author":"Ide","year":"1997","journal-title":"J Pharm Pharmacol"},{"key":"key20250417095309_b85-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/s0955-2863(99)00021-2","article-title":"Antioxidant effects of fructosyl arginine, a Maillard reaction product in aged garlic extract","volume":"10","author":"Ide","year":"1999","journal-title":"J Nutr Biochem"},{"key":"key20250417095309_b86-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.nutres.2015.09.018","article-title":"Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expression via the nuclear factor erythroid 2-related factor 2-antioxidant response element signaling pathway in human endothelial cells","volume":"36","author":"Hiramatsu","year":"2016","journal-title":"Nutr Res"},{"key":"key20250417095309_b87-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.niox.2019.01.003","article-title":"S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells","volume":"84","author":"Tsuneyoshi","year":"2019","journal-title":"Nitric Oxide"},{"key":"key20250417095309_b88-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.3892\/etm.2019.8380","article-title":"BACH1 mediates the antioxidant properties of aged garlic extract","volume":"19","author":"Tsuneyoshi","year":"2020","journal-title":"Exp Ther Med"},{"key":"key20250417095309_b89-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/s0891-5849(01)00460-9","article-title":"Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine","volume":"30","author":"Kim","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"key20250417095309_b90-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.1039\/d3fo00412k","article-title":"Improving endothelial health with food-derived H2S donors: An in vitro study with S-allyl cysteine and with a black-garlic extract enriched in sulfur-containing compounds","volume":"14","author":"Geddo","year":"2023","journal-title":"Food Funct"},{"key":"key20250417095309_b91-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.bbrc.2015.08.020","article-title":"Dehydrodiconiferyl alcohol suppresses monocyte adhesion to endothelial cells by attenuation of JNK signaling pathway","volume":"465","author":"Tsuneyoshi","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"key20250417095309_b92-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1093\/jn\/138.6.996","article-title":"Diallyl disulfide and diallyl trisulfide suppress oxidized LDL-induced vascular cell adhesion molecule and E-selectin expression through protein kinase A- and B-dependent signaling pathways","volume":"138","author":"Lei","year":"2008","journal-title":"J Nutr"},{"issue":"1600797","key":"key20250417095309_b93-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201600797","article-title":"Aged garlic extract suppresses the increase of plasma glycated albumin level and enhances the AMP-activated protein kinase in adipose tissue in TSOD mice","volume":"61","author":"Miki","year":"2017","journal-title":"Mol Nutr Food Res"},{"key":"key20250417095309_b94-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1161\/01.cir.95.3.662","article-title":"L-arginine reduces human monocyte adhesion to vascular endothelium and endothelial expression of cell adhesion molecules","volume":"95","author":"Adams","year":"1997","journal-title":"Circulation"},{"key":"key20250417095309_b95-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1172\/JCI115937","article-title":"Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit","volume":"90","author":"Cooke","year":"1992","journal-title":"J Clin Invest"},{"key":"key20250417095309_b96-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1161\/01.cir.89.5.2176","article-title":"Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine","volume":"89","author":"Tsao","year":"1994","journal-title":"Circulation"},{"issue":"17","key":"key20250417095309_b97-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00692-w","article-title":"S-1-propenylcysteine improves TNF-\u03b1-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1\/RhoA\/Rac pathway","volume":"19","author":"Kunimura","year":"2021","journal-title":"Cell Commun Signal"},{"key":"key20250417095309_b98-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1161\/CIRCRESAHA.107.149724","article-title":"Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet","volume":"100","author":"Mehta","year":"2007","journal-title":"Circ Res"},{"key":"key20250417095309_b99-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1172\/JCI9259","article-title":"Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice","volume":"105","author":"Febbraio","year":"2000","journal-title":"J Clin Invest"},{"key":"key20250417095309_b100-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"49982","DOI":"10.1074\/jbc.M209649200","article-title":"Scavenger receptors class A-I\/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages","volume":"277","author":"Kunjathoor","year":"2002","journal-title":"J Biol Chem"},{"key":"key20250417095309_b101-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1002\/ptr.3008","article-title":"Aged garlic extract inhibits CD36 expression in human macrophages via modulation of the PPARgamma pathway","volume":"24","author":"Morihara","year":"2010","journal-title":"Phytother Res"},{"key":"key20250417095309_b102-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"755S","DOI":"10.1093\/jn\/136.3.755S","article-title":"Aged garlic extract inhibits homocysteine-induced CD36 expression and foam cell formation in human macrophages","volume":"136 (3 Suppl)","author":"Ide","year":"2006","journal-title":"J Nutr"},{"key":"key20250417095309_b103-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.jep.2011.01.021","article-title":"Aged garlic extract inhibits homocysteine-induced scavenger receptor CD36 expression and oxidized low-density lipoprotein cholesterol uptake in human macrophages in vitro","volume":"134","author":"Morihara","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"key20250417095309_b104-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jphs.2021.11.005","article-title":"ABCA1 and ABCG1 as potential therapeutic targets for the prevention of