{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:16:46Z","timestamp":1790957806086,"version":"4.1.0"},"reference-count":99,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2025.12884","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T11:27:43Z","timestamp":1747135663000},"page":"1-11","source":"Crossref","is-referenced-by-count":7,"title":["Potential applications of components of aged garlic extract in mitigating pro\u2011inflammatory gene expression linked to human diseases (Review)"],"prefix":"10.3892","volume":"30","author":[{"given":"Enzo","family":"Agostinelli","sequence":"first","affiliation":[{"name":"Department of Sensory Organs, Sapienza University of Rome, Policlinico Umberto I, I-00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Marzaro","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Public Health, University of Verona, I-37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gambari","sequence":"additional","affiliation":[{"name":"Research Center on Innovative Therapies for Cystic Fibrosis, University of Ferrara, I-44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Finotti","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Biotechnology, Ferrara University, I-44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"key20250611105102_b1-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.3892\/ijo.2018.4452","article-title":"The anti-oxidant, aged garlic extract, exerts cytotoxic effects on wild-type and multidrug-resistant human cancer cells by altering mitochondrial permeability","volume":"53","author":"Ohkubo","year":"2018","journal-title":"Int J Oncol"},{"key":"key20250611105102_b2-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1055\/s-2006-959522","article-title":"Antioxidant and radical scavenging effects of aged garlic extract and its constituents","volume":"60","author":"Imai","year":"1994","journal-title":"Planta Medica"},{"issue":"3691","key":"key20250611105102_b3-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.3390\/nu15173691","article-title":"Antihypertensive effects of an optimized aged garlic extract in subjects with grade I hyper-tension and antihypertensive drug therapy: A Randomized, triple-blind controlled trial","volume":"15","author":"Serrano","year":"2023","journal-title":"Nutrients"},{"issue":"e0286454","key":"key20250611105102_b4-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0286454","article-title":"Aged black garlic extract inhibits the growth of estrogen receptor-positive breast cancer cells by downregulating MCL-1 expression through the ROS-JNK pathway","volume":"18","author":"Yang","year":"2023","journal-title":"PLoS One"},{"key":"key20250611105102_b5-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"146","DOI":"10.2174\/2772432819666230504093227","article-title":"A review on the efficacy of plant-derived bio-active compounds cur-cumin and aged garlic extract in modulating cancer and age-related diseases","volume":"19","author":"Das","year":"2024","journal-title":"Curr Rev Clin Exp Pharmacol"},{"issue":"1010S-5S","key":"key20250611105102_b6-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.3.1010S","article-title":"Antioxidant health effects of aged garlic extract","volume":"131(3s)","author":"Borek","year":"2001","journal-title":"J Nutr"},{"key":"key20250611105102_b7-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.clnesp.2017.11.010","article-title":"Aged garlic extract supplementation modifies inflammation and immunity of adults with obesity: A randomized, double-blind, placebo-controlled clinical trial","volume":"24","author":"Xu","year":"2018","journal-title":"Clin Nutr ESPEN"},{"key":"key20250611105102_b8-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"4177","DOI":"10.1002\/ptr.8270","article-title":"Anti-inflammatory and anti-hyperalgesic effects induced by an aqueous aged black garlic extract in rodent models of ulcerative colitis and colitis-associated visceral pain","volume":"38","author":"Libero","year":"2024","journal-title":"Phytother Res"},{"issue":"6636875","key":"key20250611105102_b9-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6636875","article-title":"Aged garlic extract reduces IL-6: A double-blind placebo-controlled trial in females with a low risk of cardiovascular disease","volume":"2021","author":"Wlosinska","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"key20250611105102_b10-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"6818","DOI":"10.1007\/s11356-020-10997-5","article-title":"Aged garlic extract rescues ethephon-induced kidney damage by modulating oxidative stress, apoptosis, inflammation, and histopathological changes in rats","volume":"28","author":"Albrakati","year":"2021","journal-title":"Environ Sci Pollut Res Int"},{"key":"key20250611105102_b11-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1165\/rcmb.2018-0145ED","article-title":"Targeting IL-8 in cystic fibrosis: Enough but Not too much","volume":"59","author":"McElvaney","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20250611105102_b12-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1183\/09031936.03.00031803","article-title":"Fluticasone reduces IL-6 and IL-8 production of cystic fibrosis bronchial epithelial cells via IKK-beta kinase