{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:13:19Z","timestamp":1790741599080,"version":"4.1.0"},"reference-count":36,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.3892\/ijmm.2014.1895","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T12:58:40Z","timestamp":1407848320000},"page":"1195-1200","source":"Crossref","is-referenced-by-count":21,"title":["Elucidating the role of DEPTOR in Alzheimer\u2019s disease"],"prefix":"10.3892","volume":"34","author":[{"given":"JULIE","family":"DAVIES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ELENA","family":"ZACHARIADES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KARLY-RAI","family":"ROGERS-BROADWAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EMMANOUIL","family":"KARTERIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2014,8,12]]},"reference":[{"key":"key20180107231005_b1-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1111\/j.1582-4934.2008.00509.x","article-title":"mTOR-dependent signalling in Alzheimer\u2019s disease","volume":"12","author":"Pei","year":"2008","journal-title":"J Cell Mol Med"},{"key":"key20180107231005_b2-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","article-title":"Alzheimer\u2019s disease","volume":"368","author":"Blennow","year":"2006","journal-title":"Lancet"},{"key":"key20180107231005_b3-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/369756a0","article-title":"A mammalian protein targeted by G1-arresting rapamycin-receptor complex","volume":"369","author":"Brown","year":"1994","journal-title":"Nature"},{"key":"key20180107231005_b4-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1126\/science.1063518","article-title":"Mammalian TOR: a homeostatic ATP sensor","volume":"294","author":"Dennis","year":"2001","journal-title":"Science"},{"key":"key20180107231005_b5-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","article-title":"TOR signaling in growth and metabolism","volume":"124","author":"Wullschleger","year":"2006","journal-title":"Cell"},{"key":"key20180107231005_b6-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tins.2009.11.003","article-title":"mTOR signaling: at the crossroads of plasticity, memory and disease","volume":"2","author":"Hoeffer","year":"2010","journal-title":"Trends Neurosci"},{"key":"key20180107231005_b7-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cell.2006.09.014","article-title":"Dendritic protein synthesis, synaptic plasticity, and memory","volume":"127","author":"Sutton","year":"2006","journal-title":"Cell"},{"key":"key20180107231005_b8-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nature08221","article-title":"Rapamycin fed late in life extends lifespan in genetically heterogeneous mice","volume":"460","author":"Harrison","year":"2009","journal-title":"Nature"},{"key":"key20180107231005_b9-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1126\/science.1177221","article-title":"Ribosomal protein S6 kinase 1 signaling regulates mammalian life span","volume":"326","author":"Selman","year":"2009","journal-title":"Science"},{"key":"key20180107231005_b10-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1523\/JNEUROSCI.0800-08.2008","article-title":"Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer\u2019s disease","volume":"28","author":"Boland","year":"2008","journal-title":"J Neurosci"},{"key":"key20180107231005_b11-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1471-4159.2005.03187.x","article-title":"mTOR\/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer\u2019s disease","volume":"94","author":"Lafay-Chebassier","year":"2005","journal-title":"J Neurochem"},{"key":"key20180107231005_b12-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"e9979","DOI":"10.1371\/journal.pone.0009979","article-title":"Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer\u2019s disease","volume":"5","author":"Spilman","year":"2010","journal-title":"PLoS One"},{"key":"key20180107231005_b13-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"e12845","DOI":"10.1371\/journal.pone.0012845","article-title":"Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer\u2019s disease","volume":"5","author":"Ma","year":"2010","journal-title":"PLoS One"},{"key":"key20180107231005_b14-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2009.03.046","article-title":"DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival","volume":"137","author":"Peterson","year":"2009","journal-title":"Cell"},{"key":"key20180107231005_b15-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/jmcb\/mjp012","article-title":"Dynamic balancing: DEPTOR tips the scales","volume":"1","author":"Proud","year":"2009","journal-title":"J Mol Cell Biol"},{"key":"key20180107231005_b16-ijmm-34-05-1195","first-page":"3529","article-title":"Differential expression of mTOR signalling components in drug resistance in ovarian cancer","volume":"30","author":"Foster","year":"2010","journal-title":"Anticancer Res"},{"key":"key20180107231005_b17-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"36387","DOI":"10.1074\/jbc.M110.169284","article-title":"Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR","volume":"285","author":"Liu","year":"2010","journal-title":"J Biol Chem"},{"key":"key20180107231005_b18-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"349","DOI":"10.33588\/rn.5406.2011611","article-title":"Resveratrol: a neuroprotective polyphenol in the Mediterranean diet","volume":"54","author":"Lopez-Miranda","year":"2012","journal-title":"Rev Neurol"},{"key":"key20180107231005_b19-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2012.02.019","article-title":"Resveratrol