atherosclerosis","volume":"148","author":"Matsuo","year":"2022","journal-title":"J Pharmacol Sci"},{"key":"key20250417095309_b105-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/ptr.4713","article-title":"S-Allylcysteine, a garlic compound, increases ABCA1 expression in human THP-1 macrophages","volume":"27","author":"Malekpour-Dehkordi","year":"2013","journal-title":"Phytother Res"},{"issue":"e48080","key":"key20250417095309_b106-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048080","article-title":"Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice","volume":"7","author":"Lammers","year":"2012","journal-title":"PLoS One"},{"key":"key20250417095309_b107-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.1172\/JCI33372","article-title":"Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice","volume":"117","author":"Yvan-Charvet","year":"2007","journal-title":"J Clin Invest"},{"key":"key20250417095309_b108-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1172\/JCI32057","article-title":"Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo","volume":"117","author":"Wang","year":"2007","journal-title":"J Clin Invest"},{"key":"key20250417095309_b109-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1161\/01.ATV.0000208364.22732.16","article-title":"Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice","volume":"26","author":"Van Eck","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1185587","key":"key20250417095309_b110-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1185587","article-title":"Macrophage polarization states in atherosclerosis","volume":"14","author":"Wu","year":"2023","journal-title":"Front Immunol"},{"issue":"35234","key":"key20250417095309_b111-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1038\/srep35234","article-title":"Bone marrow-derived and peritoneal macrophages have different inflammatory response to oxLDL and M1\/M2 marker expression-implications for atherosclerosis research","volume":"6","author":"Bisgaard","year":"2016","journal-title":"Sci Rep"},{"issue":"e8852","key":"key20250417095309_b112-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008852","article-title":"Macrophage plasticity in experimental atherosclerosis","volume":"5","author":"Khallou-Laschet","year":"2010","journal-title":"PLoS One"},{"issue":"e0204305","key":"key20250417095309_b113-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204305","article-title":"Molecular imaging of MMP activity discriminates unstable from stable plaque phenotypes in shear-stress induced murine atherosclerosis","volume":"13","author":"Seifert","year":"2018","journal-title":"PLoS One"},{"key":"key20250417095309_b114-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.intimp.2017.11.037","article-title":"Crocin alleviates coronary atherosclerosis via inhibiting lipid synthesis and inducing M2 macrophage polarization","volume":"55","author":"Li","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"key20250417095309_b115-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/biof.1199","article-title":"Pomegranate juice polyphenols induce a phenotypic switch in macrophage polarization favoring a M2 anti-inflammatory state","volume":"41","author":"Aharoni","year":"2015","journal-title":"Biofactors"},{"issue":"6724903","key":"key20250417095309_b116-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6724903","article-title":"M2 macrophages as a potential target for antiatherosclerosis treatment","volume":"2019","author":"Bi","year":"2019","journal-title":"Neural Plast"},{"issue":"112760","key":"key20250417095309_b117-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112760","article-title":"Diallyl disulfide suppresses the lipopolysaccharide-driven inflammatory response of macrophages by activating the Nrf2 pathway","volume":"159","author":"Zhang","year":"2022","journal-title":"Food Chem Toxicol"},{"key":"key20250417095309_b118-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1210\/jc.2004-1685","article-title":"Effect of thiazolidinedione treatment on progression of subclinical atherosclerosis in premenopausal women at high risk for type 2 diabetes","volume":"90","author":"Xiang","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"512","key":"key20250417095309_b119-ETM-29-5-12854","article-title":"Pioglitazone inhibits progression of atherosclerosis","volume":"5","year":"2008","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"key20250417095309_b120-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ijcard.2008.08.031","article-title":"Pioglitazone induces regression of coronary atherosclerotic plaques in patients with type 2 diabetes mellitus or impaired glucose tolerance: A randomized prospective study using intravascular ultrasound","volume":"138","author":"Nakayama","year":"2010","journal-title":"Int J Cardiol"},{"issue":"e031121","key":"key20250417095309_b121-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.031121","article-title":"Phenotypic switching of vascular smooth muscle cells in atherosclerosis","volume":"12","author":"Chen","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"key20250417095309_b122-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1093\/cvr\/cvy010","article-title":"Role of smooth muscle cells in vascular calcification: Implications in atherosclerosis and arterial stiffness","volume":"114","author":"Durham","year":"2018","journal-title":"Cardiovasc Res"},{"issue":"005","key":"key20250417095309_b123-ETM-29-5-12854","article-title":"The effects of aged garlic extract on coronary artery calcification progression","volume":"S5","author":"Hom","year":"2015","journal-title":"J Nutr Food Sci"},{"key":"key20250417095309_b124-ETM-29-5-12854","first-page":"177","article-title":"Aged garlic extract and one of the constituent, (+)-(2S,3R)-dehydrodiconiferyl alcohol, inhibits alkaline phosphatase activity induced by inflammation factors in human vascular smooth muscle cells","volume":"5","author":"Yamakawa","year":"2014","journal-title":"Food Nutr Sci"},{"key":"key20250417095309_b125-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"5087","DOI":"10.1182\/blood-2006-12-027698","article-title":"The