pathway","volume":"21","author":"Escotte","year":"2003","journal-title":"Eur Respir J"},{"key":"key20250611105102_b13-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1164\/rccm.201405-0992OC","article-title":"CXCR2 antagonist MK-7123. A phase 2 proof-of-concept trial for chronic obstructive pulmonary disease","volume":"191","author":"Rennard","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"key20250611105102_b14-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.pupt.2015.08.002","article-title":"Combined anti CXC receptors 1 and 2 therapy is a promising anti-inflammatory treatment for respiratory diseases by reducing neutrophil migration and activation","volume":"34","author":"Planagum\u00e0","year":"2015","journal-title":"Pulm Pharmacol Ther"},{"key":"key20250611105102_b15-ETM-30-1-12884","author":"Yang"},{"key":"key20250611105102_b16-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1056\/NEJMoa2028700","article-title":"Tocilizumab in hospitalized patients with severe Covid-19 pneumonia","volume":"384","author":"Rosas","year":"2021","journal-title":"N Engl J Med"},{"key":"key20250611105102_b17-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.jiph.2021.06.004","article-title":"Interleukin-6 (IL-6) inhibitors as therapeutic agents for coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis","volume":"14","author":"Pinzon","year":"2021","journal-title":"J Infect Public Health"},{"issue":"47","key":"key20250611105102_b18-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14010047","article-title":"Effect of anti-interleukin-6 agents on psychopathology in a sample of patients with post-COVID-19 syndrome: an observational study","volume":"14","author":"Simonetti","year":"2024","journal-title":"Brain Sci"},{"key":"key20250611105102_b19-ETM-30-1-12884","author":"Holms"},{"key":"key20250611105102_b20-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nrd3800","article-title":"Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases","volume":"11","author":"Dinarello","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"key20250611105102_b21-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"5077","DOI":"10.2147\/JIR.S474707","article-title":"Interplay of TLR4 and SARS-CoV-2: Unveiling the complex mechanisms of inflammation and severity in COVID-19 infections","volume":"17","author":"Asaba","year":"2024","journal-title":"J Inflamm Res"},{"key":"key20250611105102_b22-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1093\/rheumatology\/kead493","article-title":"Inhibition of TLR4 signalling to dampen joint inflammation in osteoarthritis","volume":"63","author":"Bartels","year":"2024","journal-title":"Rheumatology (Oxford)"},{"key":"key20250611105102_b23-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1517\/14728220802515293","article-title":"Toll-like receptors as therapeutic targets in cystic fibrosis","volume":"12","author":"Greene","year":"2008","journal-title":"Expert Opin Ther Targets"},{"key":"key20250611105102_b24-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1021\/jf0106648","article-title":"Physical, chemical, and biological properties of s-allylcysteine, an amino acid derived from garlic","volume":"50","author":"Kodera","year":"2002","journal-title":"J Agric Food Chem"},{"key":"key20250611105102_b25-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.3892\/etm.2019.8383","article-title":"Aged garlic extract and its constituent, S-allyl-L-cysteine, induce the apoptosis of neuroblastoma cancer cells due to mitochondrial membrane depolarization","volume":"19","author":"Kanamori","year":"2020","journal-title":"Exp Ther Med"},{"issue":"570","key":"key20250611105102_b26-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22040570","article-title":"Chemical and biological properties of S-1-Propenyl-l-cysteine in aged garlic extract","volume":"22","author":"Kodera","year":"2017","journal-title":"Molecules"},{"key":"key20250611105102_b27-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1172\/JCI2865","article-title":"Activation of NF-kappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells","volume":"101","author":"DiMango","year":"1998","journal-title":"J Clin Invest"},{"key":"key20250611105102_b28-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"6069","DOI":"10.4049\/jimmunol.1100821","article-title":"Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells","volume":"187","author":"Bezzerri","year":"2011","journal-title":"J Immunol"},{"key":"key20250611105102_b29-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4161\/adna.21061","article-title":"Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic fibrosis IB3-1 cells: Recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene","volume":"3","author":"Finotti","year":"2012","journal-title":"Artif DNA PNA XNA"},{"key":"key20250611105102_b30-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1165\/rcmb.2013-0160OC","article-title":"Expression of microRNA-93 and Interleukin-8 during Pseudomonas aeruginosa-mediated induction of proinflammatory responses","volume":"50","author":"Fabbri","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"236","key":"key20250611105102_b31-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00236","article-title":"\u03b2-sitosterol reduces the expression