{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:47:24Z","timestamp":1773161244027,"version":"3.50.1"},"reference-count":32,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.3892\/ijmm.2014.1920","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T19:18:31Z","timestamp":1409858311000},"page":"1277-1285","source":"Crossref","is-referenced-by-count":30,"title":["Homocysteine reduces protein S-nitrosylation in endothelium"],"prefix":"10.3892","volume":"34","author":[{"given":"YULONG","family":"CHEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SIHAI","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YANLI","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YAFENG","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LIANG","family":"BAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RUIHAN","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIANGLIN","family":"FAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ENQI","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2014,9,4]]},"reference":[{"key":"key20180107231039_b1-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.cardiores.2007.03.016","article-title":"Signalling by NO-induced protein S-nitrosylation and S-glutathionylation: convergences and divergences","volume":"75","author":"Mart\u00ednez-Ruiz","year":"2007","journal-title":"Cardiovasc Res"},{"key":"key20180107231039_b2-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1161\/CIRCRESAHA.109.207381","article-title":"S-nitrosylation in cardiovascular signaling","volume":"106","author":"Lima","year":"2010","journal-title":"Circ Res"},{"key":"key20180107231039_b3-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/cvr\/cvp368","article-title":"17beta-Estradiol induces protein S-nitrosylation in the endothelium","volume":"85","author":"Chakrabarti","year":"2010","journal-title":"Cardiovasc Res"},{"key":"key20180107231039_b4-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1161\/01.RES.0000202707.79018.0a","article-title":"Hypercontractile female hearts exhibit increased S-nitrosylation of the L-type Ca2t channel alpha1 subunit and reduced ischemia\/reperfusion injury","volume":"98","author":"Sun","year":"2006","journal-title":"Circ Res"},{"key":"key20180107231039_b5-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cardiores.2007.03.030","article-title":"Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells","volume":"75","author":"Selemidis","year":"2007","journal-title":"Cardiovasc Res"},{"key":"key20180107231039_b6-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1242\/jcs.03361","article-title":"Nitric oxide promotes endothelial cell survival signaling through S-nitrosylation and activation of dynamin-2","volume":"120","author":"Kang-Decker","year":"2007","journal-title":"J Cell Sci"},{"key":"key20180107231039_b7-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1021\/bi002239y","article-title":"Inhibition of NF-kappa B by S-nitrosylation","volume":"40","author":"Marshall","year":"2001","journal-title":"Biochemistry"},{"key":"key20180107231039_b8-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"41383","DOI":"10.1074\/jbc.M107566200","article-title":"TNFalpha and oxLDL reduce protein S-nitrosylation in endothelial cells","volume":"276","author":"Hoffmann","year":"2001","journal-title":"J Biol Chem"},{"key":"key20180107231039_b9-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.2337\/db06-1294","article-title":"High glucose attenuates protein S-nitrosylation in endothelial cells: role of oxidative stress","volume":"58","author":"Wadham","year":"2007","journal-title":"Diabetes"},{"key":"key20180107231039_b10-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-5793(03)00917-7","article-title":"Shear stress increases the amount of S-nitrosylated molecules in endothelial cells: important role for signal transduction","volume":"551","author":"Hoffmann","year":"2003","journal-title":"FEBS Lett"},{"key":"key20180107231039_b11-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.bbrc.2008.10.144","article-title":"Acute hypoxia enhances proteins\u2019 S-nitrosylation in endothelial cells","volume":"377","author":"Chen","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107231039_b12-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(98)11058-9","article-title":"Homocysteine and vascular disease","volume":"354","author":"Hankey","year":"1999","journal-title":"Lancet"},{"key":"key20180107231039_b13-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1161\/CIRCULATIONAHA.106.652693","article-title":"Hyperhomocysteinemia alters cardiac substrate metabolism by impairing nitric oxide bioavailability through oxidative stress","volume":"115","author":"Suematsu","year":"2007","journal-title":"Circulation"},{"key":"key20180107231039_b14-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/01.ATV.20.5.1203","article-title":"Simultaneously increased TxA(2) activity in isolated arterioles and platelets of rats with hyperhomocysteinemia","volume":"20","author":"Ungvari","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20180107231039_b15-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.freeradbiomed.2008.09.034","article-title":"Detection of protein S-nitrosylation with the biotin-switch