{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:58:27Z","timestamp":1767855507351,"version":"3.49.0"},"reference-count":41,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.3892\/ijmm.2013.1507","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T06:51:52Z","timestamp":1380091912000},"page":"1355-1365","source":"Crossref","is-referenced-by-count":2,"title":["The in vitro and in vivo treatment effects of overexpressed lentiviral vector-mediated human BMP2 gene in the femoral bone marrow stromal cells of osteoporotic rats"],"prefix":"10.3892","volume":"32","author":[{"given":"BING","family":"ZHAO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"QIANG","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIANZUN","family":"TAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUAN","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"QINGYUAN","family":"LIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2013,9,25]]},"reference":[{"key":"key20180107230206_b1-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.actbio.2012.01.009","article-title":"Sequential delivery of BMP-2 and IGF-1 using a chitosan gel with gelatin microspheres enhances early osteoblastic differentiation","volume":"8","author":"Kim","year":"2012","journal-title":"Acta Biomater"},{"key":"key20180107230206_b2-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbrc.2011.03.135","article-title":"Effects of BMP-2 and vitamin D3 on the osteogenic differentiation of adipose stem cells","volume":"408","author":"Song","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107230206_b3-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.bone.2007.01.001","article-title":"Autogenous regulation of a network of bone morphogenetic proteins (BMPs) mediates the osteogenic differentiation in murine marrow stromal cells","volume":"40","author":"Edgar","year":"2007","journal-title":"Bone"},{"key":"key20180107230206_b4-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1016\/j.biomaterials.2013.01.035","article-title":"Low dose BMP-2 treatment for bone repair using a PEGylated fibrinogen hydrogel matrix","volume":"34","author":"Ben-David","year":"2013","journal-title":"Biomaterials"},{"key":"key20180107230206_b5-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/ng1916","article-title":"BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing","volume":"38","author":"Tsuji","year":"2006","journal-title":"Nat Genet"},{"key":"key20180107230206_b6-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1034\/j.1600-0765.2001.360306.x","article-title":"Effect of aging on bone formation induced by recombinant human bone morphogenetic protein-2 combined with fibrous collagen membranes at subperiosteal sites","volume":"36","author":"Matsumoto","year":"2001","journal-title":"J Periodontal Res"},{"key":"key20180107230206_b7-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10529-012-1084-3","article-title":"BMP-2, VEGF and bFGF synergistically promote the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells","volume":"35","author":"Bai","year":"2013","journal-title":"Biotechnol Lett"},{"key":"key20180107230206_b8-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"905","DOI":"10.2106\/00004623-199907000-00002","article-title":"The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats","volume":"81","author":"Lieberman","year":"1999","journal-title":"J Bone Joint Surg Am"},{"key":"key20180107230206_b9-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S1525-0016(02)00062-X","article-title":"Efficient BMP2 gene transfer and bone formation of mesenchymal stem cells by a fiber-mutant adenoviral vector","volume":"7","author":"Tsuda","year":"2003","journal-title":"Mol Ther"},{"key":"key20180107230206_b10-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s10529-007-9532-1","article-title":"Osteogenic differentiation effects on rat bone marrow-derived mesenchymal stromal cells by lentivirus-mediated co-transfection of human BMP2 gene and VEGF165 gene","volume":"30","author":"Jiang","year":"2008","journal-title":"Biotechnol Lett"},{"key":"key20180107230206_b11-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s10856-011-4376-6","article-title":"LvBMP-2 gene-modified BMSCs combined with calcium phosphate cement scaffolds for the repair of calvarial defects in rats","volume":"22","author":"Zhu","year":"2011","journal-title":"J Mater Sci Mater Med"},{"key":"key20180107230206_b12-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.bone.2006.10.030","article-title":"Lentiviral-mediated BMP-2 gene transfer enhances healing of segmental femoral defects in