of chemotactic cytokine genes in cystic fibrosis bronchial epithelial cells","volume":"8","author":"Lampronti","year":"2017","journal-title":"Front Pharmacol"},{"issue":"14483","key":"key20250611105102_b32-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214483","article-title":"New TMA (4,6,4'-Trimethyl angelicin) analogues as anti-inflammatory agents in the treatment of cystic fibrosis lung disease","volume":"23","author":"Tupini","year":"2022","journal-title":"Int J Mol Sci"},{"key":"key20250611105102_b33-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.ijbiomac.2017.02.011","article-title":"An antisense peptide nucleic acid against Pseudomonas aeruginosa inhibiting bacterial-induced inflammatory responses in the cystic fibrosis IB3-1 cellular model system","volume":"99","author":"Montagner","year":"2017","journal-title":"Int J Biol Macromol"},{"key":"key20250611105102_b34-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1574-695X.2010.00693.x","article-title":"Cellular responses of A549 alveolar epithelial cells to serially collected Pseudomonas aeruginosa from cystic fibrosis patients at different stages of pulmonary infection","volume":"59","author":"Hawdon","year":"2010","journal-title":"FEMS Immunol Med Microbiol"},{"key":"key20250611105102_b35-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1139\/cjpp-2012-0268","article-title":"The antioxidant resveratrol down-regulates inflammation in an in-vitro model of Pseudomonas aeruginosa infection of lung epithelial cells","volume":"91","author":"Cerqueira","year":"2013","journal-title":"Can J Physiol Pharmacol"},{"key":"key20250611105102_b36-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"297","DOI":"10.2174\/18715281113129990011","article-title":"Piceatannol modulates lung epithelial cellular responses to Pseudomonas aeruginosa","volume":"12","author":"Aval","year":"2013","journal-title":"Inflamm Allergy Drug Targets"},{"key":"key20250611105102_b37-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/jgm.1546","article-title":"Sustained inhibition of IL-6 and IL-8 expression by decoy ODN to NF-\u0138B delivered through respirable large porous particles in LPS-stimulated cystic fibrosis bronchial cells","volume":"13","author":"De Stefano","year":"2011","journal-title":"J Gene Med"},{"key":"key20250611105102_b38-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.bbrc.2007.03.141","article-title":"Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling","volume":"357","author":"Muselet-Charlier","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"key20250611105102_b39-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.jcf.2008.06.002","article-title":"Anti-inflammatory effect of miglustat in bronchial epithelial cells","volume":"7","author":"Dechecchi","year":"2008","journal-title":"J Cyst Fibros"},{"key":"key20250611105102_b40-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.intimp.2012.04.010","article-title":"Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells","volume":"13","author":"Gambari","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"key20250611105102_b41-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"4870","DOI":"10.1016\/j.ejmech.2011.07.032","article-title":"Development of a novel furocoumarin derivative inhibiting NF-\u03baB dependent biological functions: Design, synthesis and biological effects","volume":"46","author":"Borgatti","year":"2011","journal-title":"Eur J Med Chem"},{"issue":"153583","key":"key20250611105102_b42-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153583","article-title":"Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein","volume":"87","author":"Gasparello","year":"2021","journal-title":"Phytomedicine"},{"issue":"108201","key":"key20250611105102_b43-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108201","article-title":"In vitro induction of interleukin-8 by SARS-CoV-2 Spike protein is inhibited in bronchial epithelial IB3-1 cells by a miR-93-5p agomiR","volume":"101","author":"Gasparello","year":"2021","journal-title":"Int Immunopharmacol"},{"issue":"104128","key":"key20250611105102_b44-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2023.11.002","article-title":"Inhibitory effects of SARS-CoV-2 spike protein and BNT162b2 vaccine on erythropoietin-induced globin gene expression in erythroid precursor cells from patients with \u03b2-thalassemia","volume":"129","author":"Cosenza","year":"2024","journal-title":"Exp Hematol"},{"issue":"5938","key":"key20250611105102_b45-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29245938","article-title":"Aged Garlic Extract (AGE) and its constituents S-allyl-cysteine (SAC) inhibit the expression of pro-inflammatory genes induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein and the BNT162b2 vaccine","volume":"29","author":"Gasparello","year":"2024","journal-title":"Molecules"},{"key":"key20250611105102_b46-ETM-30-1-12884","author":"Papi"},{"key":"key20250611105102_b47-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.1002\/eji.202149227","article-title":"The soluble cytoplasmic tail of CD45 regulates T-cell activation via TLR4 signaling","volume":"51","author":"Puck","year":"2021","journal-title":"Eur J