{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:08:30Z","timestamp":1780362510972,"version":"3.54.1"},"reference-count":28,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.3892\/ijmm.2014.1816","type":"journal-article","created":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T10:26:23Z","timestamp":1403519183000},"page":"765-771","source":"Crossref","is-referenced-by-count":24,"title":["Methylation pattern of H19 exon 1 is closely related to preeclampsia and trophoblast abnormalities"],"prefix":"10.3892","volume":"34","author":[{"given":"LINSHAN","family":"LU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHENG","family":"HOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LI","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YANHONG","family":"YANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIAOHONG","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BEILEI","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MO","family":"REN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAN","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHUO","family":"MIAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LILI","family":"YU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUANQING","family":"YAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2014,6,23]]},"reference":[{"key":"key20180107230821_b1-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1172\/JCI200422991","article-title":"Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface","volume":"114","author":"Red-Horse","year":"2004","journal-title":"J Clin Invest"},{"key":"key20180107230821_b2-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ejogrb.2003.12.030","article-title":"Pathophysiology of preeclampsia: links with implantation disorders","volume":"115","author":"Merviel","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key20180107230821_b3-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1073\/pnas.81.17.5523","article-title":"Locus unlinked to alpha-fetoprotein under the control of the murine raf and Rif genes","volume":"81","author":"Pachnis","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107230821_b4-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/j.1460-2075.1988.tb02862.x","article-title":"The structure and expression of a novel gene activated in early mouse embryogenesis","volume":"7","author":"Pachnis","year":"1988","journal-title":"The EMBO J"},{"key":"key20180107230821_b5-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1128\/MCB.10.1.28","article-title":"The product of the H19 gene may function as an RNA","volume":"10","author":"Brannan","year":"1990","journal-title":"Mol Cell Biol"},{"key":"key20180107230821_b6-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1101\/gad.9.24.3097","article-title":"Allele-specific expression and total expression levels of imprinted genes during early mouse development: implications for imprinting mechanisms","volume":"9","author":"Szabo","year":"1995","journal-title":"Genes Dev"},{"key":"key20180107230821_b7-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/ncb2521","article-title":"The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r","volume":"14","author":"Keniry","year":"2012","journal-title":"Nat Cell Biol"},{"key":"key20180107230821_b8-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1242\/dev.113.4.1105","article-title":"The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo","volume":"113","author":"Poirier","year":"1991","journal-title":"Development"},{"key":"key20180107230821_b9-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/mrd.1080320303","article-title":"Transcription of the H19 gene in differentiating cytotrophoblasts from human placenta","volume":"32","author":"Rachmilewitz","year":"1992","journal-title":"Mol Reprod Dev"},{"key":"key20180107230821_b10-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2121-14-26","article-title":"Lentivirus-mediated RNA interference targeting the H19 gene inhibits cell proliferation and apoptosis in human choriocarcinoma cell line JAR","volume":"14","author":"Yu","year":"2013","journal-title":"BMC Cell Biol"},{"key":"key20180107230821_b11-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1101\/gad.6.5.705","article-title":"Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line","volume":"6","author":"Kafri","year":"1992","journal-title":"Genes Dev"},{"key":"key20180107230821_b12-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.placenta.2010.09.011","article-title":"Evaluating DNA methylation and gene expression variability in the human term placenta","volume":"31","author":"Avila","year":"2010","journal-title":"Placenta"},{"key":"key20180107230821_b13-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.placenta.2007.04.001","article-title":"The impact of 5-azacytidine on placental weight, glycoprotein pattern and proliferating cell nuclear antigen expression in rat placenta","volume":"28","author":"Serman","year":"2007","journal-title":"Placenta"},{"key":"key20180107230821_b14-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/hr.2011.9","article-title":"Detection of global DNA methylation and paternally imprinted H19 gene methylation in preeclamptic placentas","volume":"34","author":"Gao","year":"2011","journal-title":"Hypertens Res"},{"key":"key20180107230821_b15-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1101\/gad.7.9.1663","article-title":"Epigenetic mechanisms underlying the imprinting of the mouse H19 gene","volume":"7","author":"Bartolomei","year":"1993","journal-title":"Genes Dev"},{"key":"key20180107230821_b16-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/S0021-9258(19)68144-5","article-title":"Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2\u2032-deoxycytidine","volume":"257","author":"Creusot","year":"1982","journal-title":"J Biol Chem"},{"key":"key20180107230821_b17-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.mam.2012.12.008","article-title":"Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia","volume":"34","author":"Ji","year":"2013","journal-title":"Mol Aspects Med"},{"key":"key20180107230821_b18-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S1470-2045(03)01245-2","article-title":"Epidemiology and aetiology of gestational trophoblastic diseases","volume":"4","author":"Altieri","year":"2003","journal-title":"Lancet Oncol"},{"key":"key20180107230821_b19-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/14647270400006911","article-title":"Trophoblast invasion","volume":"7","author":"Anin","year":"2004","journal-title":"Hum Fertil (Camb)"},{"key":"key20180107230821_b20-ijmm-34-03-0765","first-page":"181","article-title":"Diagnosis and management of gestational hypertension and preeclampsia","volume":"102","author":"Sibai","year":"2003","journal-title":"Obstet Gynecol"},{"key":"key20180107230821_b21-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.placenta.2009.12.003","article-title":"Decreased placental methylation at the H19\/IGF2 imprinting control region is associated with normotensive intrauterine growth restriction but not preeclampsia","volume":"31","author":"Bourque","year":"2010","journal-title":"Placenta"},{"key":"key20180107230821_b22-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"e51210","DOI":"10.1371\/journal.pone.0051210","article-title":"Quantitative allele-specific expression and DNA methylation analysis of H19, IGF2 and IGF2R in the human placenta across gestation reveals H19 imprinting plasticity","volume":"7","author":"Buckberry","year":"2012","journal-title":"PLoS One"},{"key":"key20180107230821_b23-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/ejhg.2010.63","article-title":"DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia","volume":"18","author":"Yuen","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"key20180107230821_b24-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.placenta.2009.02.011","article-title":"The H19 gene imprinting in normal pregnancy and pre-eclampsia","volume":"30","author":"Yu","year":"2009","journal-title":"Placenta"},{"key":"key20180107230821_b25-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1126\/science.1063852","article-title":"The role of DNA methylation in mammalian epigenetics","volume":"293","author":"Jones","year":"2001","journal-title":"Science"},{"key":"key20180107230821_b26-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0888-7543(92)90024-M","article-title":"CpG islands as gene markers in the human genome","volume":"13","author":"Larsen","year":"1992","journal-title":"Genomics"},{"key":"key20180107230821_b27-ijmm-34-03-0765","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ng.168","article-title":"Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians","volume":"40","author":"Smits","year":"2008","journal-title":"Nat Genet"},{"key":"key20180107230821_b28-ijmm-34-03-0765","first-page":"1111","article-title":"Paternally derived H19 is differentially expressed in malignant and nonmalignant trophoblast","volume":"55","author":"Walsh","year":"1995","journal-title":"Cancer Res"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2014.1816\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T02:49:14Z","timestamp":1649472554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2014.1816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,23]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,6,23]]},"published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.3892\/ijmm.2014.1816"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2014.1816","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,23]]}}}