rats","volume":"40","author":"Hsu","year":"2007","journal-title":"Bone"},{"key":"key20180107230206_b13-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1159\/000149907","article-title":"Use of recombinant human bone morphogenetic protein-2 to enhance posterior cervical spine fusion at 2 years of age: technical note","volume":"44","author":"Oluigbo","year":"2008","journal-title":"Pediatr Neurosurg"},{"key":"key20180107230206_b14-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1089\/ten.tea.2010.0555","article-title":"High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo","volume":"17","author":"Zara","year":"2011","journal-title":"Tissue Eng Part A"},{"key":"key20180107230206_b15-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/jgm.777","article-title":"Enhanced osteoinduction by mesenchymal stem cells transfected with a fiber- mutant adenoviral BMP2 gene","volume":"7","author":"Tsuda","year":"2005","journal-title":"J Gene Med"},{"key":"key20180107230206_b16-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1089\/089771502760341992","article-title":"Optimal treatment timing to attenuate neuronal apoptosis via Bcl-2 gene transfer in vitro and in vivo","volume":"19","author":"Yukawa","year":"2002","journal-title":"J Neurotrauma"},{"key":"key20180107230206_b17-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s11095-011-0629-9","article-title":"Magnetic nanoparticles enhance adenovirus transduction in vitro and in vivo","volume":"29","author":"Sapet","year":"2012","journal-title":"Pharm Res"},{"key":"key20180107230206_b18-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/j.1745-7254.2008.00823.x","article-title":"Lentiviral vector-mediated siRNA knockdown of SR-PSOX inhibits foam cell formation in vitro","volume":"29","author":"Zhang","year":"2008","journal-title":"Acta Pharmacol Sin"},{"key":"key20180107230206_b19-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/jor.22244","article-title":"Wnt pathway regulation by demineralized bone is approximated by both BMP-2 and TGF-\u03b21 signaling","volume":"31","author":"Zhou","year":"2013","journal-title":"J Orthop Res"},{"key":"key20180107230206_b20-ijmm-32-06-1355","first-page":"281","article-title":"The ectopic study of tissue-engineered bone with hBMP-4 gene modified bone marrow stromal cells in rabbits","volume":"118","author":"Jiang","year":"2005","journal-title":"Chin Med J (Engl)"},{"key":"key20180107230206_b21-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/jgm.292","article-title":"Bone marrow stromal cells as a genetic platform for systemic delivery of therapeutic proteins in vivo: human factor IX model","volume":"5","author":"Krebsbach","year":"2003","journal-title":"J Gene Med"},{"key":"key20180107230206_b22-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/gt.2008.133","article-title":"Transplantation of BMSCs expressing hPDGF-A\/hBD2 promotes wound healing in rats with combined radiation-wound injury","volume":"16","author":"Hao","year":"2009","journal-title":"Gene Ther"},{"key":"key20180107230206_b23-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/cgt.2009.64","article-title":"The anti-glioma effect of suicide gene therapy using BMSC expressing HSV\/TK combined with overexpression of Cx43 in glioma cells","volume":"17","author":"Huang","year":"2010","journal-title":"Cancer Gene Ther"},{"key":"key20180107230206_b24-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF00225804","article-title":"Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats","volume":"254","author":"Maniatopoulos","year":"1988","journal-title":"Cell Tissue Res"},{"key":"key20180107230206_b25-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1365-2184.2011.00747.x","article-title":"In vitro study of enhanced osteogenesis induced by HIF-1\u03b1-transduced bone marrow stem cells","volume":"44","author":"Zou","year":"2011","journal-title":"Cell Prolif"},{"key":"key20180107230206_b26-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s007740050081","article-title":"Number of osteoprogenitor cells in human bone marrow markedly decreases after skeletal maturation","volume":"17","author":"Nishida","year":"1999","journal-title":"J Bone Miner Metab"},{"key":"key20180107230206_b27-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1089\/ten.tea.2010.0620","article-title":"Reconstruction of alveolar bone defects using bone morphogenetic protein 2 mediated rabbit dental pulp stem cells seeded on nano-hydroxyapatite\/collagen\/poly(L-lactide)","volume":"17","author":"Liu","year":"2011","journal-title":"Tissue Eng Part