Immunol"},{"key":"key20250611105102_b48-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/s0891-5849(97)00006-3","article-title":"S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells","volume":"23","author":"Geng","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"key20250611105102_b49-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1128\/IAI.73.4.2504-2514.2005","article-title":"Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis","volume":"73","author":"Hoffmann","year":"2005","journal-title":"Infect Immun"},{"key":"key20250611105102_b50-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"3873","DOI":"10.1099\/mic.0.27955-0","article-title":"Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections","volume":"151","author":"Bjarnsholt","year":"2005","journal-title":"Microbiology (Reading)"},{"key":"key20250611105102_b51-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/ppul.21193","article-title":"Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis-a pilot randomized controlled trial","volume":"45","author":"Smyth","year":"2010","journal-title":"Pediatr Pulmonol"},{"issue":"3025","key":"key20250611105102_b52-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.3390\/nu16173025","article-title":"The protective effects of an aged black garlic water extract on the prostate","volume":"16","author":"Libero","year":"2024","journal-title":"Nutrients"},{"issue":"e33986","key":"key20250611105102_b53-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33986","article-title":"Aged garlic therapeutic intervention targeting inflammatory pathways in pathogenesis of bowel disorders","volume":"10","author":"Liu","year":"2024","journal-title":"Heliyon"},{"key":"key20250611105102_b54-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"14577","DOI":"10.1021\/acs.jafc.0c04520","article-title":"3-Allyltrisulfanyl-alanine formation during the preparation of aged garlic extract","volume":"68","author":"Kurita","year":"2020","journal-title":"J Agric Food Chem"},{"key":"key20250611105102_b55-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2174\/18761429113059990002","article-title":"Garlic as an anti-diabetic agent: Recent progress and patent reviews","volume":"5","author":"Padiya","year":"2013","journal-title":"Recent Pat Food Nutr Agric"},{"key":"key20250611105102_b56-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.3892\/etm.2019.8393","article-title":"Chemistry of aged garlic: Diversity of constituents in aged garlic extract and their production mechanisms via the combination of chemical and enzymatic reactions","volume":"19","author":"Kodera","year":"2020","journal-title":"Exp Ther Med"},{"key":"key20250611105102_b57-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"S80","DOI":"10.1111\/jgh.12730","article-title":"S-allyl cysteine alleviates nonsteroidal anti-inflammatory drug-induced gastric mucosal damages by increasing cyclooxygenase-2 inhibition, heme oxygenase-1 induction, and histone deacetylation inhibition","volume":"4","author":"Park","year":"2014","journal-title":"J Gastroenterol Hepatol 29 Suppl"},{"key":"key20250611105102_b58-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.neuint.2015.06.011","article-title":"On the antioxidant, neuroprotective and anti-inflammatory properties of S-allyl cysteine: An update","volume":"89","author":"Col\u00edn-Gonz\u00e1lez","year":"2015","journal-title":"Neurochem Int"},{"key":"key20250611105102_b59-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"19254","DOI":"10.18632\/aging.103757","article-title":"S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway","volume":"12","author":"Shao","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"key20250611105102_b60-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1172\/JCI11837","article-title":"Toll-like receptor-mediated NF-kappaB activation: A phylogenetically conserved paradigm in innate immunity","volume":"107","author":"Zhang","year":"2001","journal-title":"J Clin Invest"},{"issue":"17023","key":"key20250611105102_b61-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Sig Transduct Target Ther"},{"key":"key20250611105102_b62-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1111\/cbdd.13837","article-title":"Toll-like receptor 4 antagonist FP7 alleviates lipopolysaccharide-induced septic shock via NF-kB signaling pathway","volume":"97","author":"Li","year":"2021","journal-title":"Chem Biol Drug Des"},{"key":"key20250611105102_b63-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.bcp.2006.07.010","article-title":"Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity","volume":"72","author":"Doyle","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"key20250611105102_b64-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1146\/annurev.immunol.021908.132641","article-title":"Regulation and function of NF-kappaB transcription factors in the immune system","volume":"27","author":"Vallabhapurapu","year":"2009","journal-title":"Annu Rev Immunol"},{"issue":"a000158","key":"key20250611105102_b65-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000158","article-title":"The IKK complex, a central regulator of NF-kappaB activation","volume":"2","author":"Israel","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"key20250611105102_b66-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by Toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol Med"},{"key":"key20250611105102_b67-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1097\/CAD.0000000000001015","article-title":"S-allylcysteine induces cytotoxic effects in two human lung cancer cell lines via induction of oxidative damage, downregulation of Nrf2 and NF-\u0138B, and apoptosis","volume":"32","author":"Orozco-Morales","year":"2021","journal-title":"Anticancer Drugs"},{"key":"key20250611105102_b68-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1111\/exd.14041","article-title":"S-allyl cysteine inhibits TNF-\u03b1-induced inflammation in HaCaT keratinocytes by inhibition of NF-\u03baB-dependent gene expression via sustained ERK activation","volume":"28","author":"Basu","year":"2019","journal-title":"Exp Dermatol"},{"key":"key20250611105102_b69-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/glia.20225","article-title":"Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation","volume":"52","author":"Qin","year":"2005","journal-title":"Glia"},{"key":"key20250611105102_b70-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/labinvest.2013.79","article-title":"Inhibition of reactive oxygen species generation attenuates TLR4-mediated proinflammatory and proliferative phenotype of vascular smooth muscle cells","volume":"93","author":"Pi","year":"2013","journal-title":"Lab Invest"},{"key":"key20250611105102_b71-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"key20250611105102_b72-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/s0300-9084(01)01237-8","article-title":"Control of IkappaBalpha proteolysis by the ubiquitin-proteasome pathway","volume":"83","author":"Tanaka","year":"2001","journal-title":"Biochimie"},{"key":"key20250611105102_b73-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1600-065X.2012.01098.x","article-title":"Regulation of NF-\u03baB by ubiquitination and degradation of the I\u03baBs","volume":"246","author":"Kanarek","year":"2012","journal-title":"Immunol Rev"},{"issue":"318613","key":"key20250611105102_b74-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/318613","article-title":"Modulation of PPAR-\u03b3 by nutraceutics as complementary treatment for obesity-related disorders and inflammatory diseases","volume":"2012","author":"Ortu\u00f1o Sahag\u00fan","year":"2012","journal-title":"PPAR Res"},{"key":"key20250611105102_b75-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"E174","DOI":"10.1152\/ajpendo.90632.2008","article-title":"PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle","volume":"297","author":"Remels","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key20250611105102_b76-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/em.20454","article-title":"Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds","volume":"50","author":"Nian","year":"2009","journal-title":"Environ Mol Mutagen"},{"issue":"8874339","key":"key20250611105102_b77-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8874339","article-title":"COVID-19 and toll-like receptor 4 (TLR4): SARS-CoV-2 may bind and activate TLR4 to increase ACE2 expression, facilitating entry and causing hyperinflammation","volume":"2021","author":"Aboudounya","year":"2021","journal-title":"Mediators Inflamm"},{"issue":"e21893","key":"key20250611105102_b78-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21893","article-title":"SARS-CoV-2 activates the TLR4\/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19","volume":"9","author":"Sahanic","year":"2023","journal-title":"Heliyon"},{"issue":"e0304425","key":"key20250611105102_b79-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0304425","article-title":"In-silico discovery of common molecular signatures for which SARS-CoV-2 infections and lung diseases stimulate each other, and drug repurposing","volume":"19","author":"Alamin","year":"2024","journal-title":"PLoS One"},{"issue":"8078259","key":"key20250611105102_b80-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8078259","article-title":"Discovering common pathophysiological processes between COVID-19 and cystic fibrosis by differential gene expression pattern analysis","volume":"2022","author":"Hasan","year":"2022","journal-title":"Biomed Res Int"},{"issue":"105657","key":"key20250611105102_b81-ETM-30-1-12884","article-title":"S-Allyl-L-Cysteine-A garlic Bioactive: Physicochemical nature, mechanism, pharmacokinetics, and health promoting activities","volume":"107","author":"Rais","year":"2023","journal-title":"J Funct Foods"},{"key":"key20250611105102_b82-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jphs.2019.03.002","article-title":"S-allyl-l-cysteine attenuates bleomycin-induced pulmonary fibrosis and inflammation via AKT\/NF-\u03baB signaling pathway in mice","volume":"139","author":"Nie","year":"2019","journal-title":"J Pharmacol Sci"},{"key":"key20250611105102_b83-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"3306","DOI":"10.2174\/092986711796504664","article-title":"The \u2018aged garlic extract:\u2019 (AGE) and one of its active ingredients S-allyl-L-cysteine (SAC) as potential preventive and therapeutic agents for Alzheimer's disease (AD)","volume":"18","author":"Ray","year":"2011","journal-title":"Curr Med