{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:06:00Z","timestamp":1780484760159,"version":"3.54.1"},"reference-count":43,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.3892\/ijmm.2013.1259","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T11:58:25Z","timestamp":1359547105000},"page":"938-942","source":"Crossref","is-referenced-by-count":46,"title":["Nicotine favors osteoclastogenesis in human periodontal ligament cells co-cultured with CD4+ T cells by upregulating IL-1\u03b2"],"prefix":"10.3892","volume":"31","author":[{"given":"LI-ZHENG","family":"WU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DUO-MO","family":"DUAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YING-FENG","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIN","family":"GE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHI-FEI","family":"ZHOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIAO-JING","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2013,1,30]]},"reference":[{"key":"key20180107233305_b1-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1600-0765.2007.01047.x","article-title":"Effects of smoking on the ex vivo cytokine production in periodontitis","volume":"44","author":"de Heens","year":"2009","journal-title":"J Periodontal Res"},{"key":"key20180107233305_b2-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1902\/jop.2000.71.5.743","article-title":"Smoking-attributable periodontitis in the United States: findings from NHANES III. National Health and Nutrition Examination Survey","volume":"71","author":"Tomar","year":"2000","journal-title":"J Periodontol"},{"key":"key20180107233305_b3-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1902\/jop.1993.64.1.16","article-title":"Evidence for cigarette smoking as a major risk factor for periodontitis","volume":"64","author":"Haber","year":"1993","journal-title":"J Periodontol"},{"key":"key20180107233305_b4-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1600-051X.2007.01131.x","article-title":"Cigarette smoking and periodontal disease among 32-year-olds: a prospective study of a representative birth cohort","volume":"34","author":"Thomson","year":"2007","journal-title":"J Clin Periodontol"},{"key":"key20180107233305_b5-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10266-004-0043-4","article-title":"Tobacco smoking and chronic destructive periodontal disease","volume":"92","author":"Bergstr\u00f6m","year":"2004","journal-title":"Odontology"},{"key":"key20180107233305_b6-ijmm-31-04-0938","first-page":"31","article-title":"Cigarette smoking and radiographic alveolar bone height and density","volume":"76","author":"Levin","year":"2010","journal-title":"NY State Dent J"},{"key":"key20180107233305_b7-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1902\/jop.2007.060149","article-title":"A histologic and histometric assessment of the influence of nicotine on alveolar bone loss in rats","volume":"78","author":"Bosco","year":"2007","journal-title":"J Periodontol"},{"key":"key20180107233305_b8-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1600-0765.2010.01290.x","article-title":"Micro-computerized tomography analysis of alveolar bone loss in ligature- and nicotine-induced experimental periodontitis in rats","volume":"45","author":"Liu","year":"2010","journal-title":"J Periodontal Res"},{"key":"key20180107233305_b9-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00441-010-0949-9","article-title":"Functional expression of alpha 7 nicotinic acetylcholine receptors in human periodontal ligament fibroblasts and rat periodontal tissues","volume":"340","author":"Wang","year":"2010","journal-title":"Cell Tissue Res"},{"key":"key20180107233305_b10-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1399-302X.2005.00241.x","article-title":"Gene expression analysis of the CD4+ T-cell clones derived from gingival tissues of periodontitis patients","volume":"20","author":"Ito","year":"2005","journal-title":"Oral Microbiol Immunol"},{"key":"key20180107233305_b11-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1177\/00220345000790080401","article-title":"Cytokine profiles of T-lymphocytes from gingival tissues with pathological pocketing","volume":"79","author":"Takeichi","year":"2000","journal-title":"J Dent Res"},{"key":"key20180107233305_b12-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1902\/jop.1998.69.10.1098","article-title":"Early-onset and adult periodontitis associated with abnormal cytokine production by activated T lymphocytes","volume":"69","author":"Sigusch","year":"1998","journal-title":"J Periodontol"},{"key":"key20180107233305_b13-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1600-0765.2006.00920.x","article-title":"Alveolar bone loss in T helper 1\/T helper 