{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:39:00Z","timestamp":1792453140591,"version":"4.5.0"},"reference-count":43,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.3892\/ijmm.2012.1129","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T09:30:17Z","timestamp":1347960617000},"page":"1281-1286","source":"Crossref","is-referenced-by-count":64,"title":["RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis"],"prefix":"10.3892","volume":"30","author":[{"given":"NAOKO","family":"YAGISHITA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SATOKO","family":"ARATANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CRAIG","family":"LEACH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TETSUYA","family":"AMANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOSHIHISA","family":"YAMANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KO","family":"NAKATANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KUSUKI","family":"NISHIOKA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOSHIHIRO","family":"NAKAJIMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2012,9,18]]},"reference":[{"key":"key20180107234058_b1-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0889-857X(05)70201-5","article-title":"The epidemiology of rheumatoid arthritis","volume":"27","author":"Gabriel","year":"2001","journal-title":"Rheum Dis Clin North Am"},{"key":"key20180107234058_b2-ijmm-30-06-1281","first-page":"1631","article-title":"Effectiveness profiles and dose dependent retention of traditional disease modifying anti-rheumatic drugs for rheumatoid arthritis. An observational study","volume":"29","author":"Aletaha","year":"2002","journal-title":"J Rheumatol"},{"key":"key20180107234058_b3-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/S0140-6736(07)60784-3","article-title":"New therapies for treatment of rheumatoid arthritis","volume":"370","author":"Smolen","year":"2007","journal-title":"Lancet"},{"key":"key20180107234058_b4-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.2165\/11318290-000000000-00000","article-title":"Newer biological agents in the treatment of rheumatoid arthritis: do the benefits outweigh the risks?","volume":"69","author":"Nurmohamed","year":"2009","journal-title":"Drugs"},{"key":"key20180107234058_b5-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/art.1780380405","article-title":"Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes","volume":"38","author":"Nakajima","year":"1995","journal-title":"Arthritis Rheum"},{"key":"key20180107234058_b6-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1101\/gad.1096603","article-title":"Synoviolin\/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy","volume":"17","author":"Amano","year":"2003","journal-title":"Genes Dev"},{"key":"key20180107234058_b7-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1091\/mbc.9.1.209","article-title":"Der3p\/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins","volume":"9","author":"Bordallo","year":"1998","journal-title":"Mol Biol Cell"},{"key":"key20180107234058_b8-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1074\/jbc.M307734200","article-title":"Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase","volume":"279","author":"Shearer","year":"2004","journal-title":"J Biol Chem"},{"key":"key20180107234058_b9-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/sj.emboj.7600498","article-title":"Lipid-mediated, reversible misfolding of a sterol-sensing domain protein","volume":"24","author":"Shearer","year":"2005","journal-title":"EMBO J"},{"key":"key20180107234058_b10-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/art.21926","article-title":"Overexpression of synoviolin in peripheral blood and synoviocytes from rheumatoid arthritis patients and continued elevation in nonresponders to infliximab treatment","volume":"54","author":"Toh","year":"2006","journal-title":"Arthritis Rheum"},{"key":"key20180107234058_b11-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"R172","DOI":"10.1186\/ar2081","article-title":"The proinflammatory cytokines IL-1beta and TNF-alpha induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1\/2-ETS1 pathway","volume":"8","author":"Gao","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"key20180107234058_b12-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/embor.2008.37","article-title":"Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis","volume":"9","author":"Gao","year":"2008","journal-title":"EMBO Rep"},{"key":"key20180107234058_b13-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/ncprheum0699","article-title":"Synoviolin, protein folding and the maintenance of joint homeostasis","volume":"4","author":"Yagishita","year":"2008","journal-title":"Nat Clin Pract Rheumatol"},{"key":"key20180107234058_b14-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/sj.emboj.7601490","article-title":"Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase \u2018Synoviolin\u2019","volume":"26","author":"Yamasaki","year":"2007","journal-title":"EMBO J"},{"key":"key20180107234058_b15-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1097-2765(00)80482-7","article-title":"ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity","volume":"3","author":"Ohta","year":"1999","journal-title":"Mol Cell"},{"key":"key20180107234058_b16-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.4049\/jimmunol.153.7.3319","article-title":"Induction of T helper cell hyporesponsiveness in an experimental model of autoimmunity by using nonmitogenic anti-CD3 monoclonal antibody","volume":"153","author":"Hughes","year":"1994","journal-title":"J Immunol"},{"key":"key20180107234058_b17-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1002\/1529-0131(199912)42:12<2532::AID-ANR5>3.0.CO;2-2","article-title":"Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy","volume":"42","author":"Tomita","year":"1999","journal-title":"Arthritis Rheum"},{"key":"key20180107234058_b18-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1359-6446(00)00064-7","article-title":"Challenges and solutions to ultra-high-throughput screening assay miniaturization: submicroliter fluid handling","volume":"5","author":"Dunn","year":"2000","journal-title":"Drug Discov Today"},{"key":"key20180107234058_b19-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"30963","DOI":"10.1074\/jbc.274.43.30963","article-title":"The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING-finger\/IBR motif-containing domains of HHARI and H7-AP1","volume":"274","author":"Moynihan","year":"1999","journal-title":"J Biol