{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:20:08Z","timestamp":1783635608971,"version":"3.55.0"},"reference-count":45,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2025.12888","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T10:41:04Z","timestamp":1747392064000},"page":"1-12","source":"Crossref","is-referenced-by-count":2,"title":["Effect of dupilumab for the therapy of atopic dermatitis and the effect on serum TARC, HBD2 and SEA\u2011IgE levels and peripheral blood T helper cell subtypes"],"prefix":"10.3892","volume":"30","author":[{"given":"Xin","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou First People's Hospital, Guangzhou, Guangdong 510180, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Qianxi People's Hospital, Qianxi, Guizhou 551500, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aili","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianru","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujun","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongxiao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manqi","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou First People's Hospital, Guangzhou, Guangdong 510180, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihua","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou First People's Hospital, Guangzhou, Guangdong 510180, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"key20250611105112_b1-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"S99","DOI":"10.1016\/s0091-6749(99)70051-5","article-title":"Pathogenesis of atopic dermatitis","volume":"104","author":"Leung","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"key20250611105112_b2-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jdermsci.2006.06.003","article-title":"Skin barrier function, epidermal proliferation and differentiation in eczema","volume":"43","author":"Proksch","year":"2006","journal-title":"J Dermatol Sci"},{"key":"key20250611105112_b3-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s11882-008-0048-0","article-title":"Skin barrier function","volume":"8","author":"Elias","year":"2008","journal-title":"Curr Allergy Asthma Rep"},{"key":"key20250611105112_b4-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaci.2018.10.032","article-title":"Atopic dermatitis endotypes and implications for targeted therapeutics","volume":"143","author":"Czarnowicki","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"key20250611105112_b5-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1111\/bjd.19645","article-title":"Association between air pollution and atopic dermatitis in Guangzhou, China: Modification by age and season","volume":"184","author":"Wang","year":"2021","journal-title":"Br J Dermatol"},{"key":"key20250611105112_b6-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/jdv.13301","article-title":"The effect of environmental humidity and temperature on skin barrier function and dermatitis","volume":"30","author":"Engebretsen","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"key20250611105112_b7-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2332\/allergolint.10-RAI-0273","article-title":"Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases","volume":"60","author":"Takai","year":"2011","journal-title":"Allergol Int"},{"key":"key20250611105112_b8-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1038\/jid.2008.13","article-title":"Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal permeability barrier recovery","volume":"128","author":"Jeong","year":"2008","journal-title":"J Invest Dermatol"},{"key":"key20250611105112_b9-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/all.12268","article-title":"Atopic dermatitis and the atopic march revisited","volume":"69","author":"Dharmage","year":"2014","journal-title":"Allergy"},{"issue":"1","key":"key20250611105112_b10-ETM-30-1-12888","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0001-z","article-title":"Atopic dermatitis","volume":"4","author":"Weidinger","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"key20250611105112_b11-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.jaci.2012.07.012","article-title":"Progressive activation of T(H)2\/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis","volume":"130","author":"Gittler","year":"2012","journal-title":"J Allergy Clin Immunol"},{"issue":"1314","key":"key20250611105112_b12-ETM-30-1-12888","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041314","article-title":"The role of Th17-related cytokines in atopic dermatitis","volume":"21","author":"Sugaya","year":"2020","journal-title":"Int J Mol Sci"},{"key":"key20250611105112_b13-ETM-30-1-12888","first-page":"81","article-title":"Guideline for diagnosis and treatment of atopic dermatitis in China","volume":"53","author":"Gu","year":"2020","journal-title":"Chinese J