{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:24:33Z","timestamp":1791141873534,"version":"4.1.0"},"reference-count":37,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.3892\/ijmm.2014.1783","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T08:20:56Z","timestamp":1400228456000},"page":"507-512","source":"Crossref","is-referenced-by-count":16,"title":["The large intracellular loop of ptch1 mediates the non-canonical Hedgehog pathway through cyclin B1 in nevoid basal cell carcinoma syndrome"],"prefix":"10.3892","volume":"34","author":[{"given":"FEI-YAN","family":"YU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YING-YING","family":"HONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIA-FEI","family":"QU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FENG","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TIE-JUN","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2014,5,16]]},"reference":[{"key":"key20180107231047_b1-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1056\/NEJM196005052621803","article-title":"Multiple nevoid basal-cell epithelioma, jaw cysts and bifid rib: a syndrome","volume":"262","author":"Gorlin","year":"1960","journal-title":"N Engl J Med"},{"key":"key20180107231047_b2-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/00005792-198703000-00002","article-title":"Nevoid basal-cell carcinoma syndrome","volume":"66","author":"Gorlin","year":"1987","journal-title":"Medicine (Baltimore)"},{"key":"key20180107231047_b3-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0733-8635(18)30114-1","article-title":"Nevoid basal-cell carcinoma syndrome","volume":"13","author":"Gorlin","year":"1995","journal-title":"Dermatol Clin"},{"key":"key20180107231047_b4-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1750-1172-3-32","article-title":"Nevoid basal cell carcinoma syndrome (Gorlin syndrome)","volume":"3","author":"Lo Muzio","year":"2008","journal-title":"Orphanet J Rare Dis"},{"key":"key20180107231047_b5-ijmm-34-02-0507","first-page":"E338","article-title":"Gorlin-Goltz syndrome: clinicopathologic aspects","volume":"13","author":"Ortega Garc\u00eda de Amezaga","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"key20180107231047_b6-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"514","DOI":"10.4103\/0976-237X.107459","article-title":"Nevoid basal cell carcinoma syndrome (Gorlin-Goltz syndrome)","volume":"3","author":"Kiran","year":"2012","journal-title":"Contemp Clin Dent"},{"key":"key20180107231047_b7-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1177\/00220345000790061101","article-title":"PTCH gene mutations in odontogenic keratocysts","volume":"79","author":"Barreto","year":"2000","journal-title":"J Dent Res"},{"key":"key20180107231047_b8-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/humu.20296","article-title":"PTCH mutations: distribution and analyses","volume":"27","author":"Lindstr\u00f6m","year":"2006","journal-title":"Hum Mutat"},{"key":"key20180107231047_b9-ijmm-34-02-0507","first-page":"41","article-title":"PTCH gene mutations in odontogenic keratocysts","volume":"41","author":"Yuan","year":"2006","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"key20180107231047_b10-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1601-0825.2007.01369.x","article-title":"PTCH germline mutations in Chinese nevoid basal cell carcinoma syndrome patients","volume":"14","author":"Li","year":"2008","journal-title":"Oral Dis"},{"key":"key20180107231047_b11-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4248\/ijos.08013","article-title":"Identification of known and novel PTCH mutations in both syndromic and non-syndromic keratocystic odontogenic tumors","volume":"1","author":"Pan","year":"2009","journal-title":"Int J Oral Sci"},{"key":"key20180107231047_b12-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"12125","DOI":"10.1074\/jbc.271.21.12125","article-title":"A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities","volume":"271","author":"Hahn","year":"1996","journal-title":"J Biol Chem"},{"key":"key20180107231047_b13-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.272.5268.1668","article-title":"Human homolog of patched, a candidate gene for the basal cell nevus syndrome","volume":"272","author":"Johnson","year":"1996","journal-title":"Science"},{"key":"key20180107231047_b14-ijmm-34-02-0507","first-page":"21","article-title":"Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident","volume":"60","author":"Wicking","year":"1997","journal-title":"Am J Hum Genet"},{"key":"key20180107231047_b15-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/384129a0","article-title":"The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog","volume":"384","author":"Stone","year":"1996","journal-title":"Nature"},{"key":"key20180107231047_b16-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.cellsig.2009.01.033","article-title":"Hedgehog signalling: emerging evidence for non-canonical pathways","volume":"21","author":"Jenkins","year":"2009","journal-title":"Cell Signal"},{"key":"key20180107231047_b17-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"e77305","DOI":"10.1371\/journal.pone.0077305","article-title":"PTCH1 gene mutations in keratocystic odontogenic tumors: a study of 43 Chinese patients and a systematic review","volume":"8","author":"Guo","year":"2013","journal-title":"PLoS ONE"},{"key":"key20180107231047_b18-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1177\/154405910808700616","article-title":"PTCH1 and SMO gene alterations in keratocystic odontogenic tumors","volume":"87","author":"Sun","year":"2008","journal-title":"J Dent