Chem"},{"key":"key20180107234058_b20-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"14537","DOI":"10.1074\/jbc.C000881200","article-title":"The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation","volume":"276","author":"Hashizume","year":"2001","journal-title":"J Biol Chem"},{"key":"key20180107234058_b21-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nature00826","article-title":"Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth","volume":"417","author":"Urano","year":"2002","journal-title":"Nature"},{"key":"key20180107234058_b22-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.67.1.425","article-title":"The ubiquitin system","volume":"67","author":"Hershko","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"key20180107234058_b23-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev.biochem.70.1.503","article-title":"Mechanisms underlying ubiquitination","volume":"70","author":"Pickart","year":"2001","journal-title":"Annu Rev Biochem"},{"key":"key20180107234058_b24-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.biochem.78.101807.093809","article-title":"RING domain E3 ubiquitin ligases","volume":"78","author":"Deshaies","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"key20180107234058_b25-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI0216886","article-title":"Orchestrating the unfolded protein response in health and disease","volume":"110","author":"Kaufman","year":"2002","journal-title":"J Clin Invest"},{"key":"key20180107234058_b26-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2169\/internalmedicine.42.7","article-title":"Endoplasmic reticulum stress and diabetes mellitus","volume":"42","author":"Araki","year":"2003","journal-title":"Intern Med"},{"key":"key20180107234058_b27-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.2174\/138161211796197124","article-title":"The ubiquitin-proteasome system (UPS) and the mechanism of action of bortezomib","volume":"17","author":"Cvek","year":"2011","journal-title":"Curr Pharm Des"},{"key":"key20180107234058_b28-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1634\/theoncologist.7-1-9","article-title":"Development of the proteasome inhibitor PS-341","volume":"7","author":"Adams","year":"2002","journal-title":"Oncologist"},{"key":"key20180107234058_b29-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1056\/NEJMp030092","article-title":"The proteasome - an emerging therapeutic target in cancer","volume":"348","author":"Mitchell","year":"2003","journal-title":"N Engl J Med"},{"key":"key20180107234058_b30-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.ejca.2004.07.006","article-title":"The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications","volume":"40","author":"Burger","year":"2004","journal-title":"Eur J Cancer"},{"key":"key20180107234058_b31-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/156800911794519752","article-title":"Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives","volume":"11","author":"Chen","year":"2011","journal-title":"Curr Cancer Drug Targets"},{"key":"key20180107234058_b32-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrd892","article-title":"The druggable genome","volume":"1","author":"Hopkins","year":"2002","journal-title":"Nat Rev Drug Discov"},{"key":"key20180107234058_b33-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/1529-0131(200102)45:1<101::AID-ANR90>3.0.CO;2-7","article-title":"Physiology of cytokine pathways in rheumatoid arthritis","volume":"45","author":"Arend","year":"2001","journal-title":"Arthritis Rheum"},{"key":"key20180107234058_b34-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2094","article-title":"Cytokines in the pathogenesis of rheumatoid arthritis","volume":"7","author":"McInnes","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"key20180107234058_b35-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/01.bor.0000218947.42730.dd","article-title":"Synovial cell activation","volume":"18","author":"Stanczyk","year":"2006","journal-title":"Curr Opin Rheumatol"},{"key":"key20180107234058_b36-ijmm-30-06-1281","first-page":"45669","article-title":"Synovial fibroblasts: key players in rheumatoid arthritis","author":"Huber","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"key20180107234058_b37-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/ar2140","article-title":"Developments in the synovial biology field 2006","volume":"9","author":"Knedla","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"key20180107234058_b38-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"e13590","DOI":"10.1371\/journal.pone.0013590","article-title":"E3 ubiquitin ligase synoviolin is involved in liver fibrogenesis","volume":"5","author":"Hasegawa","year":"2010","journal-title":"PLoS One"},{"key":"key20180107234058_b39-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"e13416","DOI":"10.1371\/journal.pone.0013416","article-title":"Role of interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression","volume":"5","author":"Toh","year":"2010","journal-title":"PLoS One"},{"key":"key20180107234058_b40-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1073\/pnas.1016229108","article-title":"HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation","volume":"108","author":"Burr","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107234058_b41-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nrrheum.2011.8","article-title":"Therapy: Spleen tyrosine kinase inhibitors - novel therapies for RA?","volume":"7","author":"Gomez-Puerta","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"key20180107234058_b42-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1056\/NEJMoa1000500","article-title":"An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis","volume":"363","author":"Weinblatt","year":"2010","journal-title":"N Engl J Med"},{"key":"key20180107234058_b43-ijmm-30-06-1281","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1002\/art.30418","article-title":"Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1beta, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritis","volume":"63","author":"Koenders","year":"2011","journal-title":"Arthritis Rheum"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2012.1129\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T21:16:24Z","timestamp":1687727784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2012.1129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,18]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,9,18]]},"published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.3892\/ijmm.2012.1129"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2012.1129","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,18]]}}}