Dermatol"},{"key":"key20250611105112_b14-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.jaci.2015.08.015","article-title":"The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization","volume":"136","author":"Noda","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"key20250611105112_b15-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1016\/j.jid.2018.03.1517","article-title":"Patients with atopic dermatitis colonized with staphylococcus aureus have a distinct phenotype and endotype","volume":"138","author":"Simpson","year":"2018","journal-title":"J Invest Dermatol"},{"key":"key20250611105112_b16-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"340","DOI":"10.2340\/00015555-1465","article-title":"Sensitization to skin-associated microorganisms in adult patients with atopic dermatitis is of importance for disease severity","volume":"93","author":"Sonesson","year":"2013","journal-title":"Acta Derm Venereol"},{"key":"key20250611105112_b17-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000367923","article-title":"Staphylococcal exotoxins induce interleukin 22 in human th22 cells","volume":"165","author":"Niebuhr","year":"2014","journal-title":"Int Arch Allergy Immunol"},{"key":"key20250611105112_b18-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jid.2016.08.025","article-title":"IL-1\u03b2-induced protection of keratinocytes against staphylococcus aureus-secreted proteases is mediated by human \u03b2-defensin 2","volume":"137","author":"Wang","year":"2017","journal-title":"J Invest Dermatol"},{"key":"key20250611105112_b19-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1056\/NEJMoa021481","article-title":"Endogenous antimicrobial peptides and skin infections in atopic dermatitis","volume":"347","author":"Ong","year":"2002","journal-title":"N Engl J Med"},{"key":"key20250611105112_b20-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.imbio.2011.10.010","article-title":"Increased serum human \u03b2-defensin-2 levels in atopic dermatitis: relationship to IL-22 and oncostatin M","volume":"217","author":"Kanda","year":"2012","journal-title":"Immunobiology"},{"key":"key20250611105112_b21-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"e261","DOI":"10.1111\/ijd.12830","article-title":"Serum levels of thymus and activation-regulated chemokine can be used in the clinical evaluation of atopic dermatitis","volume":"54","author":"Gu","year":"2015","journal-title":"Int J Dermatol"},{"key":"key20250611105112_b22-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.jaad.2020.05.052","article-title":"The role of thymus and activation-regulated chemokine as a marker of severity of atopic dermatitis","volume":"84","author":"Himadri George","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"key20250611105112_b23-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.alit.2020.02.006","article-title":"Japanese guidelines for atopic dermatitis 2020","volume":"69","author":"Katoh","year":"2020","journal-title":"Allergol Int"},{"key":"key20250611105112_b24-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2147\/CE.S133661","article-title":"Dupilumab: An evidence-based review of its potential in the treatment of atopic dermatitis","volume":"13","author":"Eshtiaghi","year":"2018","journal-title":"Core Evid"},{"key":"key20250611105112_b25-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jaci.2018.08.022","article-title":"Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis","volume":"143","author":"Guttman-Yassky","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"key20250611105112_b26-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jid.2019.05.024","article-title":"IL-4R\u03b1 blockade by dupilumab decreases staphylococcus aureus colonization and increases microbial diversity in atopic dermatitis","volume":"140","author":"Callewaert","year":"2020","journal-title":"J Invest Dermatol"},{"key":"key20250611105112_b27-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s40257-019-00436-8","article-title":"Management recommendations for dupilumab partial and non-durable responders in atopic dermatitis","volume":"20","author":"Hendricks","year":"2019","journal-title":"Am J Clin Dermatol"},{"key":"key20250611105112_b28-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1365-2133.1994.tb08530.x","article-title":"The U.K. working party's diagnostic criteria for atopic dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis","volume":"131","author":"Williams","year":"1994","journal-title":"Br J Dermatol"},{"key":"key20250611105112_b29-ETM-30-1-12888","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/JD9.0000000000000143","article-title":"Guidelines for diagnosis and treatment of atopic dermatitis in China (2020)","volume":"4","author":"Yao","year":"2021","journal-title":"Int J Dermatol Venereol"},{"key":"key20250611105112_b30-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1111\/bjd.19457","article-title":"What are the best endpoints for eczema area and severity index and scoring atopic dermatitis in clinical practice? A prospective observational study","volume":"184","author":"Silverberg","year":"2021","journal-title":"Br J Dermatol"},{"key":"key20250611105112_b31-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1111\/bjd.15179","article-title":"Patient-oriented