technique","volume":"46","author":"Forrester","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"key20180107231039_b16-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1161\/ATVBAHA.108.164368","article-title":"Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells","volume":"28","author":"Ota","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20180107231039_b17-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.atherosclerosis.2010.12.007","article-title":"The double-faced metabolic and inflammatory effects of standard drug therapy in patients after percutaneous treatment with drug-eluting stent","volume":"215","author":"Wu","year":"2011","journal-title":"Atherosclerosis"},{"key":"key20180107231039_b18-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.yjmcc.2006.05.004","article-title":"Cigarette smoke exposure impairs VEGF-induced endothelial cell migration: role of NO and reactive oxygen species","volume":"41","author":"Michaud","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"key20180107231039_b19-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bcp.2011.04.001","article-title":"Ginsenoside Rb1 prevents homocysteine-induced endothelial dysfunction via PI3K\/Akt activation and PKC inhibition","volume":"82","author":"Lan","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"key20180107231039_b20-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.molcel.2010.07.013","article-title":"S-nitrosylation of beta-catenin by eNOS-derived NO promotes VEGF-induced endothelial cell permeability","volume":"39","author":"Thibeault","year":"2010","journal-title":"Mol Cell"},{"key":"key20180107231039_b21-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1073\/pnas.0809568106","article-title":"SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration","volume":"106","author":"Pi","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107231039_b22-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.niox.2008.02.001","article-title":"The low molecular weight S-nitrosothiol, S-nitroso-N-acetylpenicillamine, promotes cell cycle progression in rabbit aortic endothelial cells","volume":"18","author":"Oliveira","year":"2008","journal-title":"Nitric Oxide"},{"key":"key20180107231039_b23-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/CIRCRESAHA.109.215228","article-title":"Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases invascular stiffness","volume":"107","author":"Santhanam","year":"2010","journal-title":"Circ Res"},{"key":"key20180107231039_b24-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.abb.2003.12.006","article-title":"Detection and proteomic identification of S-nitrosylated proteins in endothelial cells","volume":"423","author":"Mart\u00ednez-Ruiz","year":"2004","journal-title":"Arch Biochem Biophys"},{"key":"key20180107231039_b25-ijmm-34-05-1277","first-page":"219","article-title":"Chemical pathology of homocysteine. IV Excitotoxicity, oxidative stress, endothelial dysfunction, and inflammation","volume":"39","author":"McCully","year":"2009","journal-title":"Ann Clin Lab Sci"},{"key":"key20180107231039_b26-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1161\/01.CIR.103.16.2102","article-title":"Oxidized LDL inhibits vascular endothelial growth factor-induced endothelial cell migration by an inhibitory effect on the Akt\/endothelial nitric oxide synthase pathway","volume":"103","author":"Chavakis","year":"2001","journal-title":"Circulation"},{"key":"key20180107231039_b27-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","article-title":"Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation","volume":"399","author":"Dimmeler","year":"1999","journal-title":"Nature"},{"key":"key20180107231039_b28-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"H2344","DOI":"10.1152\/ajpheart.00432.2007","article-title":"Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants","volume":"293","author":"Carluccio","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key20180107231039_b29-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/01.RES.0000108264.67601.2C","article-title":"Hyperhomocysteinemia activates nuclear factor-kappaB in endothelial cells via oxidative stress","volume":"94","author":"Au-Yeung","year":"2004","journal-title":"Circ Res"},{"key":"key20180107231039_b30-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"30667","DOI":"10.1074\/jbc.M705929200","article-title":"NOS2 regulation of NF-kappaB by S-nitrosylation of p65","volume":"282","author":"Kelleher","year":"2007","journal-title":"J Biol Chem"},{"key":"key20180107231039_b31-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"8841","DOI":"10.1073\/pnas.0403034101","article-title":"S-nitrosylation: physiological regulation of NF-kappaB","volume":"101","author":"Marshall","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107231039_b32-ijmm-34-05-1277","doi-asserted-by":"crossref","first-page":"8945","DOI":"10.1073\/pnas.0400588101","article-title":"Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation","volume":"101","author":"Reynaert","year":"2004","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2014.1920\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T23:26:57Z","timestamp":1515367617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2014.1920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,4]]},"references-count":32,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,9,4]]},"published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.3892\/ijmm.2014.1920"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2014.1920","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,4]]}}}