2 cytokine-deficient mice","volume":"42","author":"Alayan","year":"2007","journal-title":"J Periodontal Res"},{"key":"key20180107233305_b14-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1128\/IAI.67.6.2804-2809.1999","article-title":"CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice","volume":"67","author":"Baker","year":"1999","journal-title":"Infect Immun"},{"key":"key20180107233305_b15-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/00016350152509247","article-title":"T-cell contributions to alveolar bone loss in response to oral infection with Porphyromonas gingivalis","volume":"59","author":"Baker","year":"2001","journal-title":"Acta Odontol Scand"},{"key":"key20180107233305_b16-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1902\/jop.2005.76.11-S.2033","article-title":"Immune response: the key to bone resorption in periodontal disease","volume":"76","author":"Taubman","year":"2005","journal-title":"J Periodontol"},{"key":"key20180107233305_b17-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","article-title":"The molecular understanding of osteoclast differentiation","volume":"40","author":"Asagiri","year":"2007","journal-title":"Bone"},{"key":"key20180107233305_b18-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"key20180107233305_b19-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1902\/jop.2009.090098","article-title":"Effects of nicotine on antioxidant defense enzymes and RANKL expression in human periodontal ligament cells","volume":"80","author":"Lee","year":"2009","journal-title":"J Periodontol"},{"key":"key20180107233305_b20-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1034\/j.1600-051X.2003.300107.x","article-title":"Interleukin 1 and receptor antagonist levels in gingival crevicular fluid in heavy smokers versus non-smokers","volume":"30","author":"Rawlinson","year":"2003","journal-title":"J Clin Periodontol"},{"key":"key20180107233305_b21-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1600-0765.2012.01468.x","article-title":"Influence of smoking on interleukin-1beta level, oxidant status and antioxidant status in gingival crevicular fluid from chronic periodontitis patients before and after periodontal treatment","volume":"47","author":"Toker","year":"2012","journal-title":"J Periodontal Res"},{"key":"key20180107233305_b22-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1600-0757.2009.00321.x","article-title":"Cytokine responses against periodontal infection: protective and destructive roles","volume":"52","author":"Liu","year":"2010","journal-title":"Periodontol 2000"},{"key":"key20180107233305_b23-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1902\/jop.2004.75.2.196","article-title":"Cigarette smoking and the periodontal patient","volume":"75","author":"Johnson","year":"2004","journal-title":"J Periodontol"},{"key":"key20180107233305_b24-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jebdp.2005.12.018","article-title":"Periodontitis and smoking: an evidence-based appraisal","volume":"6","author":"Bergstr\u00f6m","year":"2006","journal-title":"J Evid Based Dent Pract"},{"key":"key20180107233305_b25-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1600-0722.2005.00240.x","article-title":"Smoking affects the self-healing capacity of periodontal tissues. A histological study in the rat","volume":"113","author":"Benatti","year":"2005","journal-title":"Eur J Oral Sci"},{"key":"key20180107233305_b26-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1902\/jop.2004.75.4.557","article-title":"Lymphocyte numbers and function in relation to periodontitis and smoking","volume":"75","author":"Loos","year":"2004","journal-title":"J Periodontol"},{"key":"key20180107233305_b27-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cyto.2009.05.006","article-title":"Cigarette smoking enhances T cell activation and a Th2 immune response; an aspect of the pathophysiology in periodontal disease","volume":"47","author":"de Heens","year":"2009","journal-title":"Cytokine"},{"key":"key20180107233305_b28-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1600-051X.2011.01810.x","article-title":"The RANKL-OPG system in clinical periodontology","volume":"39","author":"Belibasakis","year":"2012","journal-title":"J Clin Periodontol"},{"key":"key20180107233305_b29-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1034\/j.1600-0765.2003.00615.x","article-title":"Receptor activator NF kappaB ligand (RANKL) and osteoprotegerin (OPG) protein expression in periodontitis","volume":"38","author":"Crotti","year":"2003","journal-title":"J Periodontal Res"},{"key":"key20180107233305_b30-ijmm-31-04-0938","first-page":"17","article-title":"Expression of RANKL and OPG mRNA in periodontal disease: possible involvement in