{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:46:06Z","timestamp":1776415566743,"version":"3.51.2"},"reference-count":24,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Ther Med"],"DOI":"10.3892\/etm.2026.13114","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:03:44Z","timestamp":1772111024000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["A rare case of early\u2011onset cerebral syphilitic gummata with severe neurological decline in early\u2011stage syphilis: A case report"],"prefix":"10.3892","volume":"31","author":[{"given":"Yujie","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Jiangnan University Medical Center, Jiangnan University, Wuxi, Jiangsu 214000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jiangnan University Medical Center, Jiangnan University, Wuxi, Jiangsu 214000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, School of Science, Xi'an Jiaotong\u2011Liverpool University, Suzhou, Jiangsu 215000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youcai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nanjing No.\u00a01 People's Hospital, Nanjing, Jiangsu 210000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jiangnan University Medical Center, Jiangnan University, Wuxi, Jiangsu 214000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jiangnan University Medical Center, Jiangnan University, Wuxi, Jiangsu 214000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"key20260417104435_b1-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1056\/NEJMra1901593","article-title":"The modern epidemic of syphilis","volume":"382","author":"Ghanem","year":"2020","journal-title":"N Engl J Med"},{"key":"key20260417104435_b2-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/S0140-6736(22)02348-0","article-title":"Syphilis","volume":"402","author":"Peeling","year":"2023","journal-title":"Lancet"},{"key":"key20260417104435_b3-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1056\/NEJMra1906228","article-title":"Neurosyphilis","volume":"381","author":"Ropper","year":"2019","journal-title":"N Engl J Med"},{"key":"key20260417104435_b4-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1111\/jdv.13753","article-title":"Changes in neurosyphilis presentation: A survey on 286 patients","volume":"30","author":"Drago","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"key20260417104435_b5-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1227\/01.NEU.0000337079.12137.89","article-title":"Cerebral syphilitic gummata: A case presentation and analysis of 156 reported cases","volume":"64","author":"Fargen","year":"2009","journal-title":"Neurosurgery"},{"key":"key20260417104435_b6-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1073\/pnas.18.7.500","article-title":"Further concerning a parasympathetic center in the interbrain: VII. The effect of intraventricularly-injected histamine","volume":"18","author":"Cushing","year":"1932","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20260417104435_b7-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3171\/jns.1956.13.5.0479","article-title":"A study of the results of surgical treatment in 2,326 consecutive patients with brain tumor","volume":"13","author":"Grant","year":"1956","journal-title":"J Neurosurg"},{"key":"key20260417104435_b8-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3171\/jns.1959.16.5.0570","article-title":"A statistical study of brain tumors in the neurosurgical clinics in Japan","volume":"16","author":"Katsura","year":"1959","journal-title":"J Neurosurg"},{"issue":"906","key":"key20260417104435_b9-ETM-31-5-13114","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9050906","article-title":"Syphilitic gummata in the central nervous system: A narrative review and case report about a noteworthy clinical manifestation","volume":"9","author":"Barthel","year":"2021","journal-title":"Microorganisms"},{"key":"key20260417104435_b10-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1080\/02688697.2022.2159923","article-title":"Cerebral syphilitic gumma in the modern era: A report of an unusual case and brief review of recent published reports","volume":"38","author":"Kanayama","year":"2024","journal-title":"Br J Neurosurg"},{"key":"key20260417104435_b11-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"889","DOI":"10.4103\/0028-3886.293488","article-title":"Neurosyphilis-a forgotten disease: Case reports with ten years follow-up and review of literature","volume":"68","author":"Ramrakhiani","year":"2020","journal-title":"Neurol India"},{"key":"key20260417104435_b12-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"377","DOI":"10.4103\/0028-3886.338674","article-title":"A rare case of neurosyphilis presenting as normal pressure hydrocephalus syndrome","volume":"70","author":"Baskar","year":"2022","journal-title":"Neurol India"},{"key":"key20260417104435_b13-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jiac.2018.08.010","article-title":"Multiple cerebral syphilitic gummas mimicking brain tumor in a non-HIV-infected patient: A case report","volume":"25","author":"Sasaki","year":"2019","journal-title":"J Infect Chemother"},{"issue":"969","key":"key20260417104435_b14-ETM-31-5-13114","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.0672","article-title":"Treatment of late-stage syphilis","volume":"313","author":"Drago","year":"2015","journal-title":"JAMA"},{"key":"key20260417104435_b15-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"4501","DOI":"10.2147\/IJGM.S527864","article-title":"Clinical, radiological, and pathological features of cerebral and spinal syphilitic gumma: A cross-sectional study","volume":"18","author":"Zhang","year":"2025","journal-title":"Int J Gen Med"},{"issue":"2373305","key":"key20260417104435_b16-ETM-31-5-13114","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2024.2373305","article-title":"Early neurosyphilis with serofast state","volume":"13","author":"Zayet","year":"2024","journal-title":"Emerg Microbes Infect"},{"key":"key20260417104435_b17-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"481","DOI":"10.3109\/02688697.2016.1173190","article-title":"A case of a cerebral syphilitic gumma developed in a few months mimicking a brain tumor in a human immunodeficiency virus-negative patient","volume":"31","author":"Zhang","year":"2017","journal-title":"Br J Neurosurg"},{"key":"key20260417104435_b18-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jaad.2019.02.074","article-title":"Sexually acquired syphilis: Laboratory diagnosis, management, and prevention","volume":"82","author":"Forrestel","year":"2020","journal-title":"J Am Acad Dermatol"},{"issue":"e16887","key":"key20260417104435_b19-ETM-31-5-13114","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016887","article-title":"Multiple intracranial and spinal cord syphilitic gummas in a human immunodeficiency virus-negative man with untreated syphilis: A case report","volume":"98","author":"Shen","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"key20260417104435_b20-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"650","DOI":"10.12998\/wjcc.v12.i3.650","article-title":"Cerebral syphilitic gumma misdiagnosed as brain abscess: A case report","volume":"12","author":"Mu","year":"2024","journal-title":"World J Clin Cases"},{"key":"key20260417104435_b21-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.3201\/eid2210.160600","article-title":"Cerebral syphilitic gumma within 5 months of syphilis in HIV-infected patient","volume":"22","author":"Tsuboi","year":"2016","journal-title":"Emerg Infect Dis"},{"issue":"1254342","key":"key20260417104435_b22-ETM-31-5-13114","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1254342","article-title":"Syphilis and the host: Multi-omic analysis of host cellular responses to treponema pallidum provides novel insight into syphilis pathogenesis","volume":"14","author":"Waugh","year":"2023","journal-title":"Front Microbiol"},{"key":"key20260417104435_b23-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"e283","DOI":"10.1016\/j.ijid.2009.11.033","article-title":"When infections collide-gummatous syphilis in an HIV-infected individual","volume":"(14 Suppl 3)","author":"McVey","year":"2010","journal-title":"Int J Infect Dis"},{"key":"key20260417104435_b24-ETM-31-5-13114","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.idc.2023.02.006","article-title":"Syphilis: A modern resurgence","volume":"37","author":"Ramchandani","year":"2023","journal-title":"Infect Dis Clin North Am"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:44:46Z","timestamp":1776411886000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/etm.2026.13114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,2,26]]}},"URL":"https:\/\/doi.org\/10.3892\/etm.2026.13114","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]}}}