attenuates brain damage in a rat model of focal cerebral ischemia via up-regulation of hippocampal Bcl-2","volume":"1450","author":"Li","year":"2012","journal-title":"Brain Res"},{"key":"key20180107231005_b20-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"e29102","DOI":"10.1371\/journal.pone.0029102","article-title":"Resveratrol protects rats from Abeta-induced neurotoxicity by the reduction of iNOS expression and lipid peroxidation","volume":"6","author":"Huang","year":"2011","journal-title":"PLoS One"},{"key":"key20180107231005_b21-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1042\/CS20110378","article-title":"Placental DEPTOR as a stress sensor during pregnancy","volume":"122","author":"Mparmpakas","year":"2012","journal-title":"Clin Sci (Lond)"},{"key":"key20180107231005_b22-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1097\/00001756-200410050-00019","article-title":"Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain","volume":"15","author":"Li","year":"2004","journal-title":"Neuroreport"},{"key":"key20180107231005_b23-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1001\/archneur.65.7.906","article-title":"Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study","volume":"65","author":"Steinerman","year":"2008","journal-title":"Arch Neurol"},{"key":"key20180107231005_b24-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1074\/jbc.271.8.4077","article-title":"Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains","volume":"271","author":"Kuo","year":"1996","journal-title":"J Biol Chem"},{"key":"key20180107231005_b25-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/exnr.1999.7085","article-title":"The levels of soluble versus insoluble brain Abeta distinguish Alzheimer\u2019s disease from normal and pathologic aging","volume":"158","author":"Wang","year":"1999","journal-title":"Exp Neurol"},{"key":"key20180107231005_b26-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/1756-0500-6-366","article-title":"Optimising parameters for the differentiation of SH-SY5Y cells to study cell adhesion and cell migration","volume":"6","author":"Dwane","year":"2013","journal-title":"BMC Res Notes"},{"key":"key20180107231005_b27-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/brain\/awm260","article-title":"The beta-amyloid protein of Alzheimer\u2019s disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism","volume":"131","author":"Petratos","year":"2008","journal-title":"Brain"},{"key":"key20180107231005_b28-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"7357","DOI":"10.1074\/jbc.M512218200","article-title":"A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1","volume":"281","author":"Bachmann","year":"2006","journal-title":"J Biol Chem"},{"key":"key20180107231005_b29-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.neuroimage.2014.05.027","article-title":"Sleep deficits in mild cognitive impairment are associated with increased plasma amyloid-beta levels and cortical thinning","volume":"98","author":"Sanchez-Espinosa","year":"2014","journal-title":"Neuroimage"},{"issue":"Suppl 3","key":"key20180107231005_b30-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"S263","DOI":"10.3233\/JAD-2011-0040","article-title":"Mapping the structural brain changes in Alzheimer\u2019s disease: The independent contribution of two imaging modalities","volume":"26","author":"Canu","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"key20180107231005_b31-ijmm-34-05-1195","first-page":"339","article-title":"Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease","volume":"10","author":"Banno","year":"2014","journal-title":"Neuropsychiatr Dis Treat"},{"key":"key20180107231005_b32-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/brain\/awp295","article-title":"Neural correlates of psychotic symptoms in dementia with Lewy bodies","volume":"133","author":"Nagahama","year":"2010","journal-title":"Brain"},{"key":"key20180107231005_b33-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2147\/CIA.S51571","article-title":"The genetics of Alzheimer\u2019s disease","volume":"9","author":"Bagyinszky","year":"2014","journal-title":"Clin Interv Aging"},{"key":"key20180107231005_b34-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.pnpbp.2010.12.019","article-title":"Unraveling the biological mechanisms in Alzheimer\u2019s disease - lessons from genomics","volume":"35","author":"Borovecki","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"key20180107231005_b35-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"8924","DOI":"10.1074\/jbc.M110.180638","article-title":"Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism","volume":"286","author":"Caccamo","year":"2011","journal-title":"J Biol Chem"},{"key":"key20180107231005_b36-ijmm-34-05-1195","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/jnr.23011","article-title":"Mammalian target of rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer\u2019s disease?","volume":"90","author":"Cai","year":"2012","journal-title":"J Neurosci Res"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2014.1895\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T04:33:39Z","timestamp":1746333219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2014.1895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,12]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,8,12]]},"published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.3892\/ijmm.2014.1895"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2014.1895","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,12]]}}}