bone destruction","volume":"11","author":"Liu","year":"2003","journal-title":"Int J Mol Med"},{"key":"key20180107233305_b31-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1600-051X.2007.01061.x","article-title":"Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio","volume":"34","author":"Bostanci","year":"2007","journal-title":"J Clin Periodontol"},{"key":"key20180107233305_b32-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1600-051X.2009.01444.x","article-title":"Effect of smoking on concentrations of receptor activator of nuclear factor kappa B ligand and osteoprotegerin in human gingival crevicular fluid","volume":"36","author":"Tang","year":"2009","journal-title":"J Clin Periodontol"},{"key":"key20180107233305_b33-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1600-0765.2006.00934.x","article-title":"Smoking modulates interleukin-6:interleukin-10 and RANKL:osteoprotegerin ratios in the periodontal tissues","volume":"42","author":"Cesar-Neto","year":"2007","journal-title":"J Periodontal Res"},{"key":"key20180107233305_b34-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1600-051X.2008.01310.x","article-title":"Saliva concentrations of RANKL and osteoprotegerin in smoker versus non-smoker chronic periodontitis patients","volume":"35","author":"Buduneli","year":"2008","journal-title":"J Clin Periodontol"},{"key":"key20180107233305_b35-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1172\/JCI10763","article-title":"Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection","volume":"106","author":"Teng","year":"2000","journal-title":"J Clin Invest"},{"key":"key20180107233305_b36-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0041-0101(97)00092-5","article-title":"In vitro effects of smokeless tobacco extract on tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production, and on lymphocyte proliferation","volume":"36","author":"Seyedroudbari","year":"1998","journal-title":"Toxicon"},{"key":"key20180107233305_b37-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1600-051X.2009.01480.x","article-title":"Salivary interleukin-1beta concentration and the presence of multiple pathogens in periodontitis","volume":"36","author":"Gursoy","year":"2009","journal-title":"J Clin Periodontol"},{"key":"key20180107233305_b38-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1600-051X.2007.01057.x","article-title":"Gingival crevicular fluid interleukin-1beta, prostaglandin E2 and periodontal status in a community population","volume":"34","author":"Zhong","year":"2007","journal-title":"J Clin Periodontol"},{"key":"key20180107233305_b39-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jdent.2004.04.003","article-title":"Effect of periodontal therapy on crevicular fluid interleukin-1beta and interleukin-10 levels in chronic periodontitis","volume":"32","author":"Goutoudi","year":"2004","journal-title":"J Dent"},{"key":"key20180107233305_b40-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1177\/154405910708600708","article-title":"Intermittent force induces high RANKL expression in human periodontal ligament cells","volume":"86","author":"Nakao","year":"2007","journal-title":"J Dent Res"},{"key":"key20180107233305_b41-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1600-0765.2006.00959.x","article-title":"Mitogen-activated protein kinases mediate interleukin-1beta-induced receptor activator of nuclear factor-kappaB ligand expression in human periodontal ligament cells","volume":"42","author":"Oikawa","year":"2007","journal-title":"J Periodontal Res"},{"key":"key20180107233305_b42-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/jcp.21971","article-title":"Direct cell-cell contact between periodontal ligament fibroblasts and osteoclast precursors synergistically increases the expression of genes related to osteoclastogenesis","volume":"222","author":"Bloemen","year":"2010","journal-title":"J Cell Physiol"},{"key":"key20180107233305_b43-ijmm-31-04-0938","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/jcb.23109","article-title":"IL-1beta favors osteoclastogenesis via supporting human periodontal ligament fibroblasts","volume":"112","author":"Bloemen","year":"2011","journal-title":"J Cell Biochem"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2013.1259\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T08:52:53Z","timestamp":1714899173000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2013.1259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,30]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,1,30]]},"published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.3892\/ijmm.2013.1259"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2013.1259","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,30]]}}}