A"},{"key":"key20180107230206_b28-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s00774-010-0236-6","article-title":"Reproducibility and agreement of micro-CT and histomorphometry in human trabecular bone with different metabolic status","volume":"29","author":"Tamminen","year":"2011","journal-title":"J Bone Miner Metab"},{"key":"key20180107230206_b29-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00223-010-9426-4","article-title":"Effects of nicotine administration and nicotine cessation on bone histomorphometry and bone biomarkers in Sprague-Dawley male rats","volume":"88","author":"Hapidin","year":"2011","journal-title":"Calcif Tissue Int"},{"key":"key20180107230206_b30-ijmm-32-06-1355","first-page":"42","article-title":"Stromal stem cells: marrow-derived osteogenic precursors","volume":"136","author":"Owen","year":"1988","journal-title":"Ciba Found Symp"},{"key":"key20180107230206_b31-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1023\/B:ABME.0000007800.89194.95","article-title":"Bone marrow stromal cells (BMSCs) in bone engineering: limitations and recent advances","volume":"32","author":"Derubeis","year":"2004","journal-title":"Ann Biomed Eng"},{"key":"key20180107230206_b32-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/jor.20467","article-title":"Multilineage differentiation of porcine bone marrow stromal cells associated with specific gene expression pattern","volume":"26","author":"Zou","year":"2008","journal-title":"J Orthop Res"},{"key":"key20180107230206_b33-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1034\/j.1600-0501.2001.012002121.x","article-title":"Temporal and local appearance of alkaline phosphatase activity in early stages of guided bone regeneration. A descriptive histochemical study in humans","volume":"12","author":"Stucki","year":"2001","journal-title":"Clin Oral Implants Res"},{"key":"key20180107230206_b34-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/jor.20359","article-title":"Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells","volume":"25","author":"Luu","year":"2007","journal-title":"J Orthop Res"},{"key":"key20180107230206_b35-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s12011-011-9094-x","article-title":"Effect of boron on osteogenic differentiation of human bone marrow stromal cells","volume":"144","author":"Ying","year":"2011","journal-title":"Biol Trace Elem Res"},{"key":"key20180107230206_b36-ijmm-32-06-1355","first-page":"318","article-title":"Osteogenic potential of bone marrow mesenchymal stem cells from ovariectomied osteoporotic rat","volume":"36","author":"Li","year":"2005","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"key20180107230206_b37-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1302\/0301-620X.89B3.18270","article-title":"Interbody fusion with allograft and rhBMP-2 leads to consistent fusion but early subsidence","volume":"89","author":"Vaidya","year":"2007","journal-title":"J Bone Joint Surg Br"},{"key":"key20180107230206_b38-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s00586-007-0351-9","article-title":"Complications of anterior cervical discectomy and fusion using recombinant human bone morphogenetic protein-2","volume":"16","author":"Vaidya","year":"2007","journal-title":"Eur Spine J"},{"key":"key20180107230206_b39-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00774-003-0430-x","article-title":"Osteoclast differentiation in ectopic bone formation induced by recombinant human bone morphogenetic protein 2 (rhBMP-2)","volume":"21","author":"Irie","year":"2003","journal-title":"J Bone Miner Metab"},{"key":"key20180107230206_b40-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/nm1672","article-title":"PPAR-gamma regulates osteoclastogenesis in mice","volume":"13","author":"Wan","year":"2007","journal-title":"Nat Med"},{"key":"key20180107230206_b41-ijmm-32-06-1355","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1196\/annals.1346.015","article-title":"Canonical Wnt signaling in osteoblasts is required for osteoclast differentiation","volume":"1068","author":"Glass","year":"2006","journal-title":"Ann N Y Acad Sci"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2013.1507\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T18:14:40Z","timestamp":1515348880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2013.1507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,25]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,9,25]]},"published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.3892\/ijmm.2013.1507"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2013.1507","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,25]]}}}