growing complexity of platelet aggregation","volume":"109","author":"Jackson","year":"2007","journal-title":"Blood"},{"key":"key20250417095309_b126-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1111\/jth.13302","article-title":"Platelet signaling: A complex interplay between inhibitory and activatory networks","volume":"14","author":"Bye","year":"2016","journal-title":"J Thromb Haemost"},{"key":"key20250417095309_b127-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/pin.12921","article-title":"Pathophysiology of atherothrombosis: Mechanisms of thrombus formation on disrupted atherosclerotic plaques","volume":"70","author":"Asada","year":"2020","journal-title":"Pathol Int"},{"key":"key20250417095309_b128-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"980S","DOI":"10.1093\/jn\/131.3.980S","article-title":"Aged garlic extract, a modulator of cardiovascular risk factors: A dose-finding study on the effects of AGE on platelet functions","volume":"131 (3S)","author":"Steiner","year":"2001","journal-title":"J Nutr"},{"key":"key20250417095309_b129-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1093\/jn\/130.11.2662","article-title":"Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans","volume":"130","author":"Rahman","year":"2000","journal-title":"J Nutr"},{"key":"key20250417095309_b130-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"793S","DOI":"10.1093\/jn\/136.3.793S","article-title":"Aged garlic extract may be safe for patients on warfarin therapy","volume":"136 (3 Suppl)","author":"Macan","year":"2006","journal-title":"J Nutr"},{"key":"key20250417095309_b131-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1161\/ATVBAHA.110.207522","article-title":"Signaling during platelet adhesion and activation","volume":"30","author":"Li","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20250417095309_b132-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"30024","DOI":"10.1074\/jbc.M604504200","article-title":"Essential role of protein kinase C delta in platelet signaling, alpha IIb beta 3 activation, and thromboxane A2 release","volume":"281","author":"Yacoub","year":"2006","journal-title":"J Biol Chem"},{"issue":"48","key":"key20250417095309_b133-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00048","article-title":"Breaking the mold: Transcription factors in the anucleate platelet and platelet-derived microparticles","volume":"6","author":"Lannan","year":"2015","journal-title":"Front Immunol"},{"key":"key20250417095309_b134-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s11418-016-1055-4","article-title":"Aged garlic extract suppresses platelet aggregation by changing the functional property of platelets","volume":"71","author":"Morihara","year":"2017","journal-title":"J Nat Med"},{"key":"key20250417095309_b135-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"789S","DOI":"10.1093\/jn\/136.3.789S","article-title":"Aged garlic extract may inhibit aggregation in human platelets by suppressing calcium mobilization","volume":"136 (3 Suppl)","author":"Allison","year":"2006","journal-title":"J Nutr"},{"key":"key20250417095309_b136-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"410S","DOI":"10.3945\/jn.114.202408","article-title":"Aged garlic extract inhibits human platelet aggregation by altering intracellular signaling and platelet shape change","volume":"146","author":"Rahman","year":"2016","journal-title":"J Nutr"},{"key":"key20250417095309_b137-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.lfs.2012.09.019","article-title":"Aged garlic extract inhibits platelet activation by increasing intracellular cAMP and reducing the interaction of GPIIb\/IIIa receptor with fibrinogen","volume":"91","author":"Allison","year":"2012","journal-title":"Life Sci"},{"key":"key20250417095309_b138-ETM-29-5-12854","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0006-2952(00)00467-6","article-title":"Inhibition by diallyl trisulfide, a garlic component, of intracellular Ca(2+) mobilization without affecting inositol-1,4, 5-trisphosphate [IP(3)] formation in activated platelets","volume":"60","author":"Qi","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"key20250417095309_b139-ETM-29-5-12854","author":"Tian"},{"key":"key20250417095309_b140-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.cca.2020.10.022","article-title":"Omics research in vascular calcification","volume":"511","author":"Duan","year":"2020","journal-title":"Clin Chim Acta"},{"key":"key20250417095309_b141-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.ajpath.2023.12.007","article-title":"Omics approaches unveiling the biology of human atherosclerotic plaques","volume":"194","author":"Wu","year":"2024","journal-title":"Am J Pathol"},{"issue":"S117757","key":"key20250417095309_b142-ETM-29-5-12854","article-title":"Multi-omics integration from a large human biobank identifies key molecular mechanisms and signatures of atherosclerotic plaque instability","volume":"395 (Suppl 1)","author":"Das","year":"2024","journal-title":"Atherosclerosis"},{"key":"key20250417095309_b143-ETM-29-5-12854","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.1093\/eurheartj\/ehad361","article-title":"Subclinical atherosclerosis and accelerated epigenetic age mediated by inflammation: A multi-omics study","volume":"44","author":"S\u00e1nchez-Cabo","year":"2023","journal-title":"Eur Heart J"},{"issue":"107452","key":"key20250417095309_b144-ETM-29-5-12854","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2024.107452","article-title":"Unravelling molecular mechanisms in atherosclerosis using cellular models and omics technologies","volume":"158","author":"Kardassis","year":"2024","journal-title":"Vascul Pharmacol"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T06:53:13Z","timestamp":1744872793000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2025.12854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":144,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,3,26]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2025.12854","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,26]]}}}