eczema measure (POEM), a core instrument to measure symptoms in clinical trials: A harmonising outcome measures for eczema (HOME) statement","volume":"176","author":"Spuls","year":"2017","journal-title":"Br J Dermatol"},{"key":"key20250611105112_b32-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/bjd.19751","article-title":"Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: Results of the HOME VII consensus meeting","volume":"185","author":"Thomas","year":"2021","journal-title":"Br J Dermatol"},{"issue":"e15385","key":"key20250611105112_b33-ETM-30-1-12888","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15385","article-title":"The efficacy and safety of dupilumab for the treatment of atopic dermatitis among Chinese patients in clinical practice: A single-center retrospective study","volume":"35","author":"Li","year":"2022","journal-title":"Dermatol Ther"},{"key":"key20250611105112_b34-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1080\/09546634.2019.1682503","article-title":"Real-life experience on effectiveness and safety of dupilumab in adult patients with moderate-to-severe atopic dermatitis","volume":"32","author":"Fargnoli","year":"2021","journal-title":"J Dermatolog Treat"},{"key":"key20250611105112_b35-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1111\/jdv.15609","article-title":"Treatment of atopic dermatitis with dupilumab: Experience from a tertiary referral centre","volume":"33","author":"Olesen","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"key20250611105112_b36-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"485","DOI":"10.5114\/ada.2018.77056","article-title":"The role of Staphylococcus aureus in atopic dermatitis: Microbiological and immunological implications","volume":"36","author":"Tomczak","year":"2019","journal-title":"Postepy Dermatol Alergol"},{"issue":"404","key":"key20250611105112_b37-ETM-30-1-12888","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-2118-x","article-title":"Targeted anti-staphylococcal therapy with endolysins in atopic dermatitis and the effect on steroid use, disease severity and the microbiome: Study protocol for a randomized controlled trial (MAAS trial)","volume":"18","author":"Tott\u00e9","year":"2017","journal-title":"Trials"},{"issue":"eabe2749","key":"key20250611105112_b38-ETM-30-1-12888","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abe2749","article-title":"Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4R\u03b1 blockade","volume":"6","author":"Bangert","year":"2021","journal-title":"Sci Immunol"},{"key":"key20250611105112_b39-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/j.1600-0625.2012.01487.x","article-title":"Increased frequencies of IL-31-producing T cells are found in chronic atopic dermatitis skin","volume":"21","author":"Szegedi","year":"2012","journal-title":"Exp Dermatol"},{"key":"key20250611105112_b40-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"3695","DOI":"10.4049\/jimmunol.174.6.3695","article-title":"IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes","volume":"174","author":"Boniface","year":"2005","journal-title":"J Immunol"},{"issue":"2090","key":"key20250611105112_b41-ETM-30-1-12888","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11112090","article-title":"The pathology of type 2 inflammation-associated itch in atopic dermatitis","volume":"11","author":"Moniaga","year":"2021","journal-title":"Diagnostics (Basel)"},{"key":"key20250611105112_b42-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1038\/jid.2008.111","article-title":"Possible pathogenic role of Th17 cells for atopic dermatitis","volume":"128","author":"Koga","year":"2008","journal-title":"J Invest Dermatol"},{"key":"key20250611105112_b43-ETM-30-1-12888","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jaci.2013.04.046","article-title":"Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis","volume":"132","author":"Su\u00e1rez-Fari\u00f1as","year":"2013","journal-title":"J Allergy Clin Immunol"},{"issue":"239","key":"key20250611105112_b44-ETM-30-1-12888","doi-asserted-by":"publisher","DOI":"10.3390\/cells12020239","article-title":"Effects of dupilumab on itch-related events in atopic dermatitis: Implications for assessing treatment efficacy in clinical practice","volume":"12","author":"Kishi","year":"2023","journal-title":"Cells"},{"issue":"100003","key":"key20250611105112_b45-ETM-30-1-12888","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2021.100003","article-title":"Dupilumab effects on innate lymphoid cell and helper T cell populations in patients with atopic dermatitis","volume":"1","author":"Imai","year":"2021","journal-title":"JID Innov"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T07:51:16Z","timestamp":1749628276000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2025.12888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,5,16]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2025.12888","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,16]]}}}