{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:05:52Z","timestamp":1777676752861,"version":"3.51.4"},"reference-count":29,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.3892\/ijmm.2014.1953","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T09:29:32Z","timestamp":1412069372000},"page":"1622-1628","source":"Crossref","is-referenced-by-count":17,"title":["Mutant hypoxia-inducible factor 1\u03b1 modified bone marrow mesenchymal stem cells ameliorate cerebral ischemia"],"prefix":"10.3892","volume":"34","author":[{"given":"CHUNYU","family":"YANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HUA","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DANPING","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2014,9,30]]},"reference":[{"key":"key20180107231328_b1-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrd1199","article-title":"HIF-1 as a target for drug development","volume":"2","author":"Giaccia","year":"2003","journal-title":"Nat Rev Drug Discov"},{"key":"key20180107231328_b2-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/sj.gt.3301969","article-title":"Gene therapy progress and prospects: therapeutic angiogenesis for limb and myocardial ischemia","volume":"10","author":"Khan","year":"2003","journal-title":"Gene Ther"},{"key":"key20180107231328_b3-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.drudis.2007.08.006","article-title":"Evaluation of HIF-1 inhibitors as anticancer agents","volume":"12","author":"Semenza","year":"2007","journal-title":"Drug Discov Today"},{"key":"key20180107231328_b4-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1073\/pnas.0708474105","article-title":"Activation of the hypoxia-inducible factor-1\u03b1 pathway accelerates bone regeneration","volume":"105","author":"Wan","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107231328_b5-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm0603-677","article-title":"Regulation of angiogenesis by hypoxia: role of the HIF system","volume":"9","author":"Pugh","year":"2003","journal-title":"Nat Med"},{"key":"key20180107231328_b6-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.molcel.2010.09.022","article-title":"Hypoxia-inducible factors and the response to hypoxic stress","volume":"40","author":"Majmundar","year":"2010","journal-title":"Mol Cell"},{"key":"key20180107231328_b7-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension","volume":"92","author":"Wang","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107231328_b8-ijmm-34-06-1622","first-page":"785","article-title":"HIF1-positive and HIF1-negative glioblastoma cells compete in vitro but cooperate in tumor growth in vivo","volume":"36","author":"Fiorenzo","year":"2010","journal-title":"Int J Oncol"},{"key":"key20180107231328_b9-ijmm-34-06-1622","first-page":"699","article-title":"Erythropoietin receptors in endometrial carcinoma as related to HIF1\u03b1 and VEGF expression","volume":"23","author":"Giatromanolaki","year":"2009","journal-title":"In vivo"},{"key":"key20180107231328_b10-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/cvr\/cvq045","article-title":"Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling","volume":"86","author":"Rey","year":"2010","journal-title":"Cardiovasc Res"},{"key":"key20180107231328_b11-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1126\/science.1066373","article-title":"A conserved family of prolyl-4-hydroxylases that modify HIF","volume":"294","author":"Bruick","year":"2001","journal-title":"Science"},{"key":"key20180107231328_b12-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","article-title":"Control of T(H)17\/T(reg) balance by hypoxia-inducible factor 1","volume":"146","author":"Dang","year":"2011","journal-title":"Cell"},{"key":"key20180107231328_b13-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1161\/ATVBAHA.110.215038","article-title":"Hypoxia and upregulation of hypoxia-inducible factor 1\u03b1 stimulate venous thrombus recanalization","volume":"30","author":"Evans","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20180107231328_b14-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1095\/biolreprod.109.076117","article-title":"Estrogen rapidly activates the PI3K\/AKT pathway and hypoxia-inducible factor 1 and induces vascular endothelial growth factor A expression in luminal epithelial cells of the rat uterus","volume":"81","author":"Kazi","year":"2009","journal-title":"Biol Reprod"},{"key":"key20180107231328_b15-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.1068592","article-title":"Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch","volume":"295","author":"Lando","year":"2002","journal-title":"Science"},{"key":"key20180107231328_b16-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/01.WCB.0000110532.48786.46","article-title":"Identification of potential stroke targets by lentiviral vector mediated overexpression of HIF-1\u03b1 and HIF-2\u03b1 in a primary neuronal model of hypoxia","volume":"24","author":"Ralph","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"key":"key20180107231328_b17-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"key20180107231328_b18-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1479-5876-9-105","article-title":"Effects of transplantation with bone marrow-derived mesenchymal stem cells modified by Survivin on experimental stroke in rats","volume":"9","author":"Liu","year":"2011","journal-title":"J Transl Med"},{"key":"key20180107231328_b19-ijmm-34-06-1622","first-page":"Doc09","article-title":"Experimental treatment of stroke in spontaneously hypertensive rats by CD34+ and CD34\u2212 cord blood cells","volume":"3","author":"Boltze","year":"2005","journal-title":"Ger Med Sci"},{"key":"key20180107231328_b20-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1161\/01.STR.31.8.1965","article-title":"Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation","volume":"31","author":"Neumann-Haefelin","year":"2000","journal-title":"Stroke"},{"key":"key20180107231328_b21-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199101033240101","article-title":"Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma","volume":"324","author":"Weidner","year":"1991","journal-title":"N Engl J Med"},{"key":"key20180107231328_b22-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1523\/JNEUROSCI.4297-09.2010","article-title":"Serine racemase deletion protects against cerebral ischemia and excitotoxicity","volume":"30","author":"Mustafa","year":"2010","journal-title":"J Neurosci"},{"key":"key20180107231328_b23-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11011-012-9359-x","article-title":"Localizing coordinates of cerebral ischemic tissue without the need of staining in a rat model of focal cerebral infarct","volume":"28","author":"Ruiz-Crespo","year":"2013","journal-title":"Metab Brain Dis"},{"key":"key20180107231328_b24-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.brainres.2008.08.053","article-title":"Motoneuronotrophic factor analog GM6 reduces infarct volume and behavioral deficits following transient ischemia in the mouse","volume":"1238","author":"Yu","year":"2008","journal-title":"Brain Res"},{"key":"key20180107231328_b25-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1101\/gad.914801","article-title":"Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1\u03b1","volume":"15","author":"Elson","year":"2001","journal-title":"Genes Dev"},{"key":"key20180107231328_b26-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"161ra150","DOI":"10.1126\/scitranslmed.3004660","article-title":"Mesenchymal stem cells regulate blood-brain barrier integrity through TIMP3 release after traumatic brain injury","volume":"4","author":"Menge","year":"2012","journal-title":"Sci Transl Med"},{"key":"key20180107231328_b27-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1089\/scd.2010.0013","article-title":"Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin\/\u03b2-catenin signaling","volume":"20","author":"Pati","year":"2011","journal-title":"Stem Cells Dev"},{"key":"key20180107231328_b28-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1161\/01.STR.0000144051.32131.09","article-title":"Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption","volume":"35","author":"Warach","year":"2004","journal-title":"Stroke"},{"key":"key20180107231328_b29-ijmm-34-06-1622","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/sj.jcbfm.9600475","article-title":"Angiopoietin1\/Tie2 and VEGF\/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke","volume":"27","author":"Zacharek","year":"2007","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2014.1953\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T23:30:34Z","timestamp":1515367834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2014.1953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,30]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,9,30]]},"published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.3892\/ijmm.2014.1953"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2014.1953","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,30]]}}}