Res"},{"key":"key20180107231047_b19-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1158\/1078-0432.CCR-09-2574","article-title":"Mechanisms of inactivation of PTCH1 gene in nevoid basal cell carcinoma syndrome: modification of the two-hit hypothesis","volume":"16","author":"Pan","year":"2010","journal-title":"Clin Cancer Res"},{"key":"key20180107231047_b20-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/0022034510379016","article-title":"Odontogenic keratocyst: A cyst, or a cystic neoplasm?","volume":"90","author":"Li","year":"2011","journal-title":"J Dent Res"},{"key":"key20180107231047_b21-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0092-8674(00)00129-X","article-title":"Transducing the hedgehog signal","volume":"103","author":"Kalderon","year":"2000","journal-title":"Cell"},{"key":"key20180107231047_b22-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1158\/1078-0432.CCR-06-1736","article-title":"The hedgehog signaling pathway in cancer","volume":"12","author":"Evangelista","year":"2006","journal-title":"Clin Cancer Res"},{"key":"key20180107231047_b23-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/344503a0","article-title":"Universal control mechanism regulating onset of M-phase","volume":"344","author":"Nurse","year":"1990","journal-title":"Nature"},{"key":"key20180107231047_b24-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1002\/j.1460-2075.1991.tb04895.x","article-title":"cdc2 phosphorylation is required for its interaction with cyclin","volume":"10","author":"Ducommun","year":"1991","journal-title":"EMBO J"},{"key":"key20180107231047_b25-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1083\/jcb.113.3.485","article-title":"Expression of chickenlamin B2 in Escherichia coli: characterization of its structure, assembly, and molecular interactions","volume":"113","author":"Heitlinger","year":"1991","journal-title":"J Cell Biol"},{"key":"key20180107231047_b26-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1002\/j.1460-2075.1994.tb06688.x","article-title":"The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B","volume":"13","author":"Pines","year":"1994","journal-title":"EMBO J"},{"key":"key20180107231047_b27-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1091\/mbc.6.9.1111","article-title":"Requirement for phosphorylation of cyclin B1 for Xenopus oocyte maturation","volume":"6","author":"Li","year":"1995","journal-title":"Mol Biol Cell"},{"key":"key20180107231047_b28-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1073\/pnas.94.2.502","article-title":"Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation","volume":"94","author":"Li","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107231047_b29-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"11977","DOI":"10.1074\/jbc.274.17.11977","article-title":"Intra-M phase-promoting factor phosphorylation of cyclin B at the prophase\/metaphase transition","volume":"274","author":"Borgne","year":"1999","journal-title":"J Biol Chem"},{"key":"key20180107231047_b30-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0960-9822(99)80308-X","article-title":"Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal","volume":"9","author":"Hagting","year":"1999","journal-title":"Curr Biol"},{"key":"key20180107231047_b31-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1093\/emboj\/20.9.2214","article-title":"Patched1 interacts with cyclin B1 to regulate cell cycle progression","volume":"20","author":"Barnes","year":"2001","journal-title":"EMBO J"},{"key":"key20180107231047_b32-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/sj.onc.1208240","article-title":"Constitutive activation of the shh-ptc1 pathway by a patched1 mutation identified in BCC","volume":"24","author":"Barnes","year":"2005","journal-title":"Oncogene"},{"key":"key20180107231047_b33-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3835(01)00676-0","article-title":"The role of hedgehog signalling in tumorigenesis","volume":"173","author":"Wicking","year":"2001","journal-title":"Cancer Lett"},{"key":"key20180107231047_b34-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"313","DOI":"10.5858\/2004-128-313-MATDTO","article-title":"Molecular analysis to demonstrate that odontogenic keratocysts are neoplastic","volume":"128","author":"Agaram","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"key20180107231047_b35-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1054\/ijom.2003.0435","article-title":"Nevoid basal cell carcinoma syndrome: a review of the literature","volume":"33","author":"Manfredi","year":"2004","journal-title":"Int J Oral Maxillofac Surg"},{"key":"key20180107231047_b36-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","article-title":"Hedgehog signaling in animal development: paradigmsand principles","volume":"15","author":"Ingham","year":"2001","journal-title":"Genes Dev"},{"key":"key20180107231047_b37-ijmm-34-02-0507","doi-asserted-by":"crossref","first-page":"re6","DOI":"10.1126\/scisignal.2002906","article-title":"The Hedgehog signal transduction network","volume":"5","author":"Robbins","year":"2012","journal-title":"Sci Signal"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2014.1783\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T17:47:24Z","timestamp":1649008044000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2014.1783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,16]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,5,16]]},"published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.3892\/ijmm.2014.1783"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2014.1783","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,16]]}}}