Chem"},{"key":"key20250611105102_b84-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.3892\/etm.2019.8391","article-title":"Neuroprotective mechanisms of S-allyl-L-cysteine in neurological disease","volume":"19","author":"Kosuge","year":"2020","journal-title":"Exp Ther Med"},{"key":"key20250611105102_b85-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1139\/bcb-2021-0004","article-title":"S-allylcysteine inhibits chondrocyte inflammation to reduce human osteoarthritis via targeting RAGE, TLR4, JNK, and Nrf2 signaling: comparison with colchicine","volume":"99","author":"Elmazoglu","year":"2021","journal-title":"Biochem Cell Biol"},{"issue":"129676","key":"key20250611105102_b86-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2020.129676","article-title":"S-allyl cysteine: A potential compound against skeletal muscle atrophy","volume":"1864","author":"Gupta","year":"2020","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"key20250611105102_b87-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.bbagen.2017.12.015","article-title":"S-allyl cysteine inhibits TNF\u03b1-induced skeletal muscle wasting through suppressing proteolysis and expression of inflammatory molecules","volume":"1862","author":"Dutt","year":"2018","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"key20250611105102_b88-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"H2693","DOI":"10.1152\/ajpheart.00853.2007","article-title":"S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway","volume":"293","author":"Chuah","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key20250611105102_b89-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.3892\/ijmm.2019.4351","article-title":"S-allyl-cysteine sulfoxide (alliin) alleviates myocardial infarction by modulating cardiomyocyte necroptosis and autophagy","volume":"44","author":"Yue","year":"2019","journal-title":"Int J Mol Med"},{"key":"key20250611105102_b90-ETM-30-1-12884","first-page":"523","article-title":"Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn","volume":"30","author":"Sheela","year":"1992","journal-title":"Indian J Exp Biol"},{"issue":"3527","key":"key20250611105102_b91-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21421-x","article-title":"Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice","volume":"8","author":"Zhai","year":"2018","journal-title":"Sci Rep"},{"issue":"1154034","key":"key20250611105102_b92-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1154034","article-title":"Updates on the anticancer potential of garlic organosulfur compounds and their nanoformulations: Plant therapeutics in cancer management","volume":"14","author":"Pandey","year":"2023","journal-title":"Front Pharmacol"},{"issue":"84","key":"key20250611105102_b93-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.IJPVM_437_17","article-title":"Aged garlic and cancer: A systematic review","volume":"9","author":"Miraghajani","year":"2018","journal-title":"Int J Prev Med"},{"issue":"272","key":"key20250611105102_b94-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-024-01145-3","article-title":"S-allyl-cysteine triggers cytotoxic events in rat glioblastoma RG2 and C6 cells and improves the effect of temozolomide through the regulation of oxidative responses","volume":"15","author":"Reyes-Soto","year":"2024","journal-title":"Discov Oncol"},{"key":"key20250611105102_b95-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"1085S","DOI":"10.1093\/jn\/131.3.1085s","article-title":"In vitro effects of aged garlic extract and other nutritional supplements on sickle erythrocytes","volume":"131(3s)","author":"Ohnishi","year":"2001","journal-title":"J Nutr"},{"key":"key20250611105102_b96-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"803S","DOI":"10.1093\/jn\/136.3.803S","article-title":"Aged garlic extract is a potential therapy for sickle-cell anemia","volume":"136 (Suppl 3)","author":"Takasu","year":"2006","journal-title":"J Nutr"},{"issue":"3","key":"key20250611105102_b97-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2326-2-3","article-title":"Aged garlic extract therapy for sickle cell anemia patients","volume":"2","author":"Takasu","year":"2002","journal-title":"BMC Blood Disord"},{"key":"key20250611105102_b98-ETM-30-1-12884","doi-asserted-by":"publisher","first-page":"7963","DOI":"10.2147\/JIR.S501862","article-title":"Interplay of TLR4 and SARS-CoV-2: Possible involvement of microRNAs [Letter]","volume":"17","author":"Gambari","year":"2024","journal-title":"J Inflamm Res"},{"issue":"85","key":"key20250611105102_b99-ETM-30-1-12884","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2025.12835","article-title":"Preliminary results and a theoretical perspective of co-treatment using a miR-93-5p mimic and aged garlic extract to inhibit the expression of the pro-inflammatory interleukin-8 gene","volume":"29","author":"Gambari","year":"2025","journal-title":"Exp Ther Med"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T07:51:10Z","timestamp":1749628270000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2025.12884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":99,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,5,13